Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: A pilot study

BMC Musculoskeletal Disorders

Volumn 15, Issue 1, 2014, Pages

  Kurkó, Júlia ^a,c   Vida, András ^a   Glant, Tibor T ^a   Scanzello, Carla R ^a,b   Katz, Robert S ^a   Nair, Anjali ^a   Mikecz, Katalin ^a   Szekanecz, Zoltán ^c  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Myeloid derived suppressor cells; Rheumatoid arthritis; Synovial fluid; T cells

Indexed keywords

ANTIBODY; CD3 ANTIBODY; CELL SURFACE MARKER; MONOCLONAL ANTIBODY CD28;

ADULT; ARTICLE; CELL INFILTRATION; CELL STRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MYELOID DERIVED SUPPRESSOR CELL; NEUTROPHIL; PILOT STUDY; RHEUMATOID ARTHRITIS; SUPPRESSOR CELL; SYNOVIAL FLUID; T LYMPHOCYTE; CLINICAL TRIAL; COCULTURE; CYTOLOGY; FEMALE; IMMUNOLOGY; INNATE IMMUNITY; MALE; MIDDLE AGED; MONONUCLEAR CELL; MULTICENTER STUDY; PATHOLOGY;

ADULT; ARTHRITIS, RHEUMATOID; COCULTURE TECHNIQUES; FEMALE; HUMANS; IMMUNITY, INNATE; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PILOT PROJECTS; SYNOVIAL FLUID; T-LYMPHOCYTES;

EID: 84906925420     PISSN: None     EISSN: 14712474     Source Type: Journal    
DOI: 10.1186/1471-2474-15-281     Document Type: Article

References (34)

