Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis

Digestive Diseases

Volumn 33, Issue 3, 2015, Pages 307-313

  Reue, Karen ^a,b   Lee, Jessica M ^a   Vergnes, Laurent ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bile acid; Diet1; Fibroblast growth factor

Indexed keywords

BILE ACID; DIET1 PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 19; GLUCOSE; PROTEIN; UNCLASSIFIED DRUG; C10ORF112 PROTEIN, HUMAN; CARRIER PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYP7A1 PROTEIN, HUMAN; CYP7A1 PROTEIN, MOUSE; DIET1 PROTEIN, MOUSE; FGF19 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR 15, MOUSE; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA;

BILE ACID METABOLISM; BILE ACID SYNTHESIS; CONFERENCE PAPER; ENTEROHEPATIC CIRCULATION; GENE MUTATION; GLUCOSE HOMEOSTASIS; HOMEOSTASIS; HUMAN; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN POLYMORPHISM; PROTEIN PROTEIN INTERACTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; GENETIC POLYMORPHISM; GENETICS; HT-29 CELL LINE; INTESTINE CELL; METABOLISM; MOUSE; RAT; SECRETION (PROCESS);

ANIMALS; BILE ACIDS AND SALTS; CARRIER PROTEINS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; ENTEROCYTES; FIBROBLAST GROWTH FACTORS; GLUCOSE; HOMEOSTASIS; HT29 CELLS; HUMANS; MICE; POLYMORPHISM, GENETIC; RATS; RECEPTORS, LDL; RNA, MESSENGER;

EID: 84930579469     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000371649     Document Type: Conference Paper

References (36)

