Soft materials in neuroengineering for hard problems in neuroscience

Neuron

Volumn 86, Issue 1, 2015, Pages 175-186

  Jeong, Jae Woong ^a,b   Shin, Gunchul ^a   Park, Sung Il ^a   Yu, Ki Jun ^a   Xu, Lizhi ^a   Rogers, John A ^a  

^a University of Illinois at Urbana Champaign   (United States)

^b UCB 450   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; CARBON NANOTUBE; COLLAGEN; MACROGOL; NANOMATERIAL; POLYMER; POLYVINYL ALCOHOL; SILVER NANOPARTICLE; BIOMIMETIC MATERIAL;

BIOCOMPATIBILITY; BIOMEDICAL ENGINEERING; BIOSENSOR; COMPLIANCE (PHYSICAL); COMPOSITE MATERIAL; ELECTROCARDIOGRAPHY; ELECTROCORTICOGRAPHY; ELECTRODE; ELECTROENCEPHALOGRAPHY; ELECTRONICS; EQUIPMENT DESIGN; HUMAN; HYDROGEL; MAN MACHINE INTERACTION; NERVE CELL; NEUROSCIENCE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; YOUNG MODULUS; ANIMAL; BIOLOGICAL MODEL; BRAIN; DEVICES; ELECTRODE IMPLANT; PHYSIOLOGY; PROCEDURES;

ANIMALS; BIOMIMETIC MATERIALS; BRAIN; ELECTRODES, IMPLANTED; ELECTRONICS; HUMANS; MODELS, NEUROLOGICAL; NEUROSCIENCES;

EID: 84930332105     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.12.035     Document Type: Review

References (100)

1. Abidian M.R., Corey J.M., Kipke D.R., Martin D.C. Conducting-polymer nanotubes improve electrical properties, mechanical adhesion, neural attachment, and neurite outgrowth of neural electrodes. Small 2010, 6:421-429.
2. Adrian E.D., Matthews B.H.C. The Berger rhythm: potential changes from the occipital lobes in man. Brain. J.Neurol. 1939, 57:355-385.
3. Alba N.A., Sclabassi R.J., Sun M., Cui X.T. Novel hydrogel-based preparation-free EEG electrode. IEEE Trans. Neural Syst. Rehabil. Eng. 2010, 18:415-423.
4. Alivisatos A.P., Chun M., Church G.M., Deisseroth K., Donoghue J.P., Greenspan R.J., McEuen P.L., Roukes M.L., Sejnowski T.J., Weiss P.S., Yuste R. Neuroscience. The brain activity map. Science 2013, 339:1284-1285.
5. Anikeeva P., Andalman A.S., Witten I., Warden M., Goshen I., Grosenick L., Gunaydin L.A., Frank L.M., Deisseroth K. Optetrode: a multichannel readout for optogenetic control in freely moving mice. Nat. Neurosci. 2012, 15:163-170.
6. Aregueta-Robles U.A., Woolley A.J., Poole-Warren L.A., Lovell N.H., Green R.A. Organic electrode coatings for next-generation neural interfaces. Front Neuroeng 2014, 7:15.
7. Asplund M., Thaning E., Lundberg J., Sandberg-Nordqvist A.C., Kostyszyn B., Inganäs O., von Holst H. Toxicity evaluation of PEDOT/biomolecular composites intended for neural communication electrodes. Biomed. Mater. 2009, 4:045009.
8. Boyden E.S., Zhang F., Bamberg E., Nagel G., Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat. Neurosci. 2005, 8:1263-1268.
9. Campbell P.K., Jones K.E., Huber R.J., Horch K.W., Normann R.A. A silicon-based, three-dimensional neural interface: manufacturing processes for an intracortical electrode array. IEEE Trans. Biomed. Eng. 1991, 38:758-768.
10. Canales A., Jia X., Froriep U.P., Koppes R.A., Tringides C., Selvidge J., Lu C., Hou C., Wei L., Fink Y., Anikeeva P. Multimodality fibers for simultaneous optical, electrical and chemical communication with neural circuits Invivo. Nat. Biotechnol. 2015, 10.1038/nbt.3093.
