Fear and memory: A view of the hippocampus through the lens of the amygdala

Space, Time and Memory in the Hippocampal Formation

Volumn , Issue , 2014, Pages 465-496

  Blair, Hugh T ^a   Fanselow, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84930746463     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-7091-1292-2_17     Document Type: Chapter

References (205)

1. Adamec R, Blundell J, Burton P (2005) Role of NMDA receptors in the lateralized potentiation of amygdala afferent and efferent neural transmission produced by predator stress. Physiol Behav 86:75-91
2. Aggleton JP (ed) (2000) The amygdala: A functional analysis. Oxford University Press, Oxford
3. Alme CB, Buzzetti RA, Marrone DF, Leutgeb JK, Chawla MK, Schaner MJ, Bohanick JD, Khoboko T, Leutgeb S, Moser EI, Moser MB, McNaughton BL, Barnes CA (2010) Hippocampal granule cells opt for early retirement. Hippocampus 20:1109-1123
4. Amorapanth P, LeDoux JE, Nader K (2000) Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus. Nat Neurosci 3:74-79
5. Anagnostaras SG, Maren S, Fanselow MS (1999) Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: within-subjects examination. J Neurosci 19:1106-1114
6. Anagnostaras SG, Gale GD, Fanselow MS (2001) Hippocampus and contextual fear conditioning: recent controversies and advances. Hippocampus 11:8-17
7. Anderson MI, Jeffery KJ (2003) Heterogeneous modulation of place cell firing by changes in context. J Neurosci 23:8827-8835
8. Anderson AK, Phelps EA (2000) Expression without recognition: contributions of the human amygdala to emotional communication. Psychol Sci 11:106-111
9. Anderson MI,Killing S,Morris C,O'Donoghue A, Onyiagha D, StevensonR,Verriotis M, JefferyKJ (2006) Behavioral correlates of the distributed coding of spatial context. Hippocampus 16: 730-742
10. Bannerman DM, Matthews P, Deacon RM, Rawlins JN (2004) Medial septal lesions mimic effects of both selective dorsal and ventral hippocampal lesions. Behav Neurosci 118:1033-1041
11. Barrientos RM, O'Reilly RC, Rudy JW (2002) Memory for context is impaired by injecting anisomycin into dorsal hippocampus following context exploration. Behav Brain Res 134: 299-306
12. Bast T, Zhang WN, Feldon J (2001) The ventral hippocampus and fear conditioning in rats. Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA(A) agonist muscimol. Exp Brain Res 139:39-52
13. Bechara A, Tranel D, Damasio H, Adolphs R, Rockland C, DamasioAR(1995) Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 269:1115-1118
14. Beeman CL, Bauer PS, Pierson JL, Quinn JJ (2013) Hippocampus and medial prefrontal cortex contributions to trace and contextual fear memory expression over time. Learn Mem 20: 336-343
15. Berger TW, Alger B, Thompson RF (1976) Neuronal substrate of classical conditioning in the hippocampus. Science 192:483-485
16. Bi G, Poo M (2001) Synaptic modification by correlated activity: Hebb's postulate revisited. Annu Rev Neurosci 24:139-166
17. Bolles RC (1970) Species-specific defense reactions and avoidance learning. Psychol Rev 77: 32-48
18. Bolles RC, Fanselow MS (1980) A perceptual-defensive-recuperative model of fear and pain. Behav Brain Sci 3:291-323
19. Bolles RC, Riley AL (1973) Freezing as an avoidance response: another look at the operantrespondent distinction. Learn Motiv 4:268-275
20. Bostock E, Muller RU, Kubie JL (1991) Experience-dependent modifications of hippocampal place cell firing. Hippocampus 1:193-205
21. Bouton ME (1993) Context, time, and memory retrieval in the interference paradigms of Pavlovian conditioning. Psychol Bull 114:80-99
22. Bouton ME (2004) Context and behavioral processes in extinction. Learn Mem 11:485-494
23. Bouton ME, Bolles RC (1979) Role of conditioned contextual stimuli in reinstatement of extinguished fear. J Exp Psychol Anim Behav Processes 5:368-378
24. Bouton ME, King DA (1983) Contextual control of the extinction of conditioned fear: tests for the associative value of the context. J Exp Psychol Anim Behav Process 9:248-265
