메뉴 건너뛰기




Volumn 7, Issue 3, 2014, Pages 271-279

Empagliflozin for the treatment of Type 2 diabetes

Author keywords

Cardiovascular; Empagliflozin; Renal proximal tubule; SGLT2 inhibitors; Type 2 diabetes

Indexed keywords

DAPAGLIFLOZIN; EMPAGLIFLOZIN; GLUCOSE; HEMOGLOBIN A1C; IPRAGLIFLOZIN; METFORMIN; PIOGLITAZONE; PLACEBO; SULFONYLUREA; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; GLUCOSE BLOOD LEVEL; GLUCOSIDE; SLC5A2 PROTEIN, HUMAN; SODIUM GLUCOSE COTRANSPORTER 2;

EID: 84898917461     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1586/17512433.2014.908703     Document Type: Review
Times cited : (12)

References (49)
  • 1
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010;87(1):4-14
    • (2010) Diabetes Res Clin Pract , vol.87 , Issue.1 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 2
    • 84889022122 scopus 로고    scopus 로고
    • The growing prevalence of type 2 diabetes: Increased incidence or improved survival?
    • Maruthur NM. The growing prevalence of type 2 diabetes: increased incidence or improved survival? Curr Diab Rep 2013; 13(6):786-94
    • (2013) Curr Diab Rep , vol.13 , Issue.6 , pp. 786-794
    • Maruthur, N.M.1
  • 3
    • 79959487586 scopus 로고    scopus 로고
    • Temporal trends in the prevalence of diabetic kidney disease in the United States
    • de Boer IH, Rue TC, Hall YN, et al. Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA 2011;305(24):2532-9
    • (2011) JAMA , vol.305 , Issue.24 , pp. 2532-2539
    • De Boer, I.H.1    Rue, T.C.2    Hall, Y.N.3
  • 4
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med 2007;261(1):32-43
    • (2007) J Intern Med , vol.261 , Issue.1 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 5
    • 78651406659 scopus 로고    scopus 로고
    • SGLT2 mediates glucose reabsorption in the early proximal tubule
    • Vallon V, Platt KA, Cunard R, et al. SGLT2 mediates glucose reabsorption in the early proximal tubule. J Am Soc Nephrol 2011;22(1):104-12
    • (2011) J Am Soc Nephrol , vol.22 , Issue.1 , pp. 104-112
    • Vallon, V.1    Platt, K.A.2    Cunard, R.3
  • 6
    • 78651348100 scopus 로고    scopus 로고
    • Glucose transport by human renal Na+/Dglucose cotransporters SGLT1 and SGLT2
    • Hummel CS, Lu C, Loo DD, et al. Glucose transport by human renal Na+/Dglucose cotransporters SGLT1 and SGLT2. Am J Physiol Cell Physiol 2011;300(1): C14-21
    • (2011) Am J Physiol Cell Physiol , vol.300 , Issue.1
    • Hummel, C.S.1    Lu, C.2    Loo, D.D.3
  • 7
    • 75149196250 scopus 로고    scopus 로고
    • Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus
    • Nair S, Wilding JP. Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus. J Clin Endocrinol Metab 2010;95(1):34-42
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.1 , pp. 34-42
    • Nair, S.1    Wilding, J.P.2
  • 8
    • 84864146681 scopus 로고    scopus 로고
    • LX4211, a dual SGLT1/ SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial
    • Zambrowicz B, Freiman J, Brown PM, et al. LX4211, a dual SGLT1/ SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial. Clin Pharmacol Ther 2012;92(2):158-69
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.2 , pp. 158-169
    • Zambrowicz, B.1    Freiman, J.2    Brown, P.M.3
  • 9
    • 84882251091 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: A systematic review and meta-analysis
    • Vasilakou D, Karagiannis T, Athanasiadou E, et al. Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Ann Intern Med 2013; 159(4):262-74
    • (2013) Ann Intern Med , vol.159 , Issue.4 , pp. 262-274
    • Vasilakou, D.1    Karagiannis, T.2    Athanasiadou, E.3
  • 10
    • 84864283226 scopus 로고    scopus 로고
    • SGLT2 inhibition in diabetes mellitus: Rationale and clinical prospects
    • Ferrannini E, Solini A, SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 2012;8(8): 495-502
    • (2012) Nat Rev Endocrinol , vol.8 , Issue.8 , pp. 495-502
    • Ferrannini, E.1    Solini, A.2
  • 11
