Quantitative tissue pH measurement during cerebral ischemia using amine and amide concentration-independent detection (AACID) with MRI

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 4, 2014, Pages 690-698

  McVicar, Nevin ^a   Li, Alex X ^b   Gonçalves, Daniela F ^b,c   Bellyou, Miranda ^b   Meakin, Susan O ^a,b   Prado, Marco A M ^a,b   Bartha, Robert ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Acute stroke; Brain ischemia; Energy metabolism; Focal ischemia; Imaging; MR Spectroscopy; MRI; pH

Indexed keywords

AMIDE; AMINE; CONTRAST MEDIUM; GLUTAMIC ACID; PHOSPHORUS 31; PROTEIN; PROTON;

ACIDOSIS; AMINE AND AMIDE CONCENTRATION INDEPENDENT DETECTION; ANAEROBIC METABOLISM; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN TISSUE; CELL DAMAGE; CHEMICAL EXCHANGE SATURATION TRANSFER; CONTROLLED STUDY; HISTOLOGY; LASER DOPPLER FLOWMETRY; MACROMOLECULAR MAGNETIZATION TRANSFER; MACROMOLECULE; MAGNETIC FIELD; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROIMAGING; NON INVASIVE PROCEDURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELAXATION TIME; TEMPERATURE DEPENDENCE; WATER CONTENT;

ACIDOSIS, LACTIC; AMIDES; AMINES; ANIMALS; BIOLOGICAL MARKERS; BRAIN ISCHEMIA; CALIBRATION; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL;

EID: 84897574971     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.12     Document Type: Article

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