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Volumn 6, Issue MAY, 2015, Pages

Microvesicles: What is the role in multiple sclerosis?

Author keywords

Biomarkers; Ectosomes; Exosomes; Horizontal communication; Microglia; Microvesicles; Multiple sclerosis

Indexed keywords

ARACHIDONIC ACID; BETA1A INTERFERON; BIOLOGICAL MARKER; CD31 ANTIGEN; FINGOLIMOD; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON BETA SERINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MEMBRANE RECEPTOR; RANTES; TOLL LIKE RECEPTOR; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

EID: 84930620930     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2015.00111     Document Type: Review
Times cited : (41)

References (76)
  • 1
    • 23044435896 scopus 로고    scopus 로고
    • Astrocytes, from brain glue to communication elements: the revolution continues
    • Volterra A, Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci (2005) 6:626-40. doi: 10.1038/nrn1722.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 626-640
    • Volterra, A.1    Meldolesi, J.2
  • 2
    • 84869157553 scopus 로고    scopus 로고
    • The"quad-partite"synapse:microglia-synapse interactionsinthedevelopingandmature CNS
    • Schafer DP, Lehrman EK, Stevens B. The"quad-partite"synapse:microglia-synapse interactionsinthedevelopingandmature CNS. Glia (2013) 61:24-36. doi:10.1002/glia.22389.
    • (2013) Glia , vol.61 , pp. 24-36
    • Schafer, D.P.1    Lehrman, E.K.2    Stevens, B.3
  • 3
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • Tremblay MÈ, Lowery RL, Majewska AK. Microglial interactions with synapses are modulated by visual experience. PLoS Biol (2010) 8:e1000527. doi:10.1371/journal.pbio.1000527.
    • (2010) PLoS Biol , vol.8
    • Tremblay, M.È.1    Lowery, R.L.2    Majewska, A.K.3
  • 4
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron (2012) 74:691-705. doi:10.1016/j.neuron.2012.03.026.
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1    Lehrman, E.K.2    Kautzman, A.G.3    Koyama, R.4    Mardinly, A.R.5    Yamasaki, R.6
  • 5
    • 10644224469 scopus 로고    scopus 로고
    • Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse
    • Roumier A, Bechade C, Poncer JC, Smalla KH, Tomasello E, Vivier E, et al. Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. J Neurosci (2004) 24:11421-8. doi:10.1523/JNEUROSCI.2251-04.2004.
    • (2004) J Neurosci , vol.24 , pp. 11421-11428
    • Roumier, A.1    Bechade, C.2    Poncer, J.C.3    Smalla, K.H.4    Tomasello, E.5    Vivier, E.6
  • 6
    • 50249137611 scopus 로고    scopus 로고
    • Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function
    • Roumier A, Pascual O, Bechade C, Wakselman S, Poncer JC, Real E, et al. Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function. PLoS One (2008) 3:e2595. doi:10.1371/journal.pone.0002595.
    • (2008) PLoS One , vol.3
    • Roumier, A.1    Pascual, O.2    Bechade, C.3    Wakselman, S.4    Poncer, J.C.5    Real, E.6
  • 7
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, et al. Synaptic pruning by microglia is necessary for normal brain development. Science (2011) 333:1456-8. doi:10.1126/science.1202529.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1    Bolasco, G.2    Pagani, F.3    Maggi, L.4    Scianni, M.5    Panzanelli, P.6
  • 8
    • 84856756074 scopus 로고    scopus 로고
    • Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    • Tremblay ME, Zettel ML, Ison JR, Allen PD, Majewska AK. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia (2012) 60:541-58. doi:10.1002/glia.22287.
    • (2012) Glia , vol.60 , pp. 541-558
    • Tremblay, M.E.1    Zettel, M.L.2    Ison, J.R.3    Allen, P.D.4    Majewska, A.K.5
  • 10
    • 33645979933 scopus 로고    scopus 로고
    • Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors
    • Hayashi Y, Ishibashi H, Hashimoto K, Nakanishi H. Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors. Glia (2006) 53:660-8. doi:10.1002/glia.20322.
