A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress related acidosis

eLife

Volumn 4, Issue MAY, 2015, Pages

  Rajagopal, Ponni ^a   Tse, Eric ^b   Borst, Andrew J ^a   Delbecq, Scott P ^a   Shi, Lei ^a   Southworth, Daniel R ^b   Klevit, Rachel E ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTIDINE; HOLDASE; SMALL HEAT SHOCK PROTEIN; UNCLASSIFIED DRUG; ALPHA CRYSTALLIN; CHAPERONE; CRYAB PROTEIN, HUMAN;

ACIDOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GEL PERMEATION CHROMATOGRAPHY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR CLONING; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRESS; TRANSMISSION ELECTRON MICROSCOPY; CHEMISTRY; DIMERIZATION; HUMAN; METABOLISM; MOLECULAR MODEL;

ACIDOSIS; ALPHA-CRYSTALLIN B CHAIN; DIMERIZATION; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MOLECULAR WEIGHT; PROTEIN CONFORMATION;

EID: 84930629588     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.07304     Document Type: Article

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