Facile construction of dual-bioresponsive biodegradable micelles with superior extracellular stability and activated intracellular drug release

Journal of Controlled Release

Volumn 210, Issue , 2015, Pages 125-133

  Chen, Wei ^a,b   Meng, Fenghua ^a   Cheng, Ru ^a   Deng, Chao ^a   Feijen, Jan ^a,b   Zhong, Zhiyuan ^a  

^a SOOCHOW UNIVERSITY   (China)

^b UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Anticancer drugs; Biodegradable micelles; Controlled release; pH sensitive; Reversible crosslinking

Indexed keywords

CHEMOTHERAPY; COPOLYMERS; CYTOTOXICITY; DRUG PRODUCTS; ENZYME ACTIVITY; MICELLES; PH SENSORS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

ANTICANCER DRUG; BIODEGRADABLE MICELLES; CONTROLLED RELEASE; PH SENSITIVE; REVERSIBLE CROSSLINKING;

CROSSLINKING;

COPOLYMER; DITHIOTHREITOL; DOXORUBICIN; GLUTATHIONE; NANOPARTICLE; POLY(ETHYLENE GLYCOL) POLY(2,4,6 TRIMETHOXYBENZYLIDENE PENTAERYTHRITOL CARBONATE CO PYRIDYL DISULFIDE CARBONATE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; MICELLE; POLYMER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIODEGRADABILITY; CELL DEATH; CELL KILLING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CROSS LINKING; CYTOTOXICITY; DRUG RELEASE; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; MICELLE; MTT ASSAY; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SLOW DRUG RELEASE; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; MOUSE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE; CELL SURVIVAL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; GLUTATHIONE; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICELLES; POLYMERS;

EID: 84930638023     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.05.273     Document Type: Article

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