CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells

Cellular Signalling

Volumn 27, Issue 9, 2015, Pages 1694-1702

  Tang, Xun ^a   Chen, Xianzhen ^a   Xu, Yanfeng ^b   Qiao, Yongxia ^c   Zhang, Xiao ^a   Wang, Yulan ^a   Guan, Yu ^b   Sun, Fenyong ^a   Wang, Jiayi ^a,d  

^a TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d TONGJI UNIVERSITY   (China)

Author keywords

Apoptosis; Membrane protein; Signaling transduction; Tumorigenesis; Ubiquitination

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; BETA TRCP PROTEIN; CD146 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMURF1 PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ALCAM PROTEIN, HUMAN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; BTRC PROTEIN, HUMAN; FETOPROTEIN; LEUKOCYTE ANTIGEN; MCAM PROTEIN, HUMAN; NERVE CELL ADHESION MOLECULE; RAF PROTEIN; SMURF1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BEL 7402 CELL LINE; CARCINOMA CELL; CARCINOMA CELL LINE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; BIOLOGICAL MODEL; GENETICS; LIVER TUMOR; METABOLISM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD146; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CARCINOMA, HEPATOCELLULAR; CELL ADHESION MOLECULES, NEURONAL; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FETAL PROTEINS; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; UBIQUITIN-PROTEIN LIGASES;

EID: 84930205418     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2015.05.006     Document Type: Article

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