Inhibition of FOXO3 tumor suppressor function by βTrCP1 through ubiquitin-mediated degradation in a tumor mouse model

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Tsai, Wen Bin ^a   Chung, Young Min ^b   Zou, Yiyu ^c   Park, See Hyoung ^b   Xu, Zhaohui ^d   Nakayama, Keiko ^e   Lin, Sue Hwa ^a   Hu, Mickey C T ^b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN 1; I KAPPA B KINASE BETA; TRANSCRIPTION FACTOR FKHRL1; UBIQUITIN; UNCLASSIFIED DRUG; BTRC PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TRANSCRIPTION INITIATION; TRANSCRIPTION TERMINATION; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; UPREGULATION; ANIMAL; CELL CYCLE; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; NUDE MOUSE; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALIA;

ANIMALS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; FLUORESCENT ANTIBODY TECHNIQUE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICE; MICE, NUDE; PHOSPHORYLATION; RNA, SMALL INTERFERING; UBIQUITIN;

EID: 77955366348     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011171     Document Type: Article

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