Development of polycaprolactone porous scaffolds by combining solvent casting, particulate leaching, and polymer leaching techniques for bone tissue engineering

Journal of Biomedical Materials Research - Part A

Volumn 102, Issue 10, 2014, Pages 3379-3392

  Thadavirul, Napapaphat ^a   Pavasant, Prasit ^a   Supaphol, Pitt ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

bone scaffolds; dual leaching method; polycaprolactone; polymer leaching method; solvent casting particulate leaching method

Indexed keywords

BONE; DENSITY (SPECIFIC GRAVITY); LEACHING; POLYCAPROLACTONE; POLYMERS;

BONE SCAFFOLDS; BONE TISSUE ENGINEERING; HIGH INTERCONNECTIVITY; LEACHING METHODS; POLYCAPROLACTONE SCAFFOLDS; POLYETHYLENE GLYCOL (PEG); PREOSTEOBLASTIC CELLS; SCAFFOLDING MATERIALS;

SCAFFOLDS (BIOLOGY);

BIOMATERIAL; MACROGOL; POLYCAPROLACTONE; POLYMER; SODIUM CHLORIDE; SOLVENT; ALKALINE PHOSPHATASE; MACROGOL DERIVATIVE; POLYESTER; WATER;

ANIMAL CELL; ARTICLE; BONE CELL; BONE TISSUE; CALVARIA; CELL DIFFERENTIATION; CELL PROLIFERATION; DENSITY; IN VITRO STUDY; LEACHING; MECHANICS; MOUSE; NONHUMAN; POROSITY; PROCEDURES; TISSUE ENGINEERING; TISSUE SCAFFOLD; WATER ABSORPTION; ABSORPTION; ANIMAL; BONE; BONE MINERALIZATION; CELL ADHESION; CELL LINE; CELL SHAPE; CHEMISTRY; COMPRESSIVE STRENGTH; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; FLOW KINETICS; METABOLISM; OSTEOBLAST; PHYSIOLOGY;

ABSORPTION, PHYSICOCHEMICAL; ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CELL ADHESION; CELL LINE; CELL PROLIFERATION; CELL SHAPE; COMPRESSIVE STRENGTH; FIBROBLASTS; MICE; OSTEOBLASTS; POLYESTERS; POLYETHYLENE GLYCOLS; POROSITY; RHEOLOGY; SOLVENTS; TISSUE ENGINEERING; TISSUE SCAFFOLDS; WATER;

EID: 84906785638     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35010     Document Type: Article

References (44)

