Lack of GDAP1 Induces Neuronal Calcium and Mitochondrial Defects in a Knockout Mouse Model of Charcot-Marie-Tooth Neuropathy

PLoS Genetics

Volumn 11, Issue 4, 2015, Pages

  Barneo Muñoz, Manuela ^a,b   Juárez, Paula ^a,b   Civera Tregón, Azahara ^a   Yndriago, Laura ^a   Pla Martin, David ^a,b   Zenker, Jennifer ^c   Cuevas Martín, Carmen ^b,d,e   Estela, Anna ^a,b   Sánchez Aragó, María ^b,d,e   Forteza Vila, Jerónimo ^a,f   Cuezva, José M ^b,d,e   Chrast, Roman ^c,g   Palau, Francesc ^a,b,h  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^e UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^f UNIVERSIDAD CATÓLICA DE VALENCIA SAN VICENTE MÁRTIR   (Spain)

^g KAROLINSKA INSTITUTE   (Sweden)

^h UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; CALCIUM ION; MITOCHONDRIAL PROTEIN; OUTER MEMBRANE PROTEIN; PROTEIN GDAP1; UNCLASSIFIED DRUG; CALCIUM CHANNEL; GDAP PROTEIN; NERVE PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL LOSS; CELL VACUOLE; CONTROLLED STUDY; CYTOSOL; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EMBRYO; ENDOPLASMIC RETICULUM; FEMALE; GDAP1 GENE; GENE SILENCING; HEREDITARY MOTOR SENSORY NEUROPATHY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOTONEURON; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NERVE FIBER; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROMUSCULAR JUNCTION DISORDER; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN ACETYLATION; PROTEIN DEPLETION; SPINAL CORD VENTRAL HORN; SPINAL GANGLION; ANIMAL; AXON; C57BL MOUSE; CALCIUM SIGNALING; CYTOSKELETON; GENE DELETION; GENETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; AXONS; CALCIUM CHANNELS; CALCIUM SIGNALING; CHARCOT-MARIE-TOOTH DISEASE; CYTOSKELETON; GENE DELETION; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NERVE TISSUE PROTEINS;

EID: 84930337068     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005115     Document Type: Article

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