-
1
-
-
34547854801
-
The oncogene HER2: Its signaling and transforming functions and its role in human cancer pathogenesis
-
Moasser, M. M. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene 26, 6469-6487 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 6469-6487
-
-
Moasser, M.M.1
-
2
-
-
84878926256
-
HER2-targeted therapy in breast cancer: A systemic review on neoadjuvant trials
-
Dent, S., Oyan, B., Honig, A., Mano, M. & Howell, S. HER2-targeted therapy in breast cancer: a systemic review on neoadjuvant trials. Cancer Treat Rev 39, 622-631 (2013).
-
(2013)
Cancer Treat Rev
, vol.39
, pp. 622-631
-
-
Dent, S.1
Oyan, B.2
Honig, A.3
Mano, M.4
Howell, S.5
-
3
-
-
84856435959
-
Taxane resistance in breast cancer: A closed HER2 circuit?
-
de Hoon, J. P. et al. Taxane resistance in breast cancer: a closed HER2 circuit? Biochim Biophys Acta 1825, 197-206 (2012).
-
(2012)
Biochim Biophys Acta
, vol.1825
, pp. 197-206
-
-
De Hoon, J.P.1
-
4
-
-
79551576468
-
Mechanism of endocrine resistance in breast cancer
-
Osborne, C. K. & Schiff, R. Mechanism of endocrine resistance in breast cancer. Annu Rev Med 62, 233-247 (2011).
-
(2011)
Annu Rev Med
, vol.62
, pp. 233-247
-
-
Osborne, C.K.1
Schiff, R.2
-
5
-
-
79961077459
-
Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells
-
Zhang, W. et al. Up-regulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF7 breast cancer cells. Acta Biochim Biophys Sin 43, 647-653 (2011).
-
(2011)
Acta Biochim Biophys Sin
, vol.43
, pp. 647-653
-
-
Zhang, W.1
-
6
-
-
84866563517
-
The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer
-
Gilani, R. A. et al. The importance of HER2 signaling in the tumor-initiating cell population in aromatase inhibitor-resistant breast cancer. Breast Cancer Res Treat 135, 681-692 (2012).
-
(2012)
Breast Cancer Res Treat
, vol.135
, pp. 681-692
-
-
Gilani, R.A.1
-
7
-
-
0037945211
-
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells
-
Knuefermann, C. et al. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene 22, 3205-3212 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 3205-3212
-
-
Knuefermann, C.1
-
8
-
-
84878681301
-
The Keap1-Nrf2 system incancers: Stress response and anabolic metabolism
-
Mitshishi, Y., Motohashi, H. & Yamamoto, M. The Keap1-Nrf2 system incancers: stress response and anabolic metabolism. Front Oncol 2, 200 (2012).
-
(2012)
Front Oncol
, vol.2
, pp. 200
-
-
Mitshishi, Y.1
Motohashi, H.2
Yamamoto, M.3
-
9
-
-
84874111758
-
The Nrf2 cell defense pathway: Keap1-dependent and -independent mechanisms of regulation
-
Bryan, H. K., Olayanju, A., Goldring, C. E. & Park, B. K. The Nrf2 cell defense pathway: Keap1-dependent and -independent mechanisms of regulation. Biochem Pharmacol 85, 705-717 (2013).
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 705-717
-
-
Bryan, H.K.1
Olayanju, A.2
Goldring, C.E.3
Park, B.K.4
-
10
-
-
84867034260
-
Role of Nrf2 in oxidative stress and toxicity
-
Ma, Q. Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53, 401-426 (2013).
-
(2013)
Annu Rev Pharmacol Toxicol
, vol.53
, pp. 401-426
-
-
Ma, Q.1
-
11
-
-
84892373466
-
Regulation of Nrf2-an update
-
Niture, S. K., Khatri, R. & Jaiswal, A. K. Regulation of Nrf2-an update. Free Radic Biol Med 66, 36-44 (2014).
