Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology

Psychological Medicine

Volumn 45, Issue 10, 2015, Pages 2227-2236

  Hettema, J M ^a   Chen, X ^a   Sun, C ^a   Brown, T A ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

Anxiety disorder; candidate genes; depression; genetic associations; structural equation modeling; temperament

Indexed keywords

CATECHOL METHYLTRANSFERASE; COMT PROTEIN, HUMAN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1; RGS PROTEIN; RGS2 PROTEIN, HUMAN; SEROTONIN TRANSPORTER;

ADOLESCENT; ADULT; AGED; ANXIETY DISORDER; CAUCASIAN; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MALE; MASSACHUSETTS; MENTAL DISEASE; MENTAL STRESS; MIDDLE AGED; MOOD DISORDERS; PHENOTYPE; PHOBIA, SOCIAL; PSYCHOLOGICAL INTERVIEW; PSYCHOLOGY; REGRESSION ANALYSIS; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANXIETY DISORDERS; BOSTON; CATECHOL O-METHYLTRANSFERASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE-ENVIRONMENT INTERACTION; GLUTAMATE DECARBOXYLASE; HUMANS; INTERVIEW, PSYCHOLOGICAL; MALE; MIDDLE AGED; MOOD DISORDERS; PHENOTYPE; PHOBIA, SOCIAL; POLYMORPHISM, GENETIC; PSYCHOPATHOLOGY; REGRESSION ANALYSIS; RGS PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84930183247     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291715000021     Document Type: Article

References (63)

