The role and potential therapeutic application of myeloid-derived suppressor cells in allo- and autoimmunity

Mediators of Inflammation

Volumn 2015, Issue , 2015, Pages

  Zhang, Qi ^a,b   Fujino, Masayuki ^b,c   Xu, Jinhua ^a   Li, Xiao Kang ^a,b  

^a FUDAN UNIVERSITY   (China)

^b NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR;

ADAPTIVE IMMUNITY; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOGENEIC STEM CELL TRANSPLANTATION; ALLOIMMUNITY; AUTOIMMUNE DISEASE; AUTOIMMUNE HEPATITIS; AUTOIMMUNITY; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL FUNCTION; CELL POPULATION; DISEASE COURSE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HEART GRAFT; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY BOWEL DISEASE; KIDNEY TRANSPLANTATION; MESENCHYMAL STROMA CELL; MYELOID DERIVED SUPPRESSOR CELL; MYELOID PROGENITOR CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SKIN TRANSPLANTATION; SUPPRESSOR CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC THERAPY; UVEORETINITIS; ANIMAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOLOGY; IMMUNOLOGY; PHYSIOLOGY;

ANIMALS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; HUMANS; MYELOID CELLS; MYELOID PROGENITOR CELLS;

EID: 84930665724     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2015/421927     Document Type: Review

References (90)