11. Capadona J.R., Shanmuganathan K., Tyler D.J., Rowan S.J., Weder C. Stimuli-responsive polymer nanocomposites inspired by the sea cucumber dermis. Science 2008, 319:1370-1374.
12. Castagnola E., Ansaldo A., Maggiolini E., Ius T., Skrap M., Ricci D., Fadiga L. Smaller, softer, lower-impedance electrodes for human neuroprosthesis: a pragmatic approach. Front Neuroeng 2014, 7:8.
13. Chan G., Mooney D.J. New materials for tissue engineering: towards greater control over the biological response. Trends Biotechnol. 2008, 26:382-392.
14. Chen S., Allen M.G. Extracellular matrix-based materials for neural interfacing. MRS Bull. 2012, 37:606-613.
15. Chen R.J., Bangsaruntip S., Drouvalakis K.A., Kam N.W.S., Shim M., Li Y., Kim W., Utz P.J., Dai H. Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc. Natl. Acad. Sci. USA 2003, 100:4984-4989.
16. Chen Z., Ren W., Gao L., Liu B., Pei S., Cheng H.-M. Three-dimensional flexible and conductive interconnected graphene networks grown by chemical vapour deposition. Nat. Mater. 2011, 10:424-428.
17. Chen J.Y., Pei W., Chen S., Wu X., Zhao S., Wang H., Chen H. Poly(3,4-ethylenedioxythiophene) (PEDOT) as interface material for improving electrochemical performance of microneedles array-based dry electrode. Sens. Actuators B Chem. 2013, 188:747-756.
18. Choi W.M., Song J., Khang D.-Y., Jiang H., Huang Y.Y., Rogers J.A. Biaxially stretchable "wavy" silicon nanomembranes. Nano Lett. 2007, 7:1655-1663.
19. Chung K., Wallace J., Kim S.-Y., Kalyanasundaram S., Andalman A.S., Davidson T.J., Mirzabekov J.J., Zalocusky K.A., Mattis J., Denisin A.K., et al. Structural and molecular interrogation of intact biological systems. Nature 2013, 497:332-337.
20. Cogan S.F. Neural stimulation and recording electrodes. Annu. Rev. Biomed. Eng. 2008, 10:275-309.
21. Collura T.F. History and evolution of electroencephalographic instruments and techniques. J.Clin. Neurophysiol. 1993, 10:476-504.
22. Cui Y., Wei Q., Park H., Lieber C.M. Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science 2001, 293:1289-1292.
23. Debener S., Minow F., Emkes R., Gandras K., de Vos M. How about taking a low-cost, small, and wireless EEG for a walk?. Psychophysiology 2012, 49:1617-1621.
24. Deisseroth K. Optogenetics. Nat. Methods 2011, 8:26-29.
25. Denk W., Svoboda K. Photon upmanship: why multiphoton imaging is more than a gimmick. Neuron 1997, 18:351-357.
26. Edgington R.J., Thalhammer A., Welch J.O., Bongrain A., Bergonzo P., Scorsone E., Jackman R.B., Schoepfer R. Patterned neuronal networks using nanodiamonds and the effect of varying nanodiamond properties on neuronal adhesion and outgrowth. J.Neural Eng. 2013, 10:056022.
27. Escabí M.A., Read H.L., Viventi J., Kim D.H., Higgins N.C., Storace D.A., Liu A.S., Gifford A.M., Burke J.F., Campisi M., et al. A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings. J.Neurophysiol. 2014, 112:1566-1583.
28. Fan J.A., Yeo W.H., Su Y., Hattori Y., Lee W., Jung S.Y., Zhang Y., Liu Z., Cheng H., Falgout L., et al. Fractal design concepts for stretchable electronics. Nat. Commun. 2014, 5:3266.
29. Fiedler P., Pedrosa P., Griebel S., Fonseca C., Vaz F., Zanow F., Haueisen J. Novel flexible dry PU/TiN-multipin electrodes: first application in EEG measurements. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2011, 2011:55-58.