1. Allison PD (2003). Missing data techniques for structural equation modeling. Journal of Abnormal Psychology 112, 545-557.
2. Andrews G, Stewart G, Morris-Yates A, Holt P, Henderson S (1990). Evidence for a general neurotic syndrome. British Journal of Psychiatry 157, 6-12.
3. Antony MM, Bieling PJ, Cox BJ, Enns MW, Swinson RP (1998). Psychometric properties of the 42-item and 21-item versions of the Depression Anxiety Stress Scales in clinical groups and a community sample. Psychological Assessment 10, 176-181.
4. Barrett JC, Fry B, Maller J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265.
5. Beck AT, Steer RA, Brown GK (1996). Manual for the Beck Depression Inventory-II. Psychological Corporation: San Antonio.
6. Bienvenu OJ, Brown C, Samuels JF, Liang KY, Costa PT, Eaton WW, Nestadt G (2001). Normal personality traits and comorbidity among phobic, panic and major depressive disorders. Psychiatry Research 102, 73-85.
7. Bienvenu OJ, Hettema J, Neale MC, Prescott CA, Kendler KS (2007). Low extraversion and high neuroticism as indices of genetic and environmental risk for social phobia. American Journal of Psychiatry 164, 1714-1721.
8. Bienvenu OJ, Samuels JF, Wuyek LA, Liang KY, Wang Y, Grados MA, Cullen BA, Riddle MA, Greenberg BD, Rasmussen SA, Fyer AJ, Pinto A, Rauch SL, Pauls DL, McCracken JT, Piacentini J, Murphy DL, Knowles JA, Nestadt G (2012). Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. Psychological Medicine 42, 1-13.
9. Bloch MH, Landeros-Weisenberger A, Sen S, Dombrowski P, Kelmendi B, Coric V, Pittenger C, Leckman JF (2008). Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 147B, 850-858.
10. Brown TA (2007). Temporal course and structural relationships among dimensions of temperament and DSM-IV anxiety and mood disorder constructs. Journal of Abnormal Psychology 116, 313-328.
11. Brown TA, Di Nardo PA, Lehman CL, Campbell LA (2001). Reliability of DSM-IV anxiety and mood disorders: implications for the classification of emotional disorders. Journal of Abnormal Psychology 110, 49-58.
12. Brown TA, Naragon-Gainey K (2013). Evaluation of the unique and specific contributions of dimensions of the triple vulnerability model to the prediction of DSM-IV anxiety and mood disorder constructs. Behavior Therapy 44, 277-292.
13. Brown TA, Rosellini AJ (2011). The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. Journal of Abnormal Psychology 120, 844-856.
14. Brown TA, White KS, Barlow DH (2005). A psychometric reanalysis of the Albany Panic and Phobia Questionnaire. Behaviour Research and Therapy 43, 337-355.
15. Carver CS, White TL (1994). Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS scales. Journal of Personality and Social Psychology 67, 319-333.
16. Costa PT Jr, McCrae RR (1992). Revised NEO Personality Inventory (NEO PI-R) and NEO Five-Factor Inventory (NEO-FFI) Professional Manual. Psychological Assessment Resources: Odessa, FL.
17. Craddock N, Owen MJ, O'Donovan MC (2006). The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons. Molecular Psychiatry 11, 446-458.
18. Cross-Disorder Group of the Psychiatric GWAS Consortium (2013). Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371-1379.
19. de Moor MH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Toshiko T, Penninx BW, Esko T, Madden PA, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Sullivan P, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza R, Nutile T, Ciullo M, Rujescu D, Giegling I, Konte B,Widen E, Cousminer DL, Eriksson JG, Palotie A, Peltonen L, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens AC, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Raikkonen K, Bierut LJ, Martin NG, van Duijn CM, Boomsma DI (2012). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry 17, 337-349.
20. Di Nardo PA, Brown TA, Barlow DH (1994). Anxiety Disorders Interview Schedule for DSM-IV: Lifetime Version (ADIS-IV-L). Oxford University Press: New York.
21. Digangi J, Guffanti G, McLaughlin KA, Koenen KC (2013). Considering trauma exposure in the context of genetics studies of posttraumatic stress disorder: a systematic review. Biology of Mood and Anxiety Disorders 3, 2.
22. Domschke K, Deckert J, O'Donovan MC, Glatt SJ (2007). Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 144B, 667-673.
23. Donner J, Sipila T, Ripatti S, Kananen L, Chen X, Kendler KS, Lonnqvist J, Pirkola S, Hettema JM, Hovatta I (2012). Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 159B, 316-327.
