Neural correlates of change in major depressive disorder anhedonia following open-label ketamine

Journal of Psychopharmacology

Volumn 29, Issue 5, 2015, Pages 596-607

  Lally, Níall ^a,b   Nugent, Allison C ^a   Luckenbaugh, David A ^a   Niciu, Mark J ^a   Roiser, Jonathan P ^b   Zarate, Carlos A ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

18FDG PET; Anti anhedonic; depression; dorsal anterior cingulate cortex; glutamate; hippocampus; NMDA; orbitofrontal cortex; reward; riluzole; subiculum

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; KETAMINE; PLACEBO; RILUZOLE; ANTIDEPRESSANT AGENT;

ADULT; ANHEDONIA; ANTERIOR CINGULATE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG INFUSION; DRUG MECHANISM; EXPLORATORY RESEARCH; FEMALE; GLUCOSE METABOLISM; HIPPOCAMPUS; HUMAN; INFERIOR FRONTAL GYRUS; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MONTGOMERY ASBERG DEPRESSION RATING SCALE; NEUROBIOLOGY; OPEN STUDY; ORBITAL CORTEX; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOLOGIC TEST; RANDOMIZED CONTROLLED TRIAL; SNAITH HAMILTON PLEASURE SCALE; TREATMENT DURATION; CINGULATE GYRUS; DEPRESSIVE DISORDER, MAJOR; DEPRESSIVE DISORDER, TREATMENT-RESISTANT; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; MIDDLE AGED; PSYCHOLOGY; SCINTISCANNING; TREATMENT OUTCOME;

ADULT; ANHEDONIA; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; DEPRESSIVE DISORDER, TREATMENT-RESISTANT; DOUBLE-BLIND METHOD; FEMALE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; KETAMINE; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84930684377     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881114568041     Document Type: Article

References (70)

