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Volumn 6, Issue 2, 2015, Pages 68-81

Short commentary on empagliflozin and its potential clinical impact

Author keywords

empagliflozin; sodium glucose cotransporter type 2 inhibitors; type 2 diabetes mellitus

Indexed keywords

EMPAGLIFLOZIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR;

EID: 84930589774     PISSN: 20420188     EISSN: 20420196     Source Type: Journal    
DOI: 10.1177/2042018815578599     Document Type: Review
Times cited : (11)

References (70)
  • 1
    • 64749089393 scopus 로고    scopus 로고
    • Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus
    • Abdul-Ghani M. DeFronzo R. (2008) Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus. Endocr Pract 14: 782–790.
    • (2008) Endocr Pract , vol.14 , pp. 782-790
    • Abdul-Ghani, M.1    DeFronzo, R.2
  • 2
    • 84880000540 scopus 로고    scopus 로고
    • Canagliflozin for the treatment of type 2 diabetes
    • Babu A. (2013) Canagliflozin for the treatment of type 2 diabetes. Drugs Today (Barc) 49: 363–376.
    • (2013) Drugs Today (Barc) , vol.49 , pp. 363-376
    • Babu, A.1
  • 3
    • 84857297404 scopus 로고    scopus 로고
    • The impact of hypoglycaemia on quality of life and related patient-reported outcomes in type 2 diabetes: a narrative review
    • Barendse S. Singh H. Frier B. Speight J. (2012) The impact of hypoglycaemia on quality of life and related patient-reported outcomes in type 2 diabetes: a narrative review. Diab Med 29: 293–302.
    • (2012) Diab Med , vol.29 , pp. 293-302
    • Barendse, S.1    Singh, H.2    Frier, B.3    Speight, J.4
  • 4
    • 84899961819 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial
    • Barnett A. Mithal A. Manassie J. Jones R. Rattunde H. Woerle H. et al. (2014) Efficacy and safety of empagliflozin added to existing antidiabetes treatment in patients with type 2 diabetes and chronic kidney disease: a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 2: 369–384.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 369-384
    • Barnett, A.1    Mithal, A.2    Manassie, J.3    Jones, R.4    Rattunde, H.5    Woerle, H.6
  • 5
    • 84993680732 scopus 로고    scopus 로고
    • Boehringer Ingelheim GmbH
    • Pooled analysis data showed improvements in glycaemic parameters, body weight and blood pressure with investigational agent empagliflozin in adults with type 2 diabetes Available at: http://www.boehringer-ingelheim.com/news/news_releases/press_releases/2013/24_september_2013empagliflozin.html (accessed 10 March 2014).
    • Boehringer Ingelheim GmbH (2013) Pooled analysis data showed improvements in glycaemic parameters, body weight and blood pressure with investigational agent empagliflozin in adults with type 2 diabetes. Available at: http://www.boehringer-ingelheim.com/news/news_releases/press_releases/2013/24_september_2013empagliflozin.html (accessed 10 March 2014).
    • (2013)
  • 6
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • Bolinder J. Ljunggren Ö. Johansson L. Wilding J. Langkilde A. Sjöström C. et al. (2014) Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab 16: 159–169.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 159-169
    • Bolinder, J.1    Ljunggren, Ö.2    Johansson, L.3    Wilding, J.4    Langkilde, A.5    Sjöström, C.6
  • 7
    • 84884167643 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    • Cefalu W. Leiter L. Yoon K. Arias P. Niskanen L. Xie J. et al. (2013) Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial. Lancet 382: 941–950.
    • (2013) Lancet , vol.382 , pp. 941-950
    • Cefalu, W.1    Leiter, L.2    Yoon, K.3    Arias, P.4    Niskanen, L.5    Xie, J.6
  • 8
    • 84865636935 scopus 로고    scopus 로고
    • Dapagliflozin: an evidence-based review of its potential in the treatment of type-2 diabetes
    • Chao E. (2012) Dapagliflozin: an evidence-based review of its potential in the treatment of type-2 diabetes. Core Evid 7: 21–28.
