Neuromodulation Therapies for Geriatric Depression

Current Psychiatry Reports

Volumn 17, Issue 7, 2015, Pages

  Gálvez, Verònica ^a,b   Ho, Kerrie Anne ^a,b   Alonzo, Angelo ^a,b   Martin, Donel ^a,b   George, Duncan ^a,b   Loo, Colleen K ^a,b,c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b BLACK DOG INSTITUTE   (Australia)

^c ST GEORGE HOSPITAL   (Australia)

Author keywords

Depression; Electroconvulsive therapy (ECT); Geriatric; Neuromodulation; Repetitive transcranial magnetic stimulation (rTMS); Transcranial direct current stimulation (tDCS)

Indexed keywords

ABSENCE OF COMPLICATIONS; AGE; AGED; AGING; ANXIETY; BRAIN DEPTH STIMULATION; BRAIN DYSFUNCTION; CARDIOVASCULAR RISK; COGNITION; CONJUNCTIVITIS; CRYING; DEPRESSION; DIZZINESS; ELECTROCONVULSIVE THERAPY; ELECTRODE; GERIATRICS; HEADACHE; HUMAN; MAGNETIC SEIZURE THERAPY; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); NEUROMODULATION; PAIN; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION; REVIEW; RISK BENEFIT ANALYSIS; SAFETY; TRANSCRANIAL DIRECT CURRENT STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; VAGUS NERVE STIMULATION; ADVERSE EFFECTS; COMPLICATION; DEPRESSIVE DISORDER, MAJOR; MEMORY; MEMORY DISORDERS; PATIENT SAFETY; PROCEDURES; SEIZURE; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; COGNITION; DEEP BRAIN STIMULATION; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; ELECTROCONVULSIVE THERAPY; HUMANS; MEMORY; MEMORY DISORDERS; PATIENT SAFETY; SEIZURES; TRANSCRANIAL DIRECT CURRENT STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; TREATMENT OUTCOME; VAGUS NERVE STIMULATION;

EID: 84930204112     PISSN: 15233812     EISSN: 15351645     Source Type: Journal    
DOI: 10.1007/s11920-015-0592-y     Document Type: Review

References (130)

1. Van der Wurff FB, Stek ML, Hoogendijk WL, Beekman AT. Electroconvulsive therapy for the depressed elderly. Cochrane Database Syst Rev. 2003;(2):CD003593.
2. Katon WJ, Lin E, Russo J, Unutzer J. Increased medical costs of a population-based sample of depressed elderly patients. Arch Gen Psychiatry. 2003;60:897–903.
3. Ismail Z, Fischer C, McCall WV. What characterizes late-life depression? Psychiatr Clin North Am. 2013;36:483–96.
4. Dillon C, Allegri RF, Serrano CM, Iturry M, Salgado P, Glaser FB, et al. Late- versus early-onset geriatric depression in a memory research center. Neuropsychiatr Dis Treat. 2009;5:517–26.
5. Aziz R, Steffens DC. What are the causes of late-life depression? Psychiatr Clin North Am. 2013;36:497–516.
6. Katona CL. Psychotropics and drug interactions in the elderly patient. Int J Geriatr Psychiatry. 2001;16 Suppl 1:S86–90.
7. Beekman AT, Geerlings SW, Deeg DJ, Smit JH, Schoevers RS, de Beurs E, et al. The natural history of late-life depression: a 6-year prospective study in the community. Arch Gen Psychiatry. 2002;59:605–11.
8. Reynolds 3rd CF, Frank E, Kupfer DJ, Thase ME, Perel JM, Mazumdar S, et al. Treatment outcome in recurrent major depression: a post hoc comparison of elderly ("young old") and midlife patients. Am J Psychiatry. 1996;153:1288–92.
9. Cooper C, Katona C, Lyketsos K, Blazer D, Brodaty H, Rabins P, et al. A systematic review of treatments for refractory depression in older people. Am J Psychiatry. 2011;168:681–8.
