Enhancing accumulation and penetration of HPMA copolymer-doxorubicin conjugates in 2d and 3d prostate cancer cells via irgd conjugation with an MMP-2 Cleavable Spacer

Journal of the American Chemical Society

Volumn 137, Issue 21, 2015, Pages 6726-6729

  Peng, Zheng Hong ^a   Kopeček, Jindřich ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPOLYMERS; CYTOLOGY; DISEASES; MONOLAYERS; PEPTIDES; TUMORS; UROLOGY;

BIOLOGICAL PROPERTIES; CELL-CYCLE ARREST; DOXORUBICIN CONJUGATES; MATRIX METALLOPROTEINASE-2; METHACRYLAMIDES; PENETRATION ABILITY; PROSTATE CANCER CELLS; TUMOR-PENETRATING PEPTIDES;

CELLS;

ANTINEOPLASTIC AGENT; COPOLYMER; CYCLOPEPTIDE; DOXORUBICIN; GELATINASE A; N (2 HYDROXYPROPYL)METHACRYLAMIDE; NANOCARRIER; ACRYLAMIDE DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; ARGINYL-GLYCYL-ASPARTIC ACID; DRUG CARRIER; N-(2-HYDROXYPROPYL)METHACRYLAMIDE; OLIGOPEPTIDE; POLYMER;

AMINO ACID ANALYSIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE ARREST; CONFOCAL MICROSCOPY; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG HALF LIFE; DRUG PENETRATION; DRUG SYNTHESIS; DRUG UPTAKE; G2 PHASE CELL CYCLE CHECKPOINT; PHYSICAL CHEMISTRY; POLYMERIZATION; PROSTATE CANCER; TUMOR MICROENVIRONMENT; TUMOR SPHEROID; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; HUMAN; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ACRYLAMIDES; ANTIBIOTICS, ANTINEOPLASTIC; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MOLECULAR STRUCTURE; OLIGOPEPTIDES; POLYMERS; PROSTATIC NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84930638692     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b00922     Document Type: Article

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