    • (2006) Glia , vol.53 , pp. 660-668
    • Hayashi, Y.1    Ishibashi, H.2    Hashimoto, K.3    Nakanishi, H.4
  • 11
    • 80755168022 scopus 로고    scopus 로고
    • CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity
    • Rogers JT, Morganti JM, Bachstetter AD, Hudson CE, Peters MM, Grimmig BA, et al. CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. J Neurosci (2011) 31:16241-50. doi:10.1523/JNEUROSCI.3667-11.2011.
    • (2011) J Neurosci , vol.31 , pp. 16241-16250
    • Rogers, J.T.1    Morganti, J.M.2    Bachstetter, A.D.3    Hudson, C.E.4    Peters, M.M.5    Grimmig, B.A.6
  • 12
    • 0042968804 scopus 로고    scopus 로고
    • P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • Tsuda M, Shigemoto-Mogami Y, Koizumi S, Mizokoshi A, Kohsaka S, Salter MW, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature (2003) 424:778-83. doi:10.1038/nature01786.
    • (2003) Nature , vol.424 , pp. 778-783
    • Tsuda, M.1    Shigemoto-Mogami, Y.2    Koizumi, S.3    Mizokoshi, A.4    Kohsaka, S.5    Salter, M.W.6
  • 13
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci (2005) 8:752-8. doi:10.1038/nn1472.
    • (2005) Nat Neurosci , vol.8 , pp. 752-758
    • Davalos, D.1    Grutzendler, J.2    Yang, G.3    Kim, J.V.4    Zuo, Y.5    Jung, S.6
  • 14
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, Inoue K, et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature (2005) 438:1017-21. doi:10.1038/nature04223.
    • (2005) Nature , vol.438 , pp. 1017-1021
    • Coull, J.A.1    Beggs, S.2    Boudreau, D.3    Boivin, D.4    Tsuda, M.5    Inoue, K.6
  • 15
    • 84856384517 scopus 로고    scopus 로고
    • Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission
    • Pascual O, Ben Achour S, Rostaing P, Triller A, Bessis A. Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci U S A (2011) 109:197-205. doi:10.1073/pnas.1111098109.
    • (2011) Proc Natl Acad Sci U S A , vol.109 , pp. 197-205
    • Pascual, O.1    Ben Achour, S.2    Rostaing, P.3    Triller, A.4    Bessis, A.5
  • 16
    • 77956664066 scopus 로고    scopus 로고
    • Regulation of local translation at the synapse by BDNF
    • Santos AR, Comprido D, Duarte CB. Regulation of local translation at the synapse by BDNF. Prog Neurobiol (2010) 92:505-16. doi:10.1016/j.pneurobio.2010.08.004.
    • (2010) Prog Neurobiol , vol.92 , pp. 505-516
    • Santos, A.R.1    Comprido, D.2    Duarte, C.B.3
  • 17
    • 18944380607 scopus 로고    scopus 로고
    • Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia
    • Bianco F, Pravettoni E, Colombo A, Schenk U, Moller T, Matteoli M, et al. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol (2005) 174:7268-77. doi:10.4049/jimmunol.174.11.7268.
    • (2005) J Immunol , vol.174 , pp. 7268-7277
    • Bianco, F.1    Pravettoni, E.2    Colombo, A.3    Schenk, U.4    Moller, T.5    Matteoli, M.6
  • 18
    • 84857998516 scopus 로고    scopus 로고
    • Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
    • Antonucci F, Turola E, Riganti L, Caleo M, Gabrielli M, Perrotta C, et al. Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. EMBO J (2012) 31:1231-40. doi:10.1038/emboj.2011.489.
    • (2012) EMBO J , vol.31 , pp. 1231-1240
    • Antonucci, F.1    Turola, E.2    Riganti, L.3    Caleo, M.4    Gabrielli, M.5    Perrotta, C.6
  • 19
    • 84949623094 scopus 로고    scopus 로고
    • Active endocannabinoids are secreted on extracellular membrane vesicles
    • Gabrielli M, Battista N, Riganti L, Prada I, Antonucci F, Cantone L, et al. Active endocannabinoids are secreted on extracellular membrane vesicles. EMBO Rep (2015) 16(2):213-20. doi:10.15252/embr.201439668.
