-
1
-
-
77953928054
-
Stoking the antibiotic pipeline
-
Morel, C. M., & Mossialos, E. Stoking the antibiotic pipeline. British Med. J. 340, 1115-1118 (2010).
-
(2010)
British Med. J.
, vol.340
, pp. 1115-1118
-
-
Morel, C.M.1
Mossialos, E.2
-
2
-
-
79953740494
-
Fix the antibiotic pipeline
-
Cooper, M. A., & Shlaes, D. Fix the antibiotic pipeline. Nature 472, 32 (2011).
-
(2011)
Nature
, vol.472
, pp. 32
-
-
Cooper, M.A.1
Shlaes, D.2
-
3
-
-
84886803095
-
Antibiotics in the clinical pipeline in 2013
-
Butler, M. S., Blaskovich, M. A., & Cooper M. A. Antibiotics in the clinical pipeline in 2013. J. Antibiotics 66, 571-591 (2013).
-
(2013)
J. Antibiotics
, vol.66
, pp. 571-591
-
-
Butler, M.S.1
Blaskovich, M.A.2
Cooper, M.A.3
-
4
-
-
84878278251
-
Infectious diseases society of america. 10× '20 progress-development of new drugs active against gramnegative bacilli: An update from the infectious diseases society of america
-
Boucher, H. W. et al. Infectious Diseases Society of America. 10× '20 Progress-Development of new drugs active against gramnegative bacilli: an update from the infectious diseases society of America. Clin. Infect. Dis. 56, 1685-1694 (2013).
-
(2013)
Clin. Infect. Dis.
, vol.56
, pp. 1685-1694
-
-
Boucher, H.W.1
-
5
-
-
79953871631
-
Infectious diseases society of america. Combating antimicrobial resistance: Policy recommendations to save lives
-
Guidos R. J., Infectious Diseases Society of America. Combating antimicrobial resistance: policy recommendations to save lives. Clin Infect Dis. 52, S397-S428 (2011).
-
(2011)
Clin Infect Dis.
, vol.52
, pp. S397-S428
-
-
Guidos, R.J.1
-
7
-
-
84856477196
-
-
CDC, Threat report 2013. Available at: (Date of access: 04/02/2015
-
CDC, Centre for Disease Control and Prevention, Threat report 2013. (2014) Available at: http://www.cdc.gov/drugresistance/threat-report-2013 (Date of access: 04/02/2015).
-
(2014)
Centre for Disease Control and Prevention
-
-
-
8
-
-
84875164559
-
The true cost of antimicrobial resistance
-
Smith, R., & Coast, J. The true cost of antimicrobial resistance. British Med. J. 346, f1430 (2013).
-
(2013)
British Med. J.
, vol.346
, pp. f1430
-
-
Smith, R.1
Coast, J.2
-
9
-
-
84893089095
-
Prospects for new antibiotics: A molecule-centered perspective
-
Walsh, C. T., & Wencewicz, T. A. Prospects for new antibiotics: a molecule-centered perspective. J. Antibiotics 67, 7-22 (2014).
-
(2014)
J. Antibiotics
, vol.67
, pp. 7-22
-
-
Walsh, C.T.1
Wencewicz, T.A.2
-
10
-
-
84901809320
-
-
World Health Organization. Available at: (Date of access: 24/02/2015
-
World Health Organization. Antimicrobial Resistance: Global Report on Surveillance 2014. (2014) Available at: http://apps.who. int/iris/bitstream/10665/112642/1/9789241564748eng.pdf (Date of access: 24/02/2015).
-
(2014)
Antimicrobial Resistance: Global Report on Surveillance 2014.
-
-
-
11
-
-
84903766667
-
An intergovernmental panel on antimicrobial resistance
-
Woolhouse, M., & Farrar J. An intergovernmental panel on antimicrobial resistance. Nature 509, 555-557 (2014).
-
(2014)
Nature
, vol.509
, pp. 555-557
-
-
Woolhouse, M.1
Farrar, J.2
-
12
-
-
84901594817
-
A three-step plan for antibiotics
-
Editorial
-
Editorial, A three-step plan for antibiotics, Nature 509, 533 (2014).
-
(2014)
Nature
, vol.509
, pp. 533
-
-
-
13
-
-
77950255824
-
The 10x20 initiative: Pursuing a global commitment to develop 10 new antibacterial drugs by 2020
-
Gilbert D. N. et al. The 10x20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin. Infect. Dis. 50, 1081-1083 (2010).
