Dual-targeting and pH/redox-responsive multi-layered nanocomplexes for smart co-delivery of doxorubicin and siRNA

Biomaterials

Volumn 60, Issue , 2015, Pages 42-52

  Han, Lu ^a   Tang, Cui ^a   Yin, Chunhua ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Charge reversal; PH sensitivity; Self assembly; Synergistic cancer therapy; Targeted delivery

Indexed keywords

AMINO ACIDS; CELL PROLIFERATION; COVALENT BONDS; DRUG PRODUCTS; MOLECULAR BIOLOGY; PEPTIDES; SELF ASSEMBLY; SILICA; SILICA NANOPARTICLES; SULFUR COMPOUNDS;

CANCER THERAPY; CHARGE REVERSAL; MODIFIED MESOPOROUS SILICAS; PH SENSITIVITY; POLYALLYLAMINE HYDROCHLORIDE; RECEPTOR-MEDIATED ENDOCYTOSIS; TARGETED DELIVERY; VASCULAR ENDOTHELIAL GROWTH FACTOR;

TARGETED DRUG DELIVERY;

CHITOSAN; CITRACONIC ANHYDRIDE; CYSTEINE; DOXORUBICIN; GALACTOSE; GLUTATHIONE; LIGAND; NANOCARRIER; NANOCOMPLEX; PEPTIDE DERIVATIVE; SILICA NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION; NANOPARTICLE; POLYALLYLAMINE; POLYAMINE; SILICON DIOXIDE; TRANSACTIVATOR PROTEIN; VASCULOTROPIN A;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DEGRADATION; DRUG DELIVERY SYSTEM; ENDOSOME; FEMALE; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; INTERNALIZATION; LIVER CELL CARCINOMA; LYSOSOME; MOUSE; MTT ASSAY; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RNA INTERFERENCE; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TUMOR MICROENVIRONMENT; X RAY POWDER DIFFRACTION; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DELAYED RELEASE FORMULATION; GENETICS; NEOPLASMS; OXIDATION REDUCTION REACTION; PATHOLOGY; RNAI THERAPEUTICS; TUMOR CELL LINE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CHITOSAN; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; FEMALE; GALACTOSE; GENE PRODUCTS, TAT; HUMANS; HYDROGEN-ION CONCENTRATION; MICE, INBRED BALB C; NANOPARTICLES; NEOPLASMS; OXIDATION-REDUCTION; POLYAMINES; RNA, SMALL INTERFERING; RNAI THERAPEUTICS; SILICON DIOXIDE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84930432629     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.05.001     Document Type: Article

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