    • (2015) EMBO Rep , vol.16 , Issue.2 , pp. 213-220
    • Gabrielli, M.1    Battista, N.2    Riganti, L.3    Prada, I.4    Antonucci, F.5    Cantone, L.6
  • 20
    • 66449098305 scopus 로고    scopus 로고
    • Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis
    • Darios F, Wasser C, Shakirzyanova A, Giniatullin A, Goodman K, Munoz-Bravo JL, et al. Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. Neuron (2009) 62:683-94. doi:10.1016/j.neuron.2009.04.024.
    • (2009) Neuron , vol.62 , pp. 683-694
    • Darios, F.1    Wasser, C.2    Shakirzyanova, A.3    Giniatullin, A.4    Goodman, K.5    Munoz-Bravo, J.L.6
  • 21
    • 78650176947 scopus 로고    scopus 로고
    • Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus
    • Kanno T, Nishizaki T, Proia RL, Kajimoto T, Jahangeer S, Okada T, et al. Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus. Neuroscience (2010) 171:973-80. doi:10.1016/j.neuroscience.2010.10.021.
    • (2010) Neuroscience , vol.171 , pp. 973-980
    • Kanno, T.1    Nishizaki, T.2    Proia, R.L.3    Kajimoto, T.4    Jahangeer, S.5    Okada, T.6
  • 22
    • 77953865510 scopus 로고    scopus 로고
    • Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms
    • Norman E, Cutler RG, Flannery R, Wang Y, Mattson MP. Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. J Neurochem (2010) 114:430-9. doi:10.1111/j.1471-4159.2010.06779.x.
    • (2010) J Neurochem , vol.114 , pp. 430-439
    • Norman, E.1    Cutler, R.G.2    Flannery, R.3    Wang, Y.4    Mattson, M.P.5
  • 23
    • 9644310402 scopus 로고    scopus 로고
    • Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease
    • Raivich G, Banati R. Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Res Rev (2004) 46:261-81. doi:10.1016/j.brainresrev.2004.06.006.
    • (2004) Brain Res Rev , vol.46 , pp. 261-281
    • Raivich, G.1    Banati, R.2
  • 24
    • 84862736732 scopus 로고    scopus 로고
    • The innate immune system in demyelinating disease
    • Mayo L, Quintana FJ, Weiner HL. The innate immune system in demyelinating disease. Immunol Rev (2012) 248:170-87. doi:10.1111/j.1600-065X.2012.01135.x.
    • (2012) Immunol Rev , vol.248 , pp. 170-187
    • Mayo, L.1    Quintana, F.J.2    Weiner, H.L.3
  • 25
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, et al. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med (2005) 11:146-52. doi:10.1038/nm0405-455.
    • (2005) Nat Med , vol.11 , pp. 146-152
    • Heppner, F.L.1    Greter, M.2    Marino, D.3    Falsig, J.4    Raivich, G.5    Hövelmeyer, N.6
  • 26
    • 0032193213 scopus 로고    scopus 로고
    • Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice
    • Tran EH, Hoekstra K, van Rooijen N, Dijkstra CD, Owens T. Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J Immunol (1998) 161:3767-75.
    • (1998) J Immunol , vol.161 , pp. 3767-3775
    • Tran, E.H.1    Hoekstra, K.2    van Rooijen, N.3    Dijkstra, C.D.4    Owens, T.5
  • 27
    • 71549167047 scopus 로고    scopus 로고
    • CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    • Mildner A, Mack M, Schmidt H, Brück W, Djukic M, Zabel MD, et al. CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain (2009) 132:2487-500. doi:10.1093/brain/awp144.
    • (2009) Brain , vol.132 , pp. 2487-2500
    • Mildner, A.1    Mack, M.2    Schmidt, H.3    Brück, W.4    Djukic, M.5    Zabel, M.D.6
  • 28
    • 0033807680 scopus 로고    scopus 로고
    • CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
    • Fife BT, Huffnagle GB, Kuziel WA, Karpus WJ. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J Exp Med (2000) 192:899-905. doi:10.1084/jem.192.6.899.
