Scattered deletion of PKD1 in kidneys causes a cystic snowball effect and recapitulates polycystic kidney disease

Journal of the American Society of Nephrology

Volumn 26, Issue 6, 2015, Pages 1322-1333

  Leonhard, Wouter N ^a   Zandbergen, Malu ^a   Veraar, Kimberley ^a   Van Den Berg, Susan ^a   Van Der Weerd, Louise ^a   Breuning, Martijn ^a   De Heer, Emile ^a   Peters, Dorien J M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; POLYCYSTIN 1; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DORMANCY; GENE DELETION; GENE INACTIVATION; IMMUNOHISTOCHEMISTRY; KIDNEY CELL; KIDNEY CYST; KIDNEY INJURY; KIDNEY POLYCYSTIC DISEASE; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; UNINEPHRECTOMY; ANIMAL; COMPARATIVE STUDY; DISEASE COURSE; DISEASE MODEL; DOSE RESPONSE; GENE EXPRESSION REGULATION; GENETIC RECOMBINATION; GENETICS; GERMLINE MUTATION; HUMAN; NONPARAMETRIC TEST; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; RANDOMIZATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE DELETION; GENE EXPRESSION REGULATION; GERM-LINE MUTATION; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MICE; PHENOTYPE; POLYCYSTIC KIDNEY DISEASES; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; RANDOM ALLOCATION; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; TAMOXIFEN; TRPP CATION CHANNELS;

EID: 84930455461     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013080864     Document Type: Article

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