Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis

Human Reproduction

Volumn 30, Issue 2, 2015, Pages 417-431

  Aslani, Ferial ^a   Schuppe, Hans Christian ^a   Guazzone, Vanesa A ^b   Bhushan, Sudhanshu ^a   Wahle, Eva ^a   Lochnit, Günter ^a   Lustig, Livia ^b   Meinhardt, Andreas ^a   Fijak, Monika ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Ethyl pyruvate; Experimental autoimmune orchitis; High mobility group box protein 1; Receptor for advanced glycation end products; Testicular inflammation

Indexed keywords

ADJUVANT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTIBODY; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOKINE; ETHYLPYRUVATE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; PYRUVIC ACID DERIVATIVE; RNA; SODIUM CHLORIDE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ETHYL PYRUVATE; HBP1 PROTEIN, RAT; HMGB1 PROTEIN, HUMAN; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BIOASSAY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYTOKINE RELEASE; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL AUTOIMMUNE ORCHITIS; HOMOGENATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNIZATION; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTERVENTION STUDY; LONGITUDINAL STUDY; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; MALE INFERTILITY; NONHUMAN; ORCHITIS; PATHOGENESIS; PERITUBULAR CELL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN TARGETING; PROXIMITY LIGATION ASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE; SERTOLI CELL; SIGNAL TRANSDUCTION; SOMATIC CELL; SPERMATOGENESIS; TESTICULAR MACROPHAGE; TESTIS BIOPSY; TISSUE SECTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; BIOPSY; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; GENETICS; IMMUNOLOGY; LYMPHOCYTE; MACROPHAGE ACTIVATION; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROTEIN TRANSPORT; TESTIS; WISTAR RAT;

ANIMALIA; RATTUS;

ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AUTOIMMUNE DISEASES; BIOPSY; CELL NUCLEUS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HMGB1 PROTEIN; HUMANS; INFERTILITY, MALE; LYMPHOCYTES; MACROPHAGE ACTIVATION; MALE; MOLECULAR TARGETED THERAPY; ORCHITIS; PROTEIN TRANSPORT; PYRUVATES; RATS, WISTAR; RECOMBINANT PROTEINS; TESTIS;

EID: 84930726013     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deu320     Document Type: Article

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