    • (2000) J Exp Med , vol.192 , pp. 899-905
    • Fife, B.T.1    Huffnagle, G.B.2    Kuziel, W.A.3    Karpus, W.J.4
  • 29
    • 34250696978 scopus 로고    scopus 로고
    • Positron emission tomography imaging of neuroinflammation
    • Cagnin A, Kassiou M, Meikle SR, Banati RB. Positron emission tomography imaging of neuroinflammation. Neurotherapeutics (2007) 4:443-52. doi:10.1016/j.nurt.2007.04.006.
    • (2007) Neurotherapeutics , vol.4 , pp. 443-452
    • Cagnin, A.1    Kassiou, M.2    Meikle, S.R.3    Banati, R.B.4
  • 30
    • 84866117533 scopus 로고    scopus 로고
    • Increased PK11195 PET binding in the cortex of patients with MS correlates with disability
    • Politis M, Giannetti P, Su P, Turkheimer F, Keihaninejad S, Wu K, et al. Increased PK11195 PET binding in the cortex of patients with MS correlates with disability. Neurology (2012) 79:523-30. doi:10.1212/WNL.0b013e3182635645.
    • (2012) Neurology , vol.79 , pp. 523-530
    • Politis, M.1    Giannetti, P.2    Su, P.3    Turkheimer, F.4    Keihaninejad, S.5    Wu, K.6
  • 31
    • 84893577819 scopus 로고    scopus 로고
    • Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis
    • Giunti D, Parodi B, Cordano C, Uccelli A, Kerlero de Rosbo N. Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis. Immunology (2014) 141:328-39. doi:10.1111/imm.12177.
    • (2014) Immunology , vol.141 , pp. 328-339
    • Giunti, D.1    Parodi, B.2    Cordano, C.3    Uccelli, A.4    Kerlero de Rosbo, N.5
  • 32
    • 0028339366 scopus 로고
    • Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis
    • Bauer J, Sminia T, Wouterlood FG, Dijkstra CD. Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis. J Neurosci Res (1994) 38:365-75. doi:10.1002/jnr.490380402.
    • (1994) J Neurosci Res , vol.38 , pp. 365-375
    • Bauer, J.1    Sminia, T.2    Wouterlood, F.G.3    Dijkstra, C.D.4
  • 33
    • 0032526198 scopus 로고    scopus 로고
    • Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna
    • Lassmann H, Raine CS, Antel J, Prineas JW. Immunopathology of multiple sclerosis: report on an international meeting held at the Institute of Neurology of the University of Vienna. J Neuroimmunol (1998) 86:213-7. doi:10.1016/S0165-5728(98)00031-9.
    • (1998) J Neuroimmunol , vol.86 , pp. 213-217
    • Lassmann, H.1    Raine, C.S.2    Antel, J.3    Prineas, J.W.4
  • 34
    • 84880139919 scopus 로고    scopus 로고
    • Role of microglia in CNS autoimmunity
    • Goldmann T, Prinz M. Role of microglia in CNS autoimmunity. Clin Dev Immunol (2013) 2013:208093. doi:10.1155/2013/208093.
    • (2013) Clin Dev Immunol , vol.2013
    • Goldmann, T.1    Prinz, M.2
  • 35
    • 84940257897 scopus 로고    scopus 로고
    • Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis
    • Jiang Z, Jiang JX, Zhang GX. Macrophages: a double-edged sword in experimental autoimmune encephalomyelitis. Immunol Lett (2014) 160:17-22. doi:10.1016/j.imlet.2014.03.006.
    • (2014) Immunol Lett , vol.160 , pp. 17-22
    • Jiang, Z.1    Jiang, J.X.2    Zhang, G.X.3
  • 36
    • 34248630818 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia
    • Aravalli RN, Hu S, Lokensgard JR. Toll-like receptor 2 signaling is a mediator of apoptosis in herpes simplex virus-infected microglia. J Neuroinflammation (2007) 4:11. doi:10.1186/1742-2094-4-11.