1. Rheumatoid Arthritis: Etiology and Pathogeneis of Rheumatoid Arthritis. Firestein GS, Kelley's Textbook of Rheumatology Philadelphia, PA: W.B.Saunders Co, Ruddy S, Harris ED, Sledge CB, Kelley WN, 7 2005 996 1045
2. Genetics of rheumatoid arthritis-a comprehensive review. Kurko J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z, Clin Rev Allergy Immunol 2013 45 170 179
3. T cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles. Law SC, Street S, Yu CH, Capini C, Ramnoruth S, Nel HJ, van Gorp E, Hyde C, Lau K, Pahau H, Purcell AW, Thomas R, Arthritis Res Ther 2012 14 118
4. Anti-citrullinated protein/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis. Szodoray P, Szabo Z, Kapitany A, Gyetvai A, Lakos G, Szanto S, Szucs G, Szekanecz Z, Autoimmun Rev 2010 9 140 143
5. Of mice and men: how animal models advance our understanding of T-cell function in RA. Kobezda T, Ghassemi-Nejad S, Mikecz K, Glant TT, Szekanecz Z, Nat Rev Rheumatol 2014 10 160 170
6. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Panayi GS, Lanchbury JS, Kingsley GH, Arthritis Rheum 1992 35 729 735
7. The cytology of joint exudates in rheumatoid arthritis. Morphology and preparation techniques. Bjelle A, Norberg B, Sjogren G, Scand J Rheumatol 1982 11 124 128
8. Myeloid derived suppressor cells in human diseases. Greten TF, Manns MP, Korangy F, Int Immunopharmacol 2011 11 802 807
9. Therapeutic targeting of myeloid-derived suppressor cells. Ugel S, Delpozzo F, Desantis G, Papalini F, Simonato F, Sonda N, Zilio S, Bronte V, Curr Opin Pharmacol 2009 9 470 481
10. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Serafini P, Borrello I, Bronte V, Semin Cancer Biol 2006 16 53 65
11. Integrin signal transduction in myeloid leukocytes. Lowell CA, Berton G, J Leukoc Biol 1999 65 313 320
12. Myeloid-derived suppressor cells as regulators of the immune system. Gabrilovich DI, Nagaraj S, Nat Rev Immunol 2009 9 162 174
13. Myeloid-derived suppressor cells in human cancer. Nagaraj S, Gabrilovich DI, Cancer J 2010 16 348 353
14. Functional characterization of human CD33+ and CD11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines. Lechner MG, Megiel C, Russell SM, Bingham B, Arger N, Woo T, Epstein AL, J Transl Med 2011 9 90
15. Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway. Richards MK, Liu F, Iwasaki H, Akashi K, Link DC, Blood 2003 102 3562 3568
16. GM-CSF in inflammation and autoimmunity. Hamilton JA, Trends Immunol 2002 23 403 408
17. Neutrophil apoptosis pathways and their modifications in inflammation. Simon HU, Immunol Rev 2003 193 101 110
18. Analysis of SF and plasma cytokines provides insights into the mechanisms of inflammatory arthritis and may predict response to therapy. Wright HL, Bucknall RC, Moots RJ, Edwards SW, Rheumatology (Oxford) 2012 51 451 459
19. Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease. Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis A, Mastorodemos V, Plaitakis A, Sharpe A, Boumpas D, Verginis P, J Immunol 2012 188 1136 1146
20. Increased circulating myeloid-derived suppressor cells correlated negatively with Th17 cells in patients with rheumatoid arthritis. Jiao Z, Hua S, Wang W, Wang H, Gao J, Wang X, Scand J Rheumatol 2013 42 85 90
21. Suppression of dendritic cell maturation and T cell proliferation by synovial fluid myeloid cells from mice with autoimmune arthritis. Egelston C, Kurko J, Besenyei T, Tryniszewska B, Rauch TA, Glant TT, Mikecz K, Arthritis Rheum 2012 64 3179 3188
22. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Menard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, et al. Ann Rheum Dis 2010 69 1580 1588
23. A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. Pillay J, Kamp VM, van E H, Visser T, Tak T, Lammers JW, Ulfman LH, Leenen LP, Pickkers P, Koenderman L, J Clin Invest 2012 122 327 336
24. Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. Lechner MG, Liebertz DJ, Epstein AL, J Immunol 2010 185 2273 2284
25. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nagaraj S, Gupta K, Pisarev V, Kinarsky L, Sherman S, Kang L, Herber DL, Schneck J, Gabrilovich DI, Nat Med 2007 13 828 835
26. Myeloid-derived suppressor cells prevent type 1 diabetes in murine models. Yin B, Ma G, Yen CY, Zhou Z, Wang GX, Divino CM, Casares S, Chen SH, Yang WC, Pan PY, J Immunol 2010 185 5828 5834
27. Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis. Fujii W, Ashihara E, Hirai H, Nagahara H, Kajitani N, Fujioka K, Murakami K, Seno T, Yamamoto A, Ishino H, Kohno M, Maekawa T, Kawahito Y, J Immunol 2013 191 1073 1081
28. The biology of myeloid-derived suppressor cells: the blessing and the curse of morphological and functional heterogeneity. Youn JI, Gabrilovich DI, Eur J Immunol 2010 40 2969 2975
29. Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences. Pillay J, Tak T, Kamp VM, Koenderman L, Cell Mol Life Sci 2013 70 3813 3827
30. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Farrell AJ, Blake DR, Palmer RM, Moncada S, Ann Rheum Dis 1992 51 1219 1222
31. Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF. Dolcetti L, Peranzoni E, Ugel S, Marigo I, Fernandez GA, Mesa C, Geilich M, Winkels G, Traggia E, Casati A, Grassi F, Bronte V, Eur J Immunol 2010 40 22 35
32. Studies of T-cell activation in chronic inflammation. Cope AP, Arthritis Res 2002 4 Suppl 3 197 S211
33. CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease. Cao D, van Vollenhoven R, Klareskog L, Trollmo C, Malmstrom V, Arthritis Res Ther 2004 6 335 R346
34. T cells out of control-impaired immune regulation in the inflamed joint. Wehrens EJ, Prakken BJ, van Wijk F, Nat Rev Rheumatol 2013 9 34 42