Skin aging modulates percutaneous drug absorption: the impact of ultraviolet irradiation and ovariectomy

Age

Volumn 37, Issue 2, 2015, Pages

  Hung, Chi Feng ^a   Chen, Wei Yu ^b,c   Aljuffali, Ibrahim A ^d   Lin, Yin Ku ^e,f   Shih, Hui Chi ^f,g   Fang, Jia You ^f,g  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^f CHANG GUNG UNIVERSITY   (Taiwan)

^g CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Epidermal junction; Ovariectomy; Percutaneous absorption; Photoaging; Ultraviolet

Indexed keywords

BETA CATENIN; DEXTRAN; ESTRADIOL; FILAGGRIN; INVOLUCRIN; MESSENGER RNA; RETINOIC ACID; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL JUNCTION; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DOWN REGULATION; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG PENETRATION; DRUG UPTAKE; FEMALE; HAIR FOLLICLE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MOUSE; NONHUMAN; OVARIECTOMY; PALLOR; PHOTOAGING; PROTEIN EXPRESSION; SKIN ABSORPTION; SKIN COLOR; SKIN PERMEABILITY; SKIN STRUCTURE; SKIN WATER LOSS; STRATUM CORNEUM; TIGHT JUNCTION; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ULTRAVIOLET IRRADIATION; ADHERENS JUNCTION; ANIMAL; COLORIMETRY; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; MENOPAUSE; NUDE MOUSE; PHYSIOLOGY; RADIATION RESPONSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN; THERMOREGULATION; ULTRAVIOLET RADIATION;

ADHERENS JUNCTIONS; ANIMALS; COLORIMETRY; ENVIRONMENTAL EXPOSURE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; MENOPAUSE; MICE; MICE, NUDE; OVARIECTOMY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN; SKIN AGING; TIGHT JUNCTIONS; TRETINOIN; ULTRAVIOLET RAYS; WATER LOSS, INSENSIBLE;

EID: 84930204674     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-015-9757-1     Document Type: Article

References (43)

