Transgenic mice expressing human fetal globin are protected from malaria by a novel mechanism

Blood

Volumn 92, Issue 7, 1998, Pages 2520-2526

  Shear, Hannah L ^a   Grinberg, Leonid ^b   Gilman, John ^b   Fabry, Mary E ^b   Stamatoyannopoulos, George ^b   Goldberg, Daniel E ^b   Nagel, Ronald L ^b  

^a MONTEFIORE MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN CHAIN; HEMOGLOBIN F;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ELECTRON MICROSCOPY; ERYTHROCYTE; FEMALE; GENE MUTATION; GROWTH INHIBITION; INFECTION RESISTANCE; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SURVIVAL; TRANSGENIC MOUSE;

EID: 0032189586     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.7.2520.2520_2520_2526     Document Type: Article

References (30)

1. Nagel RL, Roth E: Malaria and red cell genetics. Blood 74:1213, 1989
2. Luzzatto L, Nwachuku-Jarrett ES, Reddy S: Increased sickling of parasitised erythrocytes as mechanism of the resistance against malaria in the sickle-cell trait. Lancet 1:319, 1970
3. Roth EF Jr, Friedman M, Ueda Y, Tellez I, Trager W, Nagel RL: Sickling rates of humans AS red cells infected in vitro with Plasmodium falciparum malaria. Science 202:650, 1978
4. Friedman MJ: Erythrocytic mechanism of sickle cell resistance to malaria. Proc Natl Acad Sci USA 75:1994, 1978
5. Friedman M, Roth EF, Nagel RL, Trager W: Plasmodium falciparum: Physiological interactions with the human sickle cell. Exp Parasitol 47:73, 1978
6. Pasvol G, Weatherall DJ: Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria. Nature 274:701, 1978
7. Shear HL, Roth EF, Fabry ME, Costantini FD, Pachnis Hood A, Nagel RL: Transgenic mice expressing human sickle hemoglobin are partially resistant to rodent malaria. Blood 81:222, 1993
8. Hood AT, Fabry ME, Costantini F, Nagel RL, Shear HL: Protection from lethal malaria in transgenic mice expressing sickle hemoglobin. Blood 87:1600, 1996
9. Flint J, Hill AVS, Bowden DK, Oppenheimer SJ, Sill PR, Serjeantson SW, Bana-Koiri J, Bhatia K, Alpers MP, Boyce AJ, Weatherall DJ, Clegg JB: High frequencies of α-thalassaemia are the result of natural selection by malaria. Nature 321: 744, 1986
10. Teo CG, Wong HB: The innate resistance of thalassaemia to malaria: A review of the evidence and possible mechanisms, in Weatherall DJ, Clegg JB (eds): The Thalassaemia Syndromes (ed 3). New York, NY, Blackwell, 1982
11. Pasvol G, Weatherall DJ, Wilson RJM, Smith DH, Gilles HM: Fetal haemoglobin and malaria. Lancet 1:1269, 1976
12. Pasvol G, Weatherall DJ, Wilson FJM: Effects of foetal haemoglobin on susceptibility of red cells to Plasmodium falciparum. Nature, 270:171, 1977
13. Friedman, MJ: Oxidant damage mediates variant red cell resistance to malaria. Nature 280:245, 1979
14. Aγ. Blood 86:648a, 1995
15. Kaul DK, Nagel RL, Llena JF, Shear HL: Cerebral malaria in mice: Demonstration of cytoadherence of infected red blood cells and microrheologic correlates. Am J Trop Med Hyg 50:512, 1994
16. S and α-globins in transgenic mice: I. Hemoglobin composition and hematological consequences. Proc Natl Acad Sci USA 89:12150, 1992
17. S and α-genes in transgenic mice: II. Red cell abnormalities, organ damage and the effect of hypoxia. Proc Natl Acad Sci USA 89:12155, 1992
18. Geriach E, Duhm J: 2,3-DPG regulation in red cells, in Rorth M, Astrup P (eds): Proceedings of the Alfred Benzon 2 Symposium. New York, NY, Academic, 1972
19. Schroeder WA, Shelton JB, Shelton JR, Huynh V, Teploe DB: High performance liquid Chromatographic separation of the globin chains of non-human hemoglobins. Hemoglobin 9:461, 1985
20. Luker KE, Francis SE, Gluzman IY, Goldberg DE: Kinetic analysis of plamepsins I and II aspartic proteases of the Plasmodium falciparum digestive vacuole. Mol Biochem Parasitol 79:71, 1996
21. Francis SE, Sullivan DJ Jr, Goldberg DE: Hemoglobin metabolism in the malaria parasite Plasmodium falciparum, Annu Rev Microbiol 51:97, 1997
22. Brockelman CR, Wongsattayanont B, Tan-Ariya P, Fucharoen S: Thalassemic erythrocytes inhibit in vitro growth of Plasmodium falciparum. J Clin Microbiol 25:56, 1987
23. Mackenstedt U, Mehlhorn H, Brockelman CR: Ulatrastructural study on the interaction of β-thalassemic-erythrocytes and Plasmodium falciparum. Int J Med Microbiol 271:356, 1989
24. Nagel RL: Disorders of hemoglobin function and stability, in Handin RI, Lux SE, Stossel TP (eds): Blood: Principles and Practice of Hematology. Philadelphia, PA, 1995, Lippincott, p 1591
25. Goldberg DE, Slater AFG, Beavis R, Chair B, Cerami A, Henderson GB: Hemoglobin degradation in the human malaria pathoge J Exp Med 173:961, 1991
26. Guzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE: Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway. J Clin Invest 93:1602,1994
27. Weiss L, Geduldig U, Weidanz W: Mechanisms of splenic control of murine malaria: Reticular cell activation and the development of a Wood-spleen barrier. Am J Anat 176:251, 1986
28. Sayles PC, Cooley AJ, Wassom DL: A spleen is not necessary to resolve infections with Plasmodium yoelii. Am J Trop Med Hyg 44:42, 1991
29. Sayles PC, Yanez DM, Wasson DL: Plasmodim yoelii: Splenectomy alters the antibody responses of infected mice. Exp Parasitol 76:377, 1993
30. Hill AVS: Malaria resistance genes: A natural selection. Trans Roy Soc Trop Med Hyg 86:225, 1992