Placental C4d deposition is a feature of defective placentation: Observations in cases of preeclampsia and miscarriage

Virchows Archiv

Volumn 466, Issue 6, 2015, Pages 717-725

  Kim, Eun Na ^a,d   Yoon, Bo Hyun ^b   Lee, Joong Yeup ^c   Hwang, Doyeong ^c   Kim, Ki Chul ^c   Lee, JoonHo ^b   Shim, Jae Yoon ^a,d   Kim, Chong Jai ^a,d  

^a University of Ulsan College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Hamchoon Women's Clinic   (South Korea)

^d Asan Medical Center   (South Korea)

Author keywords

Complement C4d; HLA antigen; Placenta; Preeclampsia; Spontaneous abortion

Indexed keywords

COMPLEMENT COMPONENT C4D; HLA ANTIBODY; COMPLEMENT C4; HLA ANTIGENS;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATIONAL STUDY; FEMALE; FETUS GROWTH; HLA SYSTEM; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MATERNAL PLASMA; NEWBORN; OBSERVATIONAL STUDY; PLACENTA FUNCTION; PREECLAMPSIA; PREMATURE LABOR; PRIORITY JOURNAL; REPRODUCTION; SPONTANEOUS ABORTION; SYNCYTIOTROPHOBLAST; ABORTION, SPONTANEOUS; FETAL GROWTH RETARDATION; HUMANS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PLACENTA; PLACENTA DISEASES; PLACENTATION; PRE-ECLAMPSIA; PREGNANCY; TISSUE ARRAY ANALYSIS;

ABORTION, SPONTANEOUS; ADULT; COMPLEMENT C4; FEMALE; FETAL GROWTH RETARDATION; HLA ANTIGENS; HUMANS; IMMUNOHISTOCHEMISTRY; PLACENTA; PLACENTA DISEASES; PLACENTATION; PRE-ECLAMPSIA; PREGNANCY; TISSUE ARRAY ANALYSIS;

EID: 84930765555     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-015-1759-y     Document Type: Article

References (42)

1. Racusen LC et al (2004) Banff 2003 meeting report: new diagnostic insights and standards. Am J Transplant 4(10):1562–1566
2. Djamali A et al (2014) Diagnosis and management of antibody-mediated rejection: current status and novel approaches. Am J Transplant 14(2):255–271
3. Kedainis RL et al (2009) Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival. Am J Transplant 9(4):812–819
4. Mauiyyedi S et al (2002) Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification. J Am Soc Nephrol 13(3):779–787
5. Lee JY et al (2014) Placental C4d as a common feature of chromosomally normal and abnormal miscarriages. Virchows Arch 464(5):613–620
6. Shamonki JM et al (2007) Excessive complement activation is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol 196(2):167 e161–165
7. Minamiguchi S et al (2013) Complement split product C4d deposition in placenta in systemic lupus erythematosus and pregnancy-induced hypertension. Pathol Int 63(3):150–157
8. Rudzinski E et al (2013) Positive C4d immunostaining of placental villous syncytiotrophoblasts supports host-versus-graft rejection in villitis of unknown etiology. Pediatr Dev Pathol 16(1):7–13
9. Buurma A et al (2012) Preeclampsia is characterized by placental complement dysregulation. Hypertension 60(5):1332–1337
10. Lee KA et al (2013) Distinct patterns of C4d immunoreactivity in placentas with villitis of unknown etiology, cytomegaloviral placentitis, and infarct. Placenta 34(5):432–435
11. Milne F et al (2005) The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community. BMJ 330(7491):576–580
12. Roberts JM, Cooper DW (2001) Pathogenesis and genetics of pre-eclampsia. Lancet 357(9249):53–56
13. Steegers EA et al (2010) Pre-eclampsia. Lancet 376(9741):631–644
14. Ghulmiyyah L, Sibai B (2012) Maternal mortality from preeclampsia/eclampsia. Semin Perinatol 36(1):56–59
15. Redman CW, Sargent IL (2010) Immunology of pre-eclampsia. Am J Reprod Immunol 63(6):534–543
16. Chaiworapongsa T et al (2013) Maternal plasma concentrations of angiogenic/antiangiogenic factors in the third trimester of pregnancy to identify the patient at risk for stillbirth at or near term and severe late preeclampsia. Am J Obstet Gynecol 208(4):287 e281–287 e215
17. Chaiworapongsa T et al (2014) Plasma concentrations of angiogenic/anti-angiogenic factors have prognostic value in women presenting with suspected preeclampsia to the obstetrical triage area: a prospective study. J Matern Fetal Neonatal Med 27(2):132–144
18. Vaisbuch E et al (2011) Circulating angiogenic and antiangiogenic factors in women with eclampsia. Am J Obstet Gynecol 204(2):152 e151–159
19. Brosens I et al (2011) The “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol 204(3):193–201
20. Brosens JJ et al (2002) The myometrial junctional zone spiral arteries in normal and abnormal pregnancies: a review of the literature. Am J Obstet Gynecol 187(5):1416–1423
21. Burton GJ et al (2009) Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta 30(6):473–482
22. Khong TY et al (1986) Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 93(10):1049–1059
23. Khong TY (2004) Placental vascular development and neonatal outcome. Semin Neonatol 9(4):255–263
24. Jauniaux E et al (2000) Onset of maternal arterial blood flow and placental oxidative stress. A possible factor in human early pregnancy failure. Am J Pathol 157(6):2111–2122
25. Burton GJ, Jauniaux E (2004) Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecol Investig 11(6):342–352
26. Becroft DM et al (2005) Placental villitis of unknown origin: epidemiologic associations. Am J Obstet Gynecol 192(1):264–271
27. Redline RW et al (2005) Placental diagnostic criteria and clinical correlation—a workshop report. Placenta 26(Suppl A):S114–S117
28. Redline RW (2008) Placental pathology: a systematic approach with clinical correlations. Placenta 29(Suppl A):S86–S91
29. Kim CJ et al (2010) The frequency, clinical significance, and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth. Mod Pathol 23(7):1000–1011
30. Lee J et al (2011) A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, anti-human leukocyte antigen antibodies, and C4d. PLoS One 6(2):e16806
31. (2000) Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 183(1):S1–S22
32. Fenton TR (2003) A new growth chart for preterm babies: Babson and Benda’s chart updated with recent data and a new format. BMC Pediatr 3:13
33. Girardi G et al (2006) Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med 203(9):2165–2175
34. Huppertz B (2008) Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 51(4):970–975
35. Burton GJ, Yung HW (2011) Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia. Pregnancy Hypertens 1(1–2):72–78
36. Frank R et al (2013) Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: a single-center, retrospective study. J Heart Lung Transplant 32(4):410–417
37. Loupy A et al (2013) Complement-binding anti-HLA antibodies and kidney-allograft survival. N Engl J Med 369(13):1215–1226
38. Dong J et al (1999) Strategies for targeting complement inhibitors in ischaemia/reperfusion injury. Mol Immunol 36(13–14):957–963
39. Weiser MR et al (1996) Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. J Exp Med 183(5):2343–2348
40. Hamer R et al (2012) Human leukocyte antigen-specific antibodies and gamma-interferon stimulate human microvascular and glomerular endothelial cells to produce complement factor C4. Transplantation 93(9):867–873
41. Bulla R et al (2009) Complement production by trophoblast cells at the feto-maternal interface. J Reprod Immunol 82(2):119–125
42. Jauniaux E, Burton GJ (2005) Pathophysiology of histological changes in early pregnancy loss. Placenta 26(2–3):114–123