    • (2012) Core Evid , vol.7 , pp. 21-28
    • Chao, E.1
  • 9
    • 84893214045 scopus 로고    scopus 로고
    • Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
    • Cherney D. Perkins B. Soleymanlou N. Maione M. Lai V. Lee A. et al. (2014) Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 129: 587–597.
    • (2014) Circulation , vol.129 , pp. 587-597
    • Cherney, D.1    Perkins, B.2    Soleymanlou, N.3    Maione, M.4    Lai, V.5    Lee, A.6
  • 10
    • 84886689057 scopus 로고    scopus 로고
    • Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes
    • Suppl. 2
    • de Fronzo R. Eldor R. Abdul-Ghani M. (2013) Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes. Diabetes Care 36(Suppl. 2): S127–S138.
    • (2013) Diabetes Care , vol.36 , pp. S127-S138
    • de Fronzo, R.1    Eldor, R.2    Abdul-Ghani, M.3
  • 11
    • 84928176749 scopus 로고    scopus 로고
    • Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin
    • de Fronzo R. Lewin A. Patel S. Liu D. Kaste R. Woerle H. et al. (2015) Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin. Diabetes Care 38: 384–393.
    • (2015) Diabetes Care , vol.38 , pp. 384-393
    • de Fronzo, R.1    Lewin, A.2    Patel, S.3    Liu, D.4    Kaste, R.5    Woerle, H.6
  • 13
    • 62949147825 scopus 로고    scopus 로고
    • European Medicines Agency
    • Forxiga (dapagliflozin) EMA Assessment Report. Procedure no. EMEA/H/C/002322. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002322/WC500136024.pdf (accessed 10 March 2014).
    • European Medicines Agency (2012) Forxiga (dapagliflozin). EMA Assessment Report. Procedure no. EMEA/H/C/002322. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002322/WC500136024.pdf (accessed 10 March 2014).
    • (2012)
  • 14
    • 84951272628 scopus 로고    scopus 로고
    • European Medicines Agency
    • Forxiga (dapagliflozin) Summary of product characteristics October Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002322/WC500136026.pdf (accessed 10 March 2015).
    • European Medicines Agency (2014 a) Forxiga (dapagliflozin). Summary of product characteristics (October 2014). Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002322/WC500136026.pdf (accessed 10 March 2015).
    • (2014)
  • 15
    • 84951272628 scopus 로고    scopus 로고
    • European Medicines Agency
    • Invokana (canagliflozin). Summary of product characteristics September Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002649/WC500156456.pdf (accessed 10 March 2015).
    • European Medicines Agency (2014 b) Invokana (canagliflozin). Summary of product characteristics (September 2014). Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002649/WC500156456.pdf (accessed 10 March 2015).
    • (2014)
  • 16
    • 84951272628 scopus 로고    scopus 로고
    • European Medicines Agency
    • Jardiance (empagliflozin) CHMP Assessment Report March Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002677/WC500168594.pdf (accessed 10 March 2015).
    • European Medicines Agency (2014 c) Jardiance (empagliflozin). CHMP Assessment Report (March 2014). Available at: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002677/WC500168594.pdf (accessed 10 March 2015).
    • (2014)
  • 17
    • 84951272628 scopus 로고    scopus 로고
    • European Medicines Agency
    • Jardiance (empagliflozin) Summary of product characteristics June Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002677/human_med_001764.jsp&mid=WC0b01ac058001d124 (accessed 10 March 2015).
    • European Medicines Agency (2014 d) Jardiance (empagliflozin). Summary of product characteristics (June 2014). Available at: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/002677/human_med_001764.jsp&mid=WC0b01ac058001d124 (accessed 10 March 2015).
    • (2014)
  • 18
    • 84951272628 scopus 로고    scopus 로고
    • European Medicines Agency
    • Summary of the risk management plan (RMP) for Jardiance (empagliflozin) April Available at: http://www.fimea.fi/download/27456_Jardiance_RMP_summary-EN.pdf (accessed 10 March 2015).
    • European Medicines Agency (2014 e) Summary of the risk management plan (RMP) for Jardiance (empagliflozin) (April 2014). Available at: http://www.fimea.fi/download/27456_Jardiance_RMP_summary-EN.pdf (accessed 10 March 2015).