30. Fine A., Amos W.B., Durbin R.M., McNaughton P.A. Confocal microscopy: applications in neurobiology. Trends Neurosci. 1988, 11:346-351.
31. Flusberg B.A., Nimmerjahn A., Cocker E.D., Mukamel E.A., Barretto R.P., Ko T.H., Burns L.D., Jung J.C., Schnitzer M.J. High-speed, miniaturized fluorescence microscopy in freely moving mice. Nat. Methods 2008, 5:935-938.
32. George P.M., Lyckman A.W., LaVan D.A., Hegde A., Leung Y., Avasare R., Testa C., Alexander P.M., Langer R., Sur M. Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics. Biomaterials 2005, 26:3511-3519.
33. Gerard M., Chaubey A., Malhotra B.D. Application of conducting polymers to biosensors. Biosens. Bioelectron. 2002, 17:345-359.
34. Gerwig R., Fuchsberger K., Schroeppel B., Link G.S., Heusel G., Kraushaar U., Schuhmann W., Stett A., Stelzle M. PEDOT-CNT composite microelectrodes for recording and electrostimulation applications: fabrication, morphology, and electrical properties. Front Neuroeng 2012, 5:8.
35. Ghosh K.K., Burns L.D., Cocker E.D., Nimmerjahn A., Ziv Y., Gamal A.E., Schnitzer M.J. Miniaturized integration of a fluorescence microscope. Nat. Methods 2011, 8:871-878.
36. Green R.A., Baek S., Poole-Warren L.A., Martens P.J. Conducting polymer-hydrogels for medical electrode applications. Sci. Technol. Adv. Mater. 2010, 11:014107.
37. Green R.A., Lim K.S., Henderson W.C., Hassarati R.T., Martens P.J., Lovell N.H., Poole-Warren L.A. Living electrodes: tissue engineering the neural interface. Proc. IEEE Eng. Med. Biol. Soc. Conf. 2013, 6957-6960.
38. Grill W.M., Norman S.E., Bellamkonda R.V. Implanted neural interfaces: biochallenges and engineered solutions. Annu. Rev. Biomed. Eng. 2009, 11:1-24.
39. Guimarda N.K., Gomezb N., Schmidt C.E. Conducting polymers in biomedical engineering. Prog. Polym. Sci. 2007, 32:876-921.
40. Guo L., Ma M., Zhang N., Langer R., Anderson D.G. Stretchable polymeric multielectrode array for conformal neural interfacing. Adv. Mater. 2014, 26:1427-1433.
41. HajjHassan M., Chodavarapu V., Musallam S. NeuroMEMS: Neural probel microtechnologies. Sensors (Basel Switzerland) 2008, 8:6704-6726.
42. He W., Bellamkonda R. Indwelling Neural Implants: Strategies for Contending with the. Vivo Environment 2008, CRC Press, Boca Raton, FL. W.M. Reichert (Ed.).
43. Hopper A.P., Dugan J.M., Gill A.A., Fox O.J.L., May P.W., Haycock J.W., Claeyssens F. Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth. Biomed. Mater. 2014, 9:045009.
44. Humpolicek P., Kasparkova V., Saha P., Stejskal J. Biocompatibility of polyaniline. Synth. Met. 2012, 162:722-727.
45. Jacobs C.B., Peairs M.J., Venton B.J. Review: Carbon nanotube based electrochemical sensors for biomolecules. Anal. Chim. Acta 2010, 662:105-127.
46. Jang K.I., Han S.Y., Xu S., Mathewson K.E., Zhang Y., Jeong J.W., Kim G.T., Webb R.C., Lee J.W., Dawidczyk T.J., et al. Rugged and breathable forms of stretchable electronics with adherent composite substrates for transcutaneous monitoring. Nat. Commun. 2014, 5:4779.
47. Jung H.C., Moon J.H., Baek D.H., Lee J.H., Choi Y.Y., Hong J.S., Lee S.H. CNT/PDMS composite flexible dry electrodes for long-term ECG monitoring. IEEE Trans. Biomed. Eng. 2012, 59:1472-1479.