10. Dew MA, Whyte EM, Lenze EJ, Houck PR, Mulsant BH, Pollock BG, et al. Recovery from major depression in older adults receiving augmentation of antidepressant pharmacotherapy. Am J Psychiatry. 2007;164:892–9.
11. Coffey CE, Fochtmann LJ, Greenberg RM, Isenberg KE, Kellner CH, Moench LA, et al. The practice of electroconvulsive therapy: recommendations for treatment, training, and privileging: a task force report of the American Psychiatric Association. 2nd ed. Washington, D.C: American Psychiatric Association; 2001.
12. Leiknes KA, Jarosh-von Schweder L, Hoie B. Contemporary use and practice of electroconvulsive therapy worldwide. Brain Behav. 2012;2:283–344.
13. Glen T, Scott AI. Rates of electroconvulsive therapy use in Edinburgh (1992–1997). J Affect Disord. 1999;54:81–5.
14. Plakiotis C, George K, O'Connor DW. Is electroconvulsive therapy use among young-old and old-old adults comparable? A 10-year population-level analysis of service provision. J ECT. 2014;30:232–41.
15. Chanpattana W. A questionnaire survey of ECT practice in Australia. J ECT. 2007;23:89–92.
16. Organization WH. Figures and Facts About Suicide. In: Department of Mental Health WHO, editor. Geneva, Switzerland: http://whqlibdoc.who.int/hq/1999/WHO_MNH_MBD_99.1.pdf; 1999. p. 1–122.
17. Pearson JL. Recent research on suicide in the elderly. Curr Psychiatry Rep. 2002;4:59–63.
18. Conwell Y, Duberstein PR, Cox C, Herrmann J, Forbes N, Caine ED. Age differences in behaviors leading to completed suicide. Am J Geriatr Psychiatry. 1998;6:122–6.
19. McCall WV, Cohen W, Reboussin B, Lawton P. Pretreatment differences in specific symptoms and quality of life among depressed inpatients who do and do not receive electroconvulsive therapy: a hypothesis regarding why the elderly are more likely to receive ECT. J ECT. 1999;15:193–201.
20. Mulsant BH, Houck PR, Gildengers AG, Andreescu C, Dew MA, Pollock BG, et al. What is the optimal duration of a short-term antidepressant trial when treating geriatric depression? J Clin Psychopharmacol. 2006;26:113–20.
21. Group UER. Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet. 2003;361:799–808.
22. Spaans HP, Sienaert P, Bouckaert F, van den Berg JF, Verwijk E, Kho KH, et al. Speed of remission in elderly patients with depression: electroconvulsive therapy v. medication. Br J Psychiatry. 2015;206:67–71. First study evidencing ECT is superior to pharmacotherapy in the treatment of severe unipolar geriatric depression.
23. Kok RM, Nolen WA, Heeren TJ. Venlafaxine versus nortriptyline in the treatment of elderly depressed inpatients: a randomised, double-blind, controlled trial. Int J Geriatr Psychiatry. 2007;22:1247–54.
24. Spaans HP, Verwijk E, Comijs HC, Kok RM, Sienaert P, Bouckaert F, et al. Efficacy and cognitive side effects after brief pulse and ultrabrief pulse right unilateral electroconvulsive therapy for major depression: a randomized, double-blind, controlled study. J Clin Psychiatry. 2013;74:e1029–36.
25. Paykel ES. Achieving gains beyond response. Acta Psychiatr Scand Suppl. 2002;415:12–7.
26. O'Connor MK, Knapp R, Husain M, Rummans TA, Petrides G, Smith G, et al. The influence of age on the response of major depression to electroconvulsive therapy: a C.O.R.E. Report. Am J Geriatr Psychiatry. 2001;9:382–90.
27. van der Wurff FB, Stek ML, Hoogendijk WJ, Beekman AT. The efficacy and safety of ECT in depressed older adults: a literature review. Int J Geriatr Psychiatry. 2003;18:894–904.