    • (2007) J Neuroinflammation , vol.4 , pp. 11
    • Aravalli, R.N.1    Hu, S.2    Lokensgard, J.R.3
  • 37
    • 34548447524 scopus 로고    scopus 로고
    • Th1 polarization of CD4+ T cells by toll-like receptor 3-activated human microglia
    • Jack CS, Arbour N, Blain M, Meier UC, Prat A, Antel JP. Th1 polarization of CD4+ T cells by toll-like receptor 3-activated human microglia. J Neuropathol Exp Neurol (2007) 66:848-59. doi:10.1097/nen.0b013e3181492a7.
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 848-859
    • Jack, C.S.1    Arbour, N.2    Blain, M.3    Meier, U.C.4    Prat, A.5    Antel, J.P.6
  • 38
    • 0036644961 scopus 로고    scopus 로고
    • Cytokines, chemokines, and cytokine receptors in human microglia
    • Lee YB, Nagai A, Kim SU. Cytokines, chemokines, and cytokine receptors in human microglia. J Neurosci Res (2002) 69:94-103. doi:10.1002/jnr.10253.
    • (2002) J Neurosci Res , vol.69 , pp. 94-103
    • Lee, Y.B.1    Nagai, A.2    Kim, S.U.3
  • 39
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of toll-like receptors in the human central nervous system
    • Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol (2002) 61(11):1013-21.
    • (2002) J Neuropathol Exp Neurol , vol.61 , Issue.11 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    van Noort, J.M.4
  • 40
    • 65549086460 scopus 로고    scopus 로고
    • Regulation of autoimmune encephalomyelitis by toll-like receptors
    • Marta M, Meier UC, Lobell A. Regulation of autoimmune encephalomyelitis by toll-like receptors. Autoimmun Rev (2009) 8:506-9. doi:10.1016/j.autrev.2009.01.006.
    • (2009) Autoimmun Rev , vol.8 , pp. 506-509
    • Marta, M.1    Meier, U.C.2    Lobell, A.3
  • 41
    • 77951214891 scopus 로고    scopus 로고
    • Role of the innate immune system in the pathogenesis of multiple sclerosis
    • Gandhi R, Laroni A, Weiner HL. Role of the innate immune system in the pathogenesis of multiple sclerosis. J Neuroimmunol (2010) 221:7-14. doi:10.1016/j.jneuroim.2009.10.015.
    • (2010) J Neuroimmunol , vol.221 , pp. 7-14
    • Gandhi, R.1    Laroni, A.2    Weiner, H.L.3
  • 42
    • 16244417773 scopus 로고    scopus 로고
    • Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis
    • McMahon EJ, Bailey SL, Castenada CV, Waldner H, Miller SD. Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis. Nat Med (2005) 11:335-9. doi:10.1038/nm1202.
    • (2005) Nat Med , vol.11 , pp. 335-339
    • McMahon, E.J.1    Bailey, S.L.2    Castenada, C.V.3    Waldner, H.4    Miller, S.D.5
  • 43
    • 79954562214 scopus 로고    scopus 로고
    • CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease
    • Duncan DS, Miller SD. CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. PLoS One (2011) 6:e18548. doi:10.1371/journal.pone.0018548.
    • (2011) PLoS One , vol.6
    • Duncan, D.S.1    Miller, S.D.2
  • 44
    • 34250679758 scopus 로고    scopus 로고
    • Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis
    • Piccio L, Buonsanti C, Mariani M, Cella M, Gilfillan S, Cross AH, et al. Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol (2007) 37:1290-301. doi:10.1002/eji.200636837.
    • (2007) Eur J Immunol , vol.37 , pp. 1290-1301
    • Piccio, L.1    Buonsanti, C.2    Mariani, M.3    Cella, M.4    Gilfillan, S.5    Cross, A.H.6
  • 45
    • 77955661661 scopus 로고    scopus 로고
    • Protective effects of microglia in multiple sclerosis
    • Napoli I, Neumann H. Protective effects of microglia in multiple sclerosis. Exp Neurol (2010) 225:24-8. doi:10.1016/j.expneurol.2009.04.024.
    • (2010) Exp Neurol , vol.225 , pp. 24-28
    • Napoli, I.1    Neumann, H.2
  • 46
    • 0036154041 scopus 로고    scopus 로고
    • BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?
    • Stadelmann C, Kerschensteiner M, Misgeld T, Bruck W, Hohlfeld R, Lassmann H. BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells? Brain (2002) 125:75-85. doi:10.1093/brain/awf015.
