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Volumn 53, Issue 4, 2016, Pages 2451-2467

Hydrogen Sulfide Ameliorates Homocysteine-Induced Alzheimer’s Disease-Like Pathology, Blood–Brain Barrier Disruption, and Synaptic Disorder

Author keywords

Alzheimer s disease; Blood brain barrier dysfunction; Cerebrovascular pathology; Dementia; Homocysteine

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CLAUDIN 5; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; DIZOCILPINE; GELATINASE A; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; HYDROGEN SULFIDE; INTERCELLULAR ADHESION MOLECULE 1; MEMBRANE PROTEIN; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POSTSYNAPTIC DENSITY PROTEIN 95; SYNAPSE ASSOCIATED PROTEIN 97; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; UNCLASSIFIED DRUG; CADHERIN; DIZOCILPINE MALEATE; HOMOCYSTEINE; LEUKOCYTE ANTIGEN; MICROTUBULE ASSOCIATED PROTEIN; NERVE PROTEIN; VASCULAR ENDOTHELIAL CADHERIN;

EID: 84930153636     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9212-4     Document Type: Article
Times cited : (124)

References (40)
  • 1
    • 75649103201 scopus 로고    scopus 로고
    • Genetics of homocysteine metabolism and associated disorders
    • COI: 1:CAS:528:DC%2BC3cXjt1KjtLs%3D, PID: 19967264
    • Brustolin S, Giugliani R, Felix TM (2010) Genetics of homocysteine metabolism and associated disorders. Braz J Med Biol Res 43:1–7
    • (2010) Braz J Med Biol Res , vol.43 , pp. 1-7
    • Brustolin, S.1    Giugliani, R.2    Felix, T.M.3
  • 2
    • 77956066614 scopus 로고    scopus 로고
    • Plasma homocysteine and cognition in elderly patients with dementia or other psychogeriatric diseases
    • COI: 1:CAS:528:DC%2BC3cXht1GnsrfO, PID: 20798540
    • Nilsson K, Gustafson L, Hultberg B (2010) Plasma homocysteine and cognition in elderly patients with dementia or other psychogeriatric diseases. Dement Geriatr Cogn Disord 30:198–204
    • (2010) Dement Geriatr Cogn Disord , vol.30 , pp. 198-204
    • Nilsson, K.1    Gustafson, L.2    Hultberg, B.3
  • 5
    • 30344460654 scopus 로고    scopus 로고
    • Homocysteine and cognition—no longer a hypothesis?
    • COI: 1:CAS:528:DC%2BD28XjvVGrtA%3D%3D, PID: 16298495
    • McCaddon A, Regland B (2006) Homocysteine and cognition—no longer a hypothesis? Med Hypotheses 66:682–683
    • (2006) Med Hypotheses , vol.66 , pp. 682-683
    • McCaddon, A.1    Regland, B.2
  • 6
    • 2942538501 scopus 로고    scopus 로고
    • Plasma homocysteine levels and risk of Alzheimer disease
    • COI: 1:CAS:528:DC%2BD2cXktVKgt7Y%3D, PID: 15184599
    • Luchsinger JA, Tang MX, Shea S, Miller J, Green R, Mayeux R (2004) Plasma homocysteine levels and risk of Alzheimer disease. Neurology 62:1972–1976
    • (2004) Neurology , vol.62 , pp. 1972-1976
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Miller, J.4    Green, R.5    Mayeux, R.6
  • 8
    • 80052024330 scopus 로고    scopus 로고
    • Is hyperhomocysteinemia an Alzheimer’s disease (AD) risk factor, an AD marker, or neither?
