Complement production by trophoblast cells at the feto-maternal interface

Journal of Reproductive Immunology

Volumn 82, Issue 2, 2009, Pages 119-125

  Bulla, Roberta ^a   Bossi, Fleur ^a   Agostinis, Chiara ^a   Radillo, Oriano ^b   Colombo, Francesca ^a   De Seta, Francesco ^a,c   Tedesco, Francesco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

^c DES MOINES UNIVERSITY   (United States)

Author keywords

Complement; Cytokines; Pregnancy; Trophoblast cells

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COMPLEMENT COMPONENT C6; GAMMA INTERFERON; INTERLEUKIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA; COMPLEMENT;

ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; FETOPLACENTAL UNIT; FIRST TRIMESTER PREGNANCY; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOMODULATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; TROPHOBLAST; UPREGULATION; BIOSYNTHESIS; CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETOMATERNAL TRANSFUSION; GENETICS; IMMUNITY; IMMUNOLOGY; METABOLISM; PATHOLOGY; PREGNANCY;

CELL LINE; COMPLEMENT SYSTEM PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNITY; INTERFERON-GAMMA; MATERNAL-FETAL EXCHANGE; PREGNANCY; PREGNANCY TRIMESTER, FIRST; TROPHOBLASTS;

EID: 77953416927     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2009.06.124     Document Type: Article

References (30)

1. Abrahams V.M., Visintin I., Aldo P.B., Guller S., Romero R., and Mor G. A role for TLRs in the regulation of immune cell migration by first trimester trophoblast cells. J. Immunol. 175 (2005) 8096-8104
2. Albieri A., Kipnis T., and Bevilacqua E. A possible role for activated complement component 3 in phagocytic activity exhibited by the mouse trophoblast. Am. J. Reprod. Immunol. 41 (1999) 343-352
3. Amarante-Paffaro A., Queiroz G.S., Correa S.T., Spira B., and Bevilacqua E. Phagocytosis as a potential mechanism for microbial defense of mouse placental trophoblast cells. Reproduction 128 (2004) 207-218
4. Ashkar A.A., Di Santo J.P., and Croy B.A. Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy. J. Exp. Med. 192 (2000) 259-270
5. Bulla R., Agostinis C., Bossi F., Rizzi L., Debeus A., Tripodo C., Radillo O., De Seta F., Ghebrehiwet B., and Tedesco F. Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium. Mol. Immunol. 45 (2008) 2629-2640
6. Bulla R., Villa A., Bossi F., Cassetti A., Radillo O., Spessotto P., De Seta F., Guaschino S., and Tedesco F. VE-cadherin is a critical molecule for trophoblast-endothelial cell interaction in decidual spiral arteries. Exp. Cell Res. 303 (2005) 101-113
7. Chaouat G., Dubanchet S., and Ledee N. Cytokines: important for implantation?. J. Assist. Reprod. Genet. 24 (2007) 491-505
8. Colten H.R., and Garnier G. Regulation of complement protein gene expression. In: Volanakis J.E., and Frank M.M. (Eds). The Human Complement System in Health and Disease (1998), Marcel Dekker, Inc., New York 217-240
9. Fest S., Aldo P.B., Abrahams V.M., Visintin I., Alvero A., Chen R., Chavez S.L., Romero R., and Mor G. Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy. Am. J. Reprod. Immunol. 57 (2007) 55-66
10. Fishelson Z., Attali G., and Mevorach D. Complement and apoptosis. Mol. Immunol. 38 (2001) 207-219
11. Gagioti S., Scavone C., and Bevilacqua E. Participation of the mouse implanting trophoblast in nitric oxide production during pregnancy. Biol. Reprod. 62 (2000) 260-268
12. Girardi G., Bulla R., Salmon J.E., and Tedesco F. The complement system in the pathophysiology of pregnancy. Mol. Immunol. 43 (2006) 68-77
13. Goldberg M., Luknar-Gabor N., Keidar R., and Katz Y. Synthesis of complement proteins in the human chorion is differentially regulated by cytokines. Mol. Immunol. 44 (2007) 1737-1742
14. Graham C.H., Hawley T.S., Hawley R.G., MacDougall J.R., Kerbel R.S., Khoo N., and Lala P.K. Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp. Cell Res. 206 (1993) 204-211
15. Gasque P., Fontaine M., and Morgan B.P. Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J Immunol. 154 (1995) 4726-4733
16. Guleria I., and Pollard J.W. The trophoblast is a component of the inate immune system during pregnancy. Nat. Med. 6 (2000) 589-593
17. Hata T., Ohkawa K., Tomita M., and Kishino M. Phagocytosis of human cytotrophoblast cell invading into decidual tissue in early stage of gestation. Acta Obstet. Gynaecol. Jpn. 33 (1981) 537-544
18. Hu Y., Dutz J.P., MacCalman C.D., Yong P., Tan R., and von Dadelszen P. Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma. J. Immunol. 177 (2006) 8522-8530
19. Langeggen H., Berge K.E., Macor P., Fischetti F., Tedesco F., Hetland G., Berg K., and Johnson E. Detection of mRNA for the terminal complement components C5, C6, C8 and C9 in human umbilical vein endothelial cells in vitro. APMIS 109 (2001) 73-78
20. Langeggen H., Pausa M., Johnson E., Casarsa C., and Tedesco F. The endothelium is an extrahepatic site of synthesis of the seventh component of the complement system. Clin. Exp. Immunol. 121 (2000) 69-76
21. Lash G.E., Otun H.A., Innes B.A., Kirkley M., De Oliveira L., Searle R.F., Robson S.C., and Bulmer J.N. Interferon-gamma inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels. FASEB J. 20 (2006) 2512-2518
22. Laufer J., Katz Y., and Passwell J.H. Extrahepatic synthesis of complement proteins in inflammation. Mol. Immunol. 38 (2001) 221-229
23. Mitchell T.J., Naughton M., Norsworthy P., Davies K.A., Walport M.J., and Morley B.J. IFN-gamma up-regulates expression of the complement components C3 and C4 by stabilization of mRNA. J. Immunol. 156 (1996) 4429-4434
24. Morgan B.P., and Gasque P. Extrahepatic complement biosynthesis: where, when and why?. Clin. Exp. Immunol. 107 (1997) 1-7
25. Morley B.J., and Walport MJ. The Complements Facts Book (2000), Academic Press, London
26. Morris K.M., Aden D.P., Knowles B.B., and Colten HR. Complement biosynthesis by the human hepatoma-derived cell line HepG2. J. Clin. Invest. 70 (1982) 906-913
27. Pasch M.C., Van Den Bosch N.H., Daha M.R., Bos J.D., and Asghar S.S. Synthesis of complement components C3 and factor B in human keratinocytes is differentially regulated by cytokines. J. Invest. Dermatol. 114 (2000) 78-82
28. Ramadori G., Tedesco F., Bitter-Suermann D., and Meyer zum Buschenfelde K.H. Biosynthesis of the third (C3), eighth (C8), and ninth (C9) complement components by guinea pig hepatocyte primary cultures. Immunobiology 170 (1985) 203-210
29. Reis E.S., Barbuto J.A., and Isaac L. Complement components, regulators and receptors are produced by human monocyte-derived dendritic cells. Immunobiology 212 (2007) 151-157
30. Santoni A., Carlino C., Stabile H., and Gismondi A. Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy. Am. J. Reprod. Immunol. 59 (2008) 417-424