48. Kang M., Jung S., Zhang H., Kang T., Kang H., Yoo Y., Hong J.-P., Ahn J.-P., Kwak J., Jeon D., et al. Subcellular neural probes from single-crystal gold nanowires. ACS Nano 2014, 8:8182-8189.
49. Khodagholy D., Doublet T., Gurfinkel M., Quilichini P., Ismailova E., Leleux P., Herve T., Sanaur S., Bernard C., Malliaras G.G. Highly conformable conducting polymer electrodes for invivo recordings. Adv. Mater. 2011, 23:H268-H272.
50. Kim D.H., Viventi J., Amsden J.J., Xiao J., Vigeland L., Kim Y.S., Blanco J.A., Panilaitis B., Frechette E.S., Contreras D., et al. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nat. Mater. 2010, 9:511-517.
51. Kim D.H., Lu N., Ma R., Kim Y.S., Kim R.H., Wang S., Wu J., Won S.M., Tao H., Islam A., et al. Epidermal electronics. Science 2011, 333:838-843.
52. Kim D.H., Ghaffari R., Lu N., Rogers J.A. Flexible and stretchable electronics for biointegrated devices. Annu. Rev. Biomed. Eng. 2012, 14:113-128.
53. Kim T.I., McCall J.G., Jung Y.H., Huang X., Siuda E.R., Li Y., Song J., Song Y.M., Pao H.A., Kim R.H., et al. Injectable, cellular-scale optoelectronics with applications for wireless optogenetics. Science 2013, 340:211-216.
54. Kozai T.D.Y., Langhals N.B., Patel P.R., Deng X., Zhang H., Smith K.L., Lahann J., Kotov N.A., Kipke D.R. Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces. Nat. Mater. 2012, 11:1065-1073.
55. Kuzum D., Takano H., Shim E., Reed J.C., Juul H., Richardson A.G., de Vries J., Bink H., Dichter M.A., Lucas T.H., et al. Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging. Nat. Commun. 2014, 5:5259.
56. Ledochowitsch P., Olivero E., Blanche T., Maharbiz M.M. A transparent μECoG array for simultaneous recording and optogenetic stimulation. Proc. IEEE Eng. Med. Biol. Soc. Conf. 2011, 2937-2940.
57. Lee P., Lee J., Lee H., Yeo J., Hong S., Nam K.H., Lee D., Lee S.S., Ko S.H. Highly stretchable and highly conductive metal electrode by very long metal nanowire percolation network. Adv. Mater. 2012, 24:3326-3332.
58. Leleux P., Badier J.M., Rivnay J., Bénar C., Hervé T., Chauvel P., Malliaras G.G. Conducting polymer electrodes for electroencephalography. Adv Healthc Mater 2014, 3:490-493.
59. Li N., Zhang Q., Gao S., Song Q., Huang R., Wang L., Liu L., Dai J., Tang M., Cheng G. Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci Rep 2013, 3:1604.
60. Liu X., Yue Z., Higgins M.J., Wallace G.G. Conducting polymers with immobilised fibrillar collagen for enhanced neural interfacing. Biomaterials 2011, 32:7309-7317.
61. Livet J., Weissman T.A., Kang H., Draft R.W., Lu J., Bennis R.A., Sanes J.R., Lichtman J.W. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature 2007, 450:56-62.
62. Logothetis N.K. What we can do and what we cannot do with fMRI. Nature 2008, 453:869-878.
63. Lu Y., Wang D., Li T., Zhao X., Cao Y., Yang H., Duan Y.Y. Poly(vinyl alcohol)/poly(acrylic acid) hydrogel coatings for improving electrode-neural tissue interface. Biomaterials 2009, 30:4143-4151.
64. Merrill D.R., Bikson M., Jefferys J.G. Electrical stimulation of excitable tissue: design of efficacious and safe protocols. J.Neurosci. Methods 2005, 141:171-198.
65. Minev I.R., Chew D.J., Delivopoulos E., Fawcett J.W., Lacour S.P. High sensitivity recording of afferent nerve activity using ultra-compliant microchannel electrodes: an acute invivo validation. J.Neural Eng. 2012, 9:026005.