    • (2014)
  • 19
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • Ferrannini E. Muscelli E. Frascerra S. Baldi S. Mari A. Heise T. et al. (2014) Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Invest 124: 499–508.
    • (2014) J Clin Invest , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3    Baldi, S.4    Mari, A.5    Heise, T.6
  • 20
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial
    • Ferrannini E. Ramos S. Salsali A. Tang W. List J.F. (2010) Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care 33: 2217–2224.
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 22
    • 84898917720 scopus 로고    scopus 로고
    • Genital and urinary tract infections in diabetes: Impact of pharmacologically-induced glucosuria
    • Geerlings S. Fonseca V. Castro-Diaz D. List J. Parikh S. (2014) Genital and urinary tract infections in diabetes: Impact of pharmacologically-induced glucosuria. Diabetes Res Clin Pract 103: 373–381.
    • (2014) Diabetes Res Clin Pract , vol.103 , pp. 373-381
    • Geerlings, S.1    Fonseca, V.2    Castro-Diaz, D.3    List, J.4    Parikh, S.5
  • 23
    • 83655184724 scopus 로고    scopus 로고
    • Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors
    • Grempler R. Thomas L. Eckhardt M. Himmelsbach F. Sauer A. Sharp D. et al. (2012) Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab 14: 83–90.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 83-90
    • Grempler, R.1    Thomas, L.2    Eckhardt, M.3    Himmelsbach, F.4    Sauer, A.5    Sharp, D.6
  • 24
    • 84899941589 scopus 로고    scopus 로고
    • Empagliflozin improves glycemic parameters and cardiovascular risk factors in patients with type 2 diabetes (T2DM): pooled data from four pivotal phase III trials. Abstract 69-LB
    • Suppl. 1A
    • Hach T. Gerich J. Salsali A. Kim G. Hantel S. Woerle H. et al. (2013) Empagliflozin improves glycemic parameters and cardiovascular risk factors in patients with type 2 diabetes (T2DM): pooled data from four pivotal phase III trials. Abstract 69-LB. Diabetes 62(Suppl. 1A): LB19.
    • (2013) Diabetes , vol.62 , pp. LB19
    • Hach, T.1    Gerich, J.2    Salsali, A.3    Kim, G.4    Hantel, S.5    Woerle, H.6
  • 25
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT 2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • Han S. Hagan D. Taylor J. Xin L. Meng W. Biller S. et al. (2008) Dapagliflozin, a selective SGLT 2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 57: 1723–1729.
    • (2008) Diabetes , vol.57 , pp. 1723-1729
    • Han, S.1    Hagan, D.2    Taylor, J.3    Xin, L.4    Meng, W.5    Biller, S.6
  • 26
    • 84901455931 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
    • Häring H. Merker L. Seewaldt-Becker E. Weimer M. Meinicke T. Broedl U. et al. (2014) Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care 37: 1650–1659.
    • (2014) Diabetes Care , vol.37 , pp. 1650-1659
    • Häring, H.1    Merker, L.2    Seewaldt-Becker, E.3    Weimer, M.4    Meinicke, T.5    Broedl, U.6
  • 27
    • 84885952950 scopus 로고    scopus 로고
    • Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial
    • Häring H. Merker L. Seewaldt-Becker E. Weimer M. Meinicke T. Woerle H. et al. (2013) Empagliflozin as add-on to metformin plus sulfonylurea in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care 36: 3396–3404.
    • (2013) Diabetes Care , vol.36 , pp. 3396-3404
    • Häring, H.1    Merker, L.2    Seewaldt-Becker, E.3    Weimer, M.4    Meinicke, T.5    Woerle, H.6
  • 28
    • 84923448295 scopus 로고    scopus 로고
    • SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials
    • Inzucchi S. Zinman B. Wanner C. Ferrari R. Fitchett D. Hantel S. et al. (2015) SGLT-2 inhibitors and cardiovascular risk: proposed pathways and review of ongoing outcome trials. Diab Vasc Dis Res 12: 90–100.
