Granulocyte colony-stimulating factor-induced immature myeloid cells inhibit acute graft-versus-host disease lethality through an indoleamine dioxygenase-independent mechanism

Immunology

Volumn 128, Issue 1 PART 2, 2009, Pages

  Joo, Young Don ^b   Lee, Sun Mi ^b   Lee, Soo Woong ^b   Lee, Won Sik ^b   Lee, Sang Min ^b   Park, Ji Kyoung ^b   Choi, Il Whan ^b   Park, Sae Gwang ^b   Choi, Inhak ^a,b   Seo, Su Kil ^a,b  

^a Inje University   (South Korea)

^b Inje University College of Medicine   (South Korea)

Author keywords

Graft versus host disease; Granulocyte colony stimulating factor; Immature myeloid cells; Indoleamine 2,3 dioxygenase

Indexed keywords

CD11B ANTIGEN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INDOLEAMINE 2,3 DIOXYGENASE;

ACUTE GRAFT VERSUS HOST DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LETHALITY; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACUTE DISEASE; ANIMALS; CELL TRANSPLANTATION; FEMALE; GRAFT REJECTION; GRAFT VS HOST DISEASE; GRANULOCYTE COLONY-STIMULATING FACTOR; IMMUNOSUPPRESSION; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; INTERFERON-GAMMA; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID CELLS; T-LYMPHOCYTES;

EID: 68249138313     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03048.x     Document Type: Article

References (37)

1. Berger C, Bertz H, Schmoor C et al. Influence of recombinant human granulocyte colony-stimulating factor (filgrastim) on hematopoietic recovery and outcome following allogeneic bone marrow transplantation (BMT) from volunteer unrelated donors. Bone Marrow Transplant 1999 23 : 983 90.
2. Ringden O, Remberger M, Runde V et al. Peripheral blood stem cell transplantation from unrelated donors: a comparison with marrow transplantation. Blood 1999 94 : 455 64.
3. Miflin G, Russell NH, Hutchinson RM et al. Allogeneic peripheral blood stem cell transplantation for haematological malignancies - an analysis of kinetics of engraftment and GVHD risk. Bone Marrow Transplant 1997 19 : 9 13.
4. Ringden O, Remberger M, Runde V et al. Faster engraftment of neutrophils and platelets with peripheral blood stem cells from unrelated donors: a comparison with marrow transplantation. Bone Marrow Transplant 2000 25 (Suppl. 2 S6 8.
5. Bensinger WI, Martin PJ, Storer B et al. Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives inpatients with hematologic cancers. N Engl J Med 2001 344 : 175 81.
6. Bensinger WI, Clift R, Martin P. Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation. Blood 1996 88 : 2794 800.
7. Mohty M, Kuentz M, Michallet M et al. Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study. Blood 2002 100 : 3128 34.
8. Cutler C, Giri S, Jeyapalan S, Paniagua D, Viswanathan A, Antin JH. Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation: a meta-analysis. J Clin Oncol 2001 19 : 3685 91.
9. Edward SM, Kelli PAM, Geoffrey RH. Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL? Blood 2006 107 : 3430 5.
10. Rutella S, Zavala F, Danese S, Kared H, Leone G. Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance. J Immunol 2005 175 : 7085 91.
11. + cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. Blood 1997 89 : 1629 34.
12. Mielcarek M, Graf L, Johnson G, Torok-storb B. Production of interleukin-10 by granulocyte colony-stimulating factor-mobilized blood products: a mechanism for monocyte-mediated suppression of T-cell proliferation. Blood 1998 92 : 215 22.
13. MacDonald KP, Rowe V, Clouston AD et al. Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells. J Immunol 2005 174 : 1841 50.
14. Zeng D, Dejbakhsh-Jones S, Strober S. Granulocyte colony-stimulating factor reduces the capacity of blood mononuclear cells to induce graft-versus-host disease: impact on blood progenitor cell transplantation. Blood 1997 90 : 453 63.
15. Vasconcelos ZF, Dos Santos BM, Farache J et al. G-CSF-treated granulocytes inhibit acute graft-versus-host disease. Blood 2006 107 : 2192 9.
16. Shimizu T, Nomiyama S, Hirata F, Hayaishi O. Indoleamine 2,3-dioxygenase: purification and some properties. J Biol Chem 1978 253 : 4700 6.
17. Taylor MW, Feng G. Relationship between IFN-, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 1991 5 : 2516 22.
18. Mellor AL, Munn DH. IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol 2004 4 : 762 74.
19. Munn DH, Zhou M, Attwood JT et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998 281 : 1191 3.
20. Meisel R, Zibert A, Laryea M, Göbel U, Däubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004 103 : 4619 21.
21. Reddy P, Sun Y, Toubai T et al. Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest 2008 118 : 2562 73.
22. Romani L, Bistoni F, Perruccio K et al. Thymosin α1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance. Blood 2006 108 : 2265 74.
23. Hou DY, Muller AJ, Sharma MD et al. Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methy-tryptophan correlated with antitumor responses. Cancer Res 2007 67 : 792 801.
24. Takikawa O, Kuroiwa T, Yamazaki F, Kido R. Mechanism of interferon-β action: characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-β and evaluation of the enzyme-mediated tryptophan degradation in anticellular activity. J Biol Chem 1998 263 : 2041 8.
25. Hwu P, Du MX, Lapointe R et al. Indoleamine-2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 2000 164 : 3596 9.
26. Puccetti P. On watching the watchers: IDO and type I/II IFN. Eur J Immunol 2007 37 : 876 9.
27. Pan L, Teshima T, Hill GR et al. Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versus-leukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood 1999 93 : 4071 8.
28. Pan L, Delmonte JJ, Jalonen CK, Ferrara JL. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood 1995 86 : 4422 9.
29. Franzke A, Piao W, Lauber J et al. G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases. Blood 2003 102 : 734 9.
30. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1993 189 : 1363 72.
31. Yang YG, Dey BR, Sergio JJ, Pearson DA, Sykes M. Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest 1998 102 : 2126 35.
32. Yang YG, Qi J, Wang MG, Sykes M. Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells. Blood 2002 99 : 4207 15.
33. Hainz U, Obexer P, Winkler C et al. Monocyte-mediated T-cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem-cell transplantation. Blood 2005 105 : 4127 34.
34. Gieseke F, Schutt B, Viebahn S, Koscielniak E, Friedrich W, Handgretinger R, Muller I. Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNβR1 signaling and IDO expression. Blood 2007 110 : 2197 2200.
35. Schmielau J, Finn OJ. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 2001 61 : 4756 60.
36. Vasconcelos ZF, Santos BM, Costa ES. T-lymphocytes function from peripheral blood stem cell donors is inhibited by activated granulocytes. Cytotherapy 2003 5 : 336 45.
37. New JY, Li B, Koh WP et al. T cell infiltration and chemokine expression: relevance to the disease localization in murine graft-versus-host disease. Bone Marrow Transplant 2002 29 : 979 86.