메뉴 건너뛰기




Volumn 15, Issue 1, 2015, Pages

The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M

Author keywords

c Src; Cell surface GRP78; EGFR; Hepatocellular carcinoma; Invasion; Metastasis

Indexed keywords

ALPHA 2 MACROGLOBULIN; BIOTIN; CORTACTIN; FIBRONECTIN; GLUCOSE REGULATED PROTEIN 78; MESSENGER RNA; PAXILLIN; PROTEIN TYROSINE KINASE; CSK TYROSINE-PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PROTEIN BINDING;

EID: 84930207356     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1401-z     Document Type: Article
Times cited : (32)

References (39)
  • 1
    • 49349109364 scopus 로고    scopus 로고
    • Recent advances in the natural history of hepatocellular carcinoma
    • Trevisani F, Cantarini MC, Wands JR, Bernardi M. Recent advances in the natural history of hepatocellular carcinoma. Carcinogenesis. 2008;29:1299-305.
    • (2008) Carcinogenesis , vol.29 , pp. 1299-1305
    • Trevisani, F.1    Cantarini, M.C.2    Wands, J.R.3    Bernardi, M.4
  • 2
    • 79955637310 scopus 로고    scopus 로고
    • The biological and therapeutic relevance of mRNA translation in cancer
    • Blagden SP, Willis AE. The biological and therapeutic relevance of mRNA translation in cancer. Nat Rev Clin Oncol. 2011;8:280-91.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 280-291
    • Blagden, S.P.1    Willis, A.E.2
  • 3
    • 78651388262 scopus 로고    scopus 로고
    • Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen
    • Misra UK, Payne S, Pizzo SV. Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen. J Biol Chem. 2011;286:1248-59.
    • (2011) J Biol Chem , vol.286 , pp. 1248-1259
    • Misra, U.K.1    Payne, S.2    Pizzo, S.V.3
  • 4
    • 7244242265 scopus 로고    scopus 로고
    • alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers
    • Sukata T, Uwagawa S, Ozaki K, Sumida K, Kikuchi K, Kushida M, et al. alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. Am J Pathol. 2004;165:1479-88.
    • (2004) Am J Pathol , vol.165 , pp. 1479-1488
    • Sukata, T.1    Uwagawa, S.2    Ozaki, K.3    Sumida, K.4    Kikuchi, K.5    Kushida, M.6
  • 5
    • 77956165188 scopus 로고    scopus 로고
    • GRP78 signaling hub a receptor for targeted tumor therapy
    • Sato M, Yao VJ, Arap W, Pasqualini R. GRP78 signaling hub a receptor for targeted tumor therapy. Adv Genet. 2010;69:97-114.
    • (2010) Adv Genet , vol.69 , pp. 97-114
    • Sato, M.1    Yao, V.J.2    Arap, W.3    Pasqualini, R.4
  • 6
    • 84874112079 scopus 로고    scopus 로고
    • The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
    • Luo B, Lee AS. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene. 2013;32:805-18.
    • (2013) Oncogene , vol.32 , pp. 805-818
    • Luo, B.1    Lee, A.S.2
  • 7
    • 4544255170 scopus 로고    scopus 로고
    • Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
    • Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, Arap W, et al. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell. 2004;6:275-84.
    • (2004) Cancer Cell , vol.6 , pp. 275-284
    • Arap, M.A.1    Lahdenranta, J.2    Mintz, P.J.3    Hajitou, A.4    Sarkis, A.S.5    Arap, W.6
  • 8
    • 79952842932 scopus 로고    scopus 로고
    • The critical role of GRP78 in physiologic and pathologic stress
    • Pfaffenbach KT, Lee AS. The critical role of GRP78 in physiologic and pathologic stress. Curr Opin Cell Biol. 2011;23:150-6.
    • (2011) Curr Opin Cell Biol , vol.23 , pp. 150-156
    • Pfaffenbach, K.T.1    Lee, A.S.2