    • (2015) Diab Vasc Dis Res , vol.12 , pp. 90-100
    • Inzucchi, S.1    Zinman, B.2    Wanner, C.3    Ferrari, R.4    Fitchett, D.5    Hantel, S.6
  • 29
    • 84893766447 scopus 로고    scopus 로고
    • SGLT 2 inhibitors to control glycemia in type 2 diabetes mellitus: a new approach to an old problem
    • Jabbour S. (2014) SGLT 2 inhibitors to control glycemia in type 2 diabetes mellitus: a new approach to an old problem. Postgrad Med 126: 111–117.
    • (2014) Postgrad Med , vol.126 , pp. 111-117
    • Jabbour, S.1
  • 32
    • 84896856867 scopus 로고    scopus 로고
    • Empagliflozin (EMPA) increases genital infections but not urinary tract infections (UTIs) in pooled data from four pivotal phase III trials. Abstract 74-LB
    • Suppl. 1
    • Kim G. Gerich J. Salsali A. Hach T. Hantel S. Woerle H. et al. (2013) Empagliflozin (EMPA) increases genital infections but not urinary tract infections (UTIs) in pooled data from four pivotal phase III trials. Abstract 74-LB. Diabetes 62(Suppl. 1): LB21.
    • (2013) Diabetes , vol.62 , pp. LB21
    • Kim, G.1    Gerich, J.2    Salsali, A.3    Hach, T.4    Hantel, S.5    Woerle, H.6
  • 33
    • 84897394040 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • Kohan D. Fioretto P. Tang W. List J. (2014) Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int 85: 962–971.
    • (2014) Kidney Int , vol.85 , pp. 962-971
    • Kohan, D.1    Fioretto, P.2    Tang, W.3    List, J.4
  • 34
    • 84892477577 scopus 로고    scopus 로고
    • Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial
    • Kovacs C. Seshiah V. Swallow R. Jones R. Rattunde H. Woerle H. et al. (2013) Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab 16: 147–158.
    • (2013) Diabetes Obes Metab , vol.16 , pp. 147-158
    • Kovacs, C.1    Seshiah, V.2    Swallow, R.3    Jones, R.4    Rattunde, H.5    Woerle, H.6
  • 35
    • 84900812229 scopus 로고    scopus 로고
    • Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes
    • Lamos E. Younk L. Davis S. (2014) Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes. Expert Opin Investig Drugs 23: 875–882.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 875-882
    • Lamos, E.1    Younk, L.2    Davis, S.3
  • 36
    • 84928199102 scopus 로고    scopus 로고
    • Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes
    • Lewin A. DeFronzo R. Patel S. Liu D. Kaste R. Woerle H. et al. (2015) Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetes. Diabetes Care 38: 394–402.
    • (2015) Diabetes Care , vol.38 , pp. 394-402
    • Lewin, A.1    DeFronzo, R.2    Patel, S.3    Liu, D.4    Kaste, R.5    Woerle, H.6
  • 37
    • 84892478812 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and tolerability of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with hepatic impairment
    • Macha S. Rose P. Mattheus M. Cinca R. Pinnetti S. Broedl U. et al. (2014) Pharmacokinetics, safety and tolerability of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with hepatic impairment. Diabetes Obes Metab 16: 118–123.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 118-123
    • Macha, S.1    Rose, P.2    Mattheus, M.3    Cinca, R.4    Pinnetti, S.5    Broedl, U.6
  • 38
    • 0036838469 scopus 로고    scopus 로고
    • AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat
    • McCrimmon R. Evans M. Jacob R. Fan X. Zhu Y. Shulman G. et al. (2002) AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat. Am J Physiol Endocrinol Metab 283: E1076–E1083.
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , pp. E1076-E1083
    • McCrimmon, R.1    Evans, M.2    Jacob, R.3    Fan, X.4    Zhu, Y.5    Shulman, G.6
  • 39
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • Merovci A. Solis-Herrera C. Daniele G. Eldor R. Fiorentino T. Tripathy D. et al. (2014) Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest 124: 509–514.
    • (2014) J Clin Invest , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3    Eldor, R.4    Fiorentino, T.5    Tripathy, D.6
  • 40
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS) – a randomized placebo-controlled trial
    • e211.
    • Neal B. Perkovic V. de Zeeuw D. Mahaffey K. Fulcher G. Stein P. et al. (2013) Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS) – a randomized placebo-controlled trial. Am Heart J 166: 217–223 e211.