66. Minev I.R., Musienko P., Hirsch A., Barraud Q., Wenger N., Moraud E.M., Gandar J., Capogrosso M., Milekovic T., Asboth L., et al. Electronic dura mater for long-term multimodal neural interfaces. Science 2015, 347:159-163.
67. Mozota J., Conway B.E. Surface and bulk processes at oxidized iridium electrodes-I. Monolayer stage and transition to reversible multilayer oxide film behaviour. Electrochim. Acta 1983, 28:1-8.
68. Niedermayer E., Lopes Da Silva F.H. Electroencephalography: Basic Principles, Clinical Applications, and Related Fields 2005, Lippincott Williams & Wilkins, Philadelphia, PA. Fifth Edition.
69. Ozden I., Wang J., Lu Y., May T., Lee J., Goo W., O'Shea D.J., Kalanithi P., Diester I., Diagne M., et al. A coaxial optrode as multifunction write-read probe for optogenetic studies in non-human primates. J.Neurosci. Methods 2013, 219:142-154.
70. Pan L., Yu G., Zhai D., Lee H.R., Zhao W., Liu N., Wang H., Tee B.C.-K., Shi Y., Cui Y., Bao Z. Hierarchical nanostructured conducting polymer hydrogel with high electrochemical activity. Proc. Natl. Acad. Sci. USA 2012, 109:9287-9292.
71. Park M., Im J., Shin M., Min Y., Park J., Cho H., Park S., Shim M.-B., Jeon S., Chung D.-Y., et al. Highly stretchable electric circuits from a composite material of silver nanoparticles and elastomeric fibres. Nat. Nanotechnol. 2012, 7:803-809.
72. Patolsky F., Lieber C.M. Nanowire nanosensors. Mater. Today 2005, 8:20-28.
73. Petrossians A., Whalen Iii J.J., Weiland J.D., Mansfeld F. Electrodeposition and characterization of thin-film platinum-iridium alloys for biological interfaces. J.Electrochem. Soc. 2011, 158:D269-D276.
74. Phelps M.E. PET: the merging of biology and imaging into molecular imaging. J.Nucl. Med. 2000, 41:661-681.
75. Polikov V.S., Tresco P.A., Reichert W.M. Response of brain tissue to chronically implanted neural electrodes. J.Neurosci. Methods 2005, 148:1-18.
76. Rao L., Zhou H., Li T., Li C., Duan Y.Y. Polyethylene glycol-containing polyurethane hydrogel coatings for improving the biocompatibility of neural electrodes. Acta Biomater. 2012, 8:2233-2242.
77. Rogers J.A., Someya T., Huang Y. Materials and mechanics for stretchable electronics. Science 2010, 327:1603-1607.
78. Rubehn B., Wolff S.B.E., Tovote P., Lüthi A., Stieglitz T. A polymer-based neural microimplant for optogenetic applications: design and first invivo study. Lab Chip 2013, 13:579-588.
79. Seo D., Carmena J.M., Rabaey J.M., Maharbiz M.M., Alon E. Model validation of untethered, ultrasonic neural dust motes for cortical recording. J.Neurosci. Methods 2014, 10.1016/j.jneumeth.2014.07.025.
80. Tian B., Cohen-Karni T., Qing Q., Duan X., Xie P., Lieber C.M. Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes. Science 2010, 329:830-834.
81. Tian B., Liu J., Dvir T., Jin L., Tsui J.H., Qing Q., Suo Z., Langer R., Kohane D.S., Lieber C.M. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat. Mater. 2012, 11:986-994.
82. Tien L.W., Wu F., Tang-Schomer M.D., Yoon E., Omenetto F.G., Kaplan D.L. Silk as a multifunctional biomaterial substrate for reduced glial scarring around brain-penetrating electrodes. Adv. Funct. Mater. 2014, 23:3185-3193.
83. Tsang W.M., Stone A.L., Otten D., Aldworth Z.N., Daniel T.L., Hildebrand J.G., Levine R.B., Voldman J. Insect-machine interface: a carbon nanotube-enhanced flexible neural probe. J.Neurosci. Methods 2012, 204:355-365.