1. Lusis AJ, Attie AD, Reue K: Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet 2008; 9: 819-830.
2. Charach G, Grosskopf I, Rabinovich A, Shochat M, Weintrabu M, Rabinovich P: The association of bile acid excretion and atherosclerotic coronary artery disease. Therap Adv Gastroenterol 2011; 4: 95-101.
3. Galman C, Angelin B, Rudling M: Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19. J Intern Med 2011; 270: 580-588.
4. Islam KB, Fukiya S, Hagio M, Fujii N, Ishizuka S, Ooka T, Ogura Y, Hayashi T, Yokota A: Bile acid is a host factor that regulates the composition of the cecal microbiota in rats. Gastroenterology 2011; 141: 1773-1781.
5. Prawitt J, Caron S, Staels B: Bile acid metabolism and the pathogenesis of type 2 diabetes. Curr Diab Rep 2011; 11: 160-166.
6. Sayin SI, Wahlstrom A, Felin J, Jantti S, Marschall HU, Bamberg K, Angelin B, Hyotylainen T, Oresic M, Backhed F: Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013; 17: 225-235.
7. Steiner C, Othman A, Saely CH, Rein P, Drexel H, von Eckardstein A, Rentsch KM: Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus. PLoS One 2011; 6:e25006.
8. de Aguiar Vallim TQ, Tarling EJ, Edwards PA: Pleiotropic roles of bile acids in metabolism. Cell Metab 2013; 17: 657-669.
9. Hofmann AF: The enterohepatic circulation of bile acids in mammals: form and functions. Front Biosci 2009; 14: 2584-2598.
10. Gonzalez FJ: Nuclear receptor control of enterohepatic circulation. Compr Physiol 2012; 2: 2811-2828.
11. Russell DW: Fifty years of advances in bile acid synthesis and metabolism. J Lipid Res 2009; 50(suppl):S120-S125.
12. Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2: 217-225.
13. Kong B, Wang L, Chiang JY, Zhang Y, Klaassen CD, Guo GL: Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice. Hepatology 2012; 56: 1034-1043.
14. Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K: Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels. Cell Metab 2013; 17: 916-928.
15. Mouzeyan A, Choi J, Allayee H, Wang X, Sinsheimer J, Phan J, Castellani LW, Reue K, Lusis AJ, Davis RC: A locus conferring resistance to diet-induced hypercholesterolemia and atherosclerosis on mouse chromosome 2. J Lipid Res 2000; 41: 573-582.
16. Phan J, Pesaran T, Davis RC, Reue K: The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism. J Biol Chem 2002; 277: 469-477.
17. Reue K, Vergnes L: Approaches to lipid metabolism gene identification and characterization in the postgenomic era. J Lipid Res 2006; 47: 1891-1907.
18. McCarter SD, Johnson DL, Kitt KN, Donohue C, Adams A, Wilson JM: Regulation of tight junction assembly and epithelial polarity by a resident protein of apical endosomes. Traffic 2010; 11: 856-866.
19. Reue K, Lee JM, Vergnes L: Regulation of bile acid homeostasis by the intestinal Diet1-FGF15/19 axis. Curr Opin Lipidol 2014; 25: 140-147.
20. Yu C, Wang F, Kan M, Jin C, Jones RB, Weinstein M, Deng CX, McKeehan WL: Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem 2000; 275: 15482-15489.
21. Li T, Matozel M, Boehme S, Kong B, Nilsson LM, Guo G, Ellis E, Chiang JY: Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology 2011; 53: 996-1006.
22. Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis AJ, Davis RA: Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL/ 6J mice. Arterioscler Thromb Vasc Biol 2002; 22: 121-126.
23. Wright TJ, Ladher R, McWhirter J, Murre C, Schoenwolf GC, Mansour SL: Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Dev Biol 2004; 269: 264-275.
24. Carmosino M, Valenti G, Caplan M, Svelto M: Polarized traffic towards the cell surface: how to find the route. Biol Cell 2010; 102: 75-91.
25. He B, Guo W: The exocyst complex in polarized exocytosis. Curr Opin Cell Biol 2009; 21: 537-542.
26. Beysen C, Murphy EJ, Deines K, Chan M, Tsang E, Glass A, Turner SM, Protasio J, Riiff T, Hellerstein MK: Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: A randomised controlled study. Diabetologia 2012; 55: 432-442.
27. Schwartz SL, Lai YL, Xu J, Abby SL, Misir S, Jones MR, Nagendran S: The effect of colesevelam hydrochloride on insulin sensitivity and secretion in patients with type 2 diabetes: A pilot study. Metab Syndr Relat Disord 2010; 8: 179-188.
28. Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ: FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 2011; 331: 1621-1624.
29. Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA: FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1 pathway. Cell Metab 2011; 13: 729-738.
30. Haeusler RA, Astiarraga B, Camastra S, Accili D, Ferrannini E: Human insulin resistance is associated with increased plasma levels of 12-hydroxylated bile acids. Diabetes 2013; 62: 4184-4191.
31. Comuzzie AG, Cole SA, Laston SL, Voruganti S, Haack K, Gibbs RA, Butte NF: Novel genetic loci identified for the pathophysiogy of childhood obesity in the Hispanic population. PLoS One 2012; 12:e51954.
32. Kern F Jr: Normal plasma cholesterol in an 88-year-old man who eats 25 eggs a day. Mechanisms of adaptation. N Engl J Med 1991; 324: 896-899.
33. Pattni SS, Brydon WG, Dew T, Walters JR: Fibroblast growth factor 19 and 7-alpha-hydroxy-4-cholesten-3-one in the diagnosis of patients with possible bile acid diarrhea. Clin Transl Gastroenterol 2012; 3:e18.
34. Walters JR, Tasleem AM, Omer OS, Brydon WG, Dew T, le Roux CW: A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis. Clin Gastroenterol Hepatol 2009; 7: 1189-1194.
35. Majores M, Bagli M, Papassotiropoulos A, Schwab SG, Jessen F, Rao ML, Maier W, Heun R: Allelic association between the D10S1423 marker and Alzheimer's disease in a German population. Neurosci Lett 2000; 289: 224-226.
36. Zubenco GS, Hughes HB 3rd, Stiffler JS: D10S1423 identifies a susceptibility locus for Alzheimer's disease in a prospective, longitudinal, double-blind study of asymptomatic individuals. Mol Psychiatry 2001; 6: 413-419.