  • 9
    • 84897036337 scopus 로고    scopus 로고
    • Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential
    • Lee AS. Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer. 2014;14:263-76.
    • (2014) Nat Rev Cancer , vol.14 , pp. 263-276
    • Lee, A.S.1
  • 10
    • 85046915739 scopus 로고    scopus 로고
    • Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells
    • Misra UK, Pizzo SV. Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. Cancer Biol Ther. 2010;9:142-52.
    • (2010) Cancer Biol Ther , vol.9 , pp. 142-152
    • Misra, U.K.1    Pizzo, S.V.2
  • 11
    • 66849083879 scopus 로고    scopus 로고
    • Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis
    • Misra UK, Mowery Y, Kaczowka S, Pizzo SV. Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis. Mol Cancer Ther. 2009;8:1350-62.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1350-1362
    • Misra, U.K.1    Mowery, Y.2    Kaczowka, S.3    Pizzo, S.V.4
  • 12
    • 76749104619 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation
    • Misra UK, Kaczowka S, Pizzo SV. Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation. Biochem Biophys Res Commun. 2010;392:538-42.
    • (2010) Biochem Biophys Res Commun , vol.392 , pp. 538-542
    • Misra, U.K.1    Kaczowka, S.2    Pizzo, S.V.3
  • 14
    • 84899425243 scopus 로고    scopus 로고
    • Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity
    • Cardoso AP, Pinto ML, Pinto AT, Oliveira MI, Pinto MT, Gonçalves R, et al. Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity. Oncogene. 2014;33:2123-33.
    • (2014) Oncogene , vol.33 , pp. 2123-2133
    • Cardoso, A.P.1    Pinto, M.L.2    Pinto, A.T.3    Oliveira, M.I.4    Pinto, M.T.5    Gonçalves, R.6
  • 15
    • 84860535263 scopus 로고    scopus 로고
    • p120RasGAP-mediated activation of c-Src is critical for oncogenic Ras to induce tumor invasion
    • Chan P-C, Chen H-C. p120RasGAP-mediated activation of c-Src is critical for oncogenic Ras to induce tumor invasion. Cancer Res. 2012;72:2405-15.
    • (2012) Cancer Res , vol.72 , pp. 2405-2415
    • Chan, P.-C.1    Chen, H.-C.2
  • 16
    • 55849126233 scopus 로고    scopus 로고
    • Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family
    • Shepard HM, Brdlik CM, Schreiber H. Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family. J Clin Invest. 2008;118:3574-81.
    • (2008) J Clin Invest , vol.118 , pp. 3574-3581
    • Shepard, H.M.1    Brdlik, C.M.2    Schreiber, H.3
  • 17
    • 0033583220 scopus 로고    scopus 로고
    • c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function
    • Biscardi JS, Maa MC, Tice DA, Cox ME, Leu TH, Parsons SJ. c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function. J Biol Chem. 1999;274:8335-43.
    • (1999) J Biol Chem , vol.274 , pp. 8335-8343
    • Biscardi, J.S.1    Maa, M.C.2    Tice, D.A.3    Cox, M.E.4    Leu, T.H.5    Parsons, S.J.6
  • 18
    • 22544456920 scopus 로고    scopus 로고
    • Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK
    • Misra UK, Deedwania R, Pizzo SV. Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. J Biol Chem. 2005;280:26278-86.
    • (2005) J Biol Chem , vol.280 , pp. 26278-26286
    • Misra, U.K.1    Deedwania, R.2    Pizzo, S.V.3
  • 19
    • 57649217290 scopus 로고    scopus 로고
    • Blockade of the RhoA-JNK-c-Jun-MMP2 Cascade by Atorvastatin Reduces Osteosarcoma Cell Invasion
    • Fromigué O, Hamidouche Z, Marie PJ. Blockade of the RhoA-JNK-c-Jun-MMP2 Cascade by Atorvastatin Reduces Osteosarcoma Cell Invasion. J Biol Chem. 2008;283:30549-56.