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, et al. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 2010; 375(9733):2223-33
    • (2010) Lancet , vol.375 , Issue.9733 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3
  • 12
    • 84861098920 scopus 로고    scopus 로고
    • Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus
    • Abdul-Ghani MA, Norton L, DeFronzo RA . Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus. Curr Diab Rep 2012;12(3):230-8
    • (2012) Curr Diab Rep , vol.12 , Issue.3 , pp. 230-238
    • Abdul-Ghani, M.A.1    Norton, L.2    Defronzo, R.A.3
  • 13
    • 84898841184 scopus 로고    scopus 로고
    • FDA Briefing Document. NDA 202293 Rockville, MD: U.S. Food and Drug Administration; Available from
    • FDA Briefing Document. NDA 202293. Dapagliflozin Tablets, 5 and 10 mg. Rockville, MD: U.S. Food and Drug Administration; 2011. Available from: www. fda.gov/downloads/AdvisoryCommittees/ CommitteesMeetingMaterials/drugs/ EndocrinologicandMetabolicDrugs AdvisoryCommittee/ucm262994.pdf
    • (2011) Dapagliflozin Tablets, 5 and 10 Mg
  • 14
    • 84898857518 scopus 로고    scopus 로고
    • FDA Briefing Document. NDA 204042 Rockville, MD: U.S. Food and Drug Administration. Available from
    • FDA Briefing Document. NDA 204042. Invokana (Canagliflozin) Tablets. Rockville, MD: U.S. Food and Drug Administration. Available from: www.fda.gov/downloads/ AdvisoryCommittees/CommitteesMeeting Materials/Drugs/ Endocrinologicand MetabolicDrugsAdvisoryCommittee/ ucm334550.pdf
    • Invokana (Canagliflozin) Tablets
  • 15
    • 84898881801 scopus 로고    scopus 로고
    • Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control
    • [Epub ahead of print]
    • Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int 2013. [Epub ahead of print]
    • (2013) Kidney Int
    • Kohan, D.E.1    Fioretto, P.2    Tang, W.3    List, J.F.4
  • 16
    • 84872400230 scopus 로고    scopus 로고
    • Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
    • Vallon V, Rose M, Gerasimova M, et al. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol 2013;304(2):F156-67
    • (2013) Am J Physiol Renal Physiol , vol.304 , Issue.2
    • Vallon, V.1    Rose, M.2    Gerasimova, M.3
  • 17
    • 79952404360 scopus 로고    scopus 로고
    • SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function
    • Jurczak MJ, Lee HY, Birkenfeld AL, et al. SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function. Diabetes 2011;60(3): 890-8
    • (2011) Diabetes , vol.60 , Issue.3 , pp. 890-898
    • Jurczak, M.J.1    Lee, H.Y.2    Birkenfeld, A.L.3
  • 18
    • 84885170468 scopus 로고    scopus 로고
    • Population pharmacokinetics of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with type 2 diabetes
    • Riggs MM, Staab A, Seman L, et al. Population pharmacokinetics of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with type 2 diabetes. J Clin Pharmacol 2013; 53(10):1028-38
    • (2013) J Clin Pharmacol , vol.53 , Issue.10 , pp. 1028-1038
    • Riggs, M.M.1    Staab, A.2    Seman, L.3
  • 19
    • 84879384843 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in healthy Japanese subjects
    • Sarashina A, Koiwai K, Seman LJ, et al. Safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in healthy Japanese subjects. Drug Metab Pharmacokinet 2013;28(3):213-19
    • (2013) Drug Metab Pharmacokinet , vol.28 , Issue.3 , pp. 213-219
    • Sarashina, A.1    Koiwai, K.2    Seman, L.J.3
  • 20
    • 84887072459 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple rising doses of empagliflozin in patients with type 2 diabetes mellitus
    • Heise T, Seman L, Macha S, et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple rising doses of empagliflozin in patients with type 2 diabetes mellitus. Diabetes Ther 2013;4(2):331-45
    • (2013) Diabetes Ther , vol.4 , Issue.2 , pp. 331-345
    • Heise, T.1    Seman, L.2    Macha, S.3
  • 21
    • 84865479822 scopus 로고    scopus 로고
    • Why Do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?
