Transplantation of granulocytic myeloid-derived suppressor cells (G-MDSCs) could reduce colitis in experimental murine models

Journal of Digestive Diseases

Volumn 14, Issue 5, 2013, Pages 251-258

  Su, Hui ^a   Cong, Xu ^b   Liu, Yu Lan ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

CD11b+Gr 1+ cells; Immune regulation; Inflammatory bowel disease; Myeloid derived suppressor cell

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELOPEROXIDASE; SODIUM CHLORIDE; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; COLITIS; CONTROLLED STUDY; ENZYME ACTIVITY; FECES ANALYSIS; FEMALE; FLOW CYTOMETRY; GRANULOCYTIC MYELOID DERIVED SUPPRESSOR CELL; IN SITU HYBRIDIZATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SURVIVAL RATE; WEIGHT CHANGE; WEIGHT REDUCTION; Y CHROMOSOME;

ANIMALS; BODY WEIGHT; COLITIS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GRAFT SURVIVAL; GRANULOCYTES; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED BALB C; MYELOID CELLS; PEROXIDASE; TRINITROBENZENESULFONIC ACID;

EID: 84876453352     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/1751-2980.12029     Document Type: Article

References (17)

1. Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361: 2066-2078.
2. Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet 2007; 369: 1627-1640.
3. Gabrilovich DI, Bronte V, Chen SH etal. The terminology issue for myeloid-derived suppressor cells. Cancer Res 2007; 67: 425; author reply 426.
4. Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 2005; 5: 641-654.
5. Schmid MC, Varner JA. Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J Oncol 2010; 2010: 201026.
6. Sunderkötter C, Nikolic T, Dillon MJ etal. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol 2004; 172: 4410-4417.
7. Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol 2009; 9: 162-174.
8. Alex P, Zachos NC, Nguyen T et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis 2009; 15: 341-352.
9. Lahat G, Halperin D, Barazovsky E et al. Immunomodulatory effects of ciprofloxacin in TNBS-induced colitis in mice. Inflamm Bowel Dis 2007; 13: 557-565.
10. Scheiffele F, Fuss IJ. Induction of TNBS colitis in mice. Curr Protoc Immunol 2002; Chapter 15: Unit 15.19.
11. + cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 2004; 6: 409-421.
12. Dolcetti L, Marigo I, Mantelli B, Peranzoni E, Zanovello P, Bronte V. Myeloid-derived suppressor cell role in tumor-related inflammation. Cancer Lett 2008; 267: 216-225.
13. Komori M, Tsuji S, Tsujii M etal. Involvement of bone marrow-derived cells in healing of experimental colitis in rats. Wound Repair Regen 2005; 13: 109-118.
14. Alex P, Zachos NC, Nguyen T etal. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis 2009; 15: 341-352.
15. Steinman L. Elaborate interactions between the immune and nervous systems. Nat Immunol 2004; 5: 575-581.
16. Zhou Z, French DL, Ma G etal. Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells. Stem Cells 2010; 28: 620-632.
17. Haverkamp JM, Crist SA, Elzey BD, Cimen C, Ratliff TL. In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site. Eur J Immunol 2011; 41: 749-759.