28. Tew Jr JD, Mulsant BH, Haskett RF, Prudic J, Thase ME, Crowe RR, et al. Acute efficacy of ECT in the treatment of major depression in the old-old. Am J Psychiatry. 1999;156:1865–70.
29. Kellner CH, Knapp R, Husain MM, Rasmussen K, Sampson S, Cullum M, et al. Bifrontal, bitemporal and right unilateral electrode placement in ECT: randomised trial. Br J Psychiatry. 2010;196:226–34.
30. Sanghani SPG, Knapp R, Husain M, Sampson S, Bailine S, Rasmussen K, et al. Differential Effect of Three Electrode Placements in Older vs Younger Patients with Severe Depression treated with Electroconvulsive Therapy (ECT). Am J Geriatr Psychiatry. 2014;22:S114.
31. Rhebergen D, Huisman A, Bouckaert F, Kho K, Kok R, Sienaert P, et al. Older age is associated with rapid remission of depression after electroconvulsive therapy: a latent class growth analysis. Am J Geriatr Psychiatry. 2015;23(3):274–82. ECT predicts rapid remission in the elderly, even after controlling for potential confounders (e.g. age, gender, pulse-width).
32. Coffey CE, Figiel GS, Djang WT, Weiner RD. Subcortical hyperintensity on magnetic resonance imaging: a comparison of normal and depressed elderly subjects. Am J Psychiatry. 1990;147:187–9.
33. Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. 'Vascular depression' hypothesis. Arch Gen Psychiatry. 1997;54:915–22.
34. Fink M. Electroshock revisited. Am Sci. 2000;88:162–7.
35. Brodaty H, Luscombe G, Parker G, Wilhelm K, Hickie I, Austin MP, et al. Increased rate of psychosis and psychomotor change in depression with age. Psychol Med. 1997;27:1205–13.
36. Hickie I, Mason C, Parker G, Brodaty H. Prediction of ECT response: validation of a refined sign-based (CORE) system for defining melancholia. Br J Psychiatry. 1996;169:68–74.
37. Rasmussen KG. Electroconvulsive therapy and melancholia: review of the literature and suggestions for further study. J ECT. 2011;27:315–22.
38. Oudega ML, van Exel E, Stek ML, Wattjes MP, van der Flier WM, Comijs HC, et al. The structure of the geriatric depressed brain and response to electroconvulsive therapy. Psychiatry Res. 2014;222:1–9. Specific structural alterations in the geriatric brain might predict response and speed of response to ECT.
39. Oudega ML, van Exel E, Wattjes MP, Comijs HC, Scheltens P, Barkhof F, et al. White matter hyperintensities, medial temporal lobe atrophy, cortical atrophy, and response to electroconvulsive therapy in severely depressed elderly patients. J Clin Psychiatry. 2011;72:104–12.
40. Aizenstein HJ, Khalaf A, Walker SE, Andreescu C. Magnetic resonance imaging predictors of treatment response in late-life depression. J Geriatr Psychiatry Neurol. 2014;27:24–32.
41. O'Connor DW, Gardner B, Eppingstall B, Tofler D. Cognition in elderly patients receiving unilateral and bilateral electroconvulsive therapy: a prospective, naturalistic comparison. J Affect Disord. 2010;124:235–40.
42. Stoppe A, Louza M, Rosa M, Gil G, Rigonatti S. Fixed high-dose electroconvulsive therapy in the elderly with depression: a double-blind, randomized comparison of efficacy and tolerability between unilateral and bilateral electrode placement. J ECT. 2006;22:92–9.
43. Bjolseth TM, Engedal K, Benth JS, Dybedal GS, Gaarden TL, Tanum L. Clinical efficacy of formula-based bifrontal versus right unilateral electroconvulsive therapy (ECT) in the treatment of major depression among elderly patients: a pragmatic, randomized, assessor-blinded, controlled trial. J Affect Disord. 2014;175C:8–17.
44. Loo CK, Katalinic N, Smith DJ, Ingram A, Dowling N, Martin D et al. A randomized controlled trial of brief and ultrabrief pulse right unilateral electroconvulsive therapy. Int J Neuropsychopharmacol. 2014;18. doi: 10.1093/ijnp/pyu045.