    • Liu JJ, Lee T, DeFronzo RA. Why Do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans? Diabetes 2012;61(9):2199-204
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2199-2204
    • Liu, J.J.1    Lee, T.2    Defronzo, R.A.3
  • 22
    • 83655184724 scopus 로고    scopus 로고
    • Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: Characterisation and comparison with other SGLT-2 inhibitors
    • Grempler R, Thomas L, Eckhardt M, et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab 2012;14(1):83-90
    • (2012) Diabetes Obes Metab , vol.14 , Issue.1 , pp. 83-90
    • Grempler, R.1    Thomas, L.2    Eckhardt, M.3
  • 23
    • 84874326639 scopus 로고    scopus 로고
    • Lack of drug-drug interaction between empagliflozin, a sodium glucose cotransporter 2 inhibitor, and warfarin in healthy volunteers
    • Macha S, Rose P, Mattheus M, et al. Lack of drug-drug interaction between empagliflozin, a sodium glucose cotransporter 2 inhibitor, and warfarin in healthy volunteers. Diabetes Obes Metab 2013;15(4):316-23
    • (2013) Diabetes Obes Metab , vol.15 , Issue.4 , pp. 316-323
    • Macha, S.1    Rose, P.2    Mattheus, M.3
  • 24
    • 84874966394 scopus 로고    scopus 로고
    • Lack of clinically relevant drug-drug interaction between empagliflozin, a sodium glucose cotransporter 2 inhibitor, and verapamil, ramipril, or digoxin in healthy volunteers
    • Macha S, Sennewald R, Rose P, et al. Lack of clinically relevant drug-drug interaction between empagliflozin, a sodium glucose cotransporter 2 inhibitor, and verapamil, ramipril, or digoxin in healthy volunteers. Clin Ther 2013;35(3):226-35
    • (2013) Clin Ther , vol.35 , Issue.3 , pp. 226-235
    • Macha, S.1    Sennewald, R.2    Rose, P.3
  • 25
    • 84877030226 scopus 로고    scopus 로고
    • Effect of empagliflozin on the steady-state pharmacokinetics of ethinylestradiol and levonorgestrel in healthy female volunteers
    • Macha S, Mattheus M, Pinnetti S, et al. Effect of empagliflozin on the steady-state pharmacokinetics of ethinylestradiol and levonorgestrel in healthy female volunteers. Clin Drug Investig 2013;33(5):351-7
    • (2013) Clin Drug Investig , vol.33 , Issue.5 , pp. 351-357
    • Macha, S.1    Mattheus, M.2    Pinnetti, S.3
  • 26
    • 84893727925 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment
    • Macha S, Mattheus M, Halabi A, et al. Pharmacokinetics, pharmacodynamics and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, in subjects with renal impairment. Diabetes Obes Metab 2014;16(3):215-22
    • (2014) Diabetes Obes Metab , vol.16 , Issue.3 , pp. 215-222
    • Macha, S.1    Mattheus, M.2    Halabi, A.3
  • 27
    • 84898848371 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and tolerability of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with hepatic impairment
    • [Epub ahead of print]
    • Macha S, Rose P, Mattheus M, et al. Pharmacokinetics, safety and tolerability of empagliflozin, a sodium glucose cotransporter 2 inhibitor, in patients with hepatic impairment. Diabetes Obes Metab 2013. [Epub ahead of print]
    • (2013) Diabetes Obes Metab
    • Macha, S.1    Rose, P.2    Mattheus, M.3
  • 28
    • 84879795546 scopus 로고    scopus 로고
    • A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
    • Ferrannini E, Seman L, Seewaldt-Becker E, et al. A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes. Diabetes Obes Metab 2013;15(8):721-8
    • (2013) Diabetes Obes Metab , vol.15 , Issue.8 , pp. 721-728
    • Ferrannini, E.1    Seman, L.2    Seewaldt-Becker, E.3
  • 29
    • 84885954870 scopus 로고    scopus 로고
    • Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: A randomised, double-blind, placebo-controlled, phase 3 trial
    • Roden M WJ, Eilbracht J, Delafont B, et al. Empagliflozin monotherapy with sitagliptin as an active comparator in patients with type 2 diabetes: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol 2013;1(3):208-19