25. Broadbent NJ, Clark RE (2013) Remote context fear conditioning remains hippocampusdependent irrespective of training protocol, training-surgery interval, lesion size, and lesion method. Neurobiol Learn Mem. doi:10.1016/j.nlm.2013.08.008, pii: S1074-7427(13)00167-6
26. Burgos-Robles A, Vidal-Gonzalez I, Quirk GJ (2009) Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure. J Neurosci 29:8474-8482
27. Burman MA, Starr MJ, Gewirtz JC (2006) Dissociable effects of hippocampus lesions on expression of fear and trace fear conditioning memories in rats. Hippocampus 16:103-113
28. Cahill L, McGaugh JL (1998) Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci 21:294-299
29. Campeau S, Davis M (1995) Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 15:2301-2311
30. Canteras NS, Swanson LW (1992) Projections of the ventral subiculum to the amygdala, septum, and hypothalamus: A PHAL anterograde tract-tracing study in the rat. J Comp Neurol 324: 180-194
31. Chawla MK, Guzowski JF, Ramirez-Amaya V, Lipa P, Hoffman KL, Marriott LK, Worley PF, McNaughton BL, Barnes CA (2005) Sparse, environmentally selective expression of Arc RNA in the upper blade of the rodent fascia dentata by brief spatial experience. Hippocampus 15:579-586
32. Chowdhury N, Quinn JJ, Fanselow MS (2005) Dorsal hippocampus involvement in trace fear conditioning with long, but not short, trace intervals in mice. Behav Neurosci 119:1396-1402
33. Christian KM, Thompson RF (2003) Neural substrates of eyeblink conditioning: acquisition and retention. Learn Mem 10:427-455
34. Ciocchi S, Herry C, Grenier F, Wolff SB, Letzkus JJ, Vlachos I, Ehrlich I, Sprengel R, Deisseroth K, Stadler MB, Muller C, Luthi A (2010) Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 468:277-282
35. Corcoran KA, Maren S (2004) Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction. Learn Mem 11:598-603
36. Craske MG (1999) Anxiety disorders: psychological approaches to theory and treatment. Westview, Boulder, CO
37. Cushman JD, Maldonado J, Kwon EE, Garcia AD, Fan G, Imura T, Sofroniew MV, Fanselow MS (2012) Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories. Front Behav Neurosci 6:1-17
38. Czerniawski J, Ree F, Chia C, Otto T (2012) Dorsal versus ventral hippocampal contributions to trace and contextual conditioning: differential effects of regionally selective NMDA receptor antagonism on acquisition and expression. Hippocampus 22:1528-1539
39. Davis M (1992) The role of the amygdala in fear and anxiety. Annu Rev Neurosci 15:353-375
40. Debiec J, LeDoux JE, Nader K (2002) Cellular and systems reconsolidation in the hippocampus. Neuron 36:527-538
41. Deshmukh SS, Knierim JJ (2013) Influence of local objects on hippocampal representations: landmark vectors and memory. Hippocampus 23:253-267
42. Desmond JE, Moore JW (1988) Adaptive timing in neural networks: The conditioned response. Biol Cybern 58:405-415
43. Eldridge LL, Knowlton BJ, Furmanski CS, Bookheimer SY, Engel SA (2000) Remembering episodes: A selective role for the hippocampus during retrieval. Nat Neurosci 3:1149-1152
44. Esclassan F, Coutureau E, Di Scala G, Marchand AR (2009a) Differential contribution of dorsal and ventral hippocampus to trace and delay fear conditioning. Hippocampus 19:33-44
45. Esclassan F, Coutureau E, Di Scala G, Marchand AR (2009b) A cholinergic-dependent role for the entorhinal cortex in trace fear conditioning. J Neurosci 29(25):8087-8093. doi:10.1523/ JNEUROSCI.0543-09.2009b
46. Estes WK, Skinner BF (1941) Some quantitative properties of anxiety. J Exp Psychol 29 (5):390-400
47. Fanselow MS (1980) Conditional and unconditional components of post-shock freezing in rats. Pavlov J Biol Sci 15:177-182
48. Fanselow MS (1984) Opiate modulation of both the active and inactive components of the postshock reaction: parallels between naloxone pretreatment and shock intensity. Behav Neurosci 98:269-277
