메뉴 건너뛰기




Volumn 7, Issue , 2012, Pages 21-28

Dapagliflozin: An evidence-based review of its potential in the treatment of type-2 diabetes

Author keywords

Dapagliflozin; Kidney; SGLT2 inhibitors; Type 2 diabetes mellitus

Indexed keywords

DAPAGLIFLOZIN; GLIPIZIDE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; PHLORIZIN; PIOGLITAZONE; ROSIGLITAZONE; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; SULFONYLUREA;

EID: 84865636935     PISSN: 15551741     EISSN: None     Source Type: Journal    
DOI: 10.2147/CE.S16359     Document Type: Review
Times cited : (12)

References (35)
  • 1
    • 33644875941 scopus 로고    scopus 로고
    • Improving glucose management: Ten steps to get more patients with type 2 diabetes to glycaemic goal
    • Del Prato S, Felton AM, Munro N, et al. Improving glucose management: ten steps to get more patients with type 2 diabetes to glycaemic goal. Int J Clin Pract. 2005;59(11):1345-1355.
    • (2005) Int J Clin Pract , vol.59 , Issue.11 , pp. 1345-1355
    • Del Prato, S.1    Felton, A.M.2    Munro, N.3
  • 2
    • 84868555271 scopus 로고    scopus 로고
    • International Diabetes Federation. 5th ed. Brussels: International Diabetes Federation
    • International Diabetes Federation. Diabetes Atlas, 5th ed. Brussels: International Diabetes Federation; 2011.
    • (2011) Diabetes Atlas
  • 3
    • 79958757212 scopus 로고    scopus 로고
    • homepage on the Internet. Atlanta: Centers for Disease Control. Available from: http://www.cdc.gov/diabetes/pubs/factsheet11.htm. Accessed April 27, 2012
    • http://www.cdc.gov [homepage on the Internet]. Atlanta: Centers for Disease Control. 2011 National Diabetes Fact Sheet. Available from: http://www.cdc.gov/diabetes/pubs/factsheet11.htm. Accessed April 27, 2012.
    • 2011 National Diabetes Fact Sheet
  • 4
    • 33745863033 scopus 로고    scopus 로고
    • Islet β cell failure in type 2 diabetes
    • DOI 10.1172/JCI29103
    • Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest. 2006;116(7):1802-1812. (Pubitemid 44033300)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1802-1812
    • Prentki, M.1    Nolan, C.J.2
  • 5
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: Scientific review
    • Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA. 2002;287(3):360-372. (Pubitemid 34256388)
    • (2002) Journal of the American Medical Association , vol.287 , Issue.3 , pp. 360-372
    • Inzucchi, S.E.1
  • 6
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • DOI 10.2337/diacare.27.11.2628
    • Buse JB, Henry RR, Han J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27(11):2628-2635. (Pubitemid 39441462)
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 7
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications
    • Gerich JE. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med. 2010;27(2):136-142.
    • (2010) Diabet Med. , vol.27 , Issue.2 , pp. 136-142
    • Gerich, J.E.1
  • 8
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition - A novel strategy for diabetes treatment
    • Chao EC, Henry RR. SGLT2 inhibition - a novel strategy for diabetes treatment. Nat Rev Drug Discovery. 2010;9(7):551-559.
    • (2010) Nat Rev Drug Discovery. , vol.9 , Issue.7 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 9
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • DOI 10.1111/j.1365-2796.2006.01746.x
    • Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med. 2007;261(1):32-43. (Pubitemid 46046470)
    • (2007) Journal of Internal Medicine , vol.261 , Issue.1 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 10
    • 0037267005 scopus 로고    scopus 로고
    • Glucose transporters (GLUT and SGLT): Expanded families of sugar transport proteins
    • DOI 10.1079/BJN2002763
    • Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003;89(1):3-9. (Pubitemid 36187532)
    • (2003) British Journal of Nutrition , vol.89 , Issue.1 , pp. 3-9
    • Wood, I.S.1    Trayhurn, P.2
  • 11
    • 33644688031 scopus 로고    scopus 로고
    • Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes
    • DOI 10.2337/diabetes.54.12.3427
    • Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J. Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetes. Diabetes. 2005;54(12):3427-3434. (Pubitemid 43334332)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3427-3434
    • Rahmoune, H.1    Thompson, P.W.2    Ward, J.M.3    Smith, C.D.4    Hong, G.5    Brown, J.6