24. Erhardt A, Czibere L, Roeske D, Lucae S, Unschuld PG, Ripke S, Specht M, Kohli MA, Kloiber S, Ising M, Heck A, Pfister H, Zimmermann P, Lieb R, Putz B, Uhr M, Weber P, Deussing JM, Gonik M, Bunck M, Kebler MS, Frank E, Hohoff C, Domschke K, Krakowitzky P, Maier W, Bandelow B, Jacob C, Deckert J, Schreiber S, Strohmaier J, Nothen M, Cichon S, Rietschel M, Bettecken T, Keck ME, Landgraf R, Muller-Myhsok B, Holsboer F, Binder EB (2011). TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies. Molecular Psychiatry 16, 647-663.
25. Eysenck HJ, Eysenck SBG (1975). Manual of the Eysenck Personality Questionnaire. Hodder and Stoughton: London.
26. Foa EB, Huppert JD, Leiberg S, Langner R, Kichic R, Hajcak G, Salkovskis PM (2002). The Obsessive-Compulsive Inventory: development and validation of a short version. Psychological Assessment 14, 485-496.
27. Gyawali S, Subaran R, Weissman MM, Hershkowitz D, McKenna MC, Talati A, Fyer AJ, Wickramaratne P, Adams PB, Hodge SE, Schmidt CJ, Bannon MJ, Glatt CE (2010). Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. Biological Psychiatry 67, 331-338.
28. Hammen C, Adrian C, Gordon D, Burge D, Jaenicke C, Hiroto D (1987). Children of depressed mothers: maternal strain and symptom predictors of dysfunction. Journal of Abnormal Psychology 96, 190-198.
29. Hettema JM, An SS, Bukszar J, van den Oord EJ, Neale MC, Kendler KS, Chen X (2008). Catechol-O-methyltransferase contributes to genetic susceptibility shared among anxiety spectrum phenotypes. Biological Psychiatry 64, 302-310.
30. Hettema JM, An SS, Neale MC, Bukszar J, van den Oord EJ, Kendler KS, Chen X (2006a). Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. Molecular Psychiatry 11, 752-762.
31. Hettema JM, Neale MC, Kendler KS (2001). A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry 158, 1568-1578.
32. Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS (2006b). A population-based twin study of the relationship between neuroticism and internalizing disorders. American Journal of Psychiatry 163, 857-864.
33. Hettema JM, Sun C, Chen X, Kendler KS (2013). Genetic association study between RGS2 and anxiety-related phenotypes. Psychiatric Genetics 23, 92.
34. Hu L, Bentler PM (1999). Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Structural Equation Modeling 6, 1-55.
35. Jardine R, Martin NG, Henderson AS (1984). Genetic covariation between neuroticism and the symptoms of anxiety and depression. Genetic Epidemiology 1, 89-107.
36. Kendler KS, Gardner CO, Gatz M, Pedersen NL (2007). The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample. Psychological Medicine 37, 453-462.
37. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1993). A longitudinal twin study of personality and major depression in women. Archives of General Psychiatry 50, 853-862.
38. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 62, 593-602.
39. Khan AA, Jacobson KC, Gardner CO, Prescott CA, Kendler KS (2005). Personality and comorbidity of common psychiatric disorders. British Journal of Psychiatry 186, 190-196.
40. Koenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, Gelernter J (2009). RGS2 and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. Depression and Anxiety 26, 309-315.
41. Leygraf A, Hohoff C, Freitag C, Willis-Owen SA, Krakowitzky P, Fritze J, Franke P, Bandelow B, Fimmers R, Flint J, Deckert J (2006). Rgs 2 gene polymorphisms as modulators of anxiety in humans? Journal of Neural Transmission 113, 1921-1925.
42. Livak KJ (1999). Allelic discrimination using fluorogenic probes and the 5 nuclease assay. Genetic Analysis 14, 143-149.
43. Lovibond PF, Lovibond SH (1995). The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behaviour Research and Therapy 33, 335-343.
44. Mandelli L, Serretti A (2013). Gene environment interaction studies in depression and suicidal behavior: an update. Neuroscience and Biobehavioral Reviews 37, 2375-2397.
45. Mattick RP, Clarke JC (1998). Development and validation of measures of social phobia scrutiny fear and social interaction anxiety. Behaviour Research and Therapy 36, 455-470.
46. Meyer TJ, Miller ML, Metzger RL, Borkovec TD (1990). Development and validation of the Penn State Worry Questionnaire. Behaviour Research and Therapy 28, 487-495.
