Three-dimensional, soft neotissue arrays as high throughput platforms for the interrogation of engineered tissue environments

Biomaterials

Volumn 59, Issue , 2015, Pages 39-52

  Floren, Michael ^a   Tan, Wei ^a  

^a University of Colorado at Boulder   (United States)

Author keywords

3 Dimensional cell culture; Extracellular matrix; High throughput screening; Stem cell differentiation

Indexed keywords

ADHESION; CELL CULTURE; CELLS; COLLAGEN; CYTOLOGY; ELASTICITY; GEOMETRY; PROTEINS; STEM CELLS; THROUGHPUT; TISSUE;

3-DIMENSIONAL; ENGINEERED TISSUES; EXTRACELLULAR MATRICES; HIGH THROUGHPUT SCREENING; MECHANICAL ELASTICITIES; MESENCHYMAL STEM CELL; STEM CELL DIFFERENTIATION; SUBSTRATE STIFFNESS;

TISSUE REGENERATION;

COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; ELASTIN; FIBRONECTIN; LAMININ;

ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CONFOCAL LASER MICROSCOPY; ELASTICITY; EXTRACELLULAR MATRIX; FLUORESCENCE MICROSCOPY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN MICROARRAY; SCANNING ELECTRON MICROSCOPY; SOFT NEOTISSUE ARRAY; TISSUE ENGINEERING; TISSUE MICROARRAY; TUMOR MICROENVIRONMENT; CYTOLOGY; MESENCHYMAL STROMA CELL; METABOLISM;

CELL ADHESION; EXTRACELLULAR MATRIX; MESENCHYMAL STROMAL CELLS; MICROSCOPY, ELECTRON, SCANNING; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE ENGINEERING;

EID: 84930175321     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.04.036     Document Type: Article

References (55)