49. Fanselow MS (1986) Associative vs. topographical accounts of the immediate shock freezing deficit in rats: implications for the response selection rules governing species specific defensive reactions. Learn Motiv 17:16-39
50. Fanselow MS (1990) Factors governing one trial contextual conditioning. Anim Learn Behav 18:264-270
51. Fanselow MS (2010) From contextual fear to a dynamic view of memory systems. Trends Cogn Sci 14:7-15 PMC2818345
52. Fanselow MS, Dong HW (2010) Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65:7-19
53. Fanselow MS, Kim JJ (1994) Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D, L-2-amino-5-phosphonovaleric acid to the basolateral amygdala. Behav Neurosci 108:210-212
54. Fanselow MS, LeDoux JE (1999) Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron 23:229-232
55. Fanselow MS, Lester LS (1988) A functional behavioristic approach to aversively motivated behavior: predatory imminence as a determinant of the topography of defensive behavior. In: Bolles RC, Beecher MD (eds) Evolution and learning. Erlebaum, Hills-dale, NJ, pp 185-211
56. Fendt M, Fanselow MS (1999) The neuroanatomical and neurochemical basis of conditioned fear. Neurosci Biobehav Rev 23:743-760
57. Ferbinteanu J, Holsinger RM, McDonald RJ (1999) Lesions of the medial or lateral perforant path have different effects on hippocampal contributions to place learning and on fear conditioning to context. Behav Brain Res 101:65-84
58. Frank LM, Brown EN, Wilson M (2000) Trajectory encoding in the hippocampus and entorhinal cortex. Neuron 27:169-178
59. Frank LM, Stanley GB, Brown EN (2004) Hippocampal plasticity across multiple days of exposure to novel environments. J Neurosci 24:7681-7689
60. Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ (2004) The involvement of the anterior cingulate cortex in remote contextual fear memory. Science 7:881-883
61. Gale GD, Anagnostaras SG, Godsil BP, Mitchell S, Nozawa T, Sage JR, Wiltgen B, Fanselow MS (2004) Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats. J Neurosci 24:3810-3815
62. Garakani A, Mathew SJ, Charney DS (2006) Neurobiology of anxiety disorders and implications for treatment. Mt Sinai J Med 73:941-949
63. Garner AR, Rowland DC, Hwang SY, Baumgaertel K, Roth BL, Kentros C, Mayford M (2012) Generation of a synthetic memory trace. Science 335:1513-1516
64. Good M, Honey RC (1997) Dissociable effects of selective lesions to hippocampal subsystems on exploratory behavior, contextual learning, and spatial learning. Behav Neurosci 111:487-493
65. Goosens KA, Maren S (2001) Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats. Learn Mem 8:148-155
66. Goshen I, Brodsky M, Prakash R, Wallace J, Gradinaru V, Ramakrishnan C, Deisseroth K (2011) Dynamics of retrieval strategies for remote memories. Cell 147:678-689
67. Grossberg S, Schmajuk NA (1989) Neural dynamics of adaptive timing and temporal discrimination during associative learning. Neural Netw 2:79-102
68. Guimaraĩs M, Gregório A, Cruz A, Guyon N, Moita MA (2011) Time determines the neural circuit underlying associative fear learning. Front Behav Neurosci 5:89. doi:10.3389/fnbeh.2011.00089
69. Guzowski JF, McNaughton BL, Barnes CA, Worley PF (1999) Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nat Neurosci 2:1120-1124
70. Guzowski JF, Knierim JJ, Moser EI (2004) Ensemble dynamics of hippocampal regions CA3 and CA1. Neuron 44:581-584
71. Hafting T, Fyhn M, Molden S, Moser MB, Moser EI (2005) Microstructure of a spatial map in the entorhinal cortex. Nature 436:801-806
72. Han CJ, O'Tuathaigh CM, van Trigt L, Quinn JJ, Fanselow MS, Mongeau R, Koch C, Anderson DJ (2003) Trace but not delay fear conditioning requires attention and the anterior cingulate cortex. Proc Nat Acad Sci USA 100:13087-13092
73. Han JH, Kushner SA, Yiu AP, Cole CJ, Matynia A, Brown RA, Neve RL, Guzowski JF, Silva AJ, Josselyn SA (2007) Neuronal competition and selection during memory formation. Science 316:457-460