-
(2010)
Clin. Infect. Dis.
, vol.50
, pp. 1081-1083
-
-
Gilbert, D.N.1
-
14
-
-
84899927894
-
Antibiotic resistance sweeping developing world
-
Reardon, S. Antibiotic resistance sweeping developing world. Nature 509, 141-142 (2014).
-
(2014)
Nature
, vol.509
, pp. 141-142
-
-
Reardon, S.1
-
15
-
-
84896402755
-
Nd4bb: Addressing the antimicrobial resistance crisis
-
Rex J. H. ND4BB: addressing the antimicrobial resistance crisis. Nature Rev. Microbiol. 12, 231-232 (2014).
-
(2014)
Nature Rev. Microbiol.
, vol.12
, pp. 231-232
-
-
Rex, J.H.1
-
16
-
-
84930248241
-
-
(eds Villa T. G., & Veiga-Crespo P. Ch. 10 (Springer Verlag GmbH
-
Viñas, M., Rabanal, F., Benz, R., Vinuesa, T., & Fusté, E. in Antimicrobial compounds: current strategies and new alternatives (eds Villa, T. G., & Veiga-Crespo, P.) Ch. 10, 269-284 (Springer Verlag GmbH, 2014).
-
(2014)
Antimicrobial Compounds: Current Strategies and New Alternatives
, pp. 269-284
-
-
Viñas, M.1
Rabanal, F.2
Benz, R.3
Vinuesa, T.4
Fusté, E.5
-
17
-
-
84857411069
-
Designing antimicrobial peptides: Form follows function
-
Fjell, C. D., Hiss, J. A., Hancock, R. E. W., & Schneider, G. Designing antimicrobial peptides: form follows function. Naure. Rev. Drug Discov. 11, 37-51 (2012).
-
(2012)
Naure. Rev. Drug Discov.
, vol.11
, pp. 37-51
-
-
Fjell, C.D.1
Hiss, J.A.2
Hancock, R.E.W.3
Schneider, G.4
-
18
-
-
84860601877
-
Antimicrobial peptides: Key components of the innate immune system
-
Pasupuleti, M., Schmidtchen, A., & Malmsten, M. Antimicrobial peptides: key components of the innate immune system. Crit. Rev. Biotechnol. 32, 143-171 (2012).
-
(2012)
Crit. Rev. Biotechnol.
, vol.32
, pp. 143-171
-
-
Pasupuleti, M.1
Schmidtchen, A.2
Malmsten, M.3
-
19
-
-
0037371597
-
Mechanisms of antimicrobial peptide action and resistance
-
Yeaman, M. R., & Yount, N. Y. Mechanisms of antimicrobial peptide action and resistance. Pharmacol. Rev. 55, 27-55 (2003).
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 27-55
-
-
Yeaman, M.R.1
Yount, N.Y.2
-
20
-
-
84855865471
-
Emerging themes and therapeutic prospects for anti-infective peptides
-
Yount, N. Y., & Yeaman, M. R. Emerging themes and therapeutic prospects for anti-infective peptides. Annu. Rev. Pharmacol. Toxicol. 52, 337-360 (2012).
-
(2012)
Annu. Rev. Pharmacol. Toxicol.
, vol.52
, pp. 337-360
-
-
Yount, N.Y.1
Yeaman, M.R.2
-
21
-
-
14544282377
-
Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?
-
Brogden, K. A. Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? Nature Rev. Microbiol. 3, 238-250 (2005).
-
(2005)
Nature Rev. Microbiol.
, vol.3
, pp. 238-250
-
-
Brogden, K.A.1
-
22
-
-
80051546187
-
Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?
-
Brogden, N. K., & Brogden, K. A. Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals? Int. J. Antimicrob. Agents 38, 217-225 (2011).
-
(2011)
Int. J. Antimicrob. Agents
, vol.38
, pp. 217-225
-
-
Brogden, N.K.1
Brogden, K.A.2
-
23
-
-
77149159117
-
Peptidomimetic antibiotics target outer-membrane biogenesis in pseudomonas aeruginosa
-
Srinivas, N. et al. Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa. Science 327, 1010-1013 (2010).
-
(2010)
Science
, vol.327
, pp. 1010-1013
-
-
Srinivas, N.1
-
24
-
-
2942670459
-
Can innate immunity be enhanced to treat microbial infections?
-
Finlay, B. B., & Hancock, R. E. W. Can innate immunity be enhanced to treat microbial infections? Nat. Rev. Microbiol. 2, 497-504 (2004).