    • COI: 1:CAS:528:DC%2BC3MXhtVGrs7jN, PID: 21684021
    • Zhuo JM, Wang H, Pratico D (2011) Is hyperhomocysteinemia an Alzheimer’s disease (AD) risk factor, an AD marker, or neither? Trends Pharmacol Sci 32:562–571
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 562-571
    • Zhuo, J.M.1    Wang, H.2    Pratico, D.3
  • 9
    • 9944252377 scopus 로고    scopus 로고
    • Receptor trafficking and synaptic plasticity
    • COI: 1:CAS:528:DC%2BD2cXpvFWrsbw%3D, PID: 15550950
    • Collingridge GL, Isaac JT, Wang YT (2004) Receptor trafficking and synaptic plasticity. Nat Rev Neurosci 5:952–962
    • (2004) Nat Rev Neurosci , vol.5 , pp. 952-962
    • Collingridge, G.L.1    Isaac, J.T.2    Wang, Y.T.3
  • 10
    • 2542612948 scopus 로고    scopus 로고
    • Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses
    • COI: 1:CAS:528:DC%2BD2cXktVWhsrs%3D, PID: 15148446
    • Perez-Otano I, Ehlers MD (2004) Learning from NMDA receptor trafficking: clues to the development and maturation of glutamatergic synapses. Neurosignals 13:175–189
    • (2004) Neurosignals , vol.13 , pp. 175-189
    • Perez-Otano, I.1    Ehlers, M.D.2
  • 11
    • 84871684881 scopus 로고    scopus 로고
    • A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats
    • COI: 1:CAS:528:DC%2BC38XhsValsbfJ, PID: 23021418
    • Rai S, Kamat PK, Nath C, Shukla R (2013) A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. J Neuroimmunol 254:1–9
    • (2013) J Neuroimmunol , vol.254 , pp. 1-9
    • Rai, S.1    Kamat, P.K.2    Nath, C.3    Shukla, R.4
  • 12
    • 84902590776 scopus 로고    scopus 로고
    • Synaptic function of nicastrin in hippocampal neurons
    • COI: 1:CAS:528:DC%2BC2cXptlKrurg%3D, PID: 24889619
    • Lee SH, Sharma M, Sudhof TC, Shen J (2014) Synaptic function of nicastrin in hippocampal neurons. Proc Natl Acad Sci U S A 111:8973–8978
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 8973-8978
    • Lee, S.H.1    Sharma, M.2    Sudhof, T.C.3    Shen, J.4
  • 13
    • 34547957954 scopus 로고    scopus 로고
    • Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
    • COI: 1:CAS:528:DC%2BD2sXht1eis7bN, PID: 17387691
    • Ethell IM, Ethell DW (2007) Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets. J Neurosci Res 85:2813–2823
    • (2007) J Neurosci Res , vol.85 , pp. 2813-2823
    • Ethell, I.M.1    Ethell, D.W.2
  • 14
    • 34447552405 scopus 로고    scopus 로고
    • In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity
    • COI: 1:CAS:528:DC%2BD2sXpsVCku7s%3D, PID: 17493927
    • Bozdagi O, Nagy V, Kwei KT, Huntley GW (2007) In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity. J Neurophysiol 98:334–344
    • (2007) J Neurophysiol , vol.98 , pp. 334-344
    • Bozdagi, O.1    Nagy, V.2    Kwei, K.T.3    Huntley, G.W.4
  • 15
    • 65949118911 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling
    • COI: 1:CAS:528:DC%2BD1MXlvVGnt7Y%3D, PID: 19420267
    • Michaluk P, Mikasova L, Groc L, Frischknecht R, Choquet D, Kaczmarek L (2009) Matrix metalloproteinase-9 controls NMDA receptor surface diffusion through integrin beta1 signaling. J Neurosci 29:6007–6012
    • (2009) J Neurosci , vol.29 , pp. 6007-6012
    • Michaluk, P.1    Mikasova, L.2    Groc, L.3    Frischknecht, R.4    Choquet, D.5    Kaczmarek, L.6
  • 16
    • 84880922774 scopus 로고    scopus 로고
    • Synergy of homocysteine, microRNA, and epigenetics: a novel therapeutic approach for stroke
    • COI: 1:CAS:528:DC%2BC3sXhtFGlsLnP, PID: 23430482
    • Kalani A, Kamat PK, Tyagi SC, Tyagi N (2013) Synergy of homocysteine, microRNA, and epigenetics: a novel therapeutic approach for stroke. Mol Neurobiol 48:157–168
    • (2013) Mol Neurobiol , vol.48 , pp. 157-168
    • Kalani, A.1    Kamat, P.K.2    Tyagi, S.C.3    Tyagi, N.4