45. Tor PC, Bautovich A, Wang MJ, Martin D, Harvey S, Loo CK. A Systematic Review and Meta–Analysis of Brief versus Ultrabrief Right Unilateral Electroconvulsive Therapy for Depression. J Clin Psych. 2015. In press.
46. Loo CK, Sainsbury K, Sheehan P, Lyndon B. A comparison of RUL ultrabrief pulse (0.3 ms) ECT and standard RUL ECT. Int J Neuropsychopharmacol. 2008;11:883–90.
47. Sackeim HA, Prudic J, Nobler MS, Fitzsimons L, Lisanby SH, Payne N, et al. Effects of pulse width and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. Brain Stimul. 2008;1:71–83.
48. Coffey CE, Cummings JL. Electroconvulsive Therapy. Textbook of Geriatric Neuropsychiatry. 2nd ed. Washington DC: American Psychiatric Press; 2000. p. 829–59.
49. Sackeim HA, Decina P, Portnoy S, Neeley P, Malitz S. Studies of dosage, seizure threshold, and seizure duration in ECT. Biol Psychiatry. 1987;22:249–68.
50. Gálvez V, Hadzi-Pavlovic D, Smith D, Loo CK. Predictors of seizure threshold in right unilateral ultrabrief electroconvulsive therapy: role of concomitant medications and anaesthesia used. Brain Stimul. 2015. doi:10.1016/j.brs.2014.12.012.
51. Mayur P, Byth K, Harris A. Acute antidepressant effects of right unilateral ultra-brief ECT: a double-blind randomised controlled trial. J Affect Disord. 2013;149:426–9.
52. Coffey CE, Lucke J, Weiner RD, Krystal AD, Aque M. Seizure threshold in electroconvulsive therapy (ECT) II. The anticonvulsant effect of ECT. Biol Psychiatry. 1995;37:777–88.
53. Krystal AD, Coffey CE, Weiner RD, Holsinger T. Changes in seizure threshold over the course of electroconvulsive therapy affect therapeutic response and are detected by ictal EEG ratings. J Neuropsychiatry Clin Neurosci. 1998;10:178–86.
54. Loo CK, Mahon M, Katalinic N, Lyndon B, Hadzi-Pavlovic D. Predictors of response to ultrabrief right unilateral electroconvulsive therapy. J Affect Disord. 2011;130:192–7.
55. Kellner CH, Lisanby SH, Weiner R, Prudic J, Rudorfer MV, Young RC, et al. Speed of response to electroconvulsive therapy compared with ketamine. Psychiatry Res. 2015;225:215. Preliminary data suggests ultrabrief right unilateral ECT might be an efficacious, fast and safe ECT modality for the elderly depressed.
56. Lisanby SH, Husain MM, Knapp RG, Mueller M, McCall VW, Petrides G, et al. Ultrabrief right unilateral ECT in geriatric depression: antidepressant and cognitive outcomes. Abstracts from 69th Annual Scientific and Convention Meeting. Biol Psychiatry. 2014;75:9S.
57. van Schaik AM, Comijs HC, Sonnenberg CM, Beekman AT, Sienaert P, Stek ML. Efficacy and safety of continuation and maintenance electroconvulsive therapy in depressed elderly patients: a systematic review. Am J Geriatr Psychiatry. 2012;20:5–17.
58. Verwijk E, Comijs HC, Kok RM, Spaans HP, Tielkes CE, Scherder EJ, et al. Short- and long-term neurocognitive functioning after electroconvulsive therapy in depressed elderly: a prospective naturalistic study. Int Psychogeriatr. 2014;26:315–24.
59. Gardner BK, O'Connor DW. A review of the cognitive effects of electroconvulsive therapy in older adults. J ECT. 2008;24:68–80.
60. Tielkes CE, Comijs HC, Verwijk E, Stek ML. The effects of ECT on cognitive functioning in the elderly: a review. Int J Geriatr Psychiatry. 2008;23:789–95.