1. Reilly G.C., Engler A.J. Intrinsic extracellular matrix properties regulate stem cell differentiation. Biomechanics 2010, 43:55-62.
2. da Silva Meirelles L., Caplan A.I., Nardi N.B. In search of the invivo identity of mesenchymal stem cells. Stem Cells 2008, 26:2287.
3. Bajpai V.K., Mistriotis P., Loh Y.H., Daley G.Q., Andreadis S.T. Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates. Cardiovasc. Res. 2012, 96:391-400.
4. Suzuki S., Narita Y., Yamawaki A., Murase Y., Satake M., Mutsuga M., et al. Effects of extracellular matrix on differentiation of human bone marrow-derived mesenchymal stem cells into smooth muscle cell lineage: utility for cardiovascular tissue engineering. Cells Tissues Organs 2010, 191(4):269-280.
5. Engler J.A., Sen S., Sweeney H.L., Discher D.E. Matrix elasticity directs stem cell lineage specification. Cell 2006, 126:677-689.
6. Discher D.E., Janmey P., Wang Y.L. Tissue cells feel and respond to the stiffness of their substrate. Science 2005, 310(5751):1139e43.
7. Huebsch N., Arany P.R., Mao A.S., Shvartsman D., Ali O.A., Bencherif S.A., et al. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat. Mater. 2010, 9(6):518.
8. Wingate K., Bonani W., Tan Y., Bryant S., Tan W. Compressive elasticity of three dimensional nanofiber matrix directs mesenchymal stem cell differentiation to vascular cells with endothelial or smooth muscle cell markers. Acta Biomater. 2012, 8:1440.
9. Titmarsh D.M., Chen H., Wolvetang E.J., Cooper-White J. Arrayed cellular environments for stem cells and regenerative medicine. Biotechnol. J. 2013, 8:167-179.
10. Flaim C.J., Chien S., Bhatia S.N. An extracellular matrix microarray for probing cellular differentiation. Nat. Methods 2005, 2:119-125.
11. Ghaedi M., Tuleuova N., Zern M.A., Wu J., Revzin A. Bottom-up signaling from HGF-containing surfaces promotes hepatic differentiation of mesenchymal stem cells. Biochem. Biophys. Res. Commun. 2011, 407:295-300.
12. Anderson D.G., Levenberg S., Langer R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat. Biotechnol. 2004, 22:863-866.
13. Mei Y., Saha K., Bogatyrev S.R., Yang J., et al. Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat. Mater. 2010, 9:768-778.
14. Gobaa S., Hoehnel S., Roccio M., Negro A., Kobel S., Lutolf M.P. Artificial niche microarrays for probing single stem cell fate in high throughput. Nat. Meth. 2011, 8:949.
15. Wingate K., Floren M., Tan Y., Tseng Pi Ou N., Tan W. Tissue Eng Part A 2014, 20:2503-2512.
16. Fozdar D.Y., Soman P., Lee J.W., Han L.H., Chen S. Three-dimensional polymer constructs exhibiting a tunable negative Poisson's ratio. Adv. Funct. Mater. 2011, 21:2712-2720.
17. Zhu J., Tang C., Kottke-Marchant K., Marchant R.E. Design and synthesis of biomimetic hydrogel scaffolds with controlled organization of cyclic RGD peptides. Bioconjug. Chem. 2009, 20:333-339.
18. Seo J.H., Sakai K., Yui N. Adsorption state of fibronectin on poly(dimethylsiloxane) surfaces with varied stiffness can dominate adhesion density of fibroblasts. Acta Biomater. 2013, 9:5493-5501.
19. Trappmann B., et al. Extracellular-matrix tethering regulates stem-cell fate. Nat. Mater. 2012, 11:742-749.
20. Antia M., Baneyx G., Kubow K.E., Vogel V. Fibronectin in aging extracellular matrix fibrils is progressively unfolded by cells and elicits an enhanced rigidity response. Faraday Discuss. 2008, 139:229-249.
21. Klotzsch E., Schoen I., Ries J., Renn A., Sandoghdare V., Vogel V. Biomater. Sci. 2014, 2:883.
22. Hynes R.O. The extracellular matrix: not just pretty fibrils. Science 2009, 326:1216-1219.
23. Cole M.A., Voelcker N.H., Thissen H., Griesser H.J. Stimuli-responsive interfaces and systems for the control of protein-surface and cell-surface interactions. Biomaterials 2009, 30:1827-1850.
24. Carlson A.L., Florek C.A., Kim J.J., Neubauer T., Moore J.C., Cohen C.I., et al. Microfibrous substrate geometry as a critical trigger for organization, self-renewal, and differentiation of human embryonic stem cells within synthetic 3-dimensional microenvironments. FASEB 2012, 26:3240-3251.
25. Lim S.H., Mao H.Q. Electrospun scaffolds for stem cell engineering. Adv. Drug Deliv. Rev. 2009, 61:1084-1096.
26. MacBeath G., Schreiber S.L. Printing proteins as microarrays for high-throughput function determination. Science 2000, 289:1760.
27. Soen Y., Mori A., Palmer T.D., Brown P.O. Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. Mol. Syst. Biol. 2006, 2:37.
28. Davis G.E., Senger D.R. Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ. Res. 2005, 97:1093-1107.
