Pore size and LbL chitosan coating influence mesenchymal stem cell in vitro fibrosis and biomineralization in 3D porous poly(epsilon-caprolactone) scaffolds

Journal of Biomedical Materials Research - Part A

Volumn 103, Issue 7, 2015, Pages 2449-2459

  Mehr, Nima Ghavidel ^a,b   Li, Xian ^a   Chen, Gaoping ^a   Favis, Basil D ^a,b   Hoemann, Caroline D ^a  

^a ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

^b DEPARTMENT OF CHEMICAL ENGINEERING   (Canada)

Author keywords

3D; Cell infiltration; Chitosan; In vitro osteogenesis; Mesenchymal stem cell; Mineralization; PCL; Pore size

Indexed keywords

BIOMINERALIZATION; BONE; CELL MEMBRANES; CELLS; CHITIN; CHITOSAN; COATINGS; COMPUTERIZED TOMOGRAPHY; CYTOLOGY; DEPOSITION; FIBROBLASTS; FLOWCHARTING; MINERALOGY; MINERALS; MOBILE SECURITY; POLYELECTROLYTES; PORE SIZE; SCAFFOLDS (BIOLOGY); STEM CELLS; TISSUE ENGINEERING;

CELL INFILTRATION; MESENCHYMAL STEM CELL; MINERALIZATION; OSTEOGENESIS; PCL;

CELL CULTURE;

CALCIUM PHOSPHATE; CHITOSAN; HYDROXYAPATITE; MOLECULAR SCAFFOLD; POLYCAPROLACTONE; POROUS POLYMER; POLYESTER;

ARTICLE; BIOMINERALIZATION; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CALCIFICATION; CELL AGGREGATION; CELL EXPANSION; CELL INFILTRATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FIBROSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIGHT SCATTERING; MATERIAL COATING; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; TISSUE SCAFFOLD; CELL CULTURE; CHEMISTRY; CYTOLOGY; MESENCHYMAL STROMA CELL;

CELLS, CULTURED; CHITOSAN; HUMANS; IN VITRO TECHNIQUES; MESENCHYMAL STROMAL CELLS; POLYESTERS; TISSUE SCAFFOLDS;

EID: 84930144989     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35381     Document Type: Article

References (43)