1. Andrews SN, Jeong E, Prausnitz MR (2013) Transdermal delivery of molecules is limited by full epidermis, not just stratum corneum. Pharm Res 30:1099–1109
2. Antoniou C, Kosmadaki MG, Stratigos AJ, Katsambas AD (2010) Photoaging. Prevention and topical treatments. Am J Clin Dermatol 11:95–102
3. Calleja-Agius J, Brincat M (2012) The effect of menopause on the skin and other connective tissues. Gynecol Endocrinol 28:273–277
4. Calleja-Agius J, Muscat-Baron Y, Brincat MP (2007) Skin ageing. Menopause Int 13:60–64
5. Chen WY, Fang CL, Al-Suwayeh SA, Yang HH, Li YC, Fang JY (2013) Risk assessment of excess drug and sunscreen absorption via skin with ablative fractional laser resurfacing: optimization of the applied dose for postoperative care. Lasers Med Sci 28:1363–1374
6. Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE, Kimball AB (2005) Double-blinded placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg 31(Suppl 1):855–860
7. Cho S, Lowe L, Hamilton TA, Fisher GJ, Voorhees JJ, Kang S (2005) Long-term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis. J Am Acad Dermatol 53:769–774
8. Çömelekoğlu Ü, Yalin S, Balli E, Berköz M (2012) Ovariectomy decreases biomechanical quality of skin via oxidative stress in rat. Turk J Med Sci 42:201–209
9. Egras AM, Umland EM (2010) The role of transdermal estrogen sprays and estradiol topical emulsion in the management of menopause-associated vasomotor symptoms. Int J Gen Med 3:147–151
10. Fang JY, Yu SY, Wu PC, Huang YB, Tsai YH (2001) In vitro skin permeation of estradiol from various proniosome formulations. Int J Pharm 215:91–99
11. Farage MA, Miller KW, Berardesca E, Maibach HI (2009) Clinical implications of aging skin. Am J Clin Dermatol 10:73–86
12. Gattu S, Maibach HI (2010) Enhanced absorption through damaged skin: an overview of the in vitro human model. Skin Pharmacol Physiol 23:171–176
13. Has C, Spartà G, Kiritsi D, Weibel L, Moeller A, Vega-Warner V, Waters A, He Y, Anikster Y, Esser P, Straub BK, Hausser I, Bockenhauer D, Dekel B, Hildebrandt F, Bruckner-Tuderman L, Laube GF (2012) Integrin α3 mutations with kidney, lung, and skin disease. N Engl J Med 366:1508–1514
14. Hsieh PW, Chen WY, Aljuffali IA, Chen CC, Fang JY (2013) Co-drug strategy for promoting skin targeting and minimizing transdermal diffusion of hydroquinone and tranexamic acid. Curr Med Chem 20:4080–4092
15. Hung CF, Fang CL, Al-Suwayeh SA, Yang SY, Fang JY (2012) Evaluation of drug and sunscreen permeation via skin irradiated with UVA and UVB: comparisons of normal skin and chronologically aged skin. J Dermatol Sci 68:135–148
16. Jensen JM, Schütze S, Neumann C, Proksch E (2000) Impaired cutaneous permeability barrier function, skin hydration, and sphingomyelinase activity in keratin 10 deficient mice. J Invest Dermatol 115:708–713
17. Kawasaki H, Nagao K, Kubo A, Hata T, Shimizu A, Mizuno H, Yamada T, Amagai M (2012) Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J Allergy Clin Immunol 129:1538–1546
18. Kezic S, Kammeyer A, Calkoen F, Fluhr JW, Bos JD (2009) Natural moisturing factor components in the stratum corneum as biomarkers of filaggrin genotype: evaluation of minimally invasive methods. Br J Dermatol 161:1098–1104
19. Kirschner N, Houdek P, Fromm M, Moll I, Brandner JM (2010) Tight junctions form a barrier in human epidermis. Eur J Cell Biol 89:839–842
20. Knorr F, Lademann J, Patzelt A, Sterry W, Blume-Peytavi U, Vogt A (2009) Follicular transport route—research progress and future perspectives. Eur J Pharm Biopharm 71:173–180
21. Levin J, Friedlander SF, Del Rosso JQ (2013) Atopic dermatitis and the stratum corneum. Part 1: the role of filaggrin in the stratum corneum barrier and atopic skin. J Clin Aesthet Dermatol 6:16–22
22. Lin CH, Fang YP, Al-Suwayeh SA, Yang SY, Fang JY (2013) Percutaneous absorption and antibacterial activities of lipid nanocarriers loaded with dual drugs for acne treatment. Biol Pharm Bull 36:276–286
23. Mansouri P, Chalangari R, Chalangari KMC, Saffarian Z (2014) Chapter 25. Skin aging and immune system. In: Massoud A, Rezaei N (eds) Immunology of aging. Springer, Berlin
24. Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB (2014) Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal 20:1126–1167
25. Miura T, Takada A, Ooe M (2012) Tretinoin cyclodextrin complex (RA/CyD) causes less irritation with an equal antiwrinkle effect compared with conventional tretinoin: clinical and histologic studies of photoaged skin. Aesthet Plast Surg 36:971–981
26. Mueck AO (2012) Postmenopausal hormone replacement therapy and cardiovascular disease: the value of transdermal estradiol and micronized progesterone. Climacteric 15(Suppl 1):11–17
27. Nakai K, Yoneda K, Hosokawa Y, Moriue T, Presland RB, Fallon PG, Kabashima K, Kosaka H, Kubota Y (2012) Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies. Am J Pathol 181:969–977
28. Niessen CM (2007) Tight junctions/adherens junctions: basic structure and function. J Invest Dermatol 127:2525–2532
29. Parchami A, Fatahian Dehkordi RA (2010) Effect of ovariectomy and chronic sex steroid administration on rabbit skin. Glob Vet 4:610–615
30. Pillai S, Oresajo C, Hayward J (2005) Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation—a review. Int J Cosmet Sci 27:17–34
31. Proksch E, Folster-Holst R, Jensen JM (2006) Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci 43:159–169
32. Proksch E, Brandner JM, Jensen JM (2008) The skin: an indispensable barrier. Exp Dermatol 17:1063–1072
33. Ray S, Foote HP, Lechler T (2013) β-Catenin protects the epidermis from mechanical stresses. J Cell Biol 202:45–52
34. Roberts WE (2006) Dermatologic problems of older women. Dermatol Clin 24:271–280
35. Röck K, Meusch M, Fuchs N, Tigges J, Zipper P, Fritsche E, Krutmann J, Homey B, Reifenberger J, Fischer JW (2012) Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes. J Biol Chem 287:20056–20069
36. Šitum M, Buljan M, Čavka V, Bulat V, Krolo I, Mihić LL (2010) Skin changes in the elderly people—how strong is the influence of the UV radiation on skin aging? Coll Antropol 34(Suppl 2):9–13
37. Teichmann A, Jacobi U, Ossadnik M, Richter H, Koch S, Sterry W, Lademann J (2005) Differential stripping: determination of the amount of topically applied substances penetrated into the hair follicles. J Invest Dermatol 125:264–269
38. Tsukahara K, Nakagawa H, Moriwaki S, Kakuo S, Ohuchi A, Takema Y, Imokawa G (2004) Ovariectomy is sufficient to accelerate spontaneous skin ageing and to stimulate ultraviolet irradiation-induced photoaging of murine skin. Br J Dermatol 151:984–994
39. Tsukahara K, Moriwaki S, Hotta M, Fujimura T, Sugiyama-Nakagiri Y, Sugawara S, Kitahara T, Takema Y (2005) The effect of sunscreen on skin elastase activity induced by ultraviolet-A irradiation. Biol Pharm Bull 28:2302–2307
40. Tsukahara K, Kakuo S, Moriwaki S, Hotta M, Ohuchi A, Kitahara T, Harada N (2008) The characteristics of aromatase deficient hairless mice indicate important roles of extragonadal estrogen in the skin. J Steroid Biochem Mol Biol 108:82–90
41. Tunggal J, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24:1146–1156
42. Yamamoto T, Kurasawa M, Hattori T, Maeda T, Nakano H, Sasaki H (2008) Relationship between expression of tight junction-related molecules and perturbed epidermal barrier function in UVB-irradiated hairless mice. Arch Dermatol Res 300:61–68
43. Yuki T, Hachiya A, Kusaka A, Sriwiriyanont P, Visscher MO, Morita K, Muto M, Miyachi Y, Sugiyama Y, Inoue S (2011) Characterization of tight junctions and their disruption by UVB in human epidermis and cultured keratinocytes. J Invest Dermatol 131:744–752