Microstructure of a spatial map in the entorhinal cortex

Nature

Volumn 436, Issue 7052, 2005, Pages 801-806

  Hafting, Torkel ^a   Fyhn, Marianne ^a   Molden, Sturla ^a,b   Moser, May Britt ^a   Moser, Edvard I ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHMS; CELLS; NEURAL NETWORKS;

CORTICAL MICROCIRCUITS; ENTORHINAL CORTEX; NEURAL ALGORITHMS; SPATIAL ENVIRONMENT;

MICROSTRUCTURE;

BIOLOGY;

ALGORITHM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY POSITION; CELL ACTIVATION; DEPTH PERCEPTION; ENTORHINAL CORTEX; INFORMATION PROCESSING; MALE; NERVE CELL; NERVE CELL NETWORK; NEURONAVIGATION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPATIAL MAP; SPATIAL ORIENTATION; TOPOGRAPHY;

ACTION POTENTIALS; ANIMALS; CUES; ELECTRODES; ENTORHINAL CORTEX; ENVIRONMENT; MALE; MODELS, NEUROLOGICAL; NEURONS; ORIENTATION; RATS; RATS, LONG-EVANS; SPACE PERCEPTION;

ANIMALIA;

EID: 23844454091     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03721     Document Type: Article

References (50)