1. Bauer TW, Muschler GF,. Bone graft materials. An Overview of the Basic Science. Clin Orthop Relat Res 2000; 371: 10-27.
2. Hutmacher DW,. Scaffolds in tissue engineering bone and cartilage. Biomaterials 2000; 21: 2529-2543.
3. Ciapetti G, Ambrosio L, Savarino L, Granchi D, Cenni E, Baldini N, Pagani S, Guizzardi S, Causa F, Giunti A,. Osteoblast growth and function in porous poly ε-caprolactone matrices for bone repair: A preliminary study. Biomaterials 2003; 24: 3815-3824.
4. Rai B, Teoh SH, Ho KH, Hutmacher DW, Cao T, Chen F, Yacob K,. The effect of rhBMP-2 on canine osteoblasts seeded onto 3D bioactive polycaprolactone scaffolds. Biomaterials 2004; 25: 5499-5506.
5. Pham QP, Sharma U, Mikos AG,. Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: Characterization of scaffolds and measurement of cellular infiltration. Biomacromolecules 2006; 7: 2796-2805.
6. Yang X, Chen X, Wang H,. Acceleration of osteogenic differentiation of preosteoblastic cells by chitosan containing nanofibrous scaffolds. Biomacromolecules 2009; 10: 2772-2778.
7. Shalumon KT, Anulekha KH, Chennazhi KP, Tamura H, Nair SV, Jayakumar R,. Fabrication of chitosan/poly(caprolactone) nanofibrous scaffold for bone and skin tissue engineering. Int J Biol Macromol 2011; 48: 571-576.
8. Allaf RM, Rivero IV,. Fabrication and characterization of interconnected porous biodegradable poly(ε-caprolactone) load bearing scaffolds. J Mater Sci Mater Med 2011; 22: 1843-1853.
9. Schagemann JC, Chung HW, Mrosek EH, Stone JJ, Fitzsimmons JS, O'Driscoll SW, Reinholz GG,. Poly-epsilon-caprolactone/gel hybrid scaffolds for cartilage tissue engineering. J Biomed Mater Res A 2010; 93A: 454-463.
10. Thadavirul N, Pavasant P, Supaphol P,. Development of polycaprolactone porous scaffolds by combining solvent casting, particulate leaching, and polymer leaching techniques for bone tissue engineering. J Biomed Mater Res A 2014; 102: 3379-3392.
11. Ghavidel Mehr N, Li X, Ariganello MB, Hoemann CD, Favis BD,. Poly(epsilon-caprolactone) scaffolds of highly controlled porosity and interconnectivity derived from co-continuous polymer blends: model bead and cell infiltration behavior. J Mater Sci Mater Med 2014; 25: 2083-2093.
12. Bayramoglu G, Kayaman-Apohan N, Kahraman MV, Karadenizli S, Kuruca SE, Gungor A,. Preparation of bow tie-type methacrylated poly(caprolactone-co-lactic acid) scaffolds: Effect of collagen modification on cell growth. Polym Adv Technol 2012; 23: 1403-1413.
13. Chastain SR, Kundu AK, Dhar S, Calvert JW, Putnam AJ,. Adhesion of mesenchymal stem cells to polymer scaffolds occurs via distinct ECM ligands and controls their osteogenic differentiation. J Biomed Mater Res A 2006; 78A: 73-85.
14. Zhang H, Lin C-Y, Hollister SJ,. The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds. Biomaterials 2009; 30: 4063-4069.
15. Gloria A, Causa F, Russo T, Battista E, Della Moglie R, Zeppetelli S, De Santis R, Netti PA, Ambrosio L,. Three-dimensional poly(ε-caprolactone) bioactive scaffolds with controlled structural and surface properties. Biomacromolecules 2012; 13: 3510-3521.
16. Zhang HN, Migneco F, Lin CY, Hollister SJ,. Chemically conjugated bone morphogenetic protein-2 on three-dimensional polycaprolactone scaffolds stimulates osteogenic activity in bone marrow stromal cells. Tissue Eng A 2010; 16: 3441-3448.
17. Drevelle O, Daviau A, Lauzon M-A, Faucheux N,. Effect of BMP-2 and/or BMP-9 on preosteoblasts attached to polycaprolactone functionalized by adhesive peptides derived from bone sialoprotein. Biomaterials 2013; 34: 1051-1062.
18. Dubas ST, Kittitheeranun P, Rangkupan R, Sanchavanakit N, Potiyaraj P,. Coating of polyelectrolyte multilayer thin films on nanofibrous scaffolds to improve cell adhesion. J Appl Polym Sci 2009; 114: 1574-1579.
19. Leung M, Jana S, Tsao CT, Zhang MQ,. Tenogenic differentiation of human bone marrow stem cells via a combinatory effect of aligned chitosan-polycaprolactone nanofibers and TGF-beta 3. J Mater Chem B 2013; 1: 6516-6524.
20. Lee K, Jin G, Jang CH, Jung WK, Kim G,. Preparation and characterization of multi-layered poly(epsilon-caprolactone)/chitosan scaffolds fabricated with a combination of melt-plotting/in situ plasma treatment and a coating method for hard tissue regeneration. J Mater Chem B 2013; 1: 5831-5841.
21. Yang Z, Wu YN, Li C, Zhang TT, Zou Y, Hui JHP, Ge ZG, Lee EH,. Improved mesenchymal stem cells attachment and in vitro cartilage tissue formation on Chitosan-modified poly(l-lactide-co-epsilon-caprolactone) scaffold. Tissue Eng A 2012; 18: 242-251.