74. Haubensak W, Kunwar PS, Cai H, Ciocchi S, Wall NR, Ponnusamy R, Biag J, Dong HW, Deisseroth K, Callaway EM, Fanselow MS, Lü thi A, Anderson DJ (2010) Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature 468:270-276
75. Hebert AE, Dash PK (2004) Plasticity in the entorhinal cortex suppresses memory for contextual fear. J Neurosci 24:10111-10116
76. Hunsaker MR, Kesner RP (2008) Dissociations across the dorsal-ventral axis of CA3 and CA1 for encoding and retrieval of contextual and auditory-cued fear. Neurobiol Learn Mem 89:61-69
77. Jacobs N, Cushman J, Fanselow MS (2010) The accurate measurement of fear memory in Pavlovian conditioning: resolving the baseline issue. J Neurosci Methods 190:235-239
78. Ji J, Maren S (2005) Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction. Learn Mem 12:270-276
79. Ji J, Maren S (2007) Hippocampal involvement in contextual modulation of fear extinction. Hippocampus 17:749-758
80. Ji J, Maren S (2008) Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear. Learn Mem 15:244-251
81. Josselyn SA (2010) Continuing the search for the engram: examining the mechanism of fear memories. J Psychiatry Neurosci 35:221-228
82. Jung MW, McNaughton BL (1993) Spatial selectivity of unit activity in the hippocampal granular layer. Hippocampus 3:165-182
83. Kennedy PJ, ShapiroML (2004) Retrievingmemories via internal context requires the hippocampus. J Neurosci 24:6979-6985
84. Kentros C, Hargreaves E, Hawkins RD, Kandel ER, Shapiro M, Muller RV (1998) Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade. Science 280:2121-2126
85. Killcross S, Robbins TW, Everitt BJ (1997) Different types of fear-conditioned behaviour mediated by separate nuclei within amygdala. Nature 388:377-380
86. Kim JJ, Fanselow MS (1992) Modality-specific retrograde amnesia of fear. Science 256:675-677
87. Kim JJ, Lee HJ, Welday AC, Song EY, Cho J, Sharp P, Jung MW, Blair HT (2007) Stress-induced alterations in hippocampal plasticity, place cells, and spatial memory. Proc Natl Acad Sci USA 104:18297-18302
88. Kitamura T, Saitoh Y, Takashima N, Murayama A, Niibori Y, Ageta H, Sekiguchi M, Sugiyama H, Inokuchi K (2009) Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell 139:814-827
89. Kjelstrup KG, Tuvnes FA, Steffenach HA, Murison R, Moser EI, Moser MB (2002) Reduced fear expression after lesions of the ventral hippocampus. Proc Natl Acad Sci USA 99:10825-10830
90. Kjelstrup KB, Solstad T, Brun VH, Hafting T, Leutgeb S, Witter MP, Moser EI, Moser MB (2008) Finite scale of spatial representation in the hippocampus. Science 321:140-143
91. Knierim JJ, Lee I, Hargreaves EL (2006) Hippocampal place cells: parallel input streams, subregional processing, and implications for episodic memory. Hippocampus 16:755-764
92. Knowlton BJ, Fanselow MS (1998) The hippocampus, consolidation and on-line memory. Curr Opin Neurobiol 8:293-296
93. KrausBJ, Robinson RJ 2nd,White JA,EichenbaumH, HasselmoME(2013) Hippocampal "time cells": time versus path integration. Neuron 78:1090-1101
94. LeDoux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:55-184
95. Ledoux JE, Muller J (1997) Emotional memory and psychopathology. Philos Trans R Soc Lond B Biol Sci 352:1719-1726
96. Lee I, Yoganarasimha D, Rao G, Knierim JJ (2004) Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature 430:456-459
97. Lester LS, Fanselow MS (1985) Exposure to a cat produces opioid analgesia in rats. Behav Neurosci 99:756-759
98. Leutgeb S, Leutgeb JK, Moser MB, Moser EI (2005) Place cells, spatial maps and the population code for memory. Curr Opin Neurobiol 15:738-746
99. Leutgeb S, Leutgeb JK, Moser EI, Moser MB (2006) Fast rate coding in hippocampal CA3 cell ensembles. Hippocampus 16:765-774
100. Leutgeb JK, Leutgeb S, Moser MB, Moser EI (2007) Pattern separation in the dentate gyrus and CA3 of the hippocampus. Science 315:961-966
101. Lever C, Wills T, Cacucci F, Burgess N, O'Keefe J (2002) Long-term plasticity in hippocampal place-cell representation of environmental geometry. Nature 416:90-94