    • (2013) Lancet Diabetes Endocrinol , vol.1 , Issue.3 , pp. 208-219
    • Roden, M.W.J.1    Eilbracht, J.2    Delafont, B.3
  • 30
    • 84887191925 scopus 로고    scopus 로고
    • Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia
    • Rosenstock J, Seman LJ, Jelaska A, et al. Efficacy and safety of empagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, as add-on to metformin in type 2 diabetes with mild hyperglycaemia. Diabetes Obes Metab 2013;15(12):1154-60
    • (2013) Diabetes Obes Metab , vol.15 , Issue.12 , pp. 1154-1160
    • Rosenstock, J.1    Seman, L.J.2    Jelaska, A.3
  • 31
    • 84885952950 scopus 로고    scopus 로고
    • Empagliflozin as Add-on to Metformin Plus Sulfonylurea in Patients with Type 2 Diabetes: A 24-week, randomized, double-blind, placebo-controlled trial
    • Haring HU, Merker L, Seewaldt-Becker E, et al. Empagliflozin as Add-on to Metformin Plus Sulfonylurea in Patients With Type 2 Diabetes: a 24-week, randomized, double-blind, placebo-controlled trial. Diabetes Care 2013;36(11):3396-404
    • (2013) Diabetes Care , vol.36 , Issue.11 , pp. 3396-3404
    • Haring, H.U.1    Merker, L.2    Seewaldt-Becker, E.3
  • 33
    • 84892488165 scopus 로고    scopus 로고
    • Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: A 24-week, randomized, placebo-controlled trial
    • [Epub ahead of print]
    • Kovacs CS, Seshiah V, Swallow R, et al. Empagliflozin improves glycaemic and weight control as add-on therapy to pioglitazone or pioglitazone plus metformin in patients with type 2 diabetes: a 24-week, randomized, placebo-controlled trial. Diabetes Obes Metab 2013. [Epub ahead of print]
    • (2013) Diabetes Obes Metab
    • Kovacs, C.S.1    Seshiah, V.2    Swallow, R.3
  • 43
    • 84876665073 scopus 로고    scopus 로고
    • The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study
    • Ring A, Brand T, Macha S, et al. The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study. Cardiovasc Diabetol 2013;12(1):70
    • (2013) Cardiovasc Diabetol , vol.12 , Issue.1 , pp. 70
    • Ring, A.1    Brand, T.2    Macha, S.3
  • 44
    • 84891851923 scopus 로고    scopus 로고
    • Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: An active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    • Ferrannini E, Berk A, Hantel S, et al. Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes. Diabetes Care 2013;36(12):4015-21
    • (2013) Diabetes Care , vol.36 , Issue.12 , pp. 4015-4021
    • Ferrannini, E.1    Berk, A.2    Hantel, S.3
  • 45
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Action to Control Cardiovascular Risk in Diabetes Study G
    • Action to Control Cardiovascular Risk in Diabetes Study G, Gerstein HC, Miller ME, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358(24):2545-59
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2
  • 46
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • Group AC, Patel A, MacMahon S, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358(24):2560-72
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2560-2572
    • Group, A.C.1    Patel, A.2    Macmahon, S.3
  • 47
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356(24):2457-71
    • (2007) N Engl J Med , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 48
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): A multicentre, randomised, open-label trial
    • Home PD, Pocock SJ, Beck-Nielsen H, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 2009;373(9681): 2125-35
    • (2009) Lancet , vol.373 , Issue.9681 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3
  • 49
    • 84883765959 scopus 로고    scopus 로고
    • Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
    • Scirica BM, Bhatt DL, Braunwald E, et al. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med 2013;369(14):1317-26
    • (2013) N Engl J Med , vol.369 , Issue.14 , pp. 1317-1326
    • Scirica, B.M.1    Bhatt, D.L.2    Braunwald, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.