Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome

Journal of Clinical Investigation

Volumn 125, Issue 6, 2015, Pages 2413-2428

  Cariboni, Anna ^a,b   André, Valentina ^b   Chauvet, Sophie ^c   Cassatella, Daniele ^d   Davidson, Kathryn ^a   Caramello, Alessia ^a   Fantin, Alessandro ^a   Bouloux, Pierre ^e   Mann, Fanny ^c   Ruhrberg, Christiana ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF MILAN   (Italy)

^c AIX MARSEILLE UNIVERSITY   (France)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GONADORELIN; GONADOTROPIN; IMMUNOGLOBULIN G; LUTEINIZING HORMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PLEXIN; PLEXIN D1; PROPIDIUM IODIDE; RECOMBINANT PROTEIN; SEMAPHORIN; SEMAPHORIN 3E; TESTOSTERONE; UNCLASSIFIED DRUG; VASCULOTROPIN; GLYCOPROTEIN; MEMBRANE PROTEIN; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; PLXND1 PROTEIN, HUMAN; PLXND1 PROTEIN, MOUSE; SEMA3E PROTEIN, HUMAN; SEMA3E PROTEIN, MOUSE;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOSMIA; APOPTOSIS; ARTICLE; AUTONOMIC INNERVATION; BRAIN REGION; CELL DEATH; CELL SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; ESSENTIAL GENE; GENE FREQUENCY; GENE INTERACTION; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC DISORDER; GONADOTROPIN DEFICIENCY; HUMAN; IMMUNOREACTIVITY; KALLMANN SYNDROME; MAJOR CLINICAL STUDY; MALE; MEDIAN EMINENCE; MEDICAL HISTORY; MOUSE; NERVE CELL; NERVE CELL DIFFERENTIATION; NEURITE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TESTIS DEVELOPMENT; TESTIS DISEASE; WILD TYPE; ANIMAL; DEFICIENCY; EXOME; GENETICS; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; PATHOLOGY;

ADULT; ANIMALS; CELL ADHESION MOLECULES, NEURONAL; EXOME; GLYCOPROTEINS; GONADOTROPIN-RELEASING HORMONE; HUMANS; KALLMANN SYNDROME; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASES; SEMAPHORINS; SIGNAL TRANSDUCTION;

EID: 84930392797     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI78448     Document Type: Article

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