102. Lever C, Burton S, O'Keefe J (2006) Rearing on hind legs, environmental novelty, and the hippocampal formation. Rev Neurosci 17:111-133
103. Lever C, Burton S, Jeewajee A, O'Keefe J, Burgess N (2009) Boundary vector cells in the subiculum of the hippocampal formation. J Neurosci 29:9771-9777
104. Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, Tonegawa S (2012) Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484: 381-385
105. Lu L, Leutgeb JK, Tsao A, Henriksen EJ, Leutgeb S, Barnes CA, Witter MP, Moser MB, Moser EI (2013) Impaired hippocampal rate coding after lesions of the lateral entorhinal cortex. Nat Neurosci 16:1085-1093
106. MacDonald CJ, Lepage KQ, Eden UT, Eichenbaum H (2011) Hippocampal "time cells" bridge the gap in memory for discontiguous events. Neuron 71:737-749
107. Majak K, Pitkänen A (2003) Activation of the amygdalo-entorhinal pathway in fear-conditioning in rat. Eur J Neurosci 18:1652-1659
108. Majchrzak M, Ferry B, Marchand AR, Herbeaux K, Seillier A, Barbelivien A (2006) Entorhinal cortex lesions disrupt fear conditioning to background context but spare fear conditioning to a tone in the rat. Hippocampus 16:114-124
109. Mankin EA, Sparks FT, Slayyeh B, Sutherland RJ, Leutgeb S, Leutgeb JK (2012) Neuronal code for extended time in the hippocampus. Proc Natl Acad Sci USA 109:19462-19467
110. Manns JR, Howard MW, Eichenbaum H (2007) Gradual changes in hippocampal activity support remembering the order of events. Neuron 56:530-540
111. Maren S (2003) The amygdala, synaptic plasticity, and fear memory. Ann N Y Acad Sci 985: 106-113
112. Maren S, Fanselow MS (1995) Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo. J Neurosci 15:7548-7564
113. Maren S, Fanselow MS (1997) Electrolytic lesions of the fimbria/fornix, dorsal hippocampus, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in rats. Neurobiol Learn Mem 67:142-149
114. Maren S, Holt WG (2004) Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus. Behav Neurosci 118:97-110
115. Maren S, DeCola JP, Swain RA, Fanselow MS, Thompson RF (1994) Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in waterdeprived rats. Behav Neurosci 108:44-56
116. Maren S, Aharonov G, Fanselow MS (1997) Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav Brain Res 88:261-274
117. Maren S, Phan KL, Liberzon I (2013) The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 14:417-428
118. Markram H, Gerstner W, Sjöström PJ (2012) Spike-timing-dependent plasticity: A comprehensive overview. Front Synaptic Neurosci 4:2. doi:10.3389/fnsyn.2012.00002
119. Matus-Amat P, Higgins EA, Barrientos RM, Rudy JW (2004) The role of the dorsal hippocampus in the acquisition and retrieval of context memory representations. J Neurosci 24:2431-2439
120. McClelland JL, McNaughton BL, O'Reilly RC (1995) Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory. Psychol Rev 102:419-437
121. McEchron MD, Bouwmeester H, Tseng W, Weiss C, Disterhoft JF (1998) Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat. Hippocampus 8:638-646
122. McHugh TJ, Tonegawa S (2007) Spatial exploration is required for the formation of contextual fear memory. Behav Neurosci 121:335-339
123. McHugh TJ, Tonegawa S (2009) CA3 NMDA receptors are required for the rapid formation of a salient contextual representation. Hippocampus 19:1153-1158
124. McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA (1996) Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87:1339-1349
125. McHugh TL, Saykin AJ, Wishart HA, Flashman LA, Cleavinger HB, Rabin LA, Ma-mourian AC, Shen L (2007) Hippocampal volume and shape analysis in an older adult population. Clin Neuropsychol 21:130-145
126. McNally GP, Johansen JP, Blair HT (2011) Placing prediction into the fear circuit. Trends Neurosci 34:283-292
127. Milad MR, Quirk GJ (2012) Fear extinction as a model for translational neuroscience: ten years of progress. Annu Rev Psychol 63:129-151. doi:10.1146/annurev.psych.121208.131631
