Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: A single-center, retrospective study

Journal of Heart and Lung Transplantation

Volumn 32, Issue 4, 2013, Pages 410-417

  Frank, Renee ^a   Molina, Maria R ^b   Wald, Joyce W ^b   Goldberg, Lee R ^b   Kamoun, Malek ^a   Lal, Priti ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

AMR; C4d; CAV; DSA; graft failure; heart transplant; HLA

Indexed keywords

COMPLEMENT COMPONENT C4D; HLA ANTIBODY;

ACUTE GRAFT REJECTION; ADULT; AGED; ARTICLE; FEMALE; GRAFT DYSFUNCTION; GRAFT FAILURE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; COMPLEMENT C4B; FEMALE; HEART TRANSPLANTATION; HLA ANTIGENS; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; PEPTIDE FRAGMENTS; RETROSPECTIVE STUDIES; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84875123955     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2012.12.005     Document Type: Article

References (28)

1. S. Stewart, G.L. Winters, and M.C. Fishbein Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection J Heart Lung Transplant 24 2005 1710 1720
2. G.J. Berry, A. Angelini, and M.M. Burke The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011) J Heart Lung Transplant 30 2011 601 611
3. P.I. Terasaki, M. Ozawa, and R. Castro Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival Am J Transplant 7 2007 408 415
4. A.G. Kfoury, J. Stehlik, and D.G. Renlund Impact of repetitive episodes of antibody-mediated or cellular rejection on cardiovascular mortality in cardiac transplant recipients: defining rejection patterns J Heart Lung Transplant 25 2006 1277 1282
5. K. Shahzad, Q.A. Aziz, and J.P. Leva New-onset graft dysfunction after heart transplantation - incidence and mechanism-related outcomes J Heart Lung Transplant 30 2011 194 203
6. J.R. Braga, I.S. Santos, and M. McDonald Factors associated with the development of cardiac allograft vasculopathy - a systematic review of observational studies Clin Transplant 26 2012 E111 E124
7. W. Chen, C.J. Thoburn, and Y. Miura Autoimmune-mediated vasculopathy Clin Immunol 100 2001 57 70
8. S. de Denus, A. Al-Jazairi, and E. Loh Dyslipidemias and HMG-CoA reductase inhibitor prescription in heart transplant recipients Ann Pharmacother 38 2004 1136 1141
9. J. Kahn, P. Rehak, and M. Schweiger The impact of overweight on the development of diabetes after heart transplantation Clin Transplant 20 2006 62 66
10. K. McDonald, T.S. Rector, and E.A. Braulin Association of coronary artery disease in cardiac transplant recipients with cytomegalovirus infection Am J Cardiol 64 1989 359 362
11. M.R. Mehra, M.G. Crespo-Leiro, and A. Dipchand International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy - 2010 J Heart Lung Transplant 29 2010 717 727
12. M.E. Hammond, J. Stehlik, and G. Snow Utility of histologic parameters in screening for antibody-mediated rejection of the cardiac allograft: a study of 3,170 biopsies J Heart Lung Transplant 24 2005 2015 2021
13. M.P. Revelo, J. Stehlik, and D. Miller Antibody testing for cardiac antibody-mediated rejection: which panel correlates best with cardiovascular death? J Heart Lung Transplant 30 2011 144 150
14. E.R. Rodriguez, D.V. Skojec, and C.D. Tan Antibody-mediated rejection in human cardiac allografts: evaluation of immunoglobulins and complement activation products C4d and C3d as markers Am J Transplant 5 2005 2778 2785
15. C.D. Tan, G.G. Sokos, and D.J. Pidwell Correlation of donor-specific antibodies, complement and its regulators with graft dysfunction in cardiac antibody-mediated rejection Am J Transplant 9 2009 2075 2084
16. E.R. Vasilescu, E.K. Ho, and L. de la Torre Anti-HLA antibodies in heart transplantation Transpl Immunol 12 2004 177 183
17. R.B. Colvin, and R.N. Smith Antibody-mediated organ-allograft rejection Nat Rev Immunol 5 2005 807 817
18. A. Herskowitz, L.M. Soule, and K. Ueda Arteriolar vasculitis on endomyocardial biopsy: a histologic predictor of poor outcome in cyclosporine-treated heart transplant recipients J Heart Transplant 6 1987 127 136
19. E.H. Hammond, R.L. Yowell, and S. Nunoda Vascular (humoral) rejection in heart transplantation: pathologic observations and clinical implications J Heart Lung Transplant 8 1989 430 433
20. J. Kobashigawa, M.G. Crespo-Leiro, and S.M. Ensminger Report from a consensus conference on antibody-mediated rejection in heart transplantation J Heart Lung Transplant 30 2011 252 269
21. A.G. Kfoury, M.E. Hammond, and G.L. Snow Cardiovascular mortality among heart transplant recipients with asymptomatic antibody-mediated or stable mixed cellular and antibody-mediated rejection J Heart Lung Transplant 28 2009 781 784
22. G.W. Wu, J.A. Kobashigawa, and M.C. Fishbein Asymptomatic antibody-mediated rejection after heart transplantation predicts poor outcomes J Heart Lung Transplant 28 2009 417 422
23. S.K. Takemoto, A. Zeevi, and S. Feng National conference to assess antibody-mediated rejection in solid organ transplantation Am J Transplant 4 2004 1033 1041
24. W.M. Baldwin III, E.K. Kasper, and A.A. Zachary Beyond C4d: other complement-related diagnostic approaches to antibody-mediated rejection Am J Transplant 4 2004 311 318
25. C. Chin, G. Chen, and F. Sequeria Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients J Heart Lung Transplant 30 2011 158 163
26. M.S. Lee, W. Finch, and G. Weisz Cardiac allograft vasculopathy Rev Cardiovasc Med 12 2011 143 152
27. E.L. Moseley, C. Atkinson, and L.D. Sharples Deposition of C4d and C3d in cardiac transplants: a factor in the development of coronary artery vasculopathy J Heart Lung Transplant 29 2010 417 423
28. F. Tavora, R. Munivenkatappa, and J. Papadimitriou Endothelitis in cardiac allograft biopsy specimens: possible relationship to antibody-mediated rejection J Heart Lung Transplant 30 2011 435 444