Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on ßGlcN(1虠1)αGlcN scaffold

Innate Immunity

Volumn 21, Issue 5, 2015, Pages 490-503

  Garate, Jose Antonio ^a   Stöckl, Johannes ^b   Del Carmen Fernández Alonso, María ^c   Artner, Daniel ^a   Haegman, Mira ^d   Oostenbrink, Chris ^a   Jiménez Barbero, Jesús ^c   Beyaert, Rudi ^d   Heine, Holger ^e   Kosma, Paul ^a   Zamyatina, Alla ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^d GHENT UNIVERSITY   (Belgium)

^e RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Antagonist; glycolipids; lipid A; lipopolysaccharide; MD 2; molecular dynamics simulation; NMR; Toll like receptor 4

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 8; LIPID A; LIPOPOLYSACCHARIDE; MOLECULAR SCAFFOLD; MYELOID DIFFERENTIATION FACTOR 2; RECEPTOR PROTEIN; SIALOADHESIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; ENDOTOXIN; GLUCOSAMINE; LY96 PROTEIN, HUMAN; PROTEIN MD 2;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ASSAY; CELL SURFACE; CONFORMATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DOWN REGULATION; EPITHELIUM CELL; ESCHERICHIA COLI; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOFLUORESCENCE; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; UPREGULATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ESCHERICHIA COLI;

BINDING SITES; CELL LINE; CYTOKINES; DENDRITIC CELLS; ENDOTOXINS; EPITHELIAL CELLS; ESCHERICHIA COLI; GLUCOSAMINE; HUMANS; IMMUNITY, INNATE; LIPID A; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MOLECULAR CONFORMATION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84930403920     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425914550426     Document Type: Article

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