22. Sasmazel HT,. Novel hybrid scaffolds for the cultivation of osteoblast cells. Int J Biol Macromol 2011; 49: 838-846.
23. Causa F, Netti PA, Ambrosio L, Ciapetti G, Baldini N, Pagani S, Martini D, Giunti A,. Poly- -caprolactone/hydroxyapatite composites for bone regeneration: In vitro characterization and human osteoblast response. J Biomed Mater Res A 2006; 76A: 151-162.
24. Ferrand A, Eap S, Richert L, Lemoine S, Kalaskar D, Demoustier-Champagne S, Atmani H, Mély Y, Fioretti F, Schlatter G, Kuhn L, Ladam G, Benkirane-Jessel N,. Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with Chitosan-based nanoreservoirs of growth factors. Macromolecular Bioscience 2014; 14: 45-55.
25. Hoemann CD, El-Gabalawy H, McKee MD,. In vitro osteogenesis assays: Influence of the primary cell source on alkaline phosphatase activity and mineralization. Pathol Biol 2008; 57: 318-323.
26. Abrahamsson CK, Yang F, Park H, Brunger JM, Valonen PK, Langer R, Welter JF, Caplan AI, Guilak F, Freed LE,. Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds. Tissue Eng A 2010; 16: 3709-3718.
27. Erisken C, Kalyon DM, Wang HJ,. Functionally graded electrospun polycaprolactone and beta-tricalcium phosphate nanocomposites for tissue engineering applications. Biomaterials 2008; 29: 4065-4073.
28. Villalona GA, Udelsman B, Duncan DR, McGillicuddy E, Sawh-Martinez RF, Hibino N, Painter C, Mirensky T, Erickson B, Shinoka T, Breuer CK,. Cell-seeding techniques in vascular tissue engineering. Tissue Eng B Rev 2010; 16: 341-350.
29. Akay G, Birch MA, Bokhari MA,. Microcellular polyHIPE polymer supports osteoblast growth and bone formation in vitro. Biomaterials 2004; 25: 3991-4000.
30. Yuan Z, Favis BD,. Coarsening of immiscible co-continuous blends during quiescent annealing. AIChE J 2005; 51: 271-280.
31. Marchand C, Chen G, Tran-Khanh N, Sun J, Chen H, Buschmann MD, Hoemann CD,. Microdrilled cartilage defects treated with thrombin-solidified chitosan/blood implant regenerate a more hyaline, stable, and structurally integrated osteochondral unit compared to drilled controls. Tissue Eng A 2012; 18: 508-519.
32. Iliescu M, Hoemann CD, Shive MS, Chenite A, Buschmann MD,. Ultrastructure of hybrid chitosan-glycerol phosphate blood clots by environmental scanning electron microscopy. Microsc Res Tech 2008; 71: 236 -247.
33. Graziano A, D'Aquino R, Angelis M, De Francesco F, Giordano A, Laino G, Piattelli A, Traini T, De Rosa A, Papaccio G,. Scaffold's surface geometry significantly affects human stem cell bone tissue engineering. J Cell Physiol 2008; 214: 166-172.
34. Oliveira JM, Sousa RA, Kotobuki N, Tadokoro M, Hirose M, Mano JF, Reis RL, Ohgushi H,. The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles. Biomaterials 2009; 30: 804-813.
35. Lacey DC, Simmons PJ, Graves SE, Hamilton JA,. Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: Implications for bone repair during inflammation. Osteoarthritis Cartilage 2009; 17: 735-742.
36. Guzman-Morales J, El-Gabalawy H, Pham MH, Tran-Khanh N, McKee MD, Wu W, Centola M, Hoemann CD,. Effect of chitosan particles and dexamethasone on human bone marrow stromal cell osteogenesis and angiogenic factor secretion. Bone 2009; 45: 617-626.
37. Chou Y-F, Dunn JCY, Wu BM,. In vitro response of MC3T3-E1 preosteoblasts within three-dimensional apatite-coated PLGA scaffolds. J Biomed Mater Res B Appl Biomater 2005; 75B: 81-90.
38. Hong SJ, Jeong I, Noh KT, Yu HS, Lee GS, Kim HW,. Robotic dispensing of composite scaffolds and in vitro responses of bone marrow stromal cells. J Mater Sci Mater Med 2009; 20: 1955-1962.
39. Marquis ME, Lord E, Bergeron E, Drevelle O, Park H, Cabana F, Senta H, Faucheux N,. Bone cells-biomaterials interactions. Front Biosci (Landmark Ed) 2009; 14: 1023 -10 67.
40. Chappard C, Peyrin F, Bonnassie A, Lemineur G, Brunet-Imbault B, Lespessailles E, Benhamou CL,. Subchondral bone micro-architectural alterations in osteoarthritis: A synchrotron micro-computed tomography study. Osteoarthritis Cartilage 2006; 14: 215-223.
41. Frohlich M, Grayson WL, Wan LQ, Marolt D, Drobnic M, Vunjak-Novakovic G,. Tissue engineered bone grafts: Biological requirements, tissue culture and clinical relevance. Curr Stem Cell Res Ther 2008; 3: 254-264.
42. Seol YJ, Lee JY, Park Y-J,KY, Rhyu I-C, Lee S-J, Han S-B, Chung C-P,. Chitosan sponges as tissue engineering scaffolds for bone formation. Biotechnol Lett 2004; 26: 1037 -10 41.
43. Xia Y, Zhou PY, Cheng XS, Xie Y, Liang C, Li C, Xu SG,. Selective laser sintering fabrication of nano-hydroxyapatite/poly-epsilon-caprolactone scaffolds for bone tissue engineering applications. Int J Nanomed 2013; 8: 4197-4213.