29. Wagenseil J.E., Mecham R.P. Vascular extracellular matrix and arterial mechanics. Physiol. Rev. 2009, 89:957-989.
30. Battista S., Guarnieri D., Borselli C., Zeppetelli S., Borzacchiello A., Mayol L., Gerbasio D., Keene D.R., Ambrosio L., Netti P.A. The effect of matrix composition of 3D constructs on embryonic stem cell differentiation. Biomaterials 2005, 26:6194-6207.
31. Fernandes T.G., Kwon S.J., Bale S.S., Lee M.Y., Diogo M.M., Clark D.S., et al. Three-dimensional cell culture microarray for high throughput studies of stem cell fate. Biotechnol. Bioeng. 2010, 106:106-118.
32. Dolatshahi-Pirouz A., Nikkhah M., Gaharwar A.K., Hashmi B., Guermani E., Aliabadi H., et al. Acombinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells. Sci. Rep 2014, 4:3896.
33. Ranga A., Lutolf M.P. High-throughput approaches for the analysis of extrinsic regulators of stem cell fate. Curr. Opin. Cell Biol. 2012, 24:236-244.
34. Hui E.E., Bhatia S.N. Micromechanical control of cell-cell interactions. Proc. Natl. Acad. Sci. 2007, 104:5722.
35. Khetani S.R., Bhatia S.N. Microscale human liver tissue for drug development. Nat. Biotechnol. 2007, 26:120-126.
36. Oswald J., Boxberger S., Jørgensen B., Feldmann S., Ehninger G., et al. Mesenchymal stem cells can be differentiated into endothelial cells invitro. Stem Cells 2004, 22:377-384.
37. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
38. Ahsan T., Nerem R.M. Fluid shear stress promotes an endothelial-like phenotype during the early differentiation of embryonic stem cells. Tissue Eng Part A 2010, 16:3547-3553.
39. Kniazeva E., Kachgal S., Putnam A.J. Effects of extracellular matrix density and mesenchymal stem cells on neovascularization invivo. Tissue Eng Part A 2011, 17:905-914.
40. Lozito T.P., Taboas J.M., Kuo C.K., Tuan R.S. Mesenchymal stem cell modification of endothelial matrix regulates their vascular differentiation. JCell Biochem. 2009, 107:706-713.
41. Wang C.H., Wang T.M., Young T.H., Lai Y.K., Yen M.L. The critical role of ECM proteins within the human MSC niche in endothelial differentiation. Biomaterials 2013, 34:4223-4234.
42. Portalska K., Leferink A., Groen N., Fernandes H., Moroni L., van Blitterswijk C., et al. Endothelial differentiation of mesenchymal stromal cells. PLoS One 2012, 7:e46842.
43. Wu C.C., Chao Y.C., Chen C.N., Chien S., Chen Y.C., Chien C.C., et al. Synergism of biochemical and mechanical stimuli in the differentiation of human placenta-derived multipotent cells into endothelial cells. J.Biomech. 2008, 41:813-821.
44. Yang F., Cho S.W., Son S.M., Hudson S.P., Bogatyrev S., Keung L., et al. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules 2010, 11:1909-1914.
45. Abdeen A.A., Weiss J.B., Lee J., Kilian K.A. Matrix composition and mechanics direct proangiogenic signaling from mesenchymal stem cells. Tissue Eng Part A 2014, 20:2737-2745.
46. Cukierman E., Pankov R., Yamada K.M. Cell interactions with three-dimensional matrices. Curr. Opin. Cell Biol. 2002, 14:633-639.
47. Chaudhuri O., Koshy S.T., Branco da Cunha C., Shin J., Verbeke C.S., Allison K.H., et al. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat. Mater. 2014, 13:970-978.
48. Dean R.G., Balding L.C., Candido R., Burns W.C., Cao Z., Twigg S.M., et al. Connective tissue growth factor and cardiac fibrosis after myocardial infarction. J.Histochem. Cytochem 2005, 53:1245-1256.
49. Breitbach M., Bostani T., Roell W., Xia Y., Dewald O., Nygren J.M., et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 2007, 110:1362-1369.
50. Liao X., Lu S., Wu Y., Xu W., Zhuo Y., Peng Q., et al. The effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET. PLoS One 2013, 27:8.
51. Seong J., Tajik A., Sun J., Guan J.L., Humphries M.J., Craig S.E., et al. Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proc. Natl. Acad. Sci. 2013, 110:19372-19377.
52. Wen J.H., Vincent L.G., Fuhrmann A., Choi Y.S., Hribar K.C., Taylor-Weiner H., et al. Interplay of matrix stiffness and protein tethering in stem cell differentiation. Nat. Mater. 2014, 13:979-987.
53. Kshitiz M.E., Hubbi E.H., Ahn J., Downey J., Kim A., et al. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Sci. Signal 2015, 5:ra41.
54. Mammoto A., Connor K.M., Mammoto T., Yung C.W., Huh D., Aderman C.M., et al. Amechanosensitive transcriptional mechanism that controls angiogenesis. Nature 2009, 457:1103-1108.
55. Seib F.P., Prewitz M., Werner C., Bornhäuser M. Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs). Biochem. Biophys. Res. Commun. 2009, 389:663.