-
(2014)
Free Radic Biol Med
, vol.66
, pp. 36-44
-
-
Niture, S.K.1
Khatri, R.2
Jaiswal, A.K.3
-
12
-
-
0037763721
-
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
-
Nguyen, T., Sherratt, P. J. & Pickett, C. B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 43, 233-260 (2003).
-
(2003)
Annu Rev Pharmacol Toxicol
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
Sherratt, P.J.2
Pickett, C.B.3
-
13
-
-
79952256187
-
SCF/β-TrCP promotes glycogen synthase kinase-dependent degradationof the Nrf2 transcription factorinaKeap1-independent manner
-
Rada, P. et al. SCF/β-TrCP promotes glycogen synthase kinase-dependent degradationof the Nrf2 transcription factorinaKeap1-independent manner. Mol Cell Biol 31, 1121-1133 (2011).
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1121-1133
-
-
Rada, P.1
-
14
-
-
84866283856
-
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis
-
Rada, P. et al. Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Mol Cell Biol 32, 3486-3499 (2012).
-
(2012)
Mol Cell Biol
, vol.32
, pp. 3486-3499
-
-
Rada, P.1
-
15
-
-
84881476323
-
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
-
Chowdhry, S. et al. Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. Oncogene 32, 3765-3781 (2013).
-
(2013)
Oncogene
, vol.32
, pp. 3765-3781
-
-
Chowdhry, S.1
-
16
-
-
77954351267
-
CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasomemediated degradation
-
Kang, H. J., Hong, Y. B., Kim, H. J. & Bae, I. CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasomemediated degradation. J Biol Chem 285, 21258-21268 (2010).
-
(2010)
J Biol Chem
, vol.285
, pp. 21258-21268
-
-
Kang, H.J.1
Hong, Y.B.2
Kim, H.J.3
Bae, I.4
-
17
-
-
67449128222
-
Direct interaction between Nrf2 and p21Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response
-
Chen, W. et al. Direct interaction between Nrf2 and p21Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response. Mol Cell 34, 663-673 (2009).
-
(2009)
Mol Cell
, vol.34
, pp. 663-673
-
-
Chen, W.1
-
18
-
-
84857493148
-
Wilms tumor gene on the X chromosome (WTX) inhibits the degradation of NRF2 through competitive binding to KEAP1
-
Camp, N. D. et al. Wilms tumor gene on the X chromosome (WTX) inhibits the degradation of NRF2 through competitive binding to KEAP1. J Biol Chem 287, 6539-6550 (2012).
-
(2012)
J Biol Chem
, vol.287
, pp. 6539-6550
-
-
Camp, N.D.1
-
19
-
-
77649265091
-
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
-
Komatsu, M. et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12, 213-223 (2010).
-
(2010)
Nat Cell Biol
, vol.12
, pp. 213-223
-
-
Komatsu, M.1
-
20
-
-
84861312722
-
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function
-
Ma, J. et al. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol 32, 1506-1517 (2012).
-
(2012)
Mol Cell Biol
, vol.32
, pp. 1506-1517
-
-
Ma, J.1
-
21
-
-
84876011848
-
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitiniation
-
Hast, B. E. et al. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitiniation. Cancer Res 73, 2199-2210 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 2199-2210
-
-
Hast, B.E.1
-
22
-
-
84884215156
-
BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival
-
Gorrini, C. et al. BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. J Exp Med 210, 1529-1544 (2013).
-
(2013)
J Exp Med
, vol.210
, pp. 1529-1544
-
-
Gorrini, C.1
-
23
-
-
54249087596
-
RNAi-mediated silencing of nuclear factor erythroid-3-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
-
Singh, A. et al. RNAi-mediated silencing of nuclear factor erythroid-3-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res 68, 7975-7984 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 7975-7984
-
-
Singh, A.1
-
24
-
-
66149168685
-
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
-
Homma, S. et al. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer. Clin Cancer Res 15, 3423-3432 (2009).
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3423-3432
-
-
Homma, S.1
-
25
-
-
77951710223
-
Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells
-
Hong, Y. B. et al. Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells. Pancreas 39, 463-472 (2010).