1. M. R. Young, M. Newby, and H. T. Wepsic, "Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors," Cancer Research, vol. 47, no. 1, pp. 100-105, 1987.
2. S. C. Buessow, R. D. Paul, and D. M. Lopez, "Infuence of mammary tumor progression on phenotype and function of spleen and in situ lymphocytes in mice," Journal of the National Cancer Institute, vol. 73, no. 1, pp. 249-255, 1984.
3. L. P. Seung, D. A. Rowley, P. Dubey, and H. Schreiber, "Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection," Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 14, pp. 6254-6258, 1995.
4. D. I. Gabrilovich, V. Bronte, S.-H. Chen et al., "The terminology issue for myeloid-derived suppressor cells," Cancer Research, vol. 67, no. 1, p. 425, 2007.
5. D. I. Gabrilovich and S. Nagaraj, "Myeloid-derived suppressor cells as regulators of the immune system," Nature Reviews Immunology, vol. 9, no. 3, pp. 162-174, 2009.
6. P. Boros, J. C. Ochando, S.-H. Chen, and J. S. Bromberg, "Myeloid-derived suppressor cells: natural regulators for transplant tolerance," Human Immunology, vol. 71, no. 11, pp. 1061-1066, 2010.
7. J. C. Ochando and S. H. Chen, "Myeloid-derived suppressor cells in transplantation and cancer," Immunologic Research, vol. 54, no. 1-3, pp. 275-285, 2012.
8. T. Wu and Y. Zhao, "The roles of myeloid-derived suppressor cells in transplantation," Expert Review of Clinical Immunology, vol. 10, no. 10, pp. 1385-1394, 2014.
9. J. G. Cripps and J. D. Gorham, "MDSC in autoimmunity," International Immunopharmacology, vol. 11, no. 7, pp. 789-793, 2011.
10. E. Ribechini, V. Greifenberg, S. Sandwick, and M. B. Lutz, "Subsets, expansion and activation of myeloid-derived suppressor cells," Medical Microbiology and Immunology, vol. 199, no. 3, pp. 273-281, 2010.
11. D. Gabrilovich, "Mechanisms and functional signifcance of tumour-induced dendritic-cell defects," Nature Reviews Immunology, vol. 4, no. 12, pp. 941-952, 2004.
12. J. Jiang, W. Guo, and X. Liang, "Phenotypes, accumulation, and functions of myeloid-derived suppressor cells and associated treatment strategies in cancer patients," Human Immunology, vol. 75, no. 11, pp. 1128-1137, 2014.
13. + cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor," Clinical Cancer Research, vol. 1, no. 1, pp. 95-103, 1995.
14. D. M. R. Lathers, J. I. Clark, N. J. Achille, and M. R. I. Young, "Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3," Cancer Immunology, Immunotherapy, vol. 53, no. 5, pp. 422-430, 2004.
15. + progenitor cells," Human Immunology, vol. 62, no. 4, pp. 332-341, 2001.
16. A. Oserof, S. Okada, and S. Strober, "Natural suppressor (NS) cells found in the spleen of neonatal mice and adult mice given total lymphoid irradiation (TLI) express the null surface phenotype," The Journal of Immunology, vol. 132, no. 1, pp. 101-110, 1984.
17. S. Strober, "Natural suppressor (NS) cells, neonatal tolerance, and total lymphoid irradiation: exploring obscure relationships," Annual Review of Immunology, vol. 2, pp. 219-237, 1984.
18. J. H. Holda, T. Maier, and H. N. Claman, "Murine graf-versus-host disease across minor barriers: immunosuppressive aspects of natural suppressor cells," Immunological Reviews, vol. 88, pp. 87-105, 1985.
19. J. H. Holda, T. Maier, and H. N. Claman, "Graf-vs-host reactions (GVHR) across minor murine histocompatibility barriers. I. Impairment of mitogen responses and suppressor phenomena," The Journal of Immunology, vol. 134, no. 3, pp. 1397-1402, 1985.
20. + early myeloid cells with suppressor activity in spleens of murine radiation marrow chimeras: possible implications for the graf-versus-host and graf-versus-leukemia reactivity of donor lymphocyte infusions," Blood, vol. 102, no. 2, pp. 740-748, 2003.
21. B. Sprangers, B. van Wijmeersch, A. Luyckx et al., "Subclinical GvHD in non-irradiated F1 hybrids: severe lymphoid-tissue GvHD causing prolonged immune dysfunction," Bone Marrow Transplantation, vol. 46, no. 4, pp. 586-596, 2011.
22. A. Luyckx, E. Schouppe, O. Rutgeerts et al., "Subset characterization of myeloid-derived suppressor cells arising during induction of BM chimerism in mice," Bone Marrow Transplantation, vol. 47, no. 7, pp. 985-992, 2012.
23. + myeloid cells in patients following allogeneic hematopoietic stem cell transplantation," Leukemia, vol. 27, no. 2, pp. 377-388, 2013.
24. + cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells," Blood, vol. 89, no. 5, pp. 1629-1634, 1997.
