Ad 2.0: A novel recombineering platform for high-throughput generation of tailored adenoviruses

Nucleic Acids Research

Volumn 43, Issue 8, 2015, Pages

  Mück Häusl, Martin ^a,d   Solanki, Manish ^b   Zhang, Wenli ^b   Ruzsics, Zsolt ^a,c   Ehrhardt, Anja ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; RECOMBINANT DNA; VIRUS DNA;

ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; GENE SEQUENCE; GENETIC CODE; HIGH THROUGHPUT SEQUENCING; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; TISSUE ENGINEERING; TRANSGENE; VACCINATION; VIRAL GENE THERAPY; VIRUS CAPSID; VIRUS RECOMBINANT; VIRUS RECOMBINATION; ADENOVIRIDAE; GENE VECTOR; GENETIC ENGINEERING; GENETIC RECOMBINATION; GENETICS; HEK293 CELL LINE; PROCEDURES;

ADENOVIRIDAE; BACTERIA (MICROORGANISMS); MIRIDAE;

ADENOVIRIDAE; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CLONING, MOLECULAR; DNA, VIRAL; GENETIC ENGINEERING; GENETIC VECTORS; HEK293 CELLS; HUMANS; RECOMBINATION, GENETIC;

EID: 84930221680     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv031     Document Type: Article

References (25)

1. Sullivan, D.E., Dash, S., Du, H., Hiramatsu, N., Aydin, F., Kolls, J., Blanchard, J., Baskin, G. and Gerber, M.A. (1997) Liver-directed gene transfer in non-human primates. Hum. Gene Ther., 8, 1195-1206.
2. Benihoud, K., Yeh, P. and Perricaudet, M. (1999) Adenovirus vectors for gene delivery. Curr. Opin. Biotechnol., 10, 440-447.
3. Lusky, M., Christ, M., Rittner, K., Dieterle, A., Dreyer, D., Mourot, B., Schultz, H., Stoeckel, F., Pavirani, A. and Mehtali, M. (1998) In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted. J. Virol., 72, 2022-2032.
4. Parks, R.J., Chen, L., Anton, M., Sankar, U., Rudnicki, M.A. and Graham, F.L. (1996) A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl. Acad. Sci. U.S.A., 93, 13565-13570.
5. Palmer, D. and Ng, P. (2003) Improved system for helper-dependent adenoviral vector production. Mol. Ther., 8, 846-852.
6. Jager, L., Hausl, M.A., Rauschhuber, C., Wolf, N.M., Kay, M.A. and Ehrhardt, A. (2009) A rapid protocol for construction and production of high-capacity adenoviral vectors. Nat. Protoc., 4, 547-564.
7. Morral, N., Parks, R.J., Zhou, H., Langston, C., Schiedner, G., Quinones, J., Graham, F.L., Kochanek, S. and Beaudet, A.L. (1998) High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity. Hum. Gene Ther., 9, 2709-2716.
8. Muruve, D.A., Cotter, M.J., Zaiss, A.K., White, L.R., Liu, Q., Chan, T., Clark, S.A., Ross, P.J., Meulenbroek, R.A., Maelandsmo, G.M. et al. (2004) Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo. J. Virol., 78, 5966-5972.
9. Ehrhardt, A., Xu, H., Dillow, A.M., Bellinger, D.A., Nichols, T.C. and Kay, M.A. (2003) A gene-deleted adenoviral vector results in phenotypic correction of canine hemophilia B without liver toxicity or thrombocytopenia. Blood, 102, 2403-2411.
10. Roberts, D.M., Nanda, A., Havenga, M.J., Abbink, P., Lynch, D.M., Ewald, B.A., Liu, J., Thorner, A.R., Swanson, P.E., Gorgone, D.A. et al. (2006) Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity. Nature, 441, 239-243.
11. Shayakhmetov, D.M., Papayannopoulou, T., Stamatoyannopoulos, G. and Lieber, A. (2000) Efficient gene transfer into human CD34(+) cells by a retargeted adenovirus vector. J. Virol., 74, 2567-2583.
12. Chartier, C., Degryse, E., Gantzer, M., Dieterle, A., Pavirani, A. and Mehtali, M. (1996) Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J. Virol., 70, 4805-4810.
13. McGrory, W.J., Bautista, D.S. and Graham, F.L. (1988) A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology, 163, 614-617.
14. Mizuguchi, H. and Kay, M.A. (1998) Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method. Hum. Gene Ther., 9, 2577-2583.
15. Degryse, E. (1996) In vivo intermolecular recombination in Escherichia coli: application to plasmid constructions. Gene, 170, 45-50.
16. Warming, S., Costantino, N., Court, D.L., Jenkins, N.A. and Copeland, N.G. (2005) Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res., 33, e36.
17. Stanton, R.J., McSharry, B.P., Armstrong, M., Tomasec, P. and Wilkinson, G.W. (2008) Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function. Biotechniques, 45, 664-668.
18. Ruzsics, Z., Lemnitzer, F. and Thirion, C. (2014) Engineering adenovirus genome by bacterial artificial chromosome (BAC) technology. Methods Mol. Biol., 1089, 143-158.
19. Copeland, N.G., Jenkins, N.A. and Court, D.L. (2001) Recombineering: a powerful new tool for mouse functional genomics. Nat. Rev. Genet., 2, 769-779.
20. Sharan, S.K., Thomason, L.C., Kuznetsov, S.G. and Court, D.L. (2009) Recombineering: a homologous recombination-based method of genetic engineering. Nat. Protoc., 4, 206-223.
21. Shayakhmetov, D.M., Carlson, C.A., Stecher, H., Li, Q., Stamatoyannopoulos, G. and Lieber, A. (2002) A high-capacity, capsid-modified hybrid adenovirus/adeno-associated virus vector for stable transduction of human hematopoietic cells. J. Virol., 76, 1135-1143.
22. Waddington, S.N., McVey, J.H., Bhella, D., Parker, A.L., Barker, K., Atoda, H., Pink, R., Buckley, S.M., Greig, J.A., Denby, L. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132, 397-409.
23. Kawano, R., Ishizaki, M., Maeda, Y., Uchida, Y., Kimura, E. and Uchino, M. (2008) Transduction of full-length dystrophin to multiple skeletal muscles improves motor performance and life span in utrophin/dystrophin double knockout mice. Mol. Ther., 16, 825-831.
24. Bradley, R.R., Maxfield, L.F., Lynch, D.M., Iampietro, M.J., Borducchi, E.N. and Barouch, D.H. (2012) Adenovirus serotype 5-specific neutralizing antibodies target multiple hexon hypervariable regions. J. Virol., 86, 1267-1272.
25. Holkers, M., Maggio, I., Henriques, S.F., Janssen, J.M., Cathomen, T. and Goncalves, M.A. (2014) Adenoviral vector DNA for accurate genome editing with engineered nucleases. Nat. Methods., 11, 1051-1057.