61. Plakiotis C, Chin LF, O'Connor DW. Are reports of cognitive testing among older electroconvulsive therapy recipients clinically valid? J ECT. 2014;30:26–9.
62. Abete P, Della-Morte D, Gargiulo G, Basile C, Langellott A, Galizia G, et al. Cognitive impairment and cardiovascular diseases in the elderly. A heart-brain continuum hypothesis. Ageing Res Rev. 2014;18C:41–52.
63. Figiel GS, Coffey CE, Weiner RD. Brain Magnetic Resonance Imaging in Elderly Depressed Patients Receiving Electroconvulsive Therapy. Convuls Ther. 1989;5:26–34.
64. Figiel GS, Coffey CE, Djang WT, Hoffman Jr G, Doraiswamy PM. Brain magnetic resonance imaging findings in ECT-induced delirium. J Neuropsychiatry Clin Neurosci. 1990;2:53–8.
65. Legendre SA, Stern RA, Solomon DA, Furman MJ, Smith KE. The influence of cognitive reserve on memory following electroconvulsive therapy. J Neuropsychiatry Clin Neurosci. 2003;15:333–9.
66. Bai S, Loo C, Al Abed A, Dokos S. A computational model of direct brain excitation induced by electroconvulsive therapy: comparison among three conventional electrode placements. Brain Stimul. 2012;5:408–21.
67. Bai S, Loo C, Dokos S. Effects of electroconvulsive therapy stimulus pulsewidth and amplitude computed with an anatomically-realistic head model. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2559–62.
68. Sackeim HA, Prudic J, Fuller R, Keilp J, Lavori PW, Olfson M. The cognitive effects of electroconvulsive therapy in community settings. Neuropsychopharmacology. 2007;32:244–54.
69. Riva-Posse P, Hermida AP, McDonald WM. The role of electroconvulsive and neuromodulation therapies in the treatment of geriatric depression. Psychiatr Clin North Am. 2013;36:607–30.
70. Rivera FA, Lapid MI, Sampson S, Mueller PS. Safety of electroconvulsive therapy in patients with a history of heart failure and decreased left ventricular systolic heart function. J ECT. 2011;27:207–13.
71. Mueller PS, Albin SM, Barnes RD, Rasmussen Jr KG. Safety of electroconvulsive therapy in patients with unrepaired abdominal aortic aneurysm: report of 8 patients. J ECT. 2009;25:165–9.
72. O'Reardon JP, Cristancho MA, Ryley B, Patel KR, Haber HL. Electroconvulsive therapy for treatment of major depression in a 100-year-old patient with severe aortic stenosis: a 5-year follow-up report. J ECT. 2011;27:227–30.
73. de Carle AJ, Kohn R. Risk factors for falling in a psychogeriatric unit. Int J Geriatr Psychiatry. 2001;16:762–7.
74. Cattan RA, Barry PP, Mead G, Reefe WE, Gay A, Silverman M. Electroconvulsive therapy in octogenarians. J Am Geriatr Soc. 1990;38:753–8.
75. Berlim MT, van den Eynde F, Tovar-Perdomo S, Daskalakis ZJ. Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials. Psychol Med. 2014;44:225–39.
76. Su TP, Huang CC, Wei IH. Add-on rTMS for medication-resistant depression: a randomized, double-blind, sham-controlled trial in Chinese patients. J Clin Psychiatry. 2005;66:930–7.
77. Padberg F, Zwanzger P, Thoma H, Kathmann N, Haag C, Greenberg BD, et al. Repetitive transcranial magnetic stimulation (rTMS) in pharmacotherapy-refractory major depression: comparative study of fast, slow and sham rTMS. Psychiatry Research. 1999;88(3):163–171
78. Fregni F, Marcolin MA, Myczkowski M, Amiaz R, Hasey G, Rumi DO, et al. Predictors of antidepressant response in clinical trials of transcranial magnetic stimulation. Int J Neuropsychopharmacol. 2006;9:641–54.