    • (2002) Brain , vol.125 , pp. 75-85
    • Stadelmann, C.1    Kerschensteiner, M.2    Misgeld, T.3    Bruck, W.4    Hohlfeld, R.5    Lassmann, H.6
  • 47
    • 84860359394 scopus 로고    scopus 로고
    • Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration
    • Colombo E, Cordiglieri C, Melli G, Newcombe J, Krumbholz M, Parada LF, et al. Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration. J Exp Med (2012) 209:521-35. doi:10.1084/jem.20110698.
    • (2012) J Exp Med , vol.209 , pp. 521-535
    • Colombo, E.1    Cordiglieri, C.2    Melli, G.3    Newcombe, J.4    Krumbholz, M.5    Parada, L.F.6
  • 48
    • 11844253894 scopus 로고    scopus 로고
    • Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression
    • Kotter MR, Zhao C, van Rooijen N, Franklin RJ. Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression. Neurobiol Dis (2005) 18:166-75. doi:10.1016/j.nbd.2004.09.019.
    • (2005) Neurobiol Dis , vol.18 , pp. 166-175
    • Kotter, M.R.1    Zhao, C.2    van Rooijen, N.3    Franklin, R.J.4
  • 49
    • 84866327994 scopus 로고    scopus 로고
    • Multifaceted roles of tunneling nanotubes in intercellular communication
    • Marzo L, Gousset K, Zurzolo C. Multifaceted roles of tunneling nanotubes in intercellular communication. Front Physiol (2012) 3:72. doi:10.3389/fphys.2012.00072.
    • (2012) Front Physiol , vol.3 , pp. 72
    • Marzo, L.1    Gousset, K.2    Zurzolo, C.3
  • 50
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol (2009) 9:581-93. doi:10.1038/nri2567.
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 51
    • 67949097489 scopus 로고    scopus 로고
    • Exosomes-vesicular carriers for intercellular communication
    • Simons M, Raposo G. Exosomes-vesicular carriers for intercellular communication. Curr Opin Cell Biol (2009) 21:575-81. doi:10.1016/j.ceb.2009.03.007.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 575-581
    • Simons, M.1    Raposo, G.2
  • 52
    • 84881139801 scopus 로고    scopus 로고
    • Extracellular vesicles as an emerging mechanism of cell-to-cell communication
    • Tetta C, Ghigo E, Silengo L, Deregibus MC, Camussi G. Extracellular vesicles as an emerging mechanism of cell-to-cell communication. Endocrine (2013) 44:11-9. doi:10.1007/s12020-012-9839-0.
    • (2013) Endocrine , vol.44 , pp. 11-19
    • Tetta, C.1    Ghigo, E.2    Silengo, L.3    Deregibus, M.C.4    Camussi, G.5
  • 53
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: extracellular organelles important in intercellular communication
    • Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics (2010) 73:1907-20. doi:10.1016/j.jprot.2010.06.006.
    • (2010) J Proteomics , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 54
    • 84929506373 scopus 로고    scopus 로고
    • Ectosomes and exosomes: shedding the confusion between extracellular vesicles
    • S0962-8924(15)00015-X
    • Cocucci E, Meldolesi J. Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol (2015) S0962-8924(15)00015-X. doi:10.1016/j.tcb.2015.01.004.
    • (2015) Trends Cell Biol
    • Cocucci, E.1    Meldolesi, J.2
  • 55
    • 85027933779 scopus 로고    scopus 로고
    • Exosomes: immune properties and potential clinical implementations
    • Chaput N, Thery C. Exosomes: immune properties and potential clinical implementations. Semin Immunopathol (2011) 33:419-40. doi:10.1007/s00281-010-0233-9.
    • (2011) Semin Immunopathol , vol.33 , pp. 419-440
    • Chaput, N.1    Thery, C.2
  • 56
    • 79960096964 scopus 로고    scopus 로고
    • Exosomes: secreted vesicles and intercellular communications
    • Thery C. Exosomes: secreted vesicles and intercellular communications. F100 Biol Rep (2011) 3:15. doi:10.3410/B3-15.