  • 12
    • 1242272759 scopus 로고    scopus 로고
    • The sodium/glucose cotransport family SLC5
    • DOI 10.1007/s00424-003-1063-6, The ABCs of Solute Carriers: Physiological, Pathological and Therapeutic Implications of Human Membrane Transport Proteins
    • Wright EM, Turk E. The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004;447(5):510-518. (Pubitemid 38241437)
    • (2004) Pflugers Archiv European Journal of Physiology , vol.447 , Issue.5 , pp. 510-518
    • Wright, E.M.1    Turk, E.2
  • 13
    • 83655193529 scopus 로고    scopus 로고
    • The role of the kidneys in glucose homeostasis: A new path towards normalizing glycaemia
    • DeFronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab. 2012;14(1):5-14.
    • (2012) Diabetes Obes Metab. , vol.14 , Issue.1 , pp. 5-14
    • DeFronzo, R.A.1    Davidson, J.A.2    Del Prato, S.3
  • 15
    • 0006340752 scopus 로고
    • The History of Diabetes
    • Kahn CR, Weir GC, editors. Philadelphia: Lea and Febiger
    • Krall LP, Levine R, Barnett D. The History of Diabetes. In: Kahn CR, Weir GC, editors. Joslin's Diabetes Mellitus. Philadelphia: Lea and Febiger; 1994:2.
    • (1994) Joslin's Diabetes Mellitus , pp. 2
    • Krall, L.P.1    Levine, R.2    Barnett, D.3
  • 17
    • 0023275573 scopus 로고
    • Correction of hyperglycemia with phlorizin normalizes tissues sensitivity to insulin in diabetic rats
    • Rossetti L, Smith D, Shulman GI, Papachristou D, DeFronzo RA. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J Clin Invest. 1987;79(5):1510-1515. (Pubitemid 17099657)
    • (1987) Journal of Clinical Investigation , vol.79 , Issue.5 , pp. 1510-1515
    • Rossetti, L.1    Smith, D.2    Shulman, G.I.3
  • 18
    • 67349275999 scopus 로고    scopus 로고
    • Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus
    • Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfister M. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus. Clin Pharmacol Ther. 2009;85(5):513-519.
    • (2009) Clin Pharmacol Ther. , vol.85 , Issue.5 , pp. 513-519
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3    Li, L.4    Kornhauser, D.5    Pfister, M.6
  • 19
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • Han S, Hagan DL, Taylor JR, et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes. 2008;57(6):1723-1729.
    • (2008) Diabetes. , vol.57 , Issue.6 , pp. 1723-1729
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3
  • 20
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: Applicability of a novel insulin-dependent treatment
    • Wilding JPH, Norwood P, T'joen C, Bastien A, List JF, Fiedorek FT. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-dependent treatment. Diabetes Care. 2009;32(9):1656-1662.
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1656-1662
    • Wilding, J.P.H.1    Norwood, P.2    T'joen, C.3    Bastien, A.4    List, J.F.5    Fiedorek, F.T.6
  • 21
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
    • Ferrannini E, Ramos SJ, Salsali A, Tang W, List JF. Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial. Diabetes Care. 2010;33(10):2217-2224.
    • (2010) Diabetes Care. , vol.33 , Issue.10 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 22
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375(9733):2223-2233.
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 23
    • 80052524011 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: A randomized, 24-week, double-blind, placebo-controlled trial
    • Strojek K, Yoon KH, Hruba V, Elze M, Langkilde AM, Parikh S. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2011;13(10):928-938.
    • (2011) Diabetes Obes Metab. , vol.13 , Issue.10 , pp. 928-938
    • Strojek, K.1    Yoon, K.H.2    Hruba, V.3    Elze, M.4    Langkilde, A.M.5    Parikh, S.6
  • 24
    • 80155124676 scopus 로고    scopus 로고
    • Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: A randomized, 52-week, double-blind, active-controlled noninferiority trial
    • Nauck MA, Del Prato S, Meier JJ, et al. Dapagliflozin versus glipizide as add-on therapy in patients with type 2 diabetes who have inadequate glycemic control with metformin: a randomized, 52-week, double-blind, active-controlled noninferiority trial. Diabetes Care. 2011;34(9):2015-2022.
    • (2011) Diabetes Care , vol.34 , Issue.9 , pp. 2015-2022
    • Nauck, M.A.1    Del Prato, S.2    Meier, J.J.3
  • 25
    • 77953181310 scopus 로고    scopus 로고
    • Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: Effects on glycaemic control and body weight
    • Zhang L, Feng Y, List J, Kasichayanula S, Pfister M. Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight. Diabetes Obes Metab. 2010;12(6):510-516.
    • (2010) Diabetes Obes Metab. , vol.12 , Issue.6 , pp. 510-516
    • Zhang, L.1    Feng, Y.2    List, J.3    Kasichayanula, S.4    Pfister, M.5
  • 26
    • 84860218907 scopus 로고    scopus 로고
    • Dapagliflozin, metformin XR, or both: Initial pharmacotherapy for type 2 diabetes, a randomised controlled trial
    • doi: 10.1111/j.1742-1241. Epub March 13, 2012
    • Henry RR, Murray AV, Marmolejo MH, Hennicken D, Ptaszynska A, List JF. Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trial. Int J Clin Pract. 2012;doi: 10.1111/j.1742-1241. Epub March 13, 2012.
    • (2012) Int J Clin Pract
    • Henry, R.R.1    Murray, A.V.2    Marmolejo, M.H.3    Hennicken, D.4    Ptaszynska, A.5    List, J.F.6
  • 27
    • 84858323889 scopus 로고    scopus 로고
    • Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: A randomized trial
    • for the Dapagliflozin 006 Study Group
    • Wilding JP, Woo V, Soler NG; for the Dapagliflozin 006 Study Group. Long-term efficacy of dapagliflozin in patients with type 2 diabetes mellitus receiving high doses of insulin: a randomized trial. Ann Intern Med. 2012;156(6):405-415.
    • (2012) Ann Intern Med , vol.156 , Issue.6 , pp. 405-415
    • Wilding, J.P.1    Woo, V.2    Soler, N.G.3
  • 28
    • 84862875221 scopus 로고    scopus 로고
    • Effects of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, on hemoglobin A1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy
    • March 23, Epub ahead of print
    • Rosenstock J, Vico M, Wei L, Salsali A, List JF. Effects of dapagliflozin, a sodium-glucose cotransporter-2 inhibitor, on hemoglobin A1c, body weight, and hypoglycemia risk in patients with type 2 diabetes inadequately controlled on pioglitazone monotherapy. Diabetes Care. March 23, 2012. [Epub ahead of print.]
    • (2012) Diabetes Care
    • Rosenstock, J.1    Vico, M.2    Wei, L.3    Salsali, A.4    List, J.F.5
  • 29
    • 84858020943 scopus 로고    scopus 로고
    • Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin
    • Bolinder J, Ljunggren O, Kullberg J, et al. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab. 2012;97(3):1020-1031.
    • (2012) J Clin Endocrinol Metab. , vol.97 , Issue.3 , pp. 1020-1031
    • Bolinder, J.1    Ljunggren, O.2    Kullberg, J.3
  • 30
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List JF, Woo V, Morales E, Tang W, Fiedorek FT. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care. 2009;32(4):650-657.
    • (2009) Diabetes Care. , vol.32 , Issue.4 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 31
    • 69549133582 scopus 로고    scopus 로고
    • Association between serum uric acid and development of type 2 diabetes
    • Kodama S, Saito K, Yachi Y, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care. 2009;32(9):1737-1742.
    • (2009) Diabetes Care. , vol.32 , Issue.9 , pp. 1737-1742
    • Kodama, S.1    Saito, K.2    Yachi, Y.3
  • 33
    • 45849141431 scopus 로고    scopus 로고
    • NDA 202293. Dapagliflozin tablets, 5 and 10 mg. Sponsor: Bristol-Myers Squibb. Advisory Committee Meeting, July 19, Washington, DC: Food and Drug Administration. Available from: http://www.fda.gov. Accessed March 26, 2012
    • http://www.fda.gov/.../AdvisoryCommittees/CommitteesMeetingMaterials/.../ EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM262990.pdf. FDA briefing document. NDA 202293. Dapagliflozin tablets, 5 and 10 mg. Sponsor: Bristol-Myers Squibb. Advisory Committee Meeting, July 19, 2011. Washington, DC: Food and Drug Administration. Available from: http://www.fda.gov. Accessed March 26, 2012.
    • (2011) FDA Briefing Document
  • 34
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DeFronzo RA. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med. 1999;131(4):281-303. (Pubitemid 29383658)
    • (1999) Annals of Internal Medicine , vol.131 , Issue.4 , pp. 281-303
    • DeFronzo, R.A.1
  • 35
    • 0034997336 scopus 로고    scopus 로고
    • Renal Na(+)-glucose cotransporters
    • Wright EM. Renal Na(+)-glucose cotransporters. Am J Physiol Renal Physiol. 2001;280(1):F10-F18.
    • (2001) Am J Physiol Renal Physiol. , vol.280 , Issue.1
    • Wright, E.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.