Gut microbiota, cirrhosis, and alcohol regulate bile acid metabolism in the gut

Digestive Diseases

Volumn 33, Issue 3, 2015, Pages 338-345

  Ridlon, Jason M ^a   Kang, Dae Joong ^b   Hylemon, Phillip B ^a   Bajaj, Jasmohan S ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b Division of Gastroenterology Hepatology and Nutrition   (United States)

Author keywords

Alcohol; Bile acid metabolism; Gut microbiota

Indexed keywords

ALCOHOL; ANTIBIOTIC AGENT; BILE ACID; DEOXYCHOLIC ACID; FARNESOID X RECEPTOR; PROBIOTIC AGENT;

ALCOHOL CONSUMPTION; BILE ACID BLOOD LEVEL; BILE ACID METABOLISM; CLOSTRIDIUM; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; DISEASE COURSE; DYSBIOSIS; FIRMICUTES; HUMAN; HYDROPHOBICITY; INFLAMMATION; INTESTINE FLORA; LIVER CIRRHOSIS; METABOLIC SYNDROME X; MICROBIAL METABOLISM; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN MODIFICATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ADVERSE EFFECTS; CHEMISTRY; COMPLICATION; DRINKING BEHAVIOR; DRUG EFFECTS; FECES; METABOLISM;

ALCOHOL DRINKING; BILE ACIDS AND SALTS; DYSBIOSIS; ETHANOL; FECES; GASTROINTESTINAL MICROBIOME; HUMANS; LIVER CIRRHOSIS; PROBIOTICS; SIGNAL TRANSDUCTION;

EID: 84930580146     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000371678     Document Type: Conference Paper

References (37)

1. Qin J, Li R, Raes J, et al: A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2009; 464: 59-65.
2. Aagaard K, Ma J, Antony KM, et al: The placenta harbors a unique microbiome. Sci Transl Med 2014; 6: 237ra65.
3. Ley RE, Peterson DA, Gordon JI: Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006; 124: 837-848.
4. Eckburg PB, Bik EM, Berstein CN, et al: Diversity of the human intestinal microbial flora. Science 2005; 308: 1635-1638.
5. Inagaki T, Moschetta A, Lee Y, et al: Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci USA 2006; 103: 3920-3925.
6. Devkota S, Wang Y, Musch MW, et al: Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/-mice. Nature 2012; 487: 104-108.
7. Reddy BS: Diet and excretion of bile acids. Cancer Res 1981; 41: 3766-3768.
8. Reddy BS, Wynder EL: Metabolic epidemiology of colon cancer: fecal bile acids and neutral sterols in colon cancer patients with adenomatous polyps. Cancer 1977; 39: 2533-2539.
9. David LA, Maurice CF, Carmody RN, et al: Diet rapidly and reproducibly alters the human gut microbiome. Nature 2013; 505: 559-563.
10. Sonnenburg JL, Xu J, Leip DD, et al: Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science 2005; 307: 1955-1959.
11. Martens EC, Chiang HC, Gordon JI: Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont. Cell Host Microbe 2008; 4: 447-457.
12. Islam KB, Fukiya S, Hagio M, et al: Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 2011; 141: 1773-1781.
13. Yokota A, Fukiya S, Islam KB, et al: Is bile acid a determinant of the gut microbiota on a high-fat diet? Gut Microbes 2012; 3: 455-459.
14. Swann JR, Want EJ, Geier FM, et al: Systemic gut microbial modulation of bile acid metabolism in host tissue compartments. Proc Natl Acad Sci USA 2011; 108: 4523-4530.
15. Makishima M, Lu TT, Xie W, et al: Vitamin D receptor as an intestinal bile acid sensor. Science 2002; 296: 1313-1316.
16. Ridlon JM, Kang D, Hylemon PB: Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006; 47: 241-259.
17. Joyce SA, MacSharry J, Casey PG, et al: Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci USA 2014; 111: 7421-7426.
18. Jones BV, Begley M, Hill C, et al: Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci USA 2008; 105: 13580-13585.
19. Begley M, Gahan CGM, Hill C: The interaction between bacteria and bile. FEMS Microbiol Rev 2005; 29: 625-651.
20. Begley M, Hill C, Gahan CGM: Bile salt hydrolase activity in probiotics. Appl Environ Microbiol 2006; 72: 1729-1738.
21. White BA, Fricke RJ, Hylemon PB: 7-Dehydroxylation of ursodeoxycholic acid by whole cells and cell extracts of Eubacterium species V. P. I. 12708. J Lipid Res 1982; 22: 145-153.
22. Kang D, Ridlon JM, Moore DR 2nd, et al: Clostridium scindens baiCD and baiH genes encode stereo-specific 7alpha/7beta-hydroxy-3-oxo-delta4-cholenoic acid oxidoreductases. Biochim Biophys Acta 2008; 1781: 16-25.
23. Macdonald IA, White BA, Hylemon PB: Separation of 7-and 7-hydroxysteroid dehydrogenase activities from Clostridium absonum ATCC# 27555 and cellular response of this organism to bile acid inducers. J Lipid Res 1983; 24: 1119-1126.
24. Chen Y, Yang F, Lu H, et al: Characterization of fecal microbial communities in patients with liver cirrhosis. Hepatology 2011; 54: 562-572.
25. Bajaj JS, Ridlon JM, Hylemon PB, et al: Linkage of gut microbiome with cognition in hepatic encephalopathy. Am J Physiol Gastrointest Liver Physiol 2012; 302:G168-G175.
26. Bajaj JS, Heuman DM, Hylemon PB, et al: Altered profile of human gut microbiome is associated with cirrhosis and its complications. J Hepatol 2014; 60: 940-947.
27. Qin N, Yang F, Li A, et al: Alteration of the human gut microbiome in liver cirrhosis. Nature 2014; 513: 59-64.
28. Ridlon JM, Alves JM, Hylemon PB, et al: Cirrhosis, bile acids and gut microbiota: unraveling a complex relationship. Gut Microbes 2013; 4: 1-6.
29. Kakiyama G, Pandak WM, Gillevet PM, et al: Modulation of the fecal bile acid profile by gut microbiota in cirrhosis. J Hepatol 2013; 58: 949-955.
30. Yoshimoto S, Loo TM, Atarashi K, et al: Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013; 499: 97-101.
31. Axelson M, Mork B, Sjovall J: Ethanol has an acute effect on bile acid biosynthesis in man. FEBS Lett 1991; 281: 155-159.
32. Chanda D, Kim YH, Li T, et al: Hepatic cannabinoid receptor type 1 mediates alcoholinduced regulation of bile acid enzyme genes expression via CREBH. PLoS One 2013; 8:e68845.
33. Kakiyama G, Hylemon PB, Zhou H, et al: Colonic inflammation and secondary bile acids in alcoholic cirrhosis. Am J Physiol Gastrointest Liver Physiol 2014; 306:G929-G937.
34. Hylemon PB, Zhou H, Pandak WM, et al: Bile acids as regulatory molecules. J Lipid Res 2009; 50: 1509-1520.
35. Bajaj JS, Heuman DM, Hylemon PB, et al: Randomized clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther 2014; 39: 1113-1125.
36. Bajaj JS, Heuman DM, Sanyal AJ, et al: Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy. PLoS One 2013; 8:e60042.
37. Zhang Y, Guo X, Guo J, et al: Lactobacillus casei reduces susceptibility to type 2 diabetes via microbiota-mediated body chloride ion influx. Sci Rep 2014; 4: 5654.