1. Argyropoulos SV, Nutt DJ. Anhedonia revisited: Is there a role for dopamine-targeting drugs for depression?. J Psychopharmacol. 2013 ; 27: 869-877
2. Bechtholt-Gompf AJ, Walther HV, Adams MA, et al. Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory. Neuropsychopharmacology. 2010 ; 35: 2049-2059
3. Behrens TE, Woolrich MW, Walton ME, et al. Learning the value of information in an uncertain world. Nat Neurosci. 2007 ; 10: 1214-1221
4. Benoit RG, Gilbert SJ, Burgess PW. A neural mechanism mediating the impact of episodic prospection on farsighted decisions. J Neurosci. 2011 ; 31: 6771-6779
5. Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000 ; 47: 351-354
6. Blaha CD, Yang CR, Floresco SB, et al. Stimulation of the ventral subiculum of the hippocampus evokes glutamate receptor-mediated changes in dopamine efflux in the rat nucleus accumbens. Eur J Neurosci. 1997 ; 9: 902-911
7. Boyer P, Tassin JP, Falissart B, et al. Sequential improvement of anxiety, depression and anhedonia with sertraline treatment in patients with major depression. J Clin Pharm Ther. 2000 ; 25: 363-371
8. Brooks RA. Alternative formula for glucose utilization using labeled deoxyglucose. J Nucl Med. 1982 ; 23: 538-539
9. Brudzynski SM, Gibson CJ. Release of dopamine in the nucleus accumbens caused by stimulation of the subiculum in freely moving rats. Brain Res Bull. 1997 ; 42: 303-308
10. Carlson PJ, Diazgranados N, Nugent AC, et al. Neural correlates of rapid antidepressant response to ketamine in treatment-resistant unipolar depression: A preliminary positron emission tomography study. Biol Psychiatry. 2013 ; 73: 1213-1221
11. Corrigan MH, Denahan AQ, Wright CE, et al. Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress Anxiety. 2000 ; 11: 58-65
12. Diazgranados N, Ibrahim L, Brutsche NE, et al. A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry. 2010 ; 67: 793-802
13. Donahue RJ, Muschamp JW, Russo SJ, et al. Effects of striatal deltaFosB overexpression and ketamine on social defeat stress-induced anhedonia in mice. Biol Psychiatry. 2014 ; 76: 550-558
14. Drevets WC. Orbitofrontal cortex function and structure in depression. Ann N Y Acad Sci. 2007 ; 1121: 499-527
15. Edwards AC, Aliev F, Bierut LJ, et al. Genome-wide association study of comorbid depressive syndrome and alcohol dependence. Psychiatr Genet. 2012 ; 22: 31-41
16. Elliott R, Dolan RJ, Frith CD. Dissociable functions in the medial and lateral orbitofrontal cortex: Evidence from human neuroimaging studies. Cereb Cortex. 2000 ; 10: 308-317
17. Eshel N, Roiser JP. Reward and punishment processing in depression. Biol Psychiatry. 2010 ; 68: 118-124
18. Fawcett J, Scheftner WA, Fogg L, et al. Time-related predictors of suicide in major affective disorder. Am J Psychiatry. 1990 ; 147: 1189-1194
19. First MB, Spitzer RL, Gibbon M, et al Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. New York, New York State Psychiatric Institute: Biometrics Research ; 2002 :
20. Garcia LS, Comim CM, Valvassori SS, et al. Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2009 ; 33: 450-455
21. Gard DE, Kring AM, Gard MG, et al. Anhedonia in schizophrenia: Distinctions between anticipatory and consummatory pleasure. Schizophr Res. 2007 ; 93: 253-260
22. Gorwood P. Neurobiological mechanisms of anhedonia. Dialogues Clin Neurosci. 2008 ; 10: 291-299
23. Hindmarch I. The behavioural toxicity of antidepressants: Effects on cognition and sexual function. Int Clin Psychopharmacol. 1998 ; 13: S5 - S8
24. Ibrahim L, Diazgranados N, Franco-Chaves J, et al. Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: Results from a 4-week, double-blind, placebo-controlled study. Neuropsychopharmacology. 2012 ; 37: 1526-1533
25. Insel T, Cuthbert B, Garvey M, et al. Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010 ; 167: 748-751
26. John CS, Smith KL, Van't Veer A, et al. Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia. Neuropsychopharmacology. 2012 ; 37: 2467-2475
27. Kringelbach ML, O'Doherty J, Rolls ET, et al. Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness. Cereb Cortex. 2003 ; 13: 1064-1071
28. Krystal JH, Petrakis IL, Limoncelli D, et al. Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients. Neuropsychopharmacology. 2003 ; 28: 2020-2028
29. Lally N, Nugent AC, Luckenbaugh D, et al. Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression. Translational Psychiatry. 2014 ; 4: e469
30. Legault M, Wise RA. Injections of N-methyl-D-aspartate into the ventral hippocampus increase extracellular dopamine in the ventral tegmental area and nucleus accumbens. Synapse. 1999 ; 31: 241-249
31. Lemke MR, Brecht HM, Koester J, et al. Anhedonia, depression, and motor functioning in Parkinson's disease during treatment with pramipexole. J Neuropsychiatry Clin Neurosci. 2005 ; 17: 214-220
32. Li N, Liu RJ, Dwyer JM, et al. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry. 2011 ; 69: 754-761
33. Luckenbaugh DA, Ibrahim L, Brutsche N, et al. Family history of alcohol dependence and antidepressant response to an N-methyl-D-aspartate antagonist in bipolar depression. Bipolar Disord. 2012 ; 14: 880-887
34. Luckenbaugh DA, Niciu MJ, Ionescu DF, et al. Do the dissociative side effects of ketamine mediate its antidepressant effects?. J Affect Disord. 2014 ; 159: 56-61