79. Aguirre I, Carretero B, Ibarra O, Kuhalainen J, Martinez J, Ferrer A, et al. Age predicts low-frequency transcranial magnetic stimulation efficacy in major depression. J Affect Disord. 2011;130:466–9.
80. Pallanti S, Cantisani A, Grassi G, Antonini S, Cecchelli C, Burian J, et al. rTMS age-dependent response in treatment-resistant depressed subjects: a mini-review. CNS Spectr. 2012;17:24–30.
81. Figiel GS, Epstein C, McDonald WM, Amazon-Leece J, Figiel L, Saldivia A, et al. The use of rapid-rate transcranial magnetic stimulation (rTMS) in refractory depressed patients. J Neuropsychiatry Clin Neurosci. 1998;10:20–5.
82. Lee JC, Blumberger DM, Fitzgerald PB, Daskalakis ZJ, Levinson AJ. The role of transcranial magnetic stimulation in treatment-resistant depression: a review. Curr Pharm Des. 2012;18:5846–52.
83. Kozel FA, Nahas Z, de Brux C, Molloy M, Lorberbaum JP, Bohning D, et al. How coil-cortex distance relates to age, motor threshold, and antidepressant response to repetitive transcranial magnetic stimulation. J Neuropsychiatry Clin Neurosci. 2000;12:376–84.
84. Lisanby SH, Husain MM, Rosenquist PB, Maixner D, Gutierrez R, Krystal A, et al. Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology. 2009;34:522–34.
85. Herwig U, Fallgatter AJ, Hoppner J, Eschweiler GW, Kron M, Hajak G, et al. Antidepressant effects of augmentative transcranial magnetic stimulation: randomised multicentre trial. Br J Psychiatry. 2007;191:441–8.
86. Mogg A, Pluck G, Eranti SV, Landau S, Purvis R, Brown RG, et al. A randomized controlled trial with 4-month follow-up of adjunctive repetitive transcranial magnetic stimulation of the left prefrontal cortex for depression. Psychol Med. 2008;38:323–33.
87. Brakemeier EL, Luborzewski A, Danker-Hopfe H, Kathmann N, Bajbouj M. Positive predictors for antidepressive response to prefrontal repetitive transcranial magnetic stimulation (rTMS). J Psychiatr Res. 2007;41:395–403.
88. Allan CL, Herrmann LL, Ebmeier KP. Transcranial magnetic stimulation in the management of mood disorders. Neuropsychobiology. 2011;64:163–9.
89. Kedzior KK, Reitz SK. Short-term efficacy of repetitive transcranial magnetic stimulation (rTMS) in depression- reanalysis of data from meta-analyses up to 2010. BMC Psychol. 2014;2:39. doi:10.1186/s40359-014-0039-y. Recent meta-analysis. Age is not found a predictor of response of rTMS.
90. Hizli Sayar G, Ozten E, Tan O, Tarhan N. Transcranial magnetic stimulation for treating depression in elderly patients. Neuropsychiatr Dis Treat. 2013;9:501–4. Most recent study examining efficacy and safety of rTMS for geriatric depression.
91. Jorge RE, Moser DJ, Acion L, Robinson RG. Treatment of vascular depression using repetitive transcranial magnetic stimulation. Arch Gen Psychiatry. 2008;65:268–76.
92. Jorge RE, Robinson RG, Tateno A, Narushima K, Acion L, Moser D, et al. Repetitive transcranial magnetic stimulation as treatment of poststroke depression: a preliminary study. Biol Psychiatry. 2004;55:398–405.
93. Abraham G, Milev R, Lazowski L, Jokic R, du Toit R, Lowe A. Repetitive transcranial magnetic stimulation for treatment of elderly patients with depression - an open label trial. Neuropsychiatr Dis Treat. 2007;3:919–24.
94. Milev R, Abraham G, Hasey G, Cabaj JL. Repetitive transcranial magnetic stimulation for treatment of medication-resistant depression in older adults: a case series. J ECT. 2009;25:44–9.