  • 17
    • 33644522107 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
    • COI: 1:CAS:528:DC%2BD28XitVans7k%3D, PID: 16481424
    • Nagy V, Bozdagi O, Matynia A, Balcerzyk M, Okulski P, Dzwonek J, Costa RM, Silva AJ et al (2006) Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci 26:1923–1934
    • (2006) J Neurosci , vol.26 , pp. 1923-1934
    • Nagy, V.1    Bozdagi, O.2    Matynia, A.3    Balcerzyk, M.4    Okulski, P.5    Dzwonek, J.6    Costa, R.M.7    Silva, A.J.8
  • 18
    • 84884343024 scopus 로고    scopus 로고
    • Hydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice
    • COI: 1:CAS:528:DC%2BC3sXhsF2ntrnO, PID: 23912038
    • Kamat PK, Kalani A, Givvimani S, Sathnur PB, Tyagi SC, Tyagi N (2013) Hydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice. Neuroscience 252:302–319
    • (2013) Neuroscience , vol.252 , pp. 302-319
    • Kamat, P.K.1    Kalani, A.2    Givvimani, S.3    Sathnur, P.B.4    Tyagi, S.C.5    Tyagi, N.6
  • 19
    • 84876027041 scopus 로고    scopus 로고
    • Okadaic acid-induced Tau phosphorylation in rat brain: role of NMDA receptor
    • COI: 1:CAS:528:DC%2BC3sXlsFChsr4%3D, PID: 23415789
    • Kamat PK, Rai S, Swarnkar S, Shukla R, Ali S, Najmi AK, Nath C (2013) Okadaic acid-induced Tau phosphorylation in rat brain: role of NMDA receptor. Neuroscience 238:97–113
    • (2013) Neuroscience , vol.238 , pp. 97-113
    • Kamat, P.K.1    Rai, S.2    Swarnkar, S.3    Shukla, R.4    Ali, S.5    Najmi, A.K.6    Nath, C.7
  • 20
    • 84871369299 scopus 로고    scopus 로고
    • Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models
    • COI: 1:CAS:528:DC%2BC3MXhsVektrrI
    • Lyon L, Saksida LM, Bussey TJ (2012) Spontaneous object recognition and its relevance to schizophrenia: a review of findings from pharmacological, genetic, lesion and developmental rodent models. Psychopharmacology (Berl) 220:647–672
    • (2012) Psychopharmacology (Berl) , vol.220 , pp. 647-672
    • Lyon, L.1    Saksida, L.M.2    Bussey, T.J.3
  • 21
    • 84868589696 scopus 로고    scopus 로고
    • Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor
    • COI: 1:CAS:528:DC%2BC38XhsFygu7jJ, PID: 22886392
    • Lominadze D, Tyagi N, Sen U, Ovechkin A, Tyagi SC (2012) Homocysteine alters cerebral microvascular integrity and causes remodeling by antagonizing GABA-A receptor. Mol Cell Biochem 371:89–96
    • (2012) Mol Cell Biochem , vol.371 , pp. 89-96
    • Lominadze, D.1    Tyagi, N.2    Sen, U.3    Ovechkin, A.4    Tyagi, S.C.5
  • 22
    • 0013939811 scopus 로고
    • Regional studies of catecholamines in the rat brain. I. The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain
    • COI: 1:CAS:528:DyaF28Xks1Kqtrw%3D, PID: 5950056
    • Glowinski J, Iversen LL (1966) Regional studies of catecholamines in the rat brain. I. The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain. J Neurochem 13:655–669
    • (1966) J Neurochem , vol.13 , pp. 655-669
    • Glowinski, J.1    Iversen, L.L.2
  • 23
    • 0034518250 scopus 로고    scopus 로고
    • Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects
    • COI: 1:STN:280:DC%2BD3Mzmslaqug%3D%3D, PID: 11115804
    • Ravaglia G, Forti P, Maioli F, Zanardi V, Dalmonte E, Grossi G, Cucinotta D, Macini P et al (2000) Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally ageing subjects. J Nutr Health Aging 4:218–222
    • (2000) J Nutr Health Aging , vol.4 , pp. 218-222
    • Ravaglia, G.1    Forti, P.2    Maioli, F.3    Zanardi, V.4    Dalmonte, E.5    Grossi, G.6    Cucinotta, D.7    Macini, P.8
  • 24
    • 0027064483 scopus 로고
    • A study of regional cerebral blood flow and cognitive performance in Alzheimer’s disease
    • PID: 1479398
