Regulated structural transitions unleash the chaperone actièity of αb-crystallin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 40, 2013, Pages

  Peschek, Jirka ^a,b   Braun, Nathalie ^a   Rohrberg, Julia ^a,c   Christiane Back, Katrin ^a   Kriehuber, Thomas ^a   Kastenmüller, Andreas ^a,d   Weinkauf, Seèil ^a   Buchner, Johannes ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GATAN INC   (United States)

Author keywords

Conditional disorder; Hsp70; Posttranslational modification; SHsp; Structure function relationship

Indexed keywords

8 ANILINO 1 NAPHTHALENESULFONIC ACID; ALPHA CRYSTALLIN; CHAPERONE; CHYMOTRYPSIN A; HEAT SHOCK PROTEIN 70; MUTANT PROTEIN; OLIGOMER; PROTEIN P53;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DISSOCIATION; DNA BINDING; HUMAN; HUMAN CELL; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

CONDITIONAL DISORDER; HSP70; POSTTRANSLATIONAL MODIFICATION; SHSP; STRUCTURE-FUNCTION RELATIONSHIP;

ALPHA-CRYSTALLIN B CHAIN; CHROMATOGRAPHY, GEL; CLONING, MOLECULAR; CRYOELECTRON MICROSCOPY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MODELS, MOLECULAR; MOLECULAR CHAPERONES; PHOSPHORYLATION; PROTEIN CONFORMATION; ROSANILINE DYES;

EID: 84885081139     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1308898110     Document Type: Article

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