95. Fabre I, Galinowski A, Oppenheim C, Gallarda T, Meder JF, De Montigny C, et al. Antidepressant efficacy and cognitive effects of repetitive transcranial magnetic stimulation in vascular depression: an open trial. Int J Geriatr Psychiatry. 2004;19:833–42.
96. Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, et al. Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry. 1993;50:7–16.
97. Wagner T, Eden U, Fregni F, Valero-Cabre A, Ramos-Estebanez C, Pronio-Stelluto V, et al. Transcranial magnetic stimulation and brain atrophy: a computer-based human brain model study. Exp Brain Res. 2008;186:539–50.
98. Mosimann UP, Marre SC, Werlen S, Schmitt W, Hess CW, Fisch HU, et al. Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly: correlation between effect size and coil-cortex distance. Arch Gen Psychiatry. 2002;59:560–1.
99. Nahas Z, Li X, Kozel FA, Mirzki D, Memon M, Miller K, et al. Safety and benefits of distance-adjusted prefrontal transcranial magnetic stimulation in depressed patients 55–75 years of age: a pilot study. Depress Anxiety. 2004;19:249–56.
100. Janicak PG, Dowd SM, Martis B, Alam D, Beedle D, Krasuski J, et al. Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: preliminary results of a randomized trial. Biol Psychiatry. 2002;51:659–67.
101. Gershon AA, Dannon PN, Grunhaus L. Transcranial magnetic stimulation in the treatment of depression. Am J Psychiatry. 2003;160:835–45.
102. Grunhaus L, Dannon PN, Schreiber S, Dolberg OH, Amiaz R, Ziv R, et al. Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study. Biol Psychiatry. 2000;47:314–24.
103. Slotema CW, Blom JD, Hoek HW, Sommer IE. Should we expand the toolbox of psychiatric treatment methods to include Repetitive Transcranial Magnetic Stimulation (rTMS)? A meta-analysis of the efficacy of rTMS in psychiatric disorders. J Clin Psychiatry. 2010;71:873–84.
104. Ren J, Li H, Palaniyappan L, Liu H, Wang J, Li C, et al. Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: a systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2014;51:181–9. Recent meta-analysis comparing efficacy of ECT and rTMS. Psychotic depression responds better to ECT than rTMS.
105. Mosimann UP, Schmitt W, Greenberg BD, Kosel M, Muri RM, Berkhoff M, et al. Repetitive transcranial magnetic stimulation: a putative add-on treatment for major depression in elderly patients. Psychiatry Res. 2004;126:123–33.
106. Manes F, Jorge R, Morcuende M, Yamada T, Paradiso S, Robinson RG. A controlled study of repetitive transcranial magnetic stimulation as a treatment of depression in the elderly. Int Psychogeriatr. 2001;13:225–31.
107. Moser DJ, Jorge RE, Manes F, Paradiso S, Benjamin ML, Robinson RG. Improved executive functioning following repetitive transcranial magnetic stimulation. Neurology. 2002;58:1288–90.
108. Arul-Anandam AP, Loo C. Transcranial direct current stimulation: a new tool for the treatment of depression? J Affect Disord. 2009;117:137–45.
109. Kalu UG, Sexton CE, Loo CK, Ebmeier KP. Transcranial direct current stimulation in the treatment of major depression: a meta-analysis. Psychol Med. 2012;42:1791–800.
110. Shiozawa P, Fregni F, Benseñor IM, Lotufo PA, Berlim MT, Daskalakis JZ, et al. Transcranial direct current stimulation for major depression: an updated systematic review and meta-analysis. Int J Neuropsychopharmacol. 2014;17:1443–52. Most recent systematic review and meta-analysis of tDCS in depression.
111. Shiozawa P, da Silva ME, Dias DR, Chaves AC, de Oliveira Diniz BS, Cordeiro Q. Transcranial direct current stimulation for depression in a 92-year-old patient: a case study. Psychogeriatrics. 2014;14:269–70. First case report of the use of tDCS to treat depression in a 92-year-old patient.