1. Hyun JC, Tae GP,. Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Adv Drug Deliv Rev 2007; 59: 249-262.
2. Woesz A,. Rapid prototyping to produce porous scaffolds with controlled architecture for possible use in bone tissue engineering. Virtual Prototyping & Bio Manufacturing in Medical Applications; 2008. p 171-205; chapter 9.
3. Sinha VR, Bansal K, Kaushik R, Kumiria R, Trehan A,. Poly-ε- caprolactone microspheres and nanospheres: An overview. Int J Pharm 2004; 278: 1-23.
4. Nam YS, Park TG,. Porous Biodegradable polymeric scaffolds by thermally induced phase separation. Biomed Mater Res 1999; 47: 7-17.
5. Hutmacher DW., Scaffolds in tissue engineering bone and cartilage. Biomater Sci Polym Ed 2001;12: 107-124.
6. Lee JH, Park TG, Park HS, Lee DS, Lee YK, Yoon SC, Nam J,. Thermal and mechanical characteristics of poly(l -lactic acid) nanocomposite scaffold. Biomaterials 2003; 24: 2773-2778.
7. Carletti E, Motta A, Migliaresi C,. Scaffolds for tissue engineering and 3D cell culture. Methods in Mol Biol 2011; 695: 17-39.
8. Kim HJ, Kim UJ, Leisk GG, Bayan C, Georgakoudi I, Kaplan DL,. Bone regeneration on macroporous aqueous-derived silk 3-D scaffolds. Macromol Biosci 2007; 7: 643-655.
9. Pattison MA, Wurster S, Webster TJ, Haberstroh KM,. Three-dimensional, nano-structured PLGA scaffolds for bladder tissue replacement applications. Biomaterials 2005; 25: 2491-2500.
10. Yoon JJ, Song SH, Lee SS, Park TG,. Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method. Biomaterials 2004; 25: 5613-5620.
11. Shin M, Abukawa H, Troulis MJ, Vacanti JP,. Development of a biodegradable scaffold with interconnected pores by heat fusion and its application to bone tissue engineering. Biomed Mater Res A 2008; 84: 702-709.
12. Sokolsky-Papkov M, Agashi K, Olaye A, Shakesheff K, Domb AJ,. Polymer carriers for drug delivery in tissue engineering. Adv Drug Deliv Rev 2007; 59: 187-206.
13. Cao Y, Croll T, Lees JG, Tuch BE, Cooper-White JJ,. Scaffolds, stem cells, and tissue engineering: A potent combination. Aust J Chem 2005; 58: 691-703.
14. Ekaputra AK, Prestwich GD, Cool SM, Hutmacher DW,. Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs. Biomacromolecules 2008; 9: 2097-2103.
15. Lin WJ, Lu CK,. Characterization and permeation of microporous poly(ε-caprolactone) films. J Membr Sci 2002; 198: 109-118.
16. Lin WJ, Lee HG,. Design of a microporous controlled delivery system for theophylline tablets. J controlled Release 2003; 89: 179-187.
17. Kesting RE,. Synthetic Polymeric Membranes: A Structural Perspective. New York: John Wiley & Sons; 1985. p 348.
18. Harris JM,. Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications; 1992. p 408.
19. Yang G, Zhang HF,. Role of polyethylene glycol in formation and structure of regenerated cellulose microporous membrane. J Membr Sci 1999; 161: 31.
20. Chuenjitkuntawown B, Inrung W, Damrongsri D, Mekaapiruk K, Supaphol P, Pavasant P,. Polycaprolactone/hydroxyapatite composite scaffolds: Preparation, characterization, and in vitro and in vivo biological responses of human primary bone cells. J Biomed Mater Res Part A 2009; 241-251.
21. Hariraksapitak P, Suwantong O, Pavasant P, Supaphol P,. Effectual drug-releasing porous scaffolds from 1,6-diisocyanatohexane-extended poly(1,4-butylene succinate) for bone tissue regeneration. Polymer, Elsevier 2008; 49: 2678-2685.
22. Mikos AG, Sarakinos G, Lyman MD, Ingber DE, Vacanti, JP, Langer RS,. Prevascularization of porous biodegradable polymers. Biotechnol Bioeng 1993; 42: 716-723.
23. Yang Q, Chen L, Shen XY, Tan ZQ,. Preparation of polycaprolactone tissue engineering scaffolds by improved solvent casting/particulate leaching method. J Macromol Sci B: Phys 2006; 45: 1171-1181.
24. Karageorgiou V, Kaplan D,. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005; 26: 5474-5491.