    • (2013) Am Heart J , vol.166 , pp. 217-223
    • Neal, B.1    Perkovic, V.2    de Zeeuw, D.3    Mahaffey, K.4    Fulcher, G.5    Stein, P.6
  • 41
    • 84897019959 scopus 로고    scopus 로고
    • Urinary tract infection in randomized phase III studies of canagliflozin, a sodium glucose co-transporter 2 inhibitor
    • Nicolle L. Capuano G. Fung A. Usiskin K. (2014) Urinary tract infection in randomized phase III studies of canagliflozin, a sodium glucose co-transporter 2 inhibitor. Postgrad Med 126: 7–17.
    • (2014) Postgrad Med , vol.126 , pp. 7-17
    • Nicolle, L.1    Capuano, G.2    Fung, A.3    Usiskin, K.4
  • 42
    • 84888055107 scopus 로고    scopus 로고
    • Canagliflozin, a novel SGLT 2 inhibitor for treatment of type 2 diabetes
    • Nigro S. Riche D. Pheng M. Baker W. (2013) Canagliflozin, a novel SGLT 2 inhibitor for treatment of type 2 diabetes. Ann Pharmacother 47: 1301–1311.
    • (2013) Ann Pharmacother , vol.47 , pp. 1301-1311
    • Nigro, S.1    Riche, D.2    Pheng, M.3    Baker, W.4
  • 43
    • 84900823374 scopus 로고    scopus 로고
    • Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studies
    • Nyirjesy P. Sobel J. Fung A. Mayer C. Capuano G. Ways K. et al. (2014) Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. Curr Med Res Opin 30: 1109–1119.
    • (2014) Curr Med Res Opin , vol.30 , pp. 1109-1119
    • Nyirjesy, P.1    Sobel, J.2    Fung, A.3    Mayer, C.4    Capuano, G.5    Ways, K.6
  • 44
    • 84899105421 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial
    • Perkins B. Cherney D. Partridge H. Soleymanlou N. Tschirhart H. Zinman B. et al. (2014) Sodium-glucose cotransporter 2 inhibition and glycemic control in type 1 diabetes: results of an 8-week open-label proof-of-concept trial. Diabetes Care 37: 1480–1483.
    • (2014) Diabetes Care , vol.37 , pp. 1480-1483
    • Perkins, B.1    Cherney, D.2    Partridge, H.3    Soleymanlou, N.4    Tschirhart, H.5    Zinman, B.6
  • 45
    • 84898600889 scopus 로고    scopus 로고
    • Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes
    • Polidori D. Mari A. Ferrannini E. (2014) Canagliflozin, a sodium glucose co-transporter 2 inhibitor, improves model-based indices of beta cell function in patients with type 2 diabetes. Diabetologia 57: 891–901.
    • (2014) Diabetologia , vol.57 , pp. 891-901
    • Polidori, D.1    Mari, A.2    Ferrannini, E.3
  • 47
    • 84908332537 scopus 로고    scopus 로고
    • Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial
    • Ridderstråle M. Andersen K. Zeller C. Kim G. Woerle H. Broedl U. (2014) Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trial. Lancet Diabetes Endocrinol 2: 691–700.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 691-700
    • Ridderstråle, M.1    Andersen, K.2    Zeller, C.3    Kim, G.4    Woerle, H.5    Broedl, U.6
  • 48
    • 84883452474 scopus 로고    scopus 로고
    • Rationale, design and baseline characteristics of a 4-year (208-week) phase III trial of empagliflozin, an SGLT 2 inhibitor, versus glimepiride as add-on to metformin in patients with type 2 diabetes mellitus with insufficient glycemic control
    • Ridderstråle M. Svaerd R. Zeller C. Kim G. Woerle H. Broedl U. (2013) Rationale, design and baseline characteristics of a 4-year (208-week) phase III trial of empagliflozin, an SGLT 2 inhibitor, versus glimepiride as add-on to metformin in patients with type 2 diabetes mellitus with insufficient glycemic control. Cardiovasc Diabetol 12: 129.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 129
    • Ridderstråle, M.1    Svaerd, R.2    Zeller, C.3    Kim, G.4    Woerle, H.5    Broedl, U.6
  • 49
    • 84885954870 scopus 로고    scopus 로고
    • Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial
    • Roden M. Weng J. Eilbracht J. Delafont B. Kim G. Woerle H. et al. (2013) Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol 1: 208–219.
