Resveratrol is neuroprotective and improves cognition in pentylenetetrazole-kindling model of epilepsy in rats

Indian Journal of Pharmaceutical Sciences

Volumn 76, Issue 2, 2014, Pages 125-131

  Meng, X J ^a   Wang, F ^a   Li, C K ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

cognition; Epilepsy; neuroprotective; pentylenetetrazole; resveratrol

Indexed keywords

ANTICONVULSIVE AGENT; NEUROPROTECTIVE AGENT; PROTEIN S100B; RESVERATROL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; EPILEPSY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; MALE; MORRIS WATER MAZE TEST; NERVE CELL NECROSIS; NEUROPROTECTION; NISSL STAINING; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; RAT; TREATMENT OUTCOME;

EID: 84899673215     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Scorze FA, Arida RM, Naffah-Mazzacoratti MG, Scerni DA, Calderazzo L, Cavalheiro EA. The pilocarpine model of epilepsy: What have we learned? An Acad Bras Cienc 2009;81:345-65.
2. Zhou Y, Liu M, Liang W. Progress in the epidemiology study of epilepsy. Chin J Epidemiol 2007;28:92-4.
3. Xu Q, Wu Z, Zhang L. Study on antiepileptic effect and mechanism of resveratrol. Acta Univ Med Anhui 2009;44:57-61.
4. Friedman LK, Goldstein B, Rafiuddin A, Roblejo P, Friedman S. Lack of resveratrol neuroprotection in developing rats treated with kainic acid. Neuroscience 2013;230:39-49.
5. Zhang F, Liu J, Shi JS. Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation. Eur J Pharmcol 2010;636:1-7.
6. Gu X, Creasy L, Kester A, Zeece M. Capillary electrophoretic determination of resveratrol in wines. J Agric Food Chem 1999;47:3223-7.
7. Mehling K, Skoog I, Guo X, Schütze M, Gustafson D, Waern M, et al. Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in Goteborg. Am J Epidemiol 2008;167:684-91.
8. German JB, Walzem RL. The health benefits of wine. Annu Rev Nutr 2000;20:561-93.
9. Shetty AK. Promise of resveratrol for easing status epilepticus and epilepsy. Pharmacol Ther 2011;131:269-86.
10. Singleton RH, Yan HQ, Fellows-Mayle W, Dixon CE. Resveratrol attenuates behavioral impairments and reduces cortical and hippocampal loss in a rat controlled cortical impact model of traumatic brain injury. J Neurotrauma 2010;27:1091-9.
11. Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res 2002;958:439-47.
12. Clasadonte J, Donq J, Hines DJ, Haydon PG. Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy. Proc Natl Acad Sci USA 2013;110:17540-5.
13. Shashoua VE, Hesse GW, Moore BW. Proteins of the brain extracellular fluid: Evidence for release of S-100 protein. J Neurochem 1984;42:1536-41.
14. Naeimi ZS, Weinhofer A, Sarahrudi K. Predictive value of S-100B protein and neuron specific-enolase as markers of traumatic brain damage in clinical use. Brain Inj 2006;20:463-8.
15. Steiner J, Bogerts B, Schroeter ML, Bernstein HG. S100B protein in neurodegenerative disorders. Clin Chem Lab Med 2011;49:409-24.
16. Koh SX, Lee JK. S100B as a marker for brain damage and blood-brain barrier disruption following exercise. Sports Med 2014;44:369-85.
17. Lu C, Li J, Sun W, Feng L, Li L, Liu A, et al. Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: A case-control study. Neurosci Lett 2010;484:139-42.
18. Albright PS, Burnham WM. Development of a new pharmacological seizure model: Effects of anticonvulsants on cortical-and amygdala-kindled seizures in the rat. Epilepsia 1980;21:681-9.
19. Xiang HX, Zhang G, Wang D. Research and application progress of the kindling effect. Hebei Med 2010;16:892-5.
20. Racine RJ. Modification of seizure activity by electrical stimulation. I. After-discharge threshold. Electroencephalogr Clin Neurophysiol 1972;32:269-79.
21. Nirogi R, Kandikere V, Mudigonda K, Bhyrapuneni G, Muddana N, Saralaya R, et al. A simple and rapid method to collect the cerebrospinal fluid of rats and its application for the assessment of drug penetration into the central nervous system. J Neurosci Methods 2009;178:116-9.
22. Malone JI, Hanna S, Saporta S, Mervis RF, Park CR, Chong L, et al. Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatr Diabetes 2008;9:531-9.
23. Li M, Wang QS, Chen Y. Resveratrol inhibits neuronal discharges in rat hippocampal CA1 area. Sheng Li Xue Bao 2005;57:355-60.
24. Gao ZB, Hu GY. Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons. Brain Res 2005;1056:68-75.
25. Gupta YK, Briyal S, Chaudhary G. Protective effect of trans-resveratrol against kainic acid induced seizures and oxidative stress in rats. Pharmacol Biochem Behav 2002;71:245-9.