84. Viventi J., Kim D.H., Moss J.D., Kim Y.S., Blanco J.A., Annetta N., Hicks A., Xiao J., Huang Y., Callans D.J., et al. A conformal, bio-Interfaced class of silicon electronics for mapping cardiac electrophysiology. Sci. Transl. Med. 2010, 2:24ra2.
85. Viventi J., Kim D.H., Vigeland L., Frechette E.S., Blanco J.A., Kim Y.S., Avrin A.E., Tiruvadi V.R., Hwang S.W., Vanleer A.C., et al. Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity invivo. Nat. Neurosci. 2011, 14:1599-1605.
86. Wang J. Carbon-nanotube based electrochemical biosensors: A review. Electroanalysis 2005, 17:7-14.
87. Wang Y., Li Z., Wang J., Li J., Lin Y. Graphene and graphene oxide: biofunctionalization and applications in biotechnology. Trends Biotechnol. 2011, 29:205-212.
88. Ward M.P., Rajdev P., Ellison C., Irazoqui P.P. Toward a comparison of microelectrodes for acute and chronic recordings. Brain Res. 2009, 1282:183-200.
89. Ware T., Simon D., Liu C., Musa T., Vasudevan S., Sloan A., Keefer E.W., Rennaker R.L., Voit W. Thiol-ene/acrylate substrates for softening intracortical electrodes. J.Biomed. Mater. Res. B Appl. Biomater. 2014, 102:1-11.
90. Wise K.D., Sodagar A.M., Yao Y., Gulari M.N., Najafi K. Microelectrodes, microelectronics, and implantable neural microsystems. Proc. IEEE 2008, 96:1184-1202.
91. Wolpaw J.R., McFarland D.J. Control of a two-dimensional movement signal by a noninvasive brain-computer interface in humans. Proc. Natl. Acad. Sci. USA 2004, 101:17849-17854.
92. Wu F., Im M., Yoon E. A flexible fish-bone-shaped neural probe strengthened by biodegradable silk coating for enhanced biocompatibility. Proc. Transducers. 2011, 966-969.
93. Wu F., Lee T., Chen F., Kaplan D., Berke J., Yoon E. A multi-shank silk-backed parylene neural probe for reliable chronic recording. Proc. Transducers. 2013, 888-891.
94. Wu F., Stark E., Im M., Cho I.J., Yoon E.S., Buzsáki G., Wise K.D., Yoon E. An implantable neural probe with monolithically integrated dielectric waveguide and recording electrodes for optogenetics applications. J.Neural Eng. 2013, 10:056012.
95. Xiang Z., Yen S.-C., Xue N., Sun T., Tsang W.M., Zhang S., Liao L.-D., Thakor N.V., Lee C. Ultra-thin flexible polyimide neural probe embedded in a dissolvable maltose-coated microneedle. J.Micromech. Microeng. 2014, 24:065015.
96. Xu S., Zhang Y., Jia L., Mathewson K.E., Jang K.I., Kim J., Fu H., Huang X., Chava P., Wang R., et al. Soft microfluidic assemblies of sensors, circuits, and radios for the skin. Science 2014, 344:70-74.
97. Yeo W.H., Kim Y.S., Lee J., Ameen A., Shi L., Li M., Wang S., Ma R., Jin S.H., Kang Z., et al. Multifunctional epidermal electronics printed directly onto the skin. Adv. Mater. 2013, 25:2773-2778.
98. Zang J., Ryu S., Pugno N., Wang Q., Tu Q., Buehler M.J., Zhao X. Multifunctionality and control of the crumpling and unfolding of large-area graphene. Nat. Mater. 2013, 12:321-325.
99. Zhang S., Tsang W.M., Srinivas M., Sun T., Singh N., Kwong D.-L., Lee C. Development of silicon electrode enhanced by carbon nanotube and gold nanoparticle composites on silicon neural probe fabricated with complementary metal-oxide-semiconductor process. Appl. Phys. Lett. 2014, 104:193105.
100. Zheng G., Patolsky F., Cui Y., Wang W.U., Lieber C.M. Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nat. Biotechnol. 2005, 23:1294-1301.