25. A. Vendramin, S. Gimondi, A. Bermema et al., "Graf mono-cytic myeloid-derived suppressor cell content predicts the risk of acute graf-versus-host disease afer allogeneic transplantation of granulocyte colony-stimulating factor-mobilized peripheral blood stem cells," Biology of Blood and Marrow Transplantation, vol. 20, no. 12, pp. 2049-2055, 2014.
26. Y.-D. Joo, S.-M. Lee, S.-W. Lee et al., "Granulocyte colony-stimulating factor-induced immature myeloid cells inhibit acute graf-versus-host disease lethality through an indoleamine dioxygenase-independent mechanism," Immunology, vol. 128, no. 1, pp. e632-e640, 2009.
27. S. L. Highfll, P. C. Rodriguez, Q. Zhou et al., "Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graf-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13," Blood, vol. 116, no. 25, pp. 5738-5747, 2010.
28. + cells efciently suppress T cell-mediated immunoreactivity and graf-versus-host disease in a murine model of allogeneic cell therapy," Biology of Blood and Marrow Transplantation, vol. 14, no. 9, pp. 973-984, 2008.
29. N. Rieber, I. Wecker, D. Neri et al., "Extracorporeal photophere-sis increases neutrophilic myeloid-derived suppressor cells in patients with GvHD," Bone Marrow Transplantation, vol. 49, no. 4, pp. 545-552, 2014.
30. D. Wang, Y. Yu, K. Haarberg et al., "Dynamic change and impact of myeloid-derived suppressor cells in allogeneic bone marrow transplantation in mice," Biology of Blood and Marrow Transplantation, vol. 19, no. 5, pp. 692-702, 2013.
31. M. R. Garcia, L. Ledgerwood, Y. Yang et al., "Monocytic sup-pressive cells mediate cardiovascular transplantation tolerance in mice," The Journal of Clinical Investigation, vol. 120, no. 7, pp. 2486-2496, 2010.
32. D. Hongo, X. Tang, J. Baker, E. G. Engleman, and S. Strober, "Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance," American Journal of Transplantation, vol. 14, no. 11, pp. 2467-2477, 2014.
33. F. Ge, S. Yuan, L. Su et al., "Alteration of innate immunity by donor IL-6 defciency in a presensitized heart transplant model," PLoS ONE, vol. 8, no. 10, Article ID e77559, 2013.
34. W. Gong, F. Ge, D. Liu et al., "Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model," Clinical Immunology, vol. 153, no. 1, pp. 8-16, 2014.
35. S. M. Brunner, G. Schiechl, W. Falk, H. J. Schlitt, E. K. Geissler, and S. Fichtner-Feigl, "Interleukin-33 prolongs allograf survival during chronic cardiac rejection," Transplant International, vol. 24, no. 10, pp. 1027-1039, 2011.
36. A.-S. Dugast, T. Haudebourg, F. Coulon et al., "Myeloid-derived suppressor cells accumulate in kidney allograf tolerance and specifcally suppress efector T cell expansion," Journal of Immunology, vol. 180, no. 12, pp. 7898-7906, 2008.
37. N. Dilek, N. Poirier, C. Usal, B. Martinet, G. Blancho, and B. Vanhove, "Control of transplant tolerance and intragraf regulatory T cell localization by Myeloid-derived suppressor cells and CCL5," The Journal of Immunology, vol. 188, no. 9, pp. 4209-4216, 2012.
38. B. D. Hock, K. A. MacKenzie, N. B. Cross et al., "Renal transplant recipients have elevated frequencies of circulating myeloid-derived suppressor cells," Nephrology Dialysis Transplantation, vol. 27, no. 1, pp. 402-410, 2012.
39. + Treg expansion," The American Journal of Transplantation, vol. 13, no. 12, pp. 3123-3131, 2013.
40. V. de Wilde, N. van Rompaey, M. Hill et al., "Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1," American Journal of Transplantation, vol. 9, no. 9, pp. 2034-2047, 2009.
41. W. Zhang, S. Liang, J. Wu, and A. Horuzsko, "Human inhibitory receptor immunoglobulin-like transcript 2 amplifes CD11b+Gr1+ myeloid-derived suppressor cells that promote long-term survival of allografs," Transplantation, vol. 86, no. 8, pp. 1125-1134, 2008.
42. + T regulatory cells prolongs skin allograf survival in mice," Cell Transplantation, vol. 20, no. 6, pp. 941-954, 2011.
43. S. M. Abraham, T. Lawrence, A. Kleiman et al., "Antiinfammatory efects of dexamethasone are partly dependent on induction of dual specifcity phosphatase 1," The Journal of Experimental Medicine, vol. 203, no. 8, pp. 1883-1889, 2006.
44. J. Liao, X. Wang, Y. Bi et al., "Dexamethasone potentiates myeloid-derived suppressor cell function in prolonging allograf survival through nitric oxide," Journal of Leukocyte Biology, vol. 96, no. 5, pp. 675-684, 2014.
45. H.-S. Chou, C.-C. Hsieh, H.-R. Yang et al., "Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice," Hepatology, vol. 53, no. 3, pp. 1007-1019, 2011.
46. E. N. Benveniste, "Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis," Journal of Molecular Medicine, vol. 75, no. 3, pp. 165-173, 1997
