Mendelian randomisation applied to drug development in cardiovascular disease: A review

Journal of Medical Genetics

Volumn 52, Issue 2, 2015, Pages 71-79

  Mokry, Lauren E ^a,b   Ahmad, Omar ^b   Forgetta, Vincenzo ^a   Thanassoulis, George ^b,c,d   Richards, J Brent ^a,b,e  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^d RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ESTER; EZETIMIBE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 6 RECEPTOR; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TOCILIZUMAB;

ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL (TOPIC); DNA SEQUENCE; DRUG COST; DRUG DEVELOPMENT; DRUG INDUSTRY; DRUG POTENCY; DRUG REPOSITIONING; DRUG SAFETY; DRUG TARGETING; EXPERIMENTAL THERAPY; GENETIC VARIABILITY; HUMAN; IN VITRO STUDY; MENDELIAN RANDOMIZATION ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; CARDIOVASCULAR DISEASES; GENETICS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPRODUCIBILITY;

ANIMALIA;

ANIMALS; CARDIOVASCULAR DISEASES; DRUG DISCOVERY; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REPRODUCIBILITY OF RESULTS;

EID: 84930650718     PISSN: 00222593     EISSN: 14686244     Source Type: Journal    
DOI: 10.1136/jmedgenet-2014-102438     Document Type: Article

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