MiR-148a is associated with obesity and modulates adipocyte differentiation of mesenchymal stem cells through wnt signaling

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Shi, Chunmei ^a,b   Zhang, Min ^a   Tong, Meiling ^a   Yang, Lei ^a,b   Pang, Lingxia ^a,b   Chen, Ling ^a,b   Xu, Guangfeng ^a   Chi, Xia ^a   Hong, Qin ^a   Ni, Yuhui ^a   Ji, Chenbo ^a,b   Guo, Xirong ^a,b  

^a WOMEN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3' UNTRANSLATED REGION; ANTISENSE OLIGONUCLEOTIDE; CREBBP PROTEIN, HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; MICRORNA; MIRN148 MICRORNA, HUMAN; PROTEIN BINDING; WNT1 PROTEIN; WNT1 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ADIPOCYTE; ADIPOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; GENETICS; HUMAN; LIPID DIET; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; OBESITY; PATHOLOGY; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; WNT SIGNALING PATHWAY;

3' UNTRANSLATED REGIONS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CREB-BINDING PROTEIN; DIET, HIGH-FAT; HUMANS; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICRORNAS; OBESITY; OLIGONUCLEOTIDES, ANTISENSE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; WNT SIGNALING PATHWAY; WNT1 PROTEIN;

EID: 84930216377     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09930     Document Type: Article

References (53)

1. Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384, 766-781 (2014).
2. An, R. Prevalence and Trends of Adult Obesity in the US, 1999-2012. ISRN Obes 2014, 185132 (2014).
3. Wise, J. Obesity rates rise substantially worldwide. BMJ 348, g3582 (2014).
4. Arner, E. et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59, 105-109 (2010).
5. Jo, J. et al. Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth. PLoS Comput Biol 5, e1000324 (2009).
6. Fox, K. E. et al. Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2. J Biol Chem 281, 40341-40353 (2006).
7. Zhang, J. W., Klemm, D. J., Vinson, C. & Lane, M. D. Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis. J Biol Chem 279, 4471-4478 (2004).
8. Holland, J. D., Klaus, A., Garratt, A. N. & Birchmeier, W. Wnt signaling in stem and cancer stem cells. Curr Opin Cell Biol 25, 254-264 (2013).
9. Wildwater, M., Sander, N., deVreede, G. & van den Heuvel, S. Cell shape and Wnt signaling redundantly control the division axis of C. elegans epithelial stem cells. Development 138, 4375-4385 (2011).
10. Locke, M., Feisst, V. & Dunbar, P. R. Concise review: human adipose-derived stem cells: separating promise from clinical need. Stem Cells 29, 404-411 (2011).
11. Schmittgen, T. D. Regulation of microRNA processing in development, differentiation and cancer. J Cell Mol Med 12, 1811-1819 (2008).
12. Mizuno, Y. et al. miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation. Biochem Biophys Res Commun 368, 267-272 (2008).
13. Kim, Y. J., Hwang, S. J., Bae, Y. C. & Jung, J. S. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 27, 3093-3102 (2009).
14. Huang, S. et al. Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression. Stem Cells Dev 21, 2531-2540 (2012).
15. Kim, Y. J. et al. miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue. J Bone Miner Res 24, 816-825 (2009).
16. Xie, H., Lim, B. & Lodish, H. F. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58, 1050-1057 (2009).
17. Kennell, J. A., Gerin, I., MacDougald, O.A. & Cadigan, K.M. The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc Natl Acad Sci U.S.A. 105, 15417-15422 (2008).
18. Esau, C. et al., MicroRNA-143 regulates adipocyte differentiation. J Biol Chem 279, 52361-52365 (2004).
19. Kim, S. Y. et al. miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression. Biochem Biophys Res Commun 392, 323-328 (2010).
20. Karbiener, M. et al. microRNA miR-27b impairs human adipocyte differentiation and targets PPARgamma. Biochem Biophys Res Commun 390, 247-251 (2009).
21. Sun, T. et al. MicroRNA let-7 regulates 3T3-L1 adipogenesis. Mol Endocrinol 23, 925-931 (2009).
22. Giordano, S. & Columbano, A. MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? Hepatology 57, 840-847 (2013).
23. Kim, J. B., Wright, H. M., Wright, M. & Spiegelman, B. M. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci U.S.A. 95, 4333-4337 (1998).
24. Massague, J. & Xi, Q. TGF-beta control of stem cell differentiation genes. Febs Lett 586, 1953-1958 (2012).
25. Tang, Q. Q. & Lane, M. D. Adipogenesis: from stem cell to adipocyte. Annu Rev Biochem 81, 715-736 (2012).
26. Veeman, M. T. et al. Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol 13, 680-685 (2003).
27. Zawel, L. et al. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1, 611-617 (1998).
28. Tang, S. J. et al. The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development 125, 1877-1887 (1998).
29. Drummond-Barbosa, D. Stem cells, their niches and the systemic environment: an aging network. Genetics 180, 1787-1797 (2008).
30. Lujambio, A. et al. A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U.S.A. 105, 13556-13562 (2008).
31. Yang, Z. et al. MicroRNA hsa-miR-138 inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells through adenovirus EID-1. Stem Cells Dev 20, 259-267 (2011).
32. Qin, L. et al. A deep investigation into the adipogenesis mechanism: profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway. BMC Genomics 11, 320 (2010).
33. Gustafson, B. & Smith, U. The WNT inhibitor Dickkopf 1 and bone morphogenetic protein 4 rescue adipogenesis in hypertrophic obesity in humans. Diabetes 61, 1217-1224 (2012).
34. Fajas, L., Fruchart, J. C. & Auwerx, J., Transcriptional control of adipogenesis. Curr Opin Cell Biol 10, 165-173 (1998).
35. Pinnick, K. E. & Karpe, F. DNA methylation of genes in adipose tissue. Proc Nutr Soc 70, 57-63 (2011).
36. Aprelikova, O. et al. Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility. Oncogene 32, 3246-3253 (2013).
37. Gokhale, A. et al. Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway. J Cancer Res Ther6, 521-529 (2010).
38. Zheng, B. et al. MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res 17, 7574-7583 (2011).
39. Song, Y. X. et al. MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation. Mol Cancer 10, 1 (2011).
40. Ross, S. E. et al. Inhibition of adipogenesis by Wnt signaling. Science 289, 950-953 (2000).
41. Longo, K. A. et al. Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem 279, 35503-35509 (2004).
42. Riggi, N. et al. EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. Genes Dev 24, 916-932 (2010).
43. Lee, Y. et al. MicroRNA genes are transcribed by RNA polymerase II. Embo J 23, 4051-4060 (2004).
44. Card, D. A. et al. Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol 28, 6426-6438 (2008).
45. Reusch, J. E., Colton, L. A. & Klemm, D. J. CREB activation induces adipogenesis in 3T3-L1 cells. Mol Cell Biol 20, 1008-1020 (2000).
46. Frontini, A. & Cinti, S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 11, 253-256(2010).
47. Nedergaard, J. & Cannon, B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab 11, 268-272 (2010).
48. Wang, H., Du S, Zhai, F. & Popkin, B. M. Trends in the distribution of body mass index among Chinese adults, aged 20-45 years (1989-2000). Int J Obes (Lond) 31, 272-278 (2007).
49. Massiera, F. et al. Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 44, 271-279 (2003).
50. Lewis, B. P., Burge, C. B. & Bartel, D. P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20 (2005).
51. Krek, A. et al. Combinatorial microRNA target predictions. Nat Genet 37, 495-500 (2005).
52. Ladunga, Istvan. Computational biology of transcription factor binding. (Humana Press, New York, NY, 2010).
53. Zhu, L. et al. MiR-335, an adipogenesis-related microRNA, is involved in adipose tissue inflammation. Cell Biochem Biophys 68, 283-290 (2014).