    • (2011) F100 Biol Rep , vol.3 , pp. 15
    • Thery, C.1
  • 57
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • Akers JC, Gonda D, Kim R, Carter BS, Chen CC. Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol (2013) 113:1-11. doi:10.1007/s11060-013-1084-8.
    • (2013) J Neurooncol , vol.113 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3    Carter, B.S.4    Chen, C.C.5
  • 58
    • 84866343704 scopus 로고    scopus 로고
    • Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
    • Verderio C, Muzio L, Turola E, Bergami A, Novellino L, Ruffini F, et al. Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann Neurol (2012) 72:610-24. doi:10.1002/ana.23627.
    • (2012) Ann Neurol , vol.72 , pp. 610-624
    • Verderio, C.1    Muzio, L.2    Turola, E.3    Bergami, A.4    Novellino, L.5    Ruffini, F.6
  • 59
    • 84866425004 scopus 로고    scopus 로고
    • Microglial microvesicles secretion and intercellular signaling
    • Turola E, Furlan R, Bianco F, Matteoli M, Verderio C. Microglial microvesicles secretion and intercellular signaling. Front Physiol (2012) 3:149. doi:10.3389/fphys.2012.00149.
    • (2012) Front Physiol , vol.3 , pp. 149
    • Turola, E.1    Furlan, R.2    Bianco, F.3    Matteoli, M.4    Verderio, C.5
  • 60
    • 33747616431 scopus 로고    scopus 로고
    • Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
    • Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia (2006) 20(9):1487-95. doi:10.1038/sj.leu.2404296.
    • (2006) Leukemia , vol.20 , Issue.9 , pp. 1487-1495
    • Ratajczak, J.1    Wysoczynski, M.2    Hayek, F.3    Janowska-Wieczorek, A.4    Ratajczak, M.Z.5
  • 61
    • 84872149261 scopus 로고    scopus 로고
    • Extracellular vesicles in physiological and pathological conditions
    • Yuana Y, Sturk A, Nieuwland R. Extracellular vesicles in physiological and pathological conditions. Blood Rev (2013) 27:31-9. doi:10.1016/j.blre.2012.12.002.
    • (2013) Blood Rev , vol.27 , pp. 31-39
    • Yuana, Y.1    Sturk, A.2    Nieuwland, R.3
  • 62
    • 84907200625 scopus 로고    scopus 로고
    • Endothelial microparticles interact with and support the proliferation of T cells
    • Wheway J, Latham SL, Combes V, Grau GER. Endothelial microparticles interact with and support the proliferation of T cells. J Immunol (2014) 193:3378-87. doi:10.4049/jimmunol.1303431.
    • (2014) J Immunol , vol.193 , pp. 3378-3387
    • Wheway, J.1    Latham, S.L.2    Combes, V.3    Grau, G.E.R.4
  • 63
    • 84897133710 scopus 로고    scopus 로고
    • Extracellular vesicles in multiple sclerosis: what are they telling us?
    • Saenz-Cuesta M, Osorio-Querejeta I, Otaegui D. Extracellular vesicles in multiple sclerosis: what are they telling us? Front Cell Neurosci (2014) 8:100. doi:10.3389/fncel.2014.00100.
    • (2014) Front Cell Neurosci , vol.8 , pp. 100
    • Saenz-Cuesta, M.1    Osorio-Querejeta, I.2    Otaegui, D.3
  • 64
    • 75849123055 scopus 로고    scopus 로고
    • Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes
    • Sbai O, Ould-Yahoui A, Ferhat L, Gueye Y, Bernard A, Charrat E, et al. Differential vesicular distribution and trafficking of MMP-2, MMP-9, and their inhibitors in astrocytes. Glia (2010) 58:344-66. doi:10.1002/glia.20927.
    • (2010) Glia , vol.58 , pp. 344-366
    • Sbai, O.1    Ould-Yahoui, A.2    Ferhat, L.3    Gueye, Y.4    Bernard, A.5    Charrat, E.6
  • 65
    • 0035933189 scopus 로고    scopus 로고
    • Elevated plasma endothelial microparticles in multiple sclerosis
    • Minagar A, Jy W, Jimenez JJ, Sheremata WA, Mauro LM, Mao WW, et al. Elevated plasma endothelial microparticles in multiple sclerosis. Neurology (2001) 56:1319-24. doi:10.1212/WNL.56.10.1319.