47. Monzani B, Rijsdijk F, Harris J, Mataix-Cols D (2014). The structure of genetic and environmental risk factors for dimensional representations of DSM-5 obsessive-compulsive spectrum disorders. JAMA Psychiatry 71, 182-189.
48. Munafò MR, Clark TG, Roberts KH, Johnstone EC (2006). Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. Neuropsychobiology 53, 1-8.
49. Muthén LK, Muthén BO (2010). Mplus User's Guide. Muthén & Muthén: Los Angeles, CA.
50. Naragon-Gainey K, Gallagher MW, Brown TA (2013). Stable "trait" variance of temperament as a predictor of the temporal course of depression and social phobia. Journal of Abnormal Psychology 122, 611-623.
51. Pauls DL (2010). The genetics of obsessive-compulsive disorder: a review. Dialogues in Clinical Neuroscience 12, 149-163.
52. Pooley EC, Fineberg N, Harrison PJ (2007). The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis. Molecular Psychiatry 12, 556-561.
53. Rapee RM, Craske MG, Barlow DH (1994-1995). Assessment instrument for panic disorder that includes fear of sensation-producing activities: the Albany Panic and Phobia Questionnaire. Anxiety 1, 114-122.
54. Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, Byrne EM, Blackwood DH, Boomsma DI, Cichon S, Heath AC, Holsboer F, Lucae S, Madden PA, Martin NG, McGuffin P, Muglia P, Noethen MM, Penninx BP, Pergadia ML, Potash JB, Rietschel M, Lin D, Muller-Myhsok B, Shi J, Steinberg S, Grabe HJ, Lichtenstein P, Magnusson P, Perlis RH, Preisig M, Smoller JW, Stefansson K, Uher R, Kutalik Z, Tansey KE, Teumer A, Viktorin A, Barnes MR, Bettecken T, Binder EB, Breuer R, Castro VM, Churchill SE, Coryell WH, Craddock N, Craig IW, Czamara D, de Geus EJ, Degenhardt F, Farmer AE, Fava M, Frank J, Gainer VS, Gallagher PJ, Gordon SD, Goryachev S, Gross M, Guipponi M, Henders AK, Herms S, Hickie IB, Hoefels S, Hoogendijk W, Hottenga JJ, Iosifescu DV, Ising M, Jones I, Jones L, Jung-Ying T, Knowles JA, Kohane IS, Kohli MA, Korszun A, Landen M, Lawson WB, Lewis G, Macintyre D, Maier W, Mattheisen M, McGrath PJ, McIntosh A, McLean A, Middeldorp CM, Middleton L, Montgomery GM, Murphy SN, Nauck M, Nolen WA, Nyholt DR, O'Donovan M, Oskarsson H, Pedersen N, Scheftner WA, Schulz A, Schulze TG, Shyn SI, Sigurdsson E, Slager SL, Smit JH, Stefansson H, Steffens M, Thorgeirsson T, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van GG, Volzke H, Weilburg JB, Willemsen G, Zitman FG, Neale B, Daly M, Levinson DF, Sullivan PF (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry 18, 497-511.
55. Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, Griem A, Kovacs M, Ott J, Merikangas KR (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301, 2462-2471.
56. Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427.
57. Simms LJ, Watson D, Doebbeling BN (2002). Confirmatory factor analyses of posttraumatic stress symptoms in deployed and nondeployed veterans of the Gulf War. Journal of Abnormal Psychology 111, 637-647.
58. Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB (2008). Influence of RGS2 on anxiety-related temperament, personality, and brain function. Archives of General Psychiatry 65, 298-308.
59. Stein DJ, Fineberg NA, Bienvenu OJ, Denys D, Lochner C, Nestadt G, Leckman JF, Rauch SL, Phillips KA (2010). Should OCD be classified as an anxiety disorder in DSM-V? Depression and Anxiety 27, 495-506.
60. Strug LJ, Suresh R, Fyer AJ, Talati A, Adams PB, Li W, Hodge SE, Gilliam TC, Weissman MM (2010). Panic disorder is associated with the serotonin transporter gene (SLC6A4) but not the promoter region (5-HTTLPR). Molecular Psychiatry 15, 166-176.
61. Tambs K, Czajkowsky N, Roysamb E, NealeMC, Reichborn-Kjennerud T,Aggen SH,Harris JR, Orstavik RE, Kendler KS (2009). Structure of genetic and environmental risk factors fordimensional representations ofDSM-IVanxiety disorders. British Journal of Psychiatry 195, 301-307.
62. Willis-Owen SA, Turri MG, Munafò MR, Surtees PG, Wainwright NW, Brixey RD, Flint J (2005). The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biological Psychiatry 58, 451-456.
63. Wray NR, James MR, Gordon SD, Dumenil T, Ryan L, Coventry WL, Statham DJ, Pergadia ML, Madden PA, Heath AC, Montgomery GW, Martin NG (2009). Accurate, large-scale genotyping of 5HTTLPR and flanking single nucleotide polymorphisms in an association study of depression, anxiety, and personality measures. Biological Psychiatry 66, 468-476.