25. Ren J, Zhao P, Ren T, Gu S, Pan K,. Poly (d,l -lactide)/ nanohydroxyapatite composite scaffolds for bone tissue engineering and biocompatibility evaluation. J Mater Sci: Mater Med 2008; 19: 1075-1082.
26. Takahashi Y, Tabata YJ., Effect of the fiber diameter and porosity of non-woven PET fabrics on the osteogenic differentiation of mesenchymal stem cells. Biomater Sci Polym Ed 2004;15: 41-57.
27. Lee H, Park TG,. Design Principles in Biomaterials and Scaffold; 2007. p 580-593; chapter 33.
28. Desmet T, Morent R, Geyter ND, Leys C, Schacht E, Dubruel P,. Nonthermal plasma technology as a versatile strategy for polymeric biomaterials surface modification: A review. Biomacromolecules 2009; 10: 2351-2378.
29. Lee HJ, Ahn SH, Kim GH,. Three-dimensional collagen/alginate hybrid scaffolds functionalized with a drug delivery system (DDS) for bone tissue regeneration. Chem Mater 2011;10.
30. Draghi L, Resta S, Pirozzolo MG, Tanzi MC,. Microspheres leaching for scaffold porosity control. J Mater Sci: Mater Med 2005; 16: 1093-1097.
31. Stamatialis DF, Papenburg BJ, Girones M, Saiful S, Bettahalli SNM, Schmitmeier S, Wessling M,. Medical applications of membranes: Drug delivery, artificial organs and tissue engineering. J Membr Sci 2008; 308: 1-34.
32. Lee CT, Huang CP, Lee YD,. Biomimetic porous scaffolds made from poly(l-lactide)-g-chondroitin sulfate blend with poly(l -lactide) for cartilage tissue engineering. Biomacromolecules 2006; 7: 2200-2209.
33. Lim YM, Gwon HJ, Shin J, Jeun JP, Nho YC,. Preparation of porous poly(e-caprolactone) scaffolds by gas foaming process and in vitro/in vivo degradation behavior using g-ray irradiation. J Ind Eng Chem 2008; 14: 436-441.
34. Sarazin P, Roy X, Favis BD,. Controlled preparation and properties of porous poly(l -lactide) obtained from a co-continuous blend of two biodegradable polymers. Biomaterials 2004; 25: 5965-5978.
35. Dorati R, Colonna C, Genta I, Modena T, Conti B,. Effect of porogen on the physico-chemical properties and degradation performance of PLGA scaffolds. Polym Degrad Stabil 2010; 95: 694-701.
36. Rezwan K, Chen QZ, Blaker JJ, Boccacini AR,. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 2006; 27: 3413-3431.
37. Wutticharoenmongkol P, Pavasant P, Supaphol P,. Osteoblastic phenotype expression of MC3T3-E1 cultured on electrospun polycaprolactone fiber mats filled with hydroxyapatite nanoparticles. Biomacromolecules 2007; 8: 2602-2610.
38. Lee YH, Lee JH, An IG, Kim C, Lee DS, Lee YK, Nam JD,. Electrospun dual-porosity structure and biodegradation morphology of montmorillonite reinforced PLLA nanocomposite scaffolds. Biomaterials 2005; 26: 3165-3172.
39. Shum AWT, Li J, Mak AFT,. Fabrication and structural characterization of porous biodegradable poly(dl -lactic-co-glycolic acid) scaffolds with controlled range of pore sizes. Polym Degrad Stabil 2005; 87: 487-493.
40. Sombatmankhong K, Sanchavanakit N, Pavasant P, Supaphol P,. Bone scaffolds from electrospun fiber mats of poly(3-hydroxybutyrate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and their blend. Polymers 2007; 48: 1419-1427.
41. Sangsanoh P, Waleetorncheepsawat S, Suwantong O, Wuttcharoenmongkol P, Weeranantanapan O, Chuenjitbuntaworn B, Cheepsunthorn P, Pavasant P, Supaphol P,. In vitro biocompatibility of Schwann cells on surfaces of biocompatible polymeric electrospun fibrous and solution-cast film scaffolds. Biomacromolecules 2007; 8: 1587-1594.
42. Chuenjitbuntaworn B, Supaphol P, Pavasant P, Damrongsri D,. Electrospun poly(l -lactic acid)/hydroxyapatite composite fibrous scaffolds for bone tissue engineering. Polym Int 2010; 59: 227-235.
43. Wutticharoenmongkol P, Sanchavanakit N, Pavasant P, Supaphol P,. Preparation and characterization of novel bone scaffolds based on electrospun polycaprolactone fibers filled with nanoparticles. J Nanosci Nanotechnol 2006; 6: 514-522.
44. Yang Q, Chen L, Shen X, Tan Z,. J Macromol Sci B: Phys 2006; 45: 1171-1181.