1. O'Keefe, J. & Nadel, L. The Hippocampus as a Cognitive Map (Clarendon, Oxford, 1978).
2. McNaughton, B. L. et al. Deciphering the hippocampal polyglot: the hippocampus as a path integration system. J. Exp. Biol. 199, 173-185 (1996).
3. Taube, J. S. Head direction cells and the neurophysiological basis for a sense of direction. Prog. Neurobiol. 55, 225-256 (1998).
4. Redish, A. D. & Touretzky, D. S. Cognitive maps beyond the hippocampus. Hippocampus 7, 15-35 (1997).
5. Redish, A. D. Beyond the Cognitive Map: From Place Cells to Episodic Memory (MIT Press, Cambridge, 1999).
6. Sharp, P. E. Complimentary roles for hippocampal versus subicular/entorhinal place cells in coding place, context, and events. Hippocampus 9, 432-443 (1999).
7. Etienne, A. S. & Jeffery, K. J. Path integration in mammals. Hippocampus 14, 180-192 (2004).
8. O'Keefe, J. & Conway, D. H. Hippocampal place units in the freely moving rat: why they fire where they fire. Exp. Brain Res. 31, 573-590 (1978).
9. O'Keefe, J. & Burgess, N. Geometric determinants of the place fields of hippocampal neurons. Nature 381, 425-428 (1996).
10. Gothard, K. M., Skaggs, W. E. & McNaughton, B. L. Dynamics of mismatch correction in the hippocampal ensemble code for space: interaction between path integration and environmental cues. J. Neurosci. 16, 8027-8040 (1996).
11. Sharp, P. E., Blair, H. T., Etkin, D. & Tzanetos, D. B. Influences of vestibular and visual motion information on the spatial firing patterns of hippocampal place cells. J. Neurosci. 15, 173-189 (1995).
12. Knierim, J. J., Kudrimoti, H. S. & McNaughton, B. L. Place cells, head direction cells, and the learning of landmark stability. J. Neurosci. 15, 1648-1659 (1995).
13. Jeffery, K. J., Donnett, J. G., Burgess, N. & O'Keefe, J. M. Directional control of hippocampal place fields. Exp. Brain Res. 117, 131-142 (1997).
14. Nadel, L. The hippocampus and space revisited. Hippocampus 1, 221-229 (1991).
15. Samsonovich, A. & McNaughton, B. L. Path integration and cognitive mapping in a continuous attractor neural network model. J. Neurosci. 17, 5900-5920 (1997).
16. Muller, R. U. & Kubie, J. L. The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells. J. Neurosci. 7, 1951-1968 (1987).
17. Bostock, E., Muller, R. U. & Kubie, J. L. Experience-dependent modifications of hippocampal place cell firing. Hippocampus 1, 193-205 (1991).
18. Leutgeb, S., Leutgeb, J. K., Treves, A., Moser, M.-B. & Moser, E. I. Distinct ensemble codes in hippocampal areas CA3 and CA1. Science 305, 1295-1298 (2004).
19. Markus, E. J. et al. Interactions between location and task affect the spatial and directional firing of hippocampal neurons. J. Neurosci. 15, 7079-7094 (1995).
20. Frank, L. M., Brown, E. N. & Wilson, M. Trajectory encoding in the hippocampus and entorhinal cortex. Neuron 27, 169-178 (2000).
21. Wood, E. R., Dudchenko, P. A., Robitsek, R. J. & Eichenbaum, H. Hippocampal neurons encode information about different types of memory episodes occurring in the same location. Neuron 27, 623-633 (2000).
22. Nakazawa, K. et al. Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297, 211-218 (2002).
23. Lee, I., Yoganarasimha, D., Rao, G. & Knierim, J. J. Comparison of population coherence of place cells in hippocampal subfields CA1 and CA3. Nature 430, 456-459 (2004).
24. Rolls, E. T. & Treves, A. Neural Networks and Brain Function (Oxford Univ. Press, Oxford, 1998).
25. Squire, L. R., Stark, C. E. & Clark, R. E. The medial temporal lobe. Annu. Rev. Neurosci. 27, 279-306 (2004).
26. Fyhn, M., Molden, S., Witter, M. P., Moser, E. I. & Moser, M. B. Spatial representation in the entorhinal cortex. Science 305, 1258-1264 (2004).
27. Wilson, M. A. & McNaughton, B. L. Dynamics of the hippocampal ensemble code for space. Science 261, 1055-1058 (1993).
28. Mountcastle, V. B. The columnar organization of the neocortex. Brain 120, 701-722 (1997).
29. Rockland, K. S. & Ichinohe, N. Some thoughts on cortical minicolumns. Exp. Brain Res. 158, 265-277 (2004).
30. Ikeda, J., Mori, K., Oka, S. & Watanabe, Y. A columnar arrangement of dendritic processes of entorhinal cortex neurons revealed by a monoclonal antibody. Brain Res. 505, 176-179 (1989).
31. Quirk, G. J., Muller, R. U., Kubie, J. L. & Ranck, J. B. Jr The positional firing properties of medial entorhinal neurons: description and comparison with hippocampal place cells. J. Neurosci. 12, 1945-1963 (1992).
32. Taube, J. S., Muller, R. U. & Ranck, J. B. Jr Head-direction cells recorded from the postsubiculum in freely moving rats. II. Effects of environmental manipulations. J. Neurosci. 10, 436-447 (1990).
33. Goodridge, J. P. & Taube, J. S. Preferential use of the landmark navigational system by head direction cells in rats. Behav. Neurosci. 109, 49-61 (1995).
34. Mittelstaedt, M. L. & Mittelstaedt, H. Homing by path integration in a mammal. Naturwissenschaften 67, 566-567 (1980).
35. Gallistel, C. R. The Organization of Learning (MIT Press, Cambridge Massachusetts, 1990).
36. Biegler, R. Possible uses of path integration in animal navigation. Anim. Learn. Behav. 28, 257-277 (2000).
37. van Haeften, T., Wouterlood, F. G., Jorritsma-Byham, B. & Witter, M. P. GABAergic presubicular projections to the medial entorhinal cortex of the rat. J. Neurosci. 17, 862-874 (1997).
38. Witter, M. P., Groenewegen, H. J., Lopes da Silva, F. H. & Lohman, A. H. Functional organization of the extrinsic and intrinsic circuitry of the parahippocampal region. Prog. Neurobiol. 33, 161-253 (1989).
39. Witter, M. P. & Amaral, D. G. in The Rat Nervous System 3rd edn (ed. Paxinos, G.) 637-703 (Academic, San Diego, 2004).
40. Parron, C. & Save, E. Evidence for entorhinal and parietal cortices involvement in path integration in the rat. Exp. Brain Res. 159, 349-359 (2004).
41. Steffenach, H.-A., Witter, M. P., Moser, M.-B. & Moser, E. I. Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex. Neuron 45, 301-313 (2005).
42. Skaggs, W. E., Knierim, J. J., Kudrimoto, H. & McNaughton, B. L. in Advances in Neural Information Processing Systems (eds Tesauro, G., Touretzky, D. S. & Leen, T. K.) Vol. 7, 173-180 (MIT Press, Cambridge, Massachusetts, 1995).
43. Lingenhohl, K. & Finch, D. M. Morphological characterization of rat entorhinal neurons in vivo: soma-dendritic structure and axonal domains. Exp. Brain Res. 84, 57-74 (1991).
44. Germroth, P., Schwerdtfeger, W. K. & Buhl, E. H. Ultrastructure and aspects of functional organization of pyramidal and nonpyramidal entorhinal projection neurons contributing to the perforant path. J. Comp. Neurol. 305, 215-231 (1991).
45. Dhillon, A. & Jones, R. S. Laminar differences in recurrent excitatory transmission in the rat entorhinal cortex in vitro. Neuroscience 99, 413-422 (2000).
46. Egorov, A. V., Hamam, B. N., Fransen, E., Hasselmo, M. E. & Alonso, A. A. Graded persistent activity in entorhinal cortex neurons. Nature 420, 173-178 (2002).
47. Iijima, T. et al. Entorhinal-hippocampal interactions revealed by real-time imaging. Science 272, 1176-1179 (1996).
48. Lorincz, A. & Buzsaki, G. Two-phase computational model training long-term memories in the entorhinal-hippocampal region. Ann. NY Acad. Sci. 911, 83-111 (2000).
49. Fyhn, M., Molden, S., Hollup, S., Moser, M.-B. & Moser, E. I. Hippocampal neurons responding to first-time dislocation of a target object. Neuron 35, 555-566 (2002).
50. Sargolini, F., Molden, S., Witter, M. P., Moser, E. I. & Moser, M.-B. Place representation in the deep layers of entorhinal cortex. Soc. Neurosci. Abstr. 30, 330.9 (2004).