128. Misane I, Tovote P, Meyer M, Spiess J, Ogren SO, Stiedl O (2005) Time-dependent involvement of the dorsal hippocampus in trace fear conditioning in mice. Hippocampus 15:418-426
129. Moita MAP, Rosis S, Zhou Y, LeDoux JE, Blair HT (2003) Hippocampal place cells acquire location-specific responses to the conditioned stimulus during auditory fear conditioning. Neuron 37:485-497
130. Moita MA, Rosis S, Zhou Y, LeDoux JE, Blair HT (2004) Putting fear in its place: remapping of hippocampal place cells during fear conditioning. J Neurosci 24:7015-7023
131. MoserMB,Moser EI (1998) Functional differentiation in the hippocampus.Hippocampus 8:608-619
132. Moser EI, Moser MB (2008) A metric for space. Hippocampus 18:1142-1156
133. Moyer JR Jr, Deyo RA, Disterhoft JF (1990) Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behav Neurosci 104:243-252
134. Muller RU, Kubie JL, Ranck JB Jr (1987) Spatial firing patterns of hippocampal complex-spike cells in a fixed environment. J Neurosci 7:1935-1950
135. Nadel L (2008) The hippocampus and context revisited. In: Mizumori SJY (ed) Hippocampal place fields: relevance to learning and memory. Oxford University Press, New York, NY, pp 3-15
136. Nadel L, Moscovitch M (1997) Memory consolidation, retrograde amnesia and the hippocampal complex. Curr Opin Neurobiol 7:217-227
137. Nadel L, Willner J (1980) Context and conditioning: A place for space. Physiol Psychol 8:218-228
138. Nader K, Majidishad P, Amorapanth P, LeDoux JE (2001) Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning. Learn Mem 8:156-163
139. Nakashiba T, Cushman JD, PelkeyKA, Renaudineau S, BuhlDL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, Tonegawa S (2012) Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell 149(1):188-201. doi:10.1016/j.cell.2012.01.046
140. Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Johnston D, Wilson MA, Tonegawa S (2002) Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297:211-218
141. Neunuebel JP, Knierim JJ (2012) Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus. J Neurosci 14:3848-3858
142. O'Keefe J, Dostrovsky J (1971) The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34:171-175
143. O'Keefe J, Nadel L (1978) The hippocampus as a cognitive map. Clarendon, Oxford
144. O'Reilly RC, McClelland JL (1994) Hippocampal conjunctive encoding, storage, and recall: avoiding a trade-off. Hippocampus 4:661-682
145. Paré D, Quirk GJ, Ledoux JE (2004) New vistas on amygdala networks in conditioned fear. J Neurophysiol 92:1-9
146. Pastalkova E, Itskov V, Amarasingham A, Buzsáki G (2008) Internally generated cell assembly sequences in the rat hippocampus. Science 321:1322-1327
147. Pevzner A, Miyashita T, Schiffman AJ, Guzowski JF (2012) Temporal dynamics of Arc gene induction in hippocampus: relationship to context memory formation. Neurobiol Learn Mem 97:313-320
148. Phelps EA, LeDoux JE (2005) Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48:175-187
149. Phillips RG, LeDoux JE (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106:274-285
150. Phillips RG, LeDoux JE (1995) Lesions of the fornix but not the entorhinal or perirhinal cortex interfere with contextual fear conditioning. J Neurosci 15:5308-5315
151. Pignatelli M, Beyeler A, Leinekugel X (2012) Neural circuits underlying the generation of theta oscillations. J Physiol Paris 106:81-92
152. Pitkänen A, Pikkarainen M, Nurminen N, Ylinen A (2000) Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat. A review. Ann N Y Acad Sci 911:369-391
153. Quinn JJ, Oommen SS, Morrison GE, Fanselow MS (2002) Post-training excitotoxic lesions of the dorsal hippocampus attenuate forward trace, backward trace, and delay fear conditioning in a temporally specific manner. Hippocampus 12:495-504
154. Quinn JJ, Ma QD, Tinsley MR, Koch C, Fanselow MS (2008a) Inverse temporal contributions of the dorsal hippocampus and medial prefrontal cortex to the expression of long-term fear memories. Learn Mem 15:368-372