-
(2010)
Pancreas
, vol.39
, pp. 463-472
-
-
Hong, Y.B.1
-
26
-
-
79953889329
-
Nrf2 is overexpressed in pancreatic cancer: Implications for cell proliferation and therapy
-
Lister, A. et al. Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy. Mol Cancer 10, 37 (2011).
-
(2011)
Mol Cancer
, vol.10
, pp. 37
-
-
Lister, A.1
-
27
-
-
84869087891
-
Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
-
Yamadori, T. et al. Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers. Oncogene 31, 4768-4777 (2012).
-
(2012)
Oncogene
, vol.31
, pp. 4768-4777
-
-
Yamadori, T.1
-
28
-
-
84896716558
-
Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine
-
Duong, H.-Q. et al. Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine. Int J Oncol 44, 959-969 (2014).
-
(2014)
Int J Oncol
, vol.44
, pp. 959-969
-
-
Duong, H.-Q.1
-
29
-
-
84901018671
-
Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: Involvement of TET-dependent DNA demethylation
-
Kang, K. A. et al. Epigenetic modification of Nrf2 in 5-fluorouracil-resistant colon cancer cells: involvement of TET-dependent DNA demethylation. Cell Death Dis 5, e1183 (2014).
-
(2014)
Cell Death Dis
, vol.5
, pp. e1183
-
-
Kang, K.A.1
-
30
-
-
7944223780
-
Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
-
Li, Y. M. et al. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 6, 459-469 (2004).
-
(2004)
Cancer Cell
, vol.6
, pp. 459-469
-
-
Li, Y.M.1
-
31
-
-
7444271583
-
BRCA1 induces antioxidant gene expression and resistance to oxidative stress
-
Bae, I. et al. BRCA1 induces antioxidant gene expression and resistance to oxidative stress. Cancer Res 64, 7893-7909 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 7893-7909
-
-
Bae, I.1
-
32
-
-
13644268144
-
Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
-
Li, J. et al. Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicol Sci 83, 313-328 (2005).
-
(2005)
Toxicol Sci
, vol.83
, pp. 313-328
-
-
Li, J.1
-
33
-
-
84859029752
-
NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity
-
Manandhar, S. et al. NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity. Free Radic Biol Med 52, 1773-1785 (2012).
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 1773-1785
-
-
Manandhar, S.1
-
34
-
-
54949132514
-
The dark side of EGFP: Defective polyubiquitination
-
Baens, M. et al. The dark side of EGFP: defective polyubiquitination. PLoS One 1, e54 (2006).
-
(2006)
PLoS One
, vol.1
, pp. e54
-
-
Baens, M.1
-
35
-
-
0028170686
-
NEU tyrosine kinase and its association with transcriptional transactivation
-
NEU tyrosine kinase and its association with transcriptional transactivation. Biochem Biophys Res Commun 203, 1589-1598 (1994).
-
(1994)
Biochem Biophys Res Commun
, vol.203
, pp. 1589-1598
-
-
Xie, Y.1
Hung, M.C.2
-
36
-
-
4544376914
-
Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
-
Wang, S. C. et al. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell 6, 251-261 (2004).
-
(2004)
Cancer Cell
, vol.6
, pp. 251-261
-
-
Wang, S.C.1
-
37
-
-
34249845380
-
Characterization of a novel tripartite nuclear localization sequence in the EGFR family
-
Hsu, S. C. & Hung, M. C. Characterization of a novel tripartite nuclear localization sequence in the EGFR family. J Biol Chem 282, 10432-10440 (2007).
-
(2007)
J Biol Chem
, vol.282
, pp. 10432-10440
-
-
Hsu, S.C.1
Hung, M.C.2
-
38
-
-
78649740898
-
Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3
-
Béguelin, W. et al. Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3. Mol Cell Biol 30, 5456-5472 (2010).
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5456-5472
-
-
Béguelin, W.1
-
39
-
-
79958789805
-
Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes
-
Li, L. Y. et al. Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res 71, 4269-4279 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 4269-4279
-
-
Li, L.Y.1
|