Design and synthesis of 4-(2,4,5-Trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors

ChemMedChem

Volumn 8, Issue 7, 2013, Pages 1104-1116

  Zhu, Linrong ^a   Li, Yuanyuan ^a   Qiu, Ling ^b   Su, Mingbo ^a   Wang, Xin ^a   Xia, Chunmei ^a   Qu, Yi ^b   Li, Jingya ^a   Li, Jia ^a   Xiong, Bing ^a   Shen, Jingkang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b Central Hospital of Xuhui District   (China)

Author keywords

1,3 diamines; Crystal structures; Dipeptidyl peptidaseIV; Inhibitors

Indexed keywords

(1 (2 AMINO 3 (2,4,5 TRIFLUOROPHENYL)PROPYL) 1H 1,2,3 TRIAZOL 4 YL)MATHANOL HYDROCHLORIDE; (1 (2 AMINO 3 (2,4,5 TRIFLUOROPHENYL)PROPYL) 1H 1,2,3, TRIAZOL 5 YL)METHANOL HYDROCHLORIDE; (1 (3 AMINO 4 (2,4,5 TRIFLUOROPHENYL)BUTYL) 1H 1,2,3 TRIAZOL 4YL)METHANOL HYDROCHLORIDE; 1 (3 AMINO 4 (2,4,5 TRIFLUOROPHENYL)BUTYL) 1H 1,2,3, TRIAZOLE 4 CARBOXYLIC ACID HYDROCHLORIDE; 1 (4 (4 METHOXYPHENYL) 1H 1,2,3 TRAIZOL 1 YL) 3 (2,4,5 TRIFLUOROPHENYL)PROPAN 2 AMINE HYDROCHLORIDE; 1 (4 PHENYL 1H 1,2,3 TRIAZOLE 1 YL) 3 (2,4,5 TRIFLUOROPHENYL)PROPAN 2 AMINE HYDROCHLORIDE; 1 (5 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL) 3 (2,4,5 TRIFLUOROPHENYL)PROPAN 2 AMINE HYDROCHLORIDE; 1 (5 PHENYL 1H 1,2,3 TRIAZOL 1 YL) 3 (2,4,5 TRIFLUOROPHENYL)PROPAN 2 AMINE HYDROCHLORIDE; 4 (4 ( M TOLYL) 1H 1,2,3 TRIAZOL 1 YL) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 AMINE HYDROCHLORIDE; 4 (4 (1 METHYL 1H IMIDAZOL 2 YL) 1H 1,2,3 TRIAZOL 1 YL) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 AMINE HYDROCHLORIDE; 4 (4 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 AMINE HYDROCHLORIDE; 4 (4 CYCLOHEXYL 1H 1,2,3 TRIAZOL 1 YL) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 AMINE HYDROCHLORIDE; 4 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 AMINE HYDROCHLORIDE; 4 (5 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 AMINE HYDROCHLORIDE; DIAMINE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; SITAGLIPTIN; TERT BUTYL (4 (1H BENZO[ D ]IMIDAZOLE 5 CARBOXAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (2 (4 FLUOROPHENYL)ACETAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (2 PHENYLACETAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (2,3 DIFLUOROBENZAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (4 (1H 1,2,4 TRIAZOL 1 YL)BENZAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (4 (METHYLSULFONYL)BENZAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (4 (TRIFLUOROMETHYL)BENZAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (4 METHOXYBENZAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 (4 SULFAMOYLBENZAMIDO) 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 AMINO 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TERT BUTYL (4 BENZAMIDO 1 (2,4,5 TRIFLUOROPHENYL)BUTAN 2 YL)CARBAMATE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; DRUG BINDING; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN DATA BANK;

ADMINISTRATION, ORAL; ANIMALS; CRYSTALLOGRAPHY, X-RAY; DIAMINES; DIPEPTIDYL PEPTIDASE 4; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879781376     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300104     Document Type: Article

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