    • O’Brien JT, Eagger S, Syed GM, Sahakian BJ, Levy R (1992) A study of regional cerebral blood flow and cognitive performance in Alzheimer’s disease. J Neurol Neurosurg Psychiatry 55:1182–1187
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 1182-1187
    • O’Brien, J.T.1    Eagger, S.2    Syed, G.M.3    Sahakian, B.J.4    Levy, R.5
  • 25
    • 0023943433 scopus 로고
    • Cerebral perfusion as a diagnostic marker of early Alzheimer’s disease
    • COI: 1:STN:280:DyaL1c3hs12rsQ%3D%3D, PID: 3368076
    • Prohovnik I, Mayeux R, Sackeim HA, Smith G, Stern Y, Alderson PO (1988) Cerebral perfusion as a diagnostic marker of early Alzheimer’s disease. Neurology 38:931–937
    • (1988) Neurology , vol.38 , pp. 931-937
    • Prohovnik, I.1    Mayeux, R.2    Sackeim, H.A.3    Smith, G.4    Stern, Y.5    Alderson, P.O.6
  • 26
    • 33645743376 scopus 로고    scopus 로고
    • Cardiovascular disease risk factors and cognitive impairment
    • PID: 16616038
    • Nash DT, Fillit H (2006) Cardiovascular disease risk factors and cognitive impairment. Am J Cardiol 97:1262–1265
    • (2006) Am J Cardiol , vol.97 , pp. 1262-1265
    • Nash, D.T.1    Fillit, H.2
  • 27
    • 61349185049 scopus 로고    scopus 로고
    • Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin
    • COI: 1:CAS:528:DC%2BD1MXisl2rsrc%3D, PID: 19103228
    • Tota S, Kamat PK, Awasthi H, Singh N, Raghubir R, Nath C, Hanif K (2009) Candesartan improves memory decline in mice: involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin. Behav Brain Res 199:235–240
    • (2009) Behav Brain Res , vol.199 , pp. 235-240
    • Tota, S.1    Kamat, P.K.2    Awasthi, H.3    Singh, N.4    Raghubir, R.5    Nath, C.6    Hanif, K.7
  • 28
    • 0029655250 scopus 로고    scopus 로고
    • Ultrastructural features of the blood–brain barrier in biopsy tissue from Alzheimer’s disease patients
    • COI: 1:STN:280:DyaK28zmvFWgsQ%3D%3D, PID: 8773140
    • Claudio L (1996) Ultrastructural features of the blood–brain barrier in biopsy tissue from Alzheimer’s disease patients. Acta Neuropathol 91:6–14
    • (1996) Acta Neuropathol , vol.91 , pp. 6-14
    • Claudio, L.1
  • 29
    • 84907598922 scopus 로고    scopus 로고
    • Disruption of blood–brain barrier in Alzheimer disease pathogenesis
    • PID: 24665385
    • Kook SY, Seok Hong H, Moon M, Mook-Jung I (2013) Disruption of blood–brain barrier in Alzheimer disease pathogenesis. Tissue Barriers 1:e23993
    • (2013) Tissue Barriers , vol.1 , pp. e23993
    • Kook, S.Y.1    Seok Hong, H.2    Moon, M.3    Mook-Jung, I.4
  • 30
    • 0036737795 scopus 로고    scopus 로고
    • Matrix metalloproteinases in neuroinflammation
    • PID: 12203394
    • Rosenberg GA (2002) Matrix metalloproteinases in neuroinflammation. Glia 39:279–291
    • (2002) Glia , vol.39 , pp. 279-291
    • Rosenberg, G.A.1
  • 31
    • 0035405886 scopus 로고    scopus 로고
    • Metalloproteinases in biology and pathology of the nervous system
    • COI: 1:CAS:528:DC%2BD3MXlslGkt7g%3D, PID: 11433375
    • Yong VW, Power C, Forsyth P, Edwards DR (2001) Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci 2:502–511
    • (2001) Nat Rev Neurosci , vol.2 , pp. 502-511
    • Yong, V.W.1    Power, C.2    Forsyth, P.3    Edwards, D.R.4
  • 32
    • 61649121740 scopus 로고    scopus 로고
    • FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage
    • COI: 1:CAS:528:DC%2BD1MXotV2qs7c%3D, PID: 18540945
    • Foster CA, Mechtcheriakova D, Storch MK, Balatoni B, Howard LM, Bornancin F, Wlachos A, Sobanov J et al (2009) FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage. Brain Pathol 19:254–266
    • (2009) Brain Pathol , vol.19 , pp. 254-266
    • Foster, C.A.1    Mechtcheriakova, D.2    Storch, M.K.3    Balatoni, B.4    Howard, L.M.5    Bornancin, F.6    Wlachos, A.7    Sobanov, J.8
  • 33
    • 0025938590 scopus 로고
    • Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease
    • COI: 1:CAS:528:DyaK38Xht1KisL0%3D, PID: 1685745
    • Frohman EM, Frohman TC, Gupta S, de Fougerolles A, van den Noort S (1991) Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer’s disease. J Neurol Sci 106:105–111
    • (1991) J Neurol Sci , vol.106 , pp. 105-111
    • Frohman, E.M.1    Frohman, T.C.2    Gupta, S.3    de Fougerolles, A.4    van den Noort, S.5
  • 34
    • 70349414487 scopus 로고    scopus 로고
    • Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men
    • COI: 1:CAS:528:DC%2BD1MXht1aju7nM, PID: 19409562
    • Wilker EH, Alexeeff SE, Poon A, Litonjua AA, Sparrow D, Vokonas PS, Mittleman MA, Schwartz J (2009) Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men. Atherosclerosis 206:480–485
    • (2009) Atherosclerosis , vol.206 , pp. 480-485
    • Wilker, E.H.1    Alexeeff, S.E.2    Poon, A.3    Litonjua, A.A.4    Sparrow, D.5    Vokonas, P.S.6    Mittleman, M.A.7    Schwartz, J.8
  • 35
    • 84891686758 scopus 로고    scopus 로고
    • Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats
    • COI: 1:CAS:528:DC%2BC2cXht1Gkurk%3D, PID: 24333387
    • Rai S, Kamat PK, Nath C, Shukla R (2014) Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats. Pharmacol Biochem Behav 117:104–117
    • (2014) Pharmacol Biochem Behav , vol.117 , pp. 104-117
    • Rai, S.1    Kamat, P.K.2    Nath, C.3    Shukla, R.4
  • 36
    • 84905054650 scopus 로고    scopus 로고
    • Mechanism of synapse redox stress in Okadaic acid (ICV) induced memory impairment: role of NMDA receptor
    • COI: 1:CAS:528:DC%2BC2cXht1yms7vL, PID: 24984170
    • Kamat PK, Rai S, Swarnkar S, Shukla R, Nath C (2014) Mechanism of synapse redox stress in Okadaic acid (ICV) induced memory impairment: role of NMDA receptor. Neurochem Int 76:32–41
    • (2014) Neurochem Int , vol.76 , pp. 32-41
    • Kamat, P.K.1    Rai, S.2    Swarnkar, S.3    Shukla, R.4    Nath, C.5
  • 37
    • 84888777988 scopus 로고    scopus 로고
    • Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/gamma-secretase
    • PID: 24298159
    • Lee H, Lee EJ, Song YS, Kim E (2014) Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/gamma-secretase. Philos Trans R Soc Lond B Biol Sci 369:20130158
    • (2014) Philos Trans R Soc Lond B Biol Sci , vol.369 , pp. 20130158
    • Lee, H.1    Lee, E.J.2    Song, Y.S.3    Kim, E.4
  • 38
    • 84908222000 scopus 로고    scopus 로고
    • Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer inverted question marks disease mouse model
    • PID: 25213836
    • Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y, Huang X, Xiong W et al (2014) Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer inverted question marks disease mouse model. Mol Brain 7:65
    • (2014) Mol Brain , vol.7 , pp. 65
    • Li, W.1    Yu, J.2    Liu, Y.3    Huang, X.4    Abumaria, N.5    Zhu, Y.6    Huang, X.7    Xiong, W.8
  • 39
    • 84901036009 scopus 로고    scopus 로고
    • The intersection of amyloid beta and tau at synapses in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXosFWjsrY%3D, PID: 24853936
    • Spires-Jones TL, Hyman BT (2014) The intersection of amyloid beta and tau at synapses in Alzheimer’s disease. Neuron 82:756–771
    • (2014) Neuron , vol.82 , pp. 756-771
    • Spires-Jones, T.L.1    Hyman, B.T.2
  • 40
    • 84924078095 scopus 로고    scopus 로고
    • Synapses, spines and kinases in mammalian learning and memory, and the impact of aging
    • van der Zee EA (2014) Synapses, spines and kinases in mammalian learning and memory, and the impact of aging. Neurosci Biobehav Rev 50C:77–85
    • (2014) Neurosci Biobehav Rev , vol.50C , pp. 77-85
    • van der Zee, E.A.1


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