155. Quinn JJ, Wied HM, Ma QD, Tinsley MR, Fanselow MS (2008b) Dorsal hippocampus involvement in delay fear conditioning depends upon the strength of the tone-footshock association. Hippocampus 18:640-654 PMID: 18306286
156. Quinn JJ, Wied HM, Liu D, Fanselow MS (2009) Post-training excitotoxic lesions of the dorsal hippocampus attenuate generalization in auditory delay fear conditioning. Eur J Neurosci 29: 1692-1700 PMID: 19419430
157. Quirk GJ (2002) Memory for extinction of conditioned fear is long-lasting and persists following spontaneous recovery. Learn Mem 9:402-407
158. Quirk GJ, Beer JS (2006) Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. Curr Opin Neurobiol 16:723-727
159. Ramirez S, Liu X, Lin PA, Suh J, Pignatelli M, Redondo RL, Ryan TJ, Tonegawa S (2013) Creating a false memory in the hippocampus. Science 341:387-391
160. Restivo L, Vetere G, Bontempi B, Ammassari-TeuleM(2009) The formation of recent and remote memory is associated with time-dependent formation of dendritic spines in the hippocampus and anterior cingulate cortex. J Neurosci 29:8206-8214
161. Rogers JL, Hunsaker MR, Kesner RP (2006) Effects of ventral and dorsal CA1 subregional lesions on trace fear conditioning. Neurobiol Learn Mem 86:72-81
162. Rudy JW (2009) Context representations, context functions, and the parahippocampalhippocampal system. Learn Mem 16:573-585
163. Rudy JW, Sutherland RJ (1995) Configural association theory and the hippocampal formation: an appraisal and reconfiguration. Hippocampus 5:375-389
164. Sah P, Westbrook RF, Lü thi A (2008) Fear conditioning and long-term potentiation in the amygdala: what really is the connection? Ann N Y Acad Sci 1129:88-95
165. Savelli F, Yoganarasimha D, Knierim JJ (2008) Influence of boundary removal on the spatial representations of the medial entorhinal cortex. Hippocampus 18:1270-1282
166. Schenberg EE, Soares JC, Oliveira MG (2005) Effects of pre-or post-training entorhinal cortex AP5 injection on fear conditioning. Physiol Behav 86:508-515
167. Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neuropsychiatry Clin Neurosci 12:103-113
168. Seidenbecher T, Laxmi TR, Stork O, Pape HC (2003) Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval. Science 301:846-850
169. Seymour B, Dolan R (2008) Emotion, decision making, and the amygdala. Neuron 58:662-671
170. Smith DM, Mizumori SJ (2006) Learning-related development of context-specific neuronal responses to places and events: The hippocampal role in context processing. J Neurosci 26: 3154-3163
171. Solstad T, Boccara CN, Kropff E, Moser MB, Moser EI (2008) Representation of geometric borders in the entorhinal cortex. Science 322:1865-1868
172. Sotres-Bayon F, Quirk GJ (2010) Prefrontal control of fear: more than just extinction. Curr Opin Neurobiol 20:231-235
173. Sparks FT, Spanswick SC, Lehmann H, Sutherland RJ (2013) Neither time nor number of contextshock pairings affect long-term dependence of memory on hippocampus. Neurobiol Learn Mem. doi:10.1016/j.nlm.2013.05.008, pii: S1074-7427(13)00089-0
174. Spear NE (1981) Extending the domain of memory retrieval. In: Spear NE, Miller RR (eds) Information processing in animals: memory mechanisms. Lawrence Erlbaum Associates, Hillsdale, NJ, pp 341-378
175. Stote DL, Fanselow MS (2004) NMDA receptor modulation of incidental learning in Pavlovian context conditioning. Behav Neurosci 118:253-257
176. Suh J, Rivest AJ, Nakashiba T, Tominaga T, Tonegawa S (2011) Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory. Science. doi:10.1126/science. 1210125
177. Swanson LW, Cowan WM (1977) An autoradiographic study of the organization of the efferent connections of the hippocampal formation in the rat. J Comp Neurol 172:49-84
178. Swanson LW, Petrovich GD (1998) What is the amygdala? Trends Neurosci 21:323-331