-
(2004)
Nat. Rev. Microbiol.
, vol.2
, pp. 497-504
-
-
Finlay, B.B.1
Hancock, R.E.W.2
-
25
-
-
0034255255
-
The role of antimicrobial peptides in animal defences
-
Hancock, R. E. W., & Scott, M. G., The role of antimicrobial peptides in animal defences. Proc. Natl. Acad. Sci. USA 97, 8856-8861 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8856-8861
-
-
Hancock, R.E.W.1
Scott, M.G.2
-
26
-
-
67650566598
-
Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: The importance of interfacial activity
-
Rathinakumar, R., Walkenhorst, W. F., & Wimley, W. C. Broad-spectrum antimicrobial peptides by rational combinatorial design and high-throughput screening: the importance of interfacial activity. J. Am. Chem. Soc. 131, 7609-7617 (2009).
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 7609-7617
-
-
Rathinakumar, R.1
Walkenhorst, W.F.2
Wimley, W.C.3
-
27
-
-
84880681078
-
Novel derivatives of polymyxins
-
Vaara, M. Novel derivatives of polymyxins. J. Antimicrob Chemother. 68, 1213-1219 (2013).
-
(2013)
J. Antimicrob Chemother.
, vol.68
, pp. 1213-1219
-
-
Vaara, M.1
-
28
-
-
84930668207
-
-
United States patent, March 10th
-
Rabanal, F., Cajal, Y., Garcia-Subirats, M., & Rodríguez M., inventors; University of Barcelona assignee. Peptide compounds that can be used as antibacterial agents. United States patent US2013053305. 2010, March 10th
-
(2010)
Inventors; University of Barcelona Assignee. Peptide Compounds That Can Be Used As Antibacterial Agents
-
-
Rabanal, F.1
Cajal, Y.2
Garcia-Subirats, M.3
Rodríguez, M.4
-
29
-
-
79955113253
-
Biodegradable nanostructures with selective lysis of microbial membranes
-
Nederberg, F. et al. Biodegradable nanostructures with selective lysis of microbial membranes. Nature Chemistry 3, 409-414 (2011).
-
(2011)
Nature Chemistry
, vol.3
, pp. 409-414
-
-
Nederberg, F.1
-
30
-
-
78650293305
-
Targeting bacterial membrane function: An underexploited mechanism for treating persistent infections
-
Hurdle, J. G., O'Neill, A. J., Chopra, I., & Lee, R. E. Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nature Rev. Microbiol. 9, 62-75 (2011).
-
(2011)
Nature Rev. Microbiol.
, vol.9
, pp. 62-75
-
-
Hurdle, J.G.1
O'Neill, A.J.2
Chopra, I.3
Lee, R.E.4
-
31
-
-
0028177604
-
Ranalexin a novel antimicrobial peptide from bullfrog (rana catesbeiana) skin, structurally related to the antibacterial antibiotic polymyxin
-
Clark, D. P., Durrel, S., Malloy, W. L., & Zasloff, M. Ranalexin, a novel antimicrobial peptide from Bullfrog (Rana Catesbeiana) skin, structurally related to the antibacterial antibiotic polymyxin. J. Biol. Chem. 269, 10849-10855 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 10849-10855
-
-
Clark, D.P.1
Durrel, S.2
Malloy, W.L.3
Zasloff, M.4
-
32
-
-
0027497613
-
Molecular mapping and detoxification of the lipid a binding site by synthetic peptides
-
Rustici, A. et al. Molecular mapping and detoxification of the lipid A binding site by synthetic peptides. Science 259, 361-364 (1993).
-
(1993)
Science
, vol.259
, pp. 361-364
-
-
Rustici, A.1
-
33
-
-
84868028805
-
Pharmacokinetics and renal disposition of polymyxin b in an animal model
-
Abdelraouf, K., Jie, H., Ledesma, K. R., Hu, M., & Tam, V. H. Pharmacokinetics and renal disposition of polymyxin B in an animal model. Antimicrob. Agents Chemother. 56, 5724-5727(2012).
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5724-5727
-
-
Abdelraouf, K.1
Jie, H.2
Ledesma, K.R.3
Hu, M.4
Tam, V.H.5
-
34
-
-
84903156436
-
Uptake of polymyxin b into renal cells
-
Abdelraouf, K., Chang, K.-T., Yin, T., Hu, M., & Tam, V. H. Uptake of polymyxin B into renal cells. Antimicrob. Agents Chemother. 58, 4200-4202 (2014).