    • (2013) Lancet Diabetes Endocrinol , vol.1 , pp. 208-219
    • Roden, M.1    Weng, J.2    Eilbracht, J.3    Delafont, B.4    Kim, G.5    Woerle, H.6
  • 51
    • 84903511385 scopus 로고    scopus 로고
    • Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes
    • Rosenstock J. Jelaska A. Frappin G. Salsali A. Kim G. Woerle H. et al. (2014) Improved glucose control with weight loss, lower insulin doses, and no increased hypoglycemia with empagliflozin added to titrated multiple daily injections of insulin in obese inadequately controlled type 2 diabetes. Diabetes Care 37: 1815–1823.
    • (2014) Diabetes Care , vol.37 , pp. 1815-1823
    • Rosenstock, J.1    Jelaska, A.2    Frappin, G.3    Salsali, A.4    Kim, G.5    Woerle, H.6
  • 52
    • 84884205365 scopus 로고    scopus 로고
    • Empagliflozin as add-on to basal insulin for 78 weeks improves glycemic control with weight loss in insulin-treated (T2DM)
    • Abstract 1102-P. Suppl. 1
    • Rosenstock J. Jelaska A. Kim G. Broedl U. Woerle H. (2013) Empagliflozin as add-on to basal insulin for 78 weeks improves glycemic control with weight loss in insulin-treated (T2DM). Abstract 1102-P. Diabetes 62(Suppl. 1): A285.
    • (2013) Diabetes , vol.62 , pp. A285
    • Rosenstock, J.1    Jelaska, A.2    Kim, G.3    Broedl, U.4    Woerle, H.5
  • 54
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats
    • Rossetti L. Smith D. Shulman G. Papachristou D. DeFronzo R. (1987) Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest 79: 1510–1515.
    • (1987) J Clin Invest , vol.79 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.3    Papachristou, D.4    DeFronzo, R.5
  • 55
    • 75749094398 scopus 로고    scopus 로고
    • Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target
    • Santer R. Calado J. (2010) Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. Clin J Am Soc Nephrol 5: 133–141.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 133-141
    • Santer, R.1    Calado, J.2
  • 56
    • 84898434447 scopus 로고    scopus 로고
    • Evaluating SGLT 2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations
    • Scheen A. (2014) Evaluating SGLT 2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations. Expert Opin Drug Metab Toxicol 10: 647–663.
    • (2014) Expert Opin Drug Metab Toxicol , vol.10 , pp. 647-663
    • Scheen, A.1
  • 57
    • 84876796916 scopus 로고    scopus 로고
    • Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society
    • Seaquist E. Anderson J. Childs B. Cryer P. Dagogo-Jack S. Fish L. et al. (2013) Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society. Diabetes Care 36: 1384–1395.
    • (2013) Diabetes Care , vol.36 , pp. 1384-1395
    • Seaquist, E.1    Anderson, J.2    Childs, B.3    Cryer, P.4    Dagogo-Jack, S.5    Fish, L.6
  • 58
    • 84899960517 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies
    • Sinclair A. Bode B. Harris S. Vijapurkar U. Mayer C. Fung A. et al. (2014) Efficacy and safety of canagliflozin compared with placebo in older patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. BMC Endocr Disord 14: 37.
    • (2014) BMC Endocr Disord , vol.14 , pp. 37
    • Sinclair, A.1    Bode, B.2    Harris, S.3    Vijapurkar, U.4    Mayer, C.5    Fung, A.6
  • 59
    • 84874291673 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise
    • Stenlöf K. Cefalu W. Kim K. Alba M. Usiskin K. Tong C. et al. (2013) Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab 15: 372–382.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 372-382
    • Stenlöf, K.1    Cefalu, W.2    Kim, K.3    Alba, M.4    Usiskin, K.5    Tong, C.6
  • 60
    • 84928196614 scopus 로고    scopus 로고
    • Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension
    • Tikkanen I. Narko K. Zeller C. Green A. Salsali A. Broedl U. et al. (2015) Empagliflozin reduces blood pressure in patients with type 2 diabetes and hypertension. Diabetes Care 38: 420–428.