179. Tayler KK, Tanaka KZ, Reijmers LG, Wiltgen BJ (2013) Reactivation of neural ensembles during the retrieval of recent and remote memory. Curr Biol 23:99-106
180. Thompson RF, Kim JJ (1996) Memory systems in the brain and localization of a memory. Proc Natl Acad Sci USA 93:13438-13444
181. Treves A, Rolls ET (1994) Computational analysis of the role of the hippocampus in memory. Hippocampus 4:374-391
182. Vazdarjanova A, Guzowski JF (2004) Differences in hippocampal neuronal population responses to modifications of an environmental context: evidence for distinct, yet complementary, functions of CA3 and CA1 ensembles. J Neurosci 24:6489-6496
183. Viskontas IV, Carr VA, Engel SA, Knowlton BJ (2009) The neural correlates of recollection: hippocampal activation declines as episodic memory fades. Hippocampus 19:265-272
184. Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H et al (2003) Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci USA 100:4287-4292
185. Wang ME, Wann EG, Yuan RK, Ramos Alvarez MM, Stead SM, Muzzio IA (2012) Long-term stabilization of place cell remapping produced by a fearful experience. J Neurosci 32: 15802-15814
186. Weiskrantz L (1956) Behavioral changes associated with ablation of the amygdaloid complex in monkeys. J Comp Physiol Psychol 49:381-391
187. Wilson MA, McNaughton BL (1993) Dynamics of the hippocampal ensemble code for space. Science 261:1055-1058
188. Erratum in: Science 1994 264(5155):16
189. Wilson A, Brooks DC, Bouton ME (1995) The role of the rat hippocampal system in several effects of context in extinction. Behav Neurosci 109:828-836
190. Wiltgen BJ, Silva AJ (2007) Memory for context becomes less specific with time. Learn Mem 14:313-317
191. Wiltgen BJ, Brown RA, Talton LE, Silva AJ (2004) New circuits for old memories: The role of the neocortex in consolidation. Neuron 44:101-108
192. Wiltgen BJ, Sanders MJ, Anagnostaras SG, Sage JR, Fanselow MS (2006) Context fear learning in the absence of the hippocampus. J Neurosci 26:5484-5491
193. Winocur G, Frankland PW, Sekeres M, Fogel S, Moscovitch M (2009) Changes in contextspecificity during memory reconsolidation: selective effects of hippocampal lesions. Learn Mem 16:722-729
194. Wood ER, Dudchenko PA, Eichenbaum H (1999) The global record of memory in hippocampal neuronal activity. Nature 397:613-616
195. Wood ER, Dudchenko PA, Robitsek RJ, Eichenbaum H (2000) Hippocampal neurons encode information about different types of memory episodes occurring in the same location. Neuron 27:623-633
196. Yassa MA, Stark CE (2011) Pattern separation in the hippocampus. Trends Neurosci 34:515-525
197. Yoon T, Otto T (2007) Differential contributions of dorsal vs. ventral hippocampus to auditory trace fear conditioning. Neurobiol Learn Mem 87:464-475
198. Young SL, Bohenek DL, Fanselow MS (1994) NMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: immunization against amnesia by contextual preexposure. Behav Neurosci 108:19-29
199. Zelikowsky M, Pham DL, Fanselow MS (2012a) Temporal factors control hippocampal contributions to fear renewal after extinction. Hippocampus 22:1096-1106
200. Zelikowsky M, Bissiere S, Fanselow MS (2012b) Contextual fear memories formed in the absence of the dorsal hippocampus decay across time. J Neurosci 32:3393-3397
201. Zelikowsky M, Bissiere S, Hast TA, Bennett RZ, Abdipranoto A, Vissel B, Fanselow MS (2013) Prefrontal microcircuit underlies contextual learning after hippocampal loss. Proc Natl Acad Sci USA 110:9938-9943
202. Zhang K, Sejnowski TJ (1999) Neural tuning: to sharpen or broaden? Neural Comput 11:75-84
203. Zhang WN, Bast T, Feldon J (2001) The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus. Behav Brain Res 126:159-174
204. Ziv Y, Burns LD, Cocker ED, Hamel EO, Ghosh KK, Kitch LJ, El Gamal A, Schnitzer MJ (2013) Long-term dynamics of CA1 hippocampal place codes. Nat Neurosci 16:264-266
205. Zola-Morgan SM, Squire LR (1990) The primate hippocampal formation: evidence for a timelimited role in memory storage. Science 250:288-290