112. Loo CK, Alonzo A, Martin D, Mitchell PB, Galvez V, Sachdev P. Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial. Br J Psychiatry. 2012;200:52–9. RCT of tDCS in depression with the largest sample of elderly participants to date. Suggests potential antidepressant efficacy with minimal negative side when tDCS is given at adequate stimulus parameters.
113. Ferrucci R, Bortolomasi M, Vergari M, Tadini L, Salvoro B, Giacopuzzi M, et al. Transcranial direct current stimulation in severe, drug-resistant major depression. J Affect Disord. 2009;118:215–9.
114. Loo CK, Sachdev P, Martin D, Pigot M, Alonzo A, Malhi GS, et al. A double-blind, sham-controlled trial of transcranial direct current stimulation for the treatment of depression. Int J Neuropsychopharmacol. 2010;13:61–9.
115. Palm U, Schiller C, Fintescu Z, Obermeier M, Keeser D, Reisinger E, et al. Transcranial direct current stimulation in treatment resistant depression: a randomized double-blind, placebo-controlled study. Brain Stimul. 2012;5:242–51.
116. Palm U, Keeser D, Schiller C, Fintescu Z, Reisinger E, Baghai TC, et al. Transcranial direct current stimulation in a patient with therapy-resistant major depression. World J Biol Psychiatry. 2009;10:632–5.
117. Brunoni AR, Boggio PS, De Raedt R, Bensenor IM, Lotufo PA, Namur V, et al. Cognitive control therapy and transcranial direct current stimulation for depression: a randomized, double-blinded, controlled trial. J Affect Disord. 2014;162:43–9.
118. Brunoni AR, Valiengo L, Baccaro A, Zanao TA, de Oliveira JF, Goulart A, et al. The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry. 2013;70:383–91.
119. Demirtas-Tatlidede A, Vahabzadeh-Hagh AM, Pascual-Leone A. Can noninvasive brain stimulation enhance cognition in neuropsychiatric disorders? Neuropharmacology. 2013;64:566–78.
120. Loo CK, Martin DM. Could transcranial direct current stimulation have unexpected additional benefits in the treatment of depressed patients? Expert Rev Neurother. 2012;12:751–3.
121. Mondino M, Bennabi D, Poulet E, Galvao F, Brunelin J, Haffen E. Can transcranial direct current stimulation (tDCS) alleviate symptoms and improve cognition in psychiatric disorders? World J Biol Psychiatry. 2014;15:261–75.
122. Fregni F, Boggio PS, Nitsche MA, Rigonatti SP, Pascual-Leone A. Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression. Depress Anxiety. 2006;23:482–4.
123. Aaronson ST, Carpenter LL, Conway CR, Reimherr FW, Lisanby SH, Schwartz TL, et al. Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: acute and chronic effects. Brain Stimul. 2013;6:631–40.
124. Puigdemont D, Portella MJ, Perez-Egea R, de Diego-Adelino J, Gironell A, Molet J, et al. Depressive relapse after initial response to subcallosal cingulate gyrus-deep brain stimulation in a patient with a treatment-resistant depression: electroconvulsive therapy as a feasible strategy. Biol Psychiatry. 2009;66:e11–2.
125. Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, et al. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology. 2008;33:368–77.
126. Morishita T, Fayad SM, Higuchi MA, Nestor KA, Foote KD. Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes. Neurotherapeutics. 2014;11:475–84.
127. Holtzheimer PE, Kelley ME, Gross RE, Filkowski MM, Garlow SJ, Barrocas A, et al. Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression. Arch Gen Psychiatry. 2012;69:150–8.
128. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, et al. Deep brain stimulation for treatment-resistant depression. Neuron. 2005;45:651–60.
129. Kayser S, Bewernick BH, Grubert C, Hadrysiewicz BL, Axmacher N, Schlaepfer TE. Antidepressant effects, of magnetic seizure therapy and electroconvulsive therapy, in treatment-resistant depression. J Psychiatr Res. 2011;45:569–76.
130. Lisanby SH, Luber B, Schlaepfer TE, Sackeim HA. Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy. Neuropsychopharmacology. 2003;28:1852–65.