47. -/~ mice: susceptibility in multiple strains," American Journal of Pathology, vol. 162, no. 1, pp. 139-150, 2003.
48. I. D. Vainchtein, J. Vinet, N. Brouwer et al., "In acute experimental autoimmune encephalomyelitis, infltrating macrophages are immune activated, whereas microglia remain immune suppressed," Glia, vol. 62, no. 10, pp. 1724-1735, 2014.
49. fa monocytes are crucial for the efector phase of autoimmunity in the central nervous system," Brain, vol. 132, part 9, pp. 2487-2500, 2009.
50. + myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease," Blood, vol. 113, no. 14, pp. 3190-3197, 2009.
51. H. Yi, C. Guo, X. Yu, D. Zuo, and X-Y Wang, "Mouse CD11b+Gr-1+ myeloid cells can promote T17 cell diferentiation and experimental autoimmune encephalomyelitis," Journal of Immunology, vol. 189, no. 9, pp. 4295-4304, 2012.
52. M. Bruchard, G. Mignot, V. Derangère et al., "Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 infammasome and promotes tumor growth," Nature Medicine, vol. 19, no. 1, pp. 57-64, 2013.
53. hi suppressive monocytes in experimental autoimmune encephalomyelitis," The Journal of Immunology, vol. 179, no. 8, pp. 5228-5237, 2007.
54. V. Moliné-Velázquez, H. Cuervo, V. Vila-Del Sol, M. C. Ortega, D. Clemente, and F. de Castro, "Myeloid-derived suppressor cells limit the infammation by promoting T lymphocyte apop-tosis in the spinal cord of a murine model of multiple sclerosis," Brain Pathology, vol. 21, no. 6, pp. 678-691, 2011.
55. D. Hertzenberg, K. Lehmann-Horn, S. Kinzel et al., "Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity," European Journal of Immunology, vol. 43, no. 8, pp. 2078-2088, 2013.
56. V. Moliné-Velázquez, M. C. Ortega, V. Vila del Sol, C. Melero-Jerez, F. de Castro, and D. Clemente, "The synthetic retinoid Am80 delays recovery in a model of multiple sclerosis by modulating myeloid-derived suppressor cell fate and viability," Neurobiology of Disease, vol. 67, pp. 149-164, 2014.
57. L. E. Sander, S. D. Sackett, U. Dierssen et al., "Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function," The Journal of Experimental Medicine, vol. 207, no. 7, pp. 1453-1464, 2010.
58. H. F. Lohr, J. F. Schlaak, G. Gerken, B. Fleischer, H.-P. Dienes, and K.-H. M. zum Buschenfelde, "Phenotypical analysis and cytokine release of liver-infltrating and peripheral blood T lymphocytes from patients with chronic hepatitis of diferent etiology," Liver, vol. 14, no. 3, pp. 161-166, 1994.
59. M. J. Hussain, A. Mustafa, H. Gallati, A. P. Mowat, G. Mieli-Vergani, and D. Vergani, "Cellular expression of tumour-necrosis factor-α and interferon-α in the liver biopsies of children with chronic liver disease," Journal of Hepatology, vol. 21, no. 5, pp. 816-821, 1994.
60. E. L. Krawitt, "Autoimmune hepatitis," The New England Journal of Medicine, vol. 354, no. 1, pp. 54-66, 2006.
61. J. G. Cripps, J. Wang, A. Maria, I. Blumenthal, and J. D. Gorham, "Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the infamed Tgf1 knockout mouse liver.," Hepatology, vol. 52, no. 4, pp. 1350-1359, 2010.
62. L. Hammerich, K. T. Warzecha, M. Stefova et al., "Cyclic adenosine monophosphate-responsive element modulator alpha overexpression impairs function of hepatic myeloid-derived suppressor cells and aggravates immune-mediated hepatitis in mice," Hepatology, vol. 61, no. 3, pp. 990-1002, 2015.
63. G. Senaldi, B. Portmann, A. P. Mowat, G. Mieli-Vergani, and D. Vergani, "Immunohistochemical features of the portal tract mononuclear cell infltrate in chronic aggressive hepatitis," Archives of Disease in Childhood, vol. 67, no. 12, pp. 1447-1453, 1992.
64. M. S. Longhi, R. R. Mitry, M. Samyn et al., "Vigorous activation of monocytes in juvenile autoimmune liver disease escapes the control of regulatory T-cells," Hepatology, vol. 50, no. 1, pp. 130-142, 2009.
65. L. A. Haile, R. von Wasielewski, J. Gamrekelashvili et al., "Myeloid-derived suppressor cells in infammatory bowel disease: a new immunoregulatory pathway," Gastroenterology, vol. 135, no. 3, pp. 871.e5-881.e5, 2008.
66. + T cells," Gastroenterology, vol. 131, no. 2, pp. 510-524, 2006.
67. Q. Guan, S. Moreno, G. Qing et al., "The role and potential therapeutic application of myeloid-derived suppressor cells in TNBS-induced colitis," Journal of Leukocyte Biology, vol. 94, no. 4, pp. 803-811, 2013.