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 4200-4202
-
-
Abdelraouf, K.1
Chang, K.-T.2
Yin, T.3
Hu, M.4
Tam, V.H.5
-
35
-
-
84863134610
-
Characterization of in vivo disulfide-reduction mediated drug release in mouse kidneys
-
Yang, J. J., Kularatne, S. A., Chen, X., Low, P. S., & Wang, E. Characterization of in vivo disulfide-reduction mediated drug release in mouse kidneys. Mol. Pharm. 9, 310-317 (2012).
-
(2012)
Mol. Pharm.
, vol.9
, pp. 310-317
-
-
Yang, J.J.1
Kularatne, S.A.2
Chen, X.3
Low, P.S.4
Wang, E.5
-
36
-
-
33748792549
-
Evaluation of disulfide reduction during receptor-mediated endocytosis by using fret imaging
-
Yang, J. J., Chen, H., Vlahov, I. R., Cheng, J.-X., & Low, P. S. Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging, Proc. Natl. Acad. Sci. USA 103, 13872-13877 (2006).
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 13872-13877
-
-
Yang, J.J.1
Chen, H.2
Vlahov, I.R.3
Cheng, J.-X.4
Low, P.S.5
-
37
-
-
84862650264
-
Peptide-drug conjugate linked via a disulfide bond for kidney targeted drug delivery
-
Geng, Q., Sun, X., Gong, T., & Zhang, Z.-R. Peptide-drug conjugate linked via a disulfide bond for kidney targeted drug delivery. Bioconjugate Chem. 23, 1200-1210 (2012).
-
(2012)
Bioconjugate Chem.
, vol.23
, pp. 1200-1210
-
-
Geng, Q.1
Sun, X.2
Gong, T.3
Zhang, Z.-R.4
-
38
-
-
77949346087
-
Structure-Activity relationships of polymyxin antibiotics
-
Velkov, T., Thompson, P. E., Nation, R. L., & Li, J. Structure-Activity relationships of polymyxin antibiotics. J. Med. Chem. 53, 1898-1916 (2010
-
(2010)
J. Med. Chem.
, vol.53
, pp. 1898-1916
-
-
Velkov, T.1
Thompson, P.E.2
Nation, R.L.3
Li, J.4
-
39
-
-
0016379789
-
Chemical synthesis, isolation and characterization of ?-n-fattyacyl colistin nonapeptide with special reference to the correlation between antimicrobial activity and carbon number of fatty acyl moiety
-
Chihara, S., Yahata, M., Tobita, T., & Koyama, Y. Chemical synthesis, isolation and characterization of ?-N-fattyacyl colistin nonapeptide with special reference to the correlation between antimicrobial activity and carbon number of fatty acyl moiety. Agric. Biol. Chem. 38, 521-529 (1974).
-
(1974)
Agric. Biol. Chem.
, vol.38
, pp. 521-529
-
-
Chihara, S.1
Yahata, M.2
Tobita, T.3
Koyama, Y.4
-
40
-
-
84900839248
-
Teaching 'old' polymyxins new tricks: New-generation lipopeptides targeting gram-negative 'superbugs
-
Velkov, T. et al. Teaching 'Old' Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative 'Superbugs'. ACS Chem. Biol. 9, 1172-1177 (2014).
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 1172-1177
-
-
Velkov, T.1
-
41
-
-
84879563263
-
Discovery of dap-3 polymyxin analogues for the treatment of multi-drug-resistant gram-negative nosocomial infections
-
Magee T. V. et al. Discovery of Dap-3 polymyxin analogues for the treatment of multi-drug-resistant gram-negative nosocomial infections. J Med Chem. 56, 5079-5093 (2013).
-
(2013)
J Med Chem.
, vol.56
, pp. 5079-5093
-
-
Magee, T.V.1
-
42
-
-
80051815004
-
First description of an escherichia coli strain producing ndm-1 carbapenemase in spain
-
Solé, M. et al. First description of an Escherichia coli strain producing NDM-1 carbapenemase in Spain. Antimicrob. Agents Chemother. 55, 4402-4404 (2011).
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 4402-4404
-
-
Solé, M.1
-
43
-
-
0034116380
-
Applications of flow cytometry to clinical microbiology
-
Alvarez-Barrientos, A., Arroyo, J., Canton, R., Nombela, C., & Sanchez-Perez, M. Applications of flow cytometry to clinical microbiology. Clinical Microbiology Reviews 13, 167-195 (2000).