35. McCabe C, Mishor Z, Cowen PJ, et al. Diminished neural processing of aversive and rewarding stimuli during selective serotonin reuptake inhibitor treatment. Biol Psychiatry. 2010 ; 67: 439-445
36. Moghaddam B, Adams B, Verma A, et al. Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 1997 ; 17: 2921-2927
37. Montgomery SA, Åsberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry. 1979 ; 134: 382-389
38. Murrough JW, Iosifescu DV, Chang LC, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: A two-site randomized controlled trial. Am J Psychiatry. 2013a ; 170: 1134-1142
39. Murrough JW, Perez AM, Pillemer S, et al. Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. Biol Psychiatry. 2013b ; 74: 250-256
40. Niciu MJ, Henter ID, Luckenbaugh DA, et al. Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: Ketamine and other compounds. Annu Rev Pharmacol Toxicol. 2014a ; 54: 119-139
41. Niciu MJ, Luckenbaugh DA, Ionescu DF, et al. Riluzole likely lacks antidepressant efficacy in ketamine non-responders. J Psychiatr Res. 2014b ; 58: 197-199
42. Nugent AC, Diazgranados N, Carlson PJ, et al. Neural correlates of rapid antidepressant response to ketamine in bipolar disorder. Bipolar Disord. 2014 ; 16: 119-128
43. Nutt D, Demyttenaere K, Janka Z, et al. The other face of depression, reduced positive affect: The role of catecholamines in causation and cure. J Psychopharmacol. 2007 ; 21: 461-471
44. O'Doherty J, Kringelbach ML, Rolls ET, et al. Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci. 2001 ; 4: 95-102
45. Opbroek A, Delgado PL, Laukes C, et al. Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?. Int J Neuropsychopharmacol. 2002 ; 5: 147-151
46. Papp M, Moryl E. New evidence for the antidepressant activity of MK-801, a non-competitive antagonist of NMDA receptors. Pol J Pharmacol. 1993 ; 45: 549-553
47. Pelizza L, Ferrari A. Anhedonia in schizophrenia and major depression: state or trait?. Ann Gen Psychiatry. 2009 ; 8: 22
48. Petrakis IL, Limoncelli D, Gueorguieva R, et al. Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. Am J Psychiatry. 2004 ; 161: 1776-1782
49. Phelps LE, Brutsche N, Moral JR, et al. Family history of alcohol dependence and initial antidepressant response to an N-methyl-D-aspartate antagonist. Biol Psychiatry. 2009 ; 65: 181-184
50. Pizzagalli DA, Iosifescu D, Hallett LA, et al. Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task. J Psychiatr Res. 2008 ; 43: 76-87
51. Price J, Cole V, Goodwin GM. Emotional side-effects of selective serotonin reuptake inhibitors: Qualitative study. Br J Psychiatry. 2009 ; 195: 211-217
52. Reus GZ, Abelaira HM, Stringari RB, et al. Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats. Metab Brain Dis. 2012 ; 27: 175-182
53. Robinson OJ, Cools R, Carlisi CO, et al. Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder. Am J Psychiatry. 2012 ; 169: 152-159
54. Sackeim HA. The definition and meaning of treatment-resistant depression. J Clin Psychiatry. 2001 ; 62: 10-17
55. Sanacora G, Treccani G, Popoli M. Towards a glutamate hypothesis of depression: An emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology. 2012 ; 62: 63-77
56. Schott BH, Minuzzi L, Krebs RM, et al. Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release. J Neurosci. 2008 ; 28: 14311-14319
57. Schumann G, Johann M, Frank J, et al. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Arch Gen Psychiatry. 2008 ; 65: 826-838
58. Shelton RC, Tomarken AJ. Can recovery from depression be achieved?. Psychiatr Serv. 2001 ; 52: 1469-1478
59. Shidara M, Richmond BJ. Anterior cingulate: Single neuronal signals related to degree of reward expectancy. Science. 2002 ; 296: 1709-1711
60. Snaith RP, Hamilton M, Morley S, et al. A scale for the assessment of hedonic tone: The Snaith-Hamilton Pleasure Scale. Br J Psychiatry. 1995 ; 167: 99-103
61. Spijker J, Bijl RV, de Graaf R, et al. Determinants of poor 1-year outcome of DSM-III-R major depression in the general population: Results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Acta Psychiatr Scand. 2001 ; 103: 122-130
62. Sweet KL, Neill DB. Amphetamine injections into the nucleus accumbens enhance the reward of stimulation of the subiculum. Ann N Y Acad Sci. 1999 ; 877: 828-830
63. Treadway MT, Zald DH. Reconsidering anhedonia in depression: Lessons from translational neuroscience. Neurosci Biobehav Rev. 2011 ; 35: 537-555
64. Uher R, Perlis RH, Henigsberg N, et al. Depression symptom dimensions as predictors of antidepressant treatment outcome: Replicable evidence for interest-activity symptoms. Psychol Med. 2012 ; 42: 967-980
65. Vollenweider FX, Vontobel P, Oye I, et al. Effects of (S)-ketamine on striatal dopamine: A [11C]raclopride PET study of a model psychosis in humans. J Psychiatr Res. 2000 ; 34: 35-43
66. Walter M, Henning A, Grimm S, et al. The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression. Arch Gen Psychiatry. 2009 ; 66: 478-486
67. Wittmann BC, Schott BH, Guderian S, et al. Reward-related FMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron. 2005 ; 45: 459-467
68. Zarate CA, Brutsche NE, Ibrahim L, et al. Replication of ketamine's antidepressant efficacy in bipolar depression: A randomized controlled add-on trial. Biol Psychiatry. 2012 ; 71: 939-946
69. Zarate CA, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry. 2006 ; 63: 856-864
70. Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging. 2001 ; 20: 45-57