    • (2015) Diabetes Care , vol.38 , pp. 420-428
    • Tikkanen, I.1    Narko, K.2    Zeller, C.3    Green, A.4    Salsali, A.5    Broedl, U.6
  • 61
    • 84993817958 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • 10 Invokana (canagliflozin) tablets. NDA 204042 January Rockville, MD: US Food and Drug Administration
    • US Food and Drug Administration (2013) Invokana (canagliflozin) tablets. NDA 204042. FDA Briefing Document (10 January 2013). Rockville, MD: US Food and Drug Administration.
    • (2013) FDA Briefing Document
  • 62
    • 84938687470 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Farxiga (dapagliflozin) label January Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/​2014/202293s003lbl.pdf (accessed 1 August 2014)
    • US Food and Drug Administration (2014 a) Farxiga (dapagliflozin) label (January 2014). Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/​2014/202293s003lbl.pdf. (accessed 1 August 2014)
    • (2014)
  • 63
    • 84938687470 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Invokana (canagliflozin) label May Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204042s002lbl.pdf (accessed 10 March 2015).
    • US Food and Drug Administration (2014 b) Invokana (canagliflozin) label (May 2014). Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204042s002lbl.pdf (accessed 10 March 2015).
    • (2014)
  • 64
    • 84938687470 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Jardiance® (empagliflozin) label (August 2014). Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204629s000lbl.pdf (accessed 10 March 2015).
    • US Food and Drug Administration (2014 c) Jardiance® (empagliflozin) label (August 2014). Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204629s000lbl.pdf (accessed 10 March 2015).
    • (2014)
  • 65
    • 84966852803 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Glyxambi® (empagliflozin and linagliptin) label January Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206073s000lbl.pdf (accessed 10 March 2015).
    • US Food and Drug Administration (2015) Glyxambi® (empagliflozin and linagliptin) label (January 2015). Available at: http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206073s000lbl.pdf (accessed 10 March 2015).
    • (2015)
  • 66
    • 84882251091 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis
    • Vasilakou D. Karagiannis T. Athanasiadou E. Mainou M. Liakos A. Bekiari E. et al. (2013) Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med 159: 262–274.
    • (2013) Ann Intern Med , vol.159 , pp. 262-274
    • Vasilakou, D.1    Karagiannis, T.2    Athanasiadou, E.3    Mainou, M.4    Liakos, A.5    Bekiari, E.6
  • 67
    • 78651349221 scopus 로고    scopus 로고
    • Biology of human sodium glucose transporters
    • Wright E. Loo D. Hirayama B. (2011) Biology of human sodium glucose transporters. Physiol Rev 91: 733–794.
    • (2011) Physiol Rev , vol.91 , pp. 733-794
    • Wright, E.1    Loo, D.2    Hirayama, B.3
  • 68
    • 84876311251 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease
    • Yale J. Bakris G. Cariou B. Yue D. David-Neto E. Xi L. et al. (2013) Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab 15: 463–473.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 463-473
    • Yale, J.1    Bakris, G.2    Cariou, B.3    Yue, D.4    David-Neto, E.5    Xi, L.6
  • 69
    • 84895484977 scopus 로고    scopus 로고
    • Dapagliflozin treatment for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
    • Zhang M. Zhang L. Wu B. Song H. An Z. Li S. (2014) Dapagliflozin treatment for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Res Rev 30: 204–221.
    • (2014) Diabetes Metab Res Rev , vol.30 , pp. 204-221
    • Zhang, M.1    Zhang, L.2    Wu, B.3    Song, H.4    An, Z.5    Li, S.6
  • 70
    • 84902756416 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOMETM
    • Zinman B. Inzucchi S. Lachin J. Wanner C. Ferrari R. Fitchett D. et al. (2014) Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOMETM). Cardiovasc Diabetol 13: 102.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 102
    • Zinman, B.1    Inzucchi, S.2    Lachin, J.3    Wanner, C.4    Ferrari, R.5    Fitchett, D.6


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