-
(2000)
Clinical Microbiology Reviews
, vol.13
, pp. 167-195
-
-
Alvarez-Barrientos, A.1
Arroyo, J.2
Canton, R.3
Nombela, C.4
Sanchez-Perez, M.5
-
44
-
-
0030884159
-
Assessment of the effects of gramicidin, formaldehyde, and surfactants on escherichia coli by flow cytometry using nucleic acid and membrane potential dyes
-
Comas, J., & Vives-Rego, J. Assessment of the effects of gramicidin, formaldehyde, and surfactants on Escherichia coli by flow cytometry using nucleic acid and membrane potential dyes. Cytometry 29, 58-64 (1997).
-
(1997)
Cytometry
, vol.29
, pp. 58-64
-
-
Comas, J.1
Vives-Rego, J.2
-
45
-
-
70350042028
-
Polymyxin b identified as an inhibitor of alternative nadh dehydrogenase and malate:quinone oxidoreductase from gram-positive bacterium mycobacterium smegmatis
-
Mogi, T. et al. Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate:quinone oxidoreductase from Gram-positive bacterium Mycobacterium smegmatis. J. Biochem. 146, 491-499 (2009).
-
(2009)
J. Biochem.
, vol.146
, pp. 491-499
-
-
Mogi, T.1
-
46
-
-
84896804072
-
A secondary mode of action of polymyxins against gram-negative bacteria involves the inhibition of nadhquinone oxidoreductase activity
-
Deris, Z. Z. et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADHquinone oxidoreductase activity. J Antibiot. (Tokyo) 67, 147-151 (2014).
-
(2014)
J Antibiot. (Tokyo
, vol.67
, pp. 147-151
-
-
Deris, Z.Z.1
-
47
-
-
0033915369
-
Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria
-
Friedrich, C. L., Moyles, D., Beveridge, T. J., & Hancock R. E. W. Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria. Antimicrob. Agents Chemother. 44, 2086-2092 (2000).
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 2086-2092
-
-
Friedrich, C.L.1
Moyles, D.2
Beveridge, T.J.3
Hancock, R.E.W.4
-
48
-
-
70149088811
-
Mesosomes are a definite event in antibiotic-treated staphylococcus aureus atcc 25923
-
Santhana R. L. et al. Mesosomes are a definite event in antibiotic-treated Staphylococcus aureus ATCC 25923. Tropical Biomedicine 24, 105-109 (2007).
-
(2007)
Tropical Biomedicine
, vol.24
, pp. 105-109
-
-
Santhana, R.L.1
-
49
-
-
33846977780
-
Gram negative outer and inner membrane models: Insertion of cyclic cationic lipopeptides
-
Clausell, A. et al. Gram negative outer and inner membrane models: insertion of cyclic cationic lipopeptides. J. Phys. Chem. B 111, 551-556 (2007).
-
(2007)
J. Phys. Chem. B
, vol.111
, pp. 551-556
-
-
Clausell, A.1
-
50
-
-
33645665230
-
Membrane association and contact formation by a synthetic analogue of polymyxin b and its fluorescent derivatives
-
Clausell, A., Rabanal, F., Garcia-Subirats, M., Alsina, M. A., & Cajal, Y. Membrane association and contact formation by a synthetic analogue of polymyxin B and its fluorescent derivatives. J Phys Chem B 110, 4465-4471 (2006).
-
(2006)
J Phys Chem B
, vol.110
, pp. 4465-4471
-
-
Clausell, A.1
Rabanal, F.2
Garcia-Subirats, M.3
Alsina, M.A.4
Cajal, Y.5
-
51
-
-
3843049752
-
Antibacterial susceptibility test: Dilutions and diffusion methods
-
(eds Murray, P. R., Baron, E. J., Jorgensen, J. H., Pfaller, M. A., & Yorken, R. H. (ASM Press Washington DC
-
Jorgensen, J. H., & Turnidge, J. D. Antibacterial susceptibility test: dilutions and diffusion methods in Manual of Clinical Microbiology (eds Murray, P. R., Baron, E. J., Jorgensen, J. H., Pfaller, M. A., & Yorken, R. H.) pp 1108 (ASM Press Washington DC, 2003).
-
(2003)
Manual of Clinical Microbiology
, pp. 1108
-
-
Jorgensen, J.H.1
Turnidge, J.D.2
-
52
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63 (1983).
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
|