    • (2008) J Biol Chem , vol.283 , pp. 30549-30556
    • Fromigué, O.1    Hamidouche, Z.2    Marie, P.J.3
  • 20
    • 84863548661 scopus 로고    scopus 로고
    • Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response
    • Sangodkar J, Dhawan NS, Melville H, Singh VJ, Yuan E, Rana H, et al. Targeting the FOXO1/KLF6 axis regulates EGFR signaling and treatment response. J Clin Invest. 2012;122:2637-51.
    • (2012) J Clin Invest , vol.122 , pp. 2637-2651
    • Sangodkar, J.1    Dhawan, N.S.2    Melville, H.3    Singh, V.J.4    Yuan, E.5    Rana, H.6
  • 21
    • 84859598676 scopus 로고    scopus 로고
    • β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy
    • Eke I, Deuse Y, Hehlgans S, Gurtner K, Krause M, Baumann M, et al. β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy. J Clin Invest. 2012;122:1529-40.
    • (2012) J Clin Invest , vol.122 , pp. 1529-1540
    • Eke, I.1    Deuse, Y.2    Hehlgans, S.3    Gurtner, K.4    Krause, M.5    Baumann, M.6
  • 22
    • 84863545530 scopus 로고    scopus 로고
    • Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation
    • Sen A, De Castro I, Defranco DB, Deng F-M, Melamed J, Kapur P, et al. Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation. J Clin Invest. 2012;122:2469-81.
    • (2012) J Clin Invest , vol.122 , pp. 2469-2481
    • Sen, A.1    Castro, I.2    Defranco, D.B.3    Deng, F.-M.4    Melamed, J.5    Kapur, P.6
  • 23
    • 60549093068 scopus 로고    scopus 로고
    • Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells
    • Wang Y, Wang W, Wang S, Wang J, Shao S, Wang Q. Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells. BMC Cancer. 2008;8:372.
    • (2008) BMC Cancer , vol.8 , pp. 372
    • Wang, Y.1    Wang, W.2    Wang, S.3    Wang, J.4    Shao, S.5    Wang, Q.6
  • 24
    • 39149110297 scopus 로고    scopus 로고
    • Detecting protein-protein interactions by Far western blotting
    • Wu Y, Li Q, Chen X-Z. Detecting protein-protein interactions by Far western blotting. Nat Protoc. 2007;2:3278-84.
    • (2007) Nat Protoc , vol.2 , pp. 3278-3284
    • Wu, Y.1    Li, Q.2    Chen, X.-Z.3
  • 26
    • 67649256065 scopus 로고    scopus 로고
    • Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways
    • Kelber JA, Panopoulos AD, Shani G, Booker EC, Belmonte JC, Vale WW, et al. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene. 2009;28:2324-36.
    • (2009) Oncogene , vol.28 , pp. 2324-2336
    • Kelber, J.A.1    Panopoulos, A.D.2    Shani, G.3    Booker, E.C.4    Belmonte, J.C.5    Vale, W.W.6
  • 27
    • 77952061607 scopus 로고    scopus 로고
    • Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP
    • Zhang Y, Liu R, Ni M, Gill P, Lee AS. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. J Biol Chem. 2010;285:15065-75.
    • (2010) J Biol Chem , vol.285 , pp. 15065-15075
    • Zhang, Y.1    Liu, R.2    Ni, M.3    Gill, P.4    Lee, A.S.5
  • 28
    • 84893732761 scopus 로고    scopus 로고
    • The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells
    • Zhang X-X, Li H-D, Zhao S, Zhao L, Song H-J, Wang G, et al. The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells. BioMed Res Int. 2013;2013:917296.
    • (2013) BioMed Res Int , vol.2013 , pp. 917296
    • Zhang, X.-X.1    Li, H.-D.2    Zhao, S.3    Zhao, L.4    Song, H.-J.5    Wang, G.6
  • 29
    • 0034693877 scopus 로고    scopus 로고
    • Role of Src expression and activation in human cancer
    • Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene. 2000;19:5636-42.
    • (2000) Oncogene , vol.19 , pp. 5636-5642
    • Irby, R.B.1    Yeatman, T.J.2
  • 31
    • 84881247984 scopus 로고    scopus 로고
    • Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells
    • Omer A-a A Q, Yuen HF, Guo K, Zhang SD, Chung T-H, Chng WJ, et al. Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells. J Clin Invest. 2013;123:3459-71.
    • (2013) J Clin Invest , vol.123 , pp. 3459-3471
    • Omer, A.A.Q.1    Yuen, H.F.2    Guo, K.3    Zhang, S.D.4    Chung, T.-H.5    Chng, W.J.6
  • 32
    • 69849111159 scopus 로고    scopus 로고
    • Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling
    • Nautiyal J, Majumder P, Patel BB, Lee FY, Majumdar APN. Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling. Cancer Lett. 2009;283:143-51.
    • (2009) Cancer Lett , vol.283 , pp. 143-151
    • Nautiyal, J.1    Majumder, P.2    Patel, B.B.3    Lee, F.Y.4    Majumdar, A.P.N.5
  • 33
    • 84927127418 scopus 로고    scopus 로고
    • Activated α2-Macroglobulin Binding to Human Prostate Cancer Cells Triggers Insulin-like Responses
    • Misra UK, Pizzo SV. Activated α2-Macroglobulin Binding to Human Prostate Cancer Cells Triggers Insulin-like Responses. J Biol Chem. 2015;290:9571-87.
    • (2015) J Biol Chem , vol.290 , pp. 9571-9587
    • Misra, U.K.1    Pizzo, S.V.2
  • 34
    • 79952769966 scopus 로고    scopus 로고
    • Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma
    • De Ridder GG, Gonzalez-Gronow M, Ray R, Pizzo SV. Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma. Melanoma Res. 2011;21:35-43.
    • (2011) Melanoma Res , vol.21 , pp. 35-43
    • Ridder, G.G.1    Gonzalez-Gronow, M.2    Ray, R.3    Pizzo, S.V.4
  • 35
    • 84925662746 scopus 로고    scopus 로고
    • Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis
    • Zhu G, Lee AS. Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. J Cell Physiol. 2015;230:1413-20.
    • (2015) J Cell Physiol , vol.230 , pp. 1413-1420
    • Zhu, G.1    Lee, A.S.2
  • 36
    • 84890705779 scopus 로고    scopus 로고
    • Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis
    • Liu R, Li X, Gao W, Zhou Y, Wey S, Mitra SK, et al. Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis. Clin Cancer Res Off J Am Assoc Cancer Res. 2013;19:6802-11.
    • (2013) Clin Cancer Res Off J Am Assoc Cancer Res , vol.19 , pp. 6802-6811
    • Liu, R.1    Li, X.2    Gao, W.3    Zhou, Y.4    Wey, S.5    Mitra, S.K.6
  • 37
    • 37849035474 scopus 로고    scopus 로고
    • GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth
    • Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol. 2008;28:666-77.
    • (2008) Mol Cell Biol , vol.28 , pp. 666-677
    • Shani, G.1    Fischer, W.H.2    Justice, N.J.3    Kelber, J.A.4    Vale, W.5    Gray, P.C.6
  • 38
    • 79951537603 scopus 로고    scopus 로고
    • Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting
    • Ni M, Zhang Y, Lee AS. Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J. 2011;434:181-8.
    • (2011) Biochem J , vol.434 , pp. 181-188
    • Ni, M.1    Zhang, Y.2    Lee, A.S.3
  • 39
    • 77952087611 scopus 로고    scopus 로고
    • The Par-4-GRP78 TRAIL, more twists and turns
    • Lee AS. The Par-4-GRP78 TRAIL, more twists and turns. Cancer Biol Ther. 2009;8:2103-5.
    • (2009) Cancer Biol Ther , vol.8 , pp. 2103-2105
    • Lee, A.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.