Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival

American Journal of Transplantation

Volumn 9, Issue 4, 2009, Pages 812-819

  Kedainis, R L ^a   Koch, M J ^a   Brennan, D C ^a   Liapis, H ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

Acute rejection; Allograft; C4d; Diffuse; Donor specific antibodies; Focal; Kidney

Indexed keywords

COMPLEMENT COMPONENT C4D; CREATININE; HLA ANTIBODY;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE DURATION; FEMALE; GLOMERULOPATHY; GRAFT RECIPIENT; GRAFT SURVIVAL; HLA MATCHING; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; KIDNEY ALLOGRAFT; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY DYSFUNCTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEINURIA; SURVIVAL TIME;

ADULT; CADAVER; COMPLEMENT C4B; FEMALE; GRAFT SURVIVAL; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; LIVING DONORS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; REOPERATION; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; SURVIVORS; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 63649089731     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02555.x     Document Type: Article

References (29)

1. Colvin RB. Antibody-mediated renal allograft rejection: Diagnosis and pathogenesis. J Am Soc Nephrol 2007 18 : 1046 1056.
2. Solez K, Colvin RB, Racusen LC et al. Banff 07 classification of renal allograft pathology: Updates and future directions. Am J Transplant 2008 8 : 753 760.
3. Racusen LC, Colvin RB, Solez K et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003 3 : 708 714.
4. Racusen LC, Solez K, Colvin RB et al. The Banff 97 working classification of renal allograft pathology. Kidney Int 1999 55 : 713 723.
5. Mauiyyedi S, Crespo M, Collins AB et al. Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology and pathologic classification. J Am Soc Nephrol 2002 13 : 779 787.
6. Rotman S, Collins AB, Colvin RB. C4d detection in allografts: Current concepts and interpretation. Transplant Rev 2005 19 : 65 77.
7. Crespo M, Pascual M, Tolkoff-Rubin N et al. Acute humoral rejection in renal allograft recipients: I. Incidence, serology and clinical characteristics. Transplantation. 2001 15 : 71 : 652 658.
8. Haas M, Rahman MH, Racusen LC et al. C4d and C3d staining in biopsies of ABO- and HLA-incompatible renal allografts: Correlation with histologic findings. Am J Transplant 2006 6 : 1829 1840.
9. Poduval RD, Kadambi PV, Josephson MA et al. Implications of immunohistochemical detection of C4d along peritubular capillaries in late acute renal allograft rejection. Transplantation 2005 79 : 228 235.
10. Worthington JE, McEwen A, McWilliam LJ et al. Association between C4d staining in renal transplant biopsies, production of donor-specific HLA antibodies, and graft outcome. Transplantation 2007 83 : 398 404.
11. Magil AB, Tinckam KJ. Focal peritubular capillary C4d deposition in acute rejection. Nephrol Dial Transplant 2006 21 : 1382 1388.
12. Lorenz M, Regele H, Schillinger M et al. Risk factors for capillary C4d deposition in kidney allografts: Evaluation of a large study cohort. Transplantation 2004 15 : 78 : 447 452.
13. Ivanyi B. Transplant capillaropathy and transplant glomerulopathy: Ultrastructural markers of chronic renal allograft rejection. Nephrol Dial Transplant 2003 18 : 655 660.
14. Mihatsch MJ, Ryffel B, Gudat F. The differential diagnosis between rejection and cyclosporine toxicity. Kidney Int Suppl 1995 52 : S63 S69.
15. Charney DA, Nadasdy T, Lo AW, Racusen LC. Plasma cell-rich acute renal allograft rejection. Transplantation 1999 68 : 791 797.
16. Gibson IW, Gwinner W, Bröcker V et al. Peritubular capillaritis in renal allografts: Prevalence, scoring system, reproducibility and clinicopathological correlates. Am J Transplant 2008 8 : 819 825.
17. Watschinger B, Pascual M. Capillary C4d deposition as a marker of humoral immunity in renal allograft rejection. J Am Soc Nephrol 2002 13 : 2420 2423.
18. Böhmig GA, Exner M, Habicht A et al. Capillary C4d deposition in kidney allografts: A specific marker of alloantibody-dependent graft injury. J Am Soc Nephrol 2002 13 : 1091 1099.
19. Mengel M, Bogers J, Bosmans JL et al. ESPRIT group. Incidence of C4d stain in protocol biopsies from renal allografts: Results from a multicenter trial. Am J Transplant 2005 5 : 1050 1056.
20. Nickeleit V, Zeiler M, Gudat F et al. Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 2002 13 : 242 251.
21. Regele H, Böhmig GA, Habicht A et al. Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 2002 13 : 2371 2380.
22. Herzenberg AM, Gill JS, Djurdjev O, Magil AB. C4d deposition in acute rejection: An independent long-term prognostic factor. J Am Soc Nephrol 2002 13 : 234 241.
23. Kawamura N, Tomita M, Hasegawa M et al. Complement C4d deposition in transplanted kidneys: Preliminary report on long-term graft survival. Clin Transplant 2005 19 (Suppl 14 27 31.
24. Mauiyyedi S, Pelle PD, Saidman S et al. Chronic humoral rejection: Identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 2001 12 : 574 582.
25. David-Neto E, Prado E, Beutel A et al. C4d-positive chronic rejection: A frequent entity with a poor outcome. Transplantation 2007 84 : 1391 1398.
26. Vongwiwatana A, Gourishankar S, Campbell PM et al. Peritubular capillary changes and C4d deposits are associated with transplant glomerulopathy but not IgA nephropathy. Am J Transplant 2004 4 : 124 129.
27. Sijpkens YW, Joosten SA, Wong MC et al. Immunologic risk factors and glomerular C4d deposits in chronic transplant glomerulopathy. Kidney Int 2004 65 : 2409 2418.
28. Sis B, Campbell PM, Mueller T et al. Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause. Am J Transplant. 2007 7 : 1743 1752.
29. Regele H, Exner M, Watschinger B et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001 16 : 2058 2066.