Negative epistasis between Sickle and foetal haemoglobin suggests a reduction in protection against malaria

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Mmbando, Bruno P ^a,b   Mgaya, Josephine ^a   Cox, Sharon E ^a,c   Mtatiro, Siana N ^a   Soka, Deogratias ^a   Rwezaula, Stella ^d   Meda, Elineema ^d   Msaki, Evarist ^a   Snow, Robert W ^e,f   Jeffries, Neal ^g   Geller, Nancy L ^g   Makani, Julie ^a,f  

^a MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (Tanzania)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d MUHIMBILI NATIONAL HOSPITAL   (Tanzania)

^e KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN F; HEMOGLOBIN S; HEMOGLOBIN VARIANT;

ADULT; AGED; ARTICLE; BLOOD SMEAR; CHILD; CONTROLLED STUDY; ELECTROPHORESIS; EPISTASIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFANT; INFECTION RISK; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALARIA; MALE; NEWBORN; PREVALENCE; RAPID TEST; RISK ASSESSMENT; SICKLE CELL ANEMIA; TANZANIA; ADOLESCENT; BLOOD; METABOLISM; MIDDLE AGED; PRESCHOOL CHILD; STATISTICAL MODEL; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANEMIA, SICKLE CELL; CHILD; CHILD, PRESCHOOL; EPISTASIS, GENETIC; FEMALE; FETAL HEMOGLOBIN; HEMOGLOBIN, SICKLE; HUMANS; INFANT; INFANT, NEWBORN; LOGISTIC MODELS; MALARIA; MALE; MIDDLE AGED; TANZANIA; YOUNG ADULT;

EID: 84930622732     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125929     Document Type: Article

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