    • (2001) Neurology , vol.56 , pp. 1319-1324
    • Minagar, A.1    Jy, W.2    Jimenez, J.J.3    Sheremata, W.A.4    Mauro, L.M.5    Mao, W.W.6
  • 66
    • 13344276666 scopus 로고    scopus 로고
    • Endothelial microparticles (EMP) bind and activate monocytes: elevated EMP-monocyte conjugates in multiple sclerosis
    • Jy W, Minagar A, Jimenez JJ, Sheremata WA, Mauro LM, Horstman LL, et al. Endothelial microparticles (EMP) bind and activate monocytes: elevated EMP-monocyte conjugates in multiple sclerosis. Front Biosci (2004) 9:3137-44. doi:10.2741/1466.
    • (2004) Front Biosci , vol.9 , pp. 3137-3144
    • Jy, W.1    Minagar, A.2    Jimenez, J.J.3    Sheremata, W.A.4    Mauro, L.M.5    Horstman, L.L.6
  • 67
    • 0032128299 scopus 로고    scopus 로고
    • Modulation of monocyte-endothelial cell interactions by platelet microparticles
    • Barry OP, Pratico D, Savani RC, Fitzgerald GA. Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest (1998) 102:136-44. doi:10.1172/JCI2592.
    • (1998) J Clin Invest , vol.102 , pp. 136-144
    • Barry, O.P.1    Pratico, D.2    Savani, R.C.3    Fitzgerald, G.A.4
  • 70
    • 84879586923 scopus 로고    scopus 로고
    • Classical and unconventional pathways of vesicular release in microglia
    • Prada I, Furlan R, Matteoli M, Verderio C. Classical and unconventional pathways of vesicular release in microglia. Glia (2013) 61(7):1003-17. doi:10.1002/glia.22497.
    • (2013) Glia , vol.61 , Issue.7 , pp. 1003-1017
    • Prada, I.1    Furlan, R.2    Matteoli, M.3    Verderio, C.4
  • 71
    • 0024976416 scopus 로고
    • Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement
    • Scolding NJ, Morgan BP, Houston WA, Linington C, Campbell AK, Compston DA. Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement. Nature (1989) 339:620-2. doi:10.1038/339620a0.
    • (1989) Nature , vol.339 , pp. 620-622
    • Scolding, N.J.1    Morgan, B.P.2    Houston, W.A.3    Linington, C.4    Campbell, A.K.5    Compston, D.A.6
  • 72
    • 20144381022 scopus 로고    scopus 로고
    • Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes
    • Jimenez J, Jy W, Mauro LM, Horstman LL, Ahn ER, Ahn YS, et al. Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes. Mult Scler (2005) 11(3):310-5. doi:10.1191/1352458505ms1184oa.
    • (2005) Mult Scler , vol.11 , Issue.3 , pp. 310-315
    • Jimenez, J.1    Jy, W.2    Mauro, L.M.3    Horstman, L.L.4    Ahn, E.R.5    Ahn, Y.S.6
  • 74
    • 33749383260 scopus 로고    scopus 로고
    • Interferon-beta1a reduces plasma CD31+ endothelial microparticles (CD31+EMP) in multiple sclerosis
    • Sheremata WA, Jy W, Delgado S, Minagar A, McLarty J, Ahn Y. Interferon-beta1a reduces plasma CD31+ endothelial microparticles (CD31+EMP) in multiple sclerosis. J Neuroinflammation (2006) 3:23. doi:10.1186/1742-2094-3-23.
    • (2006) J Neuroinflammation , vol.3 , pp. 23
    • Sheremata, W.A.1    Jy, W.2    Delgado, S.3    Minagar, A.4    McLarty, J.5    Ahn, Y.6
  • 76
    • 78650864383 scopus 로고    scopus 로고
    • Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants
    • Dawson G, Qin J. Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants. Biochem Biophys Res Commun (2011) 404:321-3. doi:10.1016/j.bbrc.2010.11.115.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 321-323
    • Dawson, G.1    Qin, J.2


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