Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors

Archiv der Pharmazie

Volumn 348, Issue 6, 2015, Pages 399-407

  Jiang, Tao ^a   Zhou, Yuren ^a   Zhu, Jianming ^a   Chen, Zhuxi ^a   Sun, Peng ^a   Zhang, Qiang ^a   Wang, Zhen ^a   Shao, Qiang ^a   Jiang, Xiangrui ^a   Li, Bo ^a   Wang, Heyao ^a   Zhu, Weiliang ^a   Shen, Jingshan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

DPP 4; Drug design; Inhibitors; P2 binding moiety; Homophenylalanine

Indexed keywords

AMIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; N [[1 [3 AMINO 3 (5,6 DIFLUORO 2,3 DIHYDRO 1H INDEN 1 YL)PROPANOYL]PYRROLIDIN 2 YL]METHYL] 2,4 DLFLUORO 5 SULFAMOYLBENZAMIDE; N [[1 [3 AMINO 3 (5,6 DIFLUORO 2,3 DIHYDRO 1H INDEN 1 YL)PROPANOYL]PYRROLIDIN 2 YL]METHYL] 3 (METHYLSULFONYL)BENZAMIDE; PYRROLIDIN 2 YLMETHYLAMIDE DERIVATIVE; SITAGLIPTIN; SULFANILAMIDE; UNCLASSIFIED DRUG; 2-AMINO-4-PHENYLBUTYRIC ACID; AMINOBUTYRIC ACID DERIVATIVE; BIOLOGICAL MARKER; DIPEPTIDYL PEPTIDASE IV; DPP4 PROTEIN, HUMAN; DPP4 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; PROTEIN BINDING;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC50; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BINDING SITE; BLOOD; C57BL MOUSE; CACO 2 CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; HUMAN; MALE; METABOLISM; MOLECULAR DOCKING; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TIME;

AMINOBUTYRATES; ANIMALS; BINDING SITES; BIOMARKERS; BLOOD GLUCOSE; CACO-2 CELLS; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DRUG DESIGN; HUMANS; MALE; MICE, INBRED C57BL; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; SITAGLIPTIN PHOSPHATE; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 84930625022     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201500082     Document Type: Article

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