68. J. Kurkó, A. Vida, T. T. Glant et al., "Identifcation of myeloid-derived suppressor cells in the synovial fuid of patients with rheumatoid arthritis: a pilot study," BMC Musculoskeletal Disorders, vol. 15, no. 1, p. 281, 2014.
69. J. Kurkó, A. Vida, T. Ocskó et al., "Suppression of proteoglycan-induced autoimmune arthritis by myeloid-derived suppressor cells generated in vitro from murine bone marrow," PLoS ONE, vol. 9, no. 11, Article ID e111815, 2014.
70. K. R. McIntosh and D. B. Drachman, "Induction of apoptosis in activated T cell blasts by suppressive macrophages: a possible immunotherapeutic approach for treatment of autoimmune disease," Cellular Immunology, vol. 193, no. 1, pp. 24-35, 1999.
71. E. C. Kerr, B. J. E. Raveney, D. A. Copland, A. D. Dick, and L. B. Nicholson, "Analysis of retinal cellular infltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations," Journal of Autoimmunity, vol. 31, no. 4, pp. 354-361, 2008.
72. B. J. E. Raveney, D. A. Copland, A. D. Dick, and L. B. Nicholson, "TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis," Journal of Immunology, vol. 183, no. 4, pp. 2321-2329, 2009.
73. ααα mouse," Clinical and Experimental Nephrology, vol. 14, no. 5, pp. 411-417, 2010.
74. E. V. Lourenço, M. Wong, B. H. Hahn, M. F. Palma-Diaz, and B. J. Skaggs, "Laquinimod delays and suppresses nephritis in lupus-prone mice and afects both myeloid and lymphoid immune cells," Arthritis & Rheumatology, vol. 66, no. 3, pp. 674-685, 2014.
75. V. Singh, U. Mueller, P. Freyschmidt-Paul, and M. Zöller, "Delayed type hypersensitivity-induced myeloid-derived suppressor cells regulate autoreactive T cells," European Journal of Immunology, vol. 41, no. 10, pp. 2871-2882, 2011.
76. F. Whitfeld-Larry, J. Felton, J. Buse, and M. A. Su, "Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients," Clinical Immunology, vol. 153, no. 1, pp. 156-164, 2014.
77. X. Gao, H. Liu, B. He, and Z. Fu, "Resistance to streptozotocin-induced autoimmune diabetes in absence of complement C3: myeloid-derived suppressor cells play a role," PLoS ONE, vol. 8, no. 6, Article ID e66334, 2013.
78. Y. Arakawa, J. Qin, H. S. Chou et al., "Cotransplantation with myeloid-derived suppressor cells protects cell transplants: a crucial role of inducible nitric oxide synthase," Transplantation, vol. 97, no. 7, pp. 740-747, 2014.
79. H.-S. Chou, C.-C. Hsieh, R. Charles et al., "Myeloid-derived suppressor cells protect islet transplants by B7-H1 mediated enhancement of T regulatory cells," Transplantation, vol. 93, no. 3, pp. 272-282, 2012.
80. Y. Li, Z. Tu, S. Qian et al., "Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis," The Journal of Immunology, vol. 193, no. 5, pp. 2127-2134, 2014.
81. Z. Tu, Y. Li, D. Smith et al., "Myeloid suppressor cells induced by retinal pigment epithelial cells inhibit autoreactive T-cell responses that lead to experimental autoimmune uveitis," Investigative Ophthalmology and Visual Science, vol. 53, no. 2, pp. 959-966, 2012.
82. Q. Zhang, M. Fujino, S. Iwasaki et al., "Generation and characterization of regulatory dendritic cells derived from murine induced pluripotent stem cells," Scientifc Reports, vol. 4, article 3979, 2014.
83. K. Takahashi and S. Yamanaka, "Induction of pluripotent stem cells from mouse embryonic and adult fbroblast cultures by defned factors," Cell, vol. 126, no. 4, pp. 663-676, 2006.
84. Y. Yoshida and S. Yamanaka, "IPS cells: a source of cardiac regeneration," Journal of Molecular and Cellular Cardiology, vol. 50, no. 2, pp. 327-332, 2011.
85. H. Su, X. Cong, and Y. L. Liu, "Transplantation of granulocytic myeloid-derived suppressor cells (G-MDSCs) could reduce colitis in experimental murine models," Journal of Digestive Diseases, vol. 14, no. 5, pp. 251-258, 2013.
86. A. Uccelli, L. Moretta, and V. Pistoia, "Mesenchymal stem cells in health and disease," Nature Reviews Immunology, vol. 8, no. 9, pp. 726-736, 2008.
87. B. L. Yen, M.-L. Yen, P.-J. Hsu et al., "Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-Met and STAT3," Stem Cell Reports, vol. 1, no. 2, pp. 139-151, 2013.
88. A. Zoso, E. M. Mazza, S. Bicciato et al., "Human fbrocytic myeloid-derived suppressor cells express IDO and promote tolerance via Treg-cell expansion," European Journal of Immunology, vol. 44, no. 11, pp. 3307-3319, 2014.
89. Z. Zhou, D. L. French, G. Ma et al., "Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells," Stem Cells, vol. 28, no. 3, pp. 620-632, 2010.
90. N. Obermajer and P. Kalinski, "Generation of myeloid-derived suppressor cells using prostaglandin E2," Trans plantation Research, vol. 1, no. 1, p. 15, 2012.