Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption

Journal of the American Society of Nephrology

Volumn 24, Issue 3, 2013, Pages 456-464

  Sharma, Neeraj ^a   Malarkey, Erik B ^a   Berbari, Nicolas F ^a   O'Connor, Amber K ^a   Heuvel, Gregory B Vanden ^b   Mrug, Michal ^c   Yoder, Bradley K ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; INTRAFLAGELLAR TRANSPORT COMPLEX PROTEIN 88; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CUX 1 TRANSGENE; EUKARYOTIC FLAGELLUM; KIDNEY CYST; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE;

EID: 84874594253     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012020154     Document Type: Article

References (31)

1. Sharma N, Berbari NF, Yoder BK: Ciliary dysfunction in developmental abnormalities and diseases. Curr Top Dev Biol 85: 371-427, 2008
2. Pedersen LB, Rosenbaum JL: Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr Top Dev Biol 85: 23-61, 2008
3. Murcia NS, RichardsWG, Yoder BK,Mucenski ML, Dunlap JR,Woychik RP: TheOak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development 127: 2347-2355, 2000 (Pubitemid 30386574)
4. Takeda S, Yonekawa Y, Tanaka Y,Okada Y,Nonaka S, Hirokawa N: Leftright asymmetry and kinesin superfamily protein KIF3A: New insights in determination of laterality and mesoderm induction by kif3A-/-mice analysis. J Cell Biol 145: 825-836, 1999 (Pubitemid 29240858)
5. Hirokawa N, Tanaka Y, Okada Y: Left-right determination: Involvement of molecular motor KIF3, cilia, and nodal flow. Cold Spring Harb Perspect Biol 1: a000802, 2009
6. Davenport JR, Watts AJ, Roper VC, Croyle MJ, van Groen T, Wyss JM, Nagy TR, Kesterson RA, Yoder BK: Disruption of intraflagellar transport in adultmice leads to obesity and slow-onset cystic kidney disease. Curr Biol 17: 1586-1594, 2007 (Pubitemid 47380400)
7. Patel V, Li L, Cobo-Stark P, Shao X, Somlo S, Lin F, Igarashi P: Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. Hum Mol Genet 17: 1578-1590, 2008 (Pubitemid 351737162)
8. Praetorius HA, Spring KR: Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 184: 71-79, 2001 (Pubitemid 33016173)
9. Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, LuW, Brown EM, Quinn SJ, Ingber DE, Zhou J: Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 33: 129-137, 2003 (Pubitemid 36177063)
10. Piontek K,Menezes LF, Garcia-GonzalezMA, Huso DL, Germino GG: A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 13: 1490-1495, 2007 (Pubitemid 350224245)
11. Lantinga-van Leeuwen IS, LeonhardWN, van derWal A, Breuning MH, de Heer E, Peters DJ: Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet 16: 3188-3196, 2007 (Pubitemid 350131335)
12. Fischer E, Legue E, Doyen A, Nato F, Nicolas JF, Torres V, Yaniv M, PontoglioM: Defective planar cell polarity in polycystic kidney disease. Nat Genet 38: 21-23, 2006 (Pubitemid 43011877)
13. Witzgall R, Brown D, Schwarz C, Bonventre JV: Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest 93: 2175-2188, 1994
14. Schumer M, Colombel MC, Sawczuk IS, Gobé G, Connor J, O'Toole KM, Olsson CA, Wise GJ, Buttyan R: Morphologic, biochemical, and molecular evidence of apoptosis during the reperfusion phase after brief periods of renal ischemia. Am J Pathol 140: 831-838, 1992
15. Beeri R, Symon Z, Brezis M, Ben-Sasson SA, Baehr PH, Rosen S, Zager RA: Rapid DNA fragmentation from hypoxia along the thick ascending limb of rat kidneys. Kidney Int 47: 1806-1810, 1995
16. Klausner JM, Paterson IS, Goldman G, Kobzik L, Rodzen C, Lawrence R, Valeri CR, Shepro D, Hechtman HB: Postischemic renal injury is mediated by neutrophils and leukotrienes. Am J Physiol 256: F794-F802, 1989
17. Gobé G,Willgoss D, Hogg N, Schoch E, Endre Z: Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury. Kidney Int 56: 1299-1304, 1999 (Pubitemid 29451235)
18. Karihaloo A, Koraishy F, Huen SC, Lee Y, Merrick D, Caplan MJ, Somlo S, Cantley LG: Macrophages promote cyst growth in polycystic kidney disease. J Am Soc Nephrol 22: 1809-1814, 2011
19. Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 121: 4210-4221, 2011
20. Vanden Heuvel GB, Bodmer R, McConnell KR, Nagami GT, Igarashi P: Expression of a cut-related homeobox gene in developing and polycystic mouse kidney. Kidney Int 50: 453-461, 1996 (Pubitemid 26274372)
21. Coqueret O, Bérubé G, Nepveu A: Themammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phase. EMBO J 17: 4680-4694, 1998 (Pubitemid 28377168)
22. Ledford AW, Brantley JG, Kemeny G, Foreman TL, Quaggin SE, Igarashi P, Oberhaus SM, Rodova M, Calvet JP, Vanden Heuvel GB: Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia. Dev Biol 245: 157-171, 2002 (Pubitemid 34461811)
23. Paul BM, VassmerD, Taylor A,Magenheimer L, CarltonCG, Piontek KB, Germino GG, Vanden Heuvel GB: Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts. Dev Dyn 240: 1493-1501, 2011
24. PazourGJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL,Witman GB, Cole DG: Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 151: 709-718, 2000
25. Haycraft CJ, Swoboda P, Taulman PD, Thomas JH, Yoder BK: The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Development 128: 1493-1505, 2001 (Pubitemid 32514834)
26. Omori S, Hida M, Fujita H, Takahashi H, Tanimura S, Kohno M, Awazu M: Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease. J Am Soc Nephrol 17: 1604-1614, 2006 (Pubitemid 43794663)
27. Bukanov NO, Smith LA, Klinger KW, Ledbetter SR, Ibraghimov-BeskrovnayaO: Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine. Nature 444: 949-952, 2006 (Pubitemid 46025010)
28. Hayashi S,McMahon AP: Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 244: 305-318, 2002 (Pubitemid 34450645)
29. BerbariNF, KinNW, Sharma N,Michaud EJ, Kesterson RA, Yoder BK: Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev Biol 360: 66-76, 2011
30. Sharma N, Kosan ZA, Stallworth JE, Berbari NF, Yoder BK: Soluble levels of cytosolic tubulin regulate ciliary length control.Mol Biol Cell 22: 806-816, 2011
31. Yoder BK, Hou X, Guay-Woodford